1xub - Revision history

OCA at 08:09, 25 October 2023

OCA — Wed, 25 Oct 2023 08:09:12 GMT

←Older revision		Revision as of 08:09, 25 October 2023
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	<StructureSection load='1xub' size='340' side='right'caption='[[1xub]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='1xub' size='340' side='right'caption='[[1xub]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xub]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_fluorescens_liquefaciens"_flugge_1886 "bacillus~~ fluorescens ~~liquefaciens" flugge 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XUB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xub]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XUB FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1u1v\|1u1v]], [[1u1w\|1u1w]], [[1u1x\|1u1x]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xub OCA], [https://pdbe.org/1xub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xub RCSB], [https://www.ebi.ac.uk/pdbsum/1xub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xub ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xub OCA], [https://pdbe.org/1xub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xub RCSB], [https://www.ebi.ac.uk/pdbsum/1xub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xub ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PHZF_PSEFL PHZF_PSEFL]] Isomerase that catalyzes the condensation of two molecules of trans-2,3-dihydro-3-hydroxyanthranilic acid (DHHA) into the phenazine ring system. The final product is not yet known.<ref>PMID:19053436</ref> <ref>PMID:15545603</ref>	+	[https://www.uniprot.org/uniprot/PHZF_PSEFL PHZF_PSEFL] Isomerase that catalyzes the condensation of two molecules of trans-2,3-dihydro-3-hydroxyanthranilic acid (DHHA) into the phenazine ring system. The final product is not yet known.<ref>PMID:19053436</ref> <ref>PMID:15545603</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus fluorescens liquefaciens flugge 1886]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bayer, P]]	+	[[Category: Pseudomonas fluorescens]]
-	[[Category: Blankenfeldt, W]]	+	[[Category: Bayer P]]
-	[[Category: Janning, P]]	+	[[Category: Blankenfeldt W]]
-	[[Category: Korniyenko, Y]]	+	[[Category: Janning P]]
-	[[Category: Kuzin~~, A P~~]]	+	[[Category: Korniyenko Y]]
-	[[Category: Mavrodi~~, D V~~]]	+	[[Category: Kuzin AP]]
-	[[Category: Skarina, T]]	+	[[Category: Mavrodi DV]]
-	[[Category: Thomashow~~, L S~~]]	+	[[Category: Skarina T]]
-	[[Category: Tong, L]]	+	[[Category: Thomashow LS]]
-	~~[[Category: Biosynthetic protein]]~~	+	[[Category: Tong L]]
-	~~[[Category: Phenazine biosynthesis~~]]	+

OCA at 16:19, 3 November 2021

OCA — Wed, 03 Nov 2021 16:19:36 GMT

←Older revision		Revision as of 16:19, 3 November 2021
Line 3:		Line 3:
	<StructureSection load='1xub' size='340' side='right'caption='[[1xub]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='1xub' size='340' side='right'caption='[[1xub]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xub]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_fluorescens_liquefaciens"_flugge_1886 "bacillus fluorescens liquefaciens" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1XUB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xub]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_fluorescens_liquefaciens"_flugge_1886 "bacillus fluorescens liquefaciens" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XUB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u1v\|1u1v]], [[1u1w\|1u1w]], [[1u1x\|1u1x]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1u1v\|1u1v]], [[1u1w\|1u1w]], [[1u1x\|1u1x]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1xub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xub OCA], [~~http~~://pdbe.org/1xub PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1xub RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1xub PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1xub ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xub OCA], [https://pdbe.org/1xub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xub RCSB], [https://www.ebi.ac.uk/pdbsum/1xub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xub ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PHZF_PSEFL PHZF_PSEFL]] Isomerase that catalyzes the condensation of two molecules of trans-2,3-dihydro-3-hydroxyanthranilic acid (DHHA) into the phenazine ring system. The final product is not yet known.<ref>PMID:19053436</ref> <ref>PMID:15545603</ref>	+	[[https://www.uniprot.org/uniprot/PHZF_PSEFL PHZF_PSEFL]] Isomerase that catalyzes the condensation of two molecules of trans-2,3-dihydro-3-hydroxyanthranilic acid (DHHA) into the phenazine ring system. The final product is not yet known.<ref>PMID:19053436</ref> <ref>PMID:15545603</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 16:55, 29 January 2020

OCA — Wed, 29 Jan 2020 16:55:51 GMT

←Older revision		Revision as of 16:55, 29 January 2020
Line 1:		Line 1:

	==Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens==		==Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens==
-	<StructureSection load='1xub' size='340' side='right' caption='[[1xub]], [[Resolution\|resolution]] 1.30Å' scene=''>	+	<StructureSection load='1xub' size='340' side='right'caption='[[1xub]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xub]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_fluorescens_liquefaciens"_flugge_1886 "bacillus fluorescens liquefaciens" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XUB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xub]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_fluorescens_liquefaciens"_flugge_1886 "bacillus fluorescens liquefaciens" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XUB FirstGlance]. <br>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus fluorescens liquefaciens flugge 1886]]		[[Category: Bacillus fluorescens liquefaciens flugge 1886]]
		+	[[Category: Large Structures]]
	[[Category: Bayer, P]]		[[Category: Bayer, P]]
	[[Category: Blankenfeldt, W]]		[[Category: Blankenfeldt, W]]

OCA at 07:13, 18 April 2018

OCA — Wed, 18 Apr 2018 07:13:15 GMT

←Older revision		Revision as of 07:13, 18 April 2018
Line 1:		Line 1:
		+
	==Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens==		==Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens==
	<StructureSection load='1xub' size='340' side='right' caption='[[1xub]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='1xub' size='340' side='right' caption='[[1xub]], [[Resolution\|resolution]] 1.30Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u1v\|1u1v]], [[1u1w\|1u1w]], [[1u1x\|1u1x]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u1v\|1u1v]], [[1u1w\|1u1w]], [[1u1x\|1u1x]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xub OCA], [http://pdbe.org/1xub PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xub RCSB], [http://www.ebi.ac.uk/pdbsum/1xub PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xub OCA], [http://pdbe.org/1xub PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xub RCSB], [http://www.ebi.ac.uk/pdbsum/1xub PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xub ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xu/1xub_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xu/1xub_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 23:26, 8 February 2016

OCA — Mon, 08 Feb 2016 23:26:23 GMT

←Older revision		Revision as of 23:26, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xub ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:23, 10 September 2015

OCA — Thu, 10 Sep 2015 16:23:00 GMT

←Older revision		Revision as of 16:23, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1xub' size='340' side='right' caption='[[1xub]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='1xub' size='340' side='right' caption='[[1xub]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xub]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudomonas_fluorescens Pseudomonas~~ fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XUB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xub]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_fluorescens_liquefaciens"_flugge_1886 "bacillus fluorescens liquefaciens" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XUB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u1v\|1u1v]], [[1u1w\|1u1w]], [[1u1x\|1u1x]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u1v\|1u1v]], [[1u1w\|1u1w]], [[1u1x\|1u1x]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xub OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xub RCSB], [http://www.ebi.ac.uk/pdbsum/1xub PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xub OCA], [http://pdbe.org/1xub PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xub RCSB], [http://www.ebi.ac.uk/pdbsum/1xub PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1xub" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Pseudomonas~~ fluorescens]]	+	[[Category: Bacillus fluorescens liquefaciens flugge 1886]]
	[[Category: Bayer, P]]		[[Category: Bayer, P]]
	[[Category: Blankenfeldt, W]]		[[Category: Blankenfeldt, W]]

OCA at 02:52, 25 December 2014

OCA — Thu, 25 Dec 2014 02:52:13 GMT

←Older revision		Revision as of 02:52, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xub]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XUB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xub]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XUB FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u1v\|1u1v]], [[1u1w\|1u1w]], [[1u1x\|1u1x]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u1v\|1u1v]], [[1u1w\|1u1w]], [[1u1x\|1u1x]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xub OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xub RCSB], [http://www.ebi.ac.uk/pdbsum/1xub PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xub OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xub RCSB], [http://www.ebi.ac.uk/pdbsum/1xub PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PHZF_PSEFL PHZF_PSEFL]] Isomerase that catalyzes the condensation of two molecules of trans-2,3-dihydro-3-hydroxyanthranilic acid (DHHA) into the phenazine ring system. The final product is not yet known.<ref>PMID:19053436</ref> <ref>PMID:15545603</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Pseudomonas fluorescens]]		[[Category: Pseudomonas fluorescens]]
-	[[Category: Bayer, P.]]	+	[[Category: Bayer, P]]
-	[[Category: Blankenfeldt, W.]]	+	[[Category: Blankenfeldt, W]]
-	[[Category: Janning, P.]]	+	[[Category: Janning, P]]
-	[[Category: Korniyenko, Y.]]	+	[[Category: Korniyenko, Y]]
-	[[Category: Kuzin, A P.]]	+	[[Category: Kuzin, A P]]
-	[[Category: Mavrodi, D V.]]	+	[[Category: Mavrodi, D V]]
-	[[Category: Skarina, T.]]	+	[[Category: Skarina, T]]
-	[[Category: Thomashow, L S.]]	+	[[Category: Thomashow, L S]]
-	[[Category: Tong, L.]]	+	[[Category: Tong, L]]
	[[Category: Biosynthetic protein]]		[[Category: Biosynthetic protein]]
	[[Category: Phenazine biosynthesis]]		[[Category: Phenazine biosynthesis]]

OCA at 18:31, 29 September 2014

OCA — Mon, 29 Sep 2014 18:31:28 GMT

←Older revision		Revision as of 18:31, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1xub.~~png~~\|~~left~~\|200px]]	+	==Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens==
		+	<StructureSection load='1xub' size='340' side='right' caption='[[1xub]], [[Resolution\|resolution]] 1.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1xub]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XUB FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u1v\|1u1v]], [[1u1w\|1u1w]], [[1u1x\|1u1x]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xub OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xub RCSB], [http://www.ebi.ac.uk/pdbsum/1xub PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xu/1xub_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Phenazines produced by Pseudomonas and Streptomyces spp. are heterocyclic nitrogen-containing metabolites with antibiotic, antitumor, and antiparasitic activity. The antibiotic properties of pyocyanin, produced by Pseudomonas aeruginosa, were recognized in the 1890s, although this blue phenazine is now known to be a virulence factor in human disease. Despite their biological significance, the biosynthesis of phenazines is not fully understood. Here we present structural and functional studies of PhzF, an enzyme essential for phenazine synthesis in Pseudomonas spp. PhzF shares topology with diaminopimelate epimerase DapF but lacks the same catalytic residues. The structure of PhzF in complex with its substrate, trans-2,3-dihydro-3-hydroxyanthranilic acid, suggests that it is an isomerase using the conserved glutamate E45 to abstract a proton from C3 of the substrate. The proton is returned to C1 of the substrate after rearrangement of the double-bond system, yielding an enol that converts to the corresponding ketone. PhzF is a dimer that may be bifunctional, providing a shielded cavity for ketone dimerization via double Schiff-base formation to produce the phenazine scaffold. Our proposed mechanism is supported by mass and NMR spectroscopy. The results are discussed in the context of related structures and protein sequences of unknown biochemical function.

-	~~{{STRUCTURE_1xub\| PDB=1xub \| SCENE= }}~~	+	Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens.,Blankenfeldt W, Kuzin AP, Skarina T, Korniyenko Y, Tong L, Bayer P, Janning P, Thomashow LS, Mavrodi DV Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16431-6. Epub 2004 Nov 15. PMID:15545603<ref>PMID:15545603</ref>

-	~~===Structure and function~~ of the ~~phenazine biosynthetic protein PhzF from Pseudomonas fluorescens===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15545603}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1xub]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1XUB OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015545603<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Pseudomonas fluorescens]]		[[Category: Pseudomonas fluorescens]]
	[[Category: Bayer, P.]]		[[Category: Bayer, P.]]

OCA: Protected "1xub" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 11:11:26 GMT

Protected "1xub" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:11, 5 January 2013

OCA at 11:11, 5 January 2013

OCA — Sat, 05 Jan 2013 11:11:23 GMT

←Older revision		Revision as of 11:11, 5 January 2013
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-	{{Seed}}
	[[Image:1xub.png\|left\|200px]]		[[Image:1xub.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1xub", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1xub\| PDB=1xub \| SCENE= }}		{{STRUCTURE_1xub\| PDB=1xub \| SCENE= }}

	===Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens===		===Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15545603}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15545603 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15545603}}		{{ABSTRACT_PUBMED_15545603}}

	==About this Structure==		==About this Structure==
-	~~1XUB~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUB OCA].	+	[[1xub]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUB OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15545603~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015545603</ref><references group="xtra"/>
	[[Category: Pseudomonas fluorescens]]		[[Category: Pseudomonas fluorescens]]
	[[Category: Bayer, P.]]		[[Category: Bayer, P.]]
Line 34:		Line 22:
	[[Category: Thomashow, L S.]]		[[Category: Thomashow, L S.]]
	[[Category: Tong, L.]]		[[Category: Tong, L.]]
		+	[[Category: Biosynthetic protein]]
	[[Category: Phenazine biosynthesis]]		[[Category: Phenazine biosynthesis]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:23:16 2009''