1xv4 - Revision history

OCA at 12:36, 10 January 2024

OCA — Wed, 10 Jan 2024 12:36:54 GMT

←Older revision		Revision as of 12:36, 10 January 2024
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	==Solution structure of antimicrobial and endotoxin-neutralizing peptide Lf11 in SDS micelles==		==Solution structure of antimicrobial and endotoxin-neutralizing peptide Lf11 in SDS micelles==
-	<StructureSection load='1xv4' size='340' side='right'caption='[[1xv4~~]], [[NMR_Ensembles_of_Models \| 7 NMR models~~]]' scene=''>	+	<StructureSection load='1xv4' size='340' side='right'caption='[[1xv4]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xv4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XV4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xv4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XV4 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand~~=~~NH2:AMINO+GROUP'>NH2</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1xv7\|1xv7]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv4 OCA], [https://pdbe.org/1xv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xv4 RCSB], [https://www.ebi.ac.uk/pdbsum/1xv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xv4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv4 OCA], [https://pdbe.org/1xv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xv4 RCSB], [https://www.ebi.ac.uk/pdbsum/1xv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xv4 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TRFL_HUMAN TRFL_HUMAN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref> Lactotransferrin has antimicrobial activity which depends on the extracellular cation concentration.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref> Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref> The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref> Isoform DeltaLf: transcription factor with antiproliferative properties and inducing cell cycle arrest. Binds to DeltaLf response element found in the SKP1, BAX, DCPS, and SELH promoters.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Japelj, B]]	+	[[Category: Japelj B]]
-	[[Category: Jerala, R]]	+	[[Category: Jerala R]]
-	[[Category: Majerle, A]]	+	[[Category: Majerle A]]
-	[[Category: Pristovsek, P]]	+	[[Category: Pristovsek P]]
-	~~[[Category: Hydrophobic core]]~~	+
-	~~[[Category: Loop]]~~	+
-	~~[[Category: Metal transport~~]]	+

OCA at 10:52, 6 April 2022

OCA — Wed, 06 Apr 2022 10:52:52 GMT

←Older revision		Revision as of 10:52, 6 April 2022
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	<StructureSection load='1xv4' size='340' side='right'caption='[[1xv4]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>		<StructureSection load='1xv4' size='340' side='right'caption='[[1xv4]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xv4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1XV4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xv4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XV4 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xv7\|1xv7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xv7\|1xv7]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1xv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv4 OCA], [~~http~~://pdbe.org/1xv4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1xv4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1xv4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1xv4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv4 OCA], [https://pdbe.org/1xv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xv4 RCSB], [https://www.ebi.ac.uk/pdbsum/1xv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xv4 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:37, 25 June 2020

OCA — Thu, 25 Jun 2020 06:37:15 GMT

←Older revision		Revision as of 06:37, 25 June 2020
Line 3:		Line 3:
	<StructureSection load='1xv4' size='340' side='right'caption='[[1xv4]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>		<StructureSection load='1xv4' size='340' side='right'caption='[[1xv4]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xv4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV4 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1XV4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xv4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1XV4 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xv7\|1xv7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xv7\|1xv7]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1xv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv4 OCA], [http://pdbe.org/1xv4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1xv4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xv4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1xv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv4 OCA], [http://pdbe.org/1xv4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1xv4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xv4 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:34, 29 January 2020

OCA — Wed, 29 Jan 2020 16:34:32 GMT

←Older revision		Revision as of 16:34, 29 January 2020
Line 1:		Line 1:

	==Solution structure of antimicrobial and endotoxin-neutralizing peptide Lf11 in SDS micelles==		==Solution structure of antimicrobial and endotoxin-neutralizing peptide Lf11 in SDS micelles==
-	<StructureSection load='1xv4' size='340' side='right' caption='[[1xv4]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>	+	<StructureSection load='1xv4' size='340' side='right'caption='[[1xv4]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xv4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XV4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xv4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XV4 FirstGlance]. <br>
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Japelj, B]]		[[Category: Japelj, B]]
	[[Category: Jerala, R]]		[[Category: Jerala, R]]

OCA at 06:54, 18 April 2018

OCA — Wed, 18 Apr 2018 06:54:58 GMT

←Older revision		Revision as of 06:54, 18 April 2018
Line 1:		Line 1:
		+
	==Solution structure of antimicrobial and endotoxin-neutralizing peptide Lf11 in SDS micelles==		==Solution structure of antimicrobial and endotoxin-neutralizing peptide Lf11 in SDS micelles==
	<StructureSection load='1xv4' size='340' side='right' caption='[[1xv4]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>		<StructureSection load='1xv4' size='340' side='right' caption='[[1xv4]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xv7\|1xv7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xv7\|1xv7]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv4 OCA], [http://pdbe.org/1xv4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1xv4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv4 OCA], [http://pdbe.org/1xv4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1xv4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xv4 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:15, 10 September 2015

OCA — Thu, 10 Sep 2015 02:15:05 GMT

←Older revision		Revision as of 02:15, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xv7\|1xv7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xv7\|1xv7]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1xv4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv4 OCA], [http://pdbe.org/1xv4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1xv4 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1xv4" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 08:50, 8 January 2015

OCA — Thu, 08 Jan 2015 08:50:20 GMT

←Older revision		Revision as of 08:50, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xv4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XV4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xv4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XV4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xv7\|1xv7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xv7\|1xv7]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1xv4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1xv4 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Japelj, B.]]	+	[[Category: Japelj, B]]
-	[[Category: Jerala, R.]]	+	[[Category: Jerala, R]]
-	[[Category: Majerle, A.]]	+	[[Category: Majerle, A]]
-	[[Category: Pristovsek, P.]]	+	[[Category: Pristovsek, P]]
	[[Category: Hydrophobic core]]		[[Category: Hydrophobic core]]
	[[Category: Loop]]		[[Category: Loop]]
	[[Category: Metal transport]]		[[Category: Metal transport]]

OCA at 23:10, 28 September 2014

OCA — Sun, 28 Sep 2014 23:10:13 GMT

←Older revision		Revision as of 23:10, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1xv4.~~png~~\|~~left~~\|~~200px~~]]	+	==Solution structure of antimicrobial and endotoxin-neutralizing peptide Lf11 in SDS micelles==
		+	<StructureSection load='1xv4' size='340' side='right' caption='[[1xv4]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1xv4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XV4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xv7\|1xv7]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1xv4 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Treatment of Gram-negative bacterial infections with antimicrobial agents can cause release of the endotoxin lipopolysaccharide (LPS), the potent initiator of sepsis, which is the major cause of mortality in intensive care units worldwide. Structural information on peptides bound to LPS can lead to the development of more effective endotoxin neutralizers. Short linear antimicrobial and endotoxin-neutralizing peptide LF11, based on the human lactoferrin, binds to LPS, inducing a peptide fold with a "T-shaped" arrangement of a hydrophobic core and two clusters of basic residues that match the distance between the two phosphate groups of LPS. Side chain arrangement of LF11 bound to LPS extends the previously proposed LPS binding pattern, emphasizing the importance of both electrostatic and hydrophobic interactions in a defined geometric arrangement. In anionic micelles, the LF11 forms amphipathic conformation with a smaller hydrophobic core than in LPS, whereas in zwitterionic micelles, the structure is even less defined. Protection of tryptophan fluorescence quenching in the order SDS>LPS>DPC and hydrogen exchange protection indicates the decreasing extent of insertion of the N terminus and potential role of peptide plasticity in differentiation between bacterial and eukaryotic membranes.

-	~~{{STRUCTURE_1xv4\| PDB=1xv4 \| SCENE= }}~~	+	Structural origin of endotoxin neutralization and antimicrobial activity of a lactoferrin-based peptide.,Japelj B, Pristovsek P, Majerle A, Jerala R J Biol Chem. 2005 Apr 29;280(17):16955-61. Epub 2005 Feb 1. PMID:15687491<ref>PMID:15687491</ref>

-	~~===Solution structure~~ of ~~antimicrobial and endotoxin-neutralizing peptide Lf11 in SDS micelles===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15687491}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1xv4]] is a 1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1XV4 OCA].~~	+

	==See Also==		==See Also==
	*[[Lactoferrin\|Lactoferrin]]		*[[Lactoferrin\|Lactoferrin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015687491<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Japelj, B.]]		[[Category: Japelj, B.]]
	[[Category: Jerala, R.]]		[[Category: Jerala, R.]]

OCA at 06:52, 20 October 2012

OCA — Sat, 20 Oct 2012 06:52:47 GMT

←Older revision		Revision as of 06:52, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1xv4]] is a 1 chain structure ~~of [[Lactoferrin]]~~. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV4 OCA].	+	[[1xv4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV4 OCA].

	==See Also==		==See Also==

OCA: Protected "1xv4" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 14:36:26 GMT

Protected "1xv4" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:36, 25 July 2012