1xvd - Revision history

OCA at 06:49, 23 August 2023

OCA — Wed, 23 Aug 2023 06:49:44 GMT

←Older revision		Revision as of 06:49, 23 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xvd]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylococcus_capsulatus Methylococcus capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XVD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xvd]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylococcus_capsulatus Methylococcus capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XVD FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>~~, ~~<scene name='pdbligand=FPN:4-FLUOROPHENOL'>FPN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1xu3\|1xu3]], [[1xu5\|1xu5]], [[1xvb\|1xvb]], [[1xvc\|1xvc]], [[1xve\|1xve]], [[1xvf\|1xvf]], [[1xvg\|1xvg]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FPN:4-FLUOROPHENOL'>FPN</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Methane_monooxygenase_(soluble) Methane monooxygenase (soluble)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.25 1.14.13.25]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xvd OCA], [https://pdbe.org/1xvd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xvd RCSB], [https://www.ebi.ac.uk/pdbsum/1xvd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xvd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xvd OCA], [https://pdbe.org/1xvd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xvd RCSB], [https://www.ebi.ac.uk/pdbsum/1xvd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xvd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MEMA_METCA MEMA_METCA]] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds. [[https://www.uniprot.org/uniprot/MEMG_METCA MEMG_METCA]] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds. [[https://www.uniprot.org/uniprot/MEMB_METCA MEMB_METCA]] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds.	+	[https://www.uniprot.org/uniprot/MEMG_METCA MEMG_METCA] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 31:

	==See Also==		==See Also==
-	*[[Methane monooxygenase\|Methane monooxygenase]]	+	*[[Methane monooxygenase 3D structures\|Methane monooxygenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 38:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Methylococcus capsulatus]]		[[Category: Methylococcus capsulatus]]
-	[[Category: Lippard~~, S J~~]]	+	[[Category: Lippard SJ]]
-	[[Category: Sazinsky~~, M H]]~~	+	[[Category: Sazinsky MH]]
-	~~[[Category: Cavity]]~~	+
-	~~[[Category: Diiron]]~~	+
-	~~[[Category: Four-helix bundle]]~~	+
-	~~[[Category: Methane]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Product binding~~]]	+

OCA at 16:20, 3 November 2021

OCA — Wed, 03 Nov 2021 16:20:21 GMT

←Older revision		Revision as of 16:20, 3 November 2021
Line 3:		Line 3:
	<StructureSection load='1xvd' size='340' side='right'caption='[[1xvd]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1xvd' size='340' side='right'caption='[[1xvd]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xvd]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Methylococcus_capsulatus Methylococcus capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1XVD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xvd]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylococcus_capsulatus Methylococcus capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XVD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FPN:4-FLUOROPHENOL'>FPN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FPN:4-FLUOROPHENOL'>FPN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xu3\|1xu3]], [[1xu5\|1xu5]], [[1xvb\|1xvb]], [[1xvc\|1xvc]], [[1xve\|1xve]], [[1xvf\|1xvf]], [[1xvg\|1xvg]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xu3\|1xu3]], [[1xu5\|1xu5]], [[1xvb\|1xvb]], [[1xvc\|1xvc]], [[1xve\|1xve]], [[1xvf\|1xvf]], [[1xvg\|1xvg]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Methane_monooxygenase_(soluble) Methane monooxygenase (soluble)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.25 1.14.13.25] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Methane_monooxygenase_(soluble) Methane monooxygenase (soluble)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.25 1.14.13.25] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1xvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xvd OCA], [~~http~~://pdbe.org/1xvd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1xvd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1xvd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1xvd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xvd OCA], [https://pdbe.org/1xvd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xvd RCSB], [https://www.ebi.ac.uk/pdbsum/1xvd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xvd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MEMA_METCA MEMA_METCA]] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds. [[~~http~~://www.uniprot.org/uniprot/MEMG_METCA MEMG_METCA]] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds. [[~~http~~://www.uniprot.org/uniprot/MEMB_METCA MEMB_METCA]] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds.	+	[[https://www.uniprot.org/uniprot/MEMA_METCA MEMA_METCA]] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds. [[https://www.uniprot.org/uniprot/MEMG_METCA MEMG_METCA]] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds. [[https://www.uniprot.org/uniprot/MEMB_METCA MEMB_METCA]] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 16:58, 29 January 2020

OCA — Wed, 29 Jan 2020 16:58:19 GMT

←Older revision		Revision as of 16:58, 29 January 2020
Line 1:		Line 1:

	==Soluble methane monooxygenase hydroxylase: 4-fluorophenol soaked structure==		==Soluble methane monooxygenase hydroxylase: 4-fluorophenol soaked structure==
-	<StructureSection load='1xvd' size='340' side='right' caption='[[1xvd]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='1xvd' size='340' side='right'caption='[[1xvd]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xvd]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylococcus_capsulatus Methylococcus capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XVD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xvd]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylococcus_capsulatus Methylococcus capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XVD FirstGlance]. <br>
Line 37:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Methylococcus capsulatus]]		[[Category: Methylococcus capsulatus]]
	[[Category: Lippard, S J]]		[[Category: Lippard, S J]]

OCA at 07:15, 18 April 2018

OCA — Wed, 18 Apr 2018 07:15:10 GMT

←Older revision		Revision as of 07:15, 18 April 2018
Line 1:		Line 1:
		+
	==Soluble methane monooxygenase hydroxylase: 4-fluorophenol soaked structure==		==Soluble methane monooxygenase hydroxylase: 4-fluorophenol soaked structure==
	<StructureSection load='1xvd' size='340' side='right' caption='[[1xvd]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1xvd' size='340' side='right' caption='[[1xvd]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xu3\|1xu3]], [[1xu5\|1xu5]], [[1xvb\|1xvb]], [[1xvc\|1xvc]], [[1xve\|1xve]], [[1xvf\|1xvf]], [[1xvg\|1xvg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xu3\|1xu3]], [[1xu5\|1xu5]], [[1xvb\|1xvb]], [[1xvc\|1xvc]], [[1xve\|1xve]], [[1xvf\|1xvf]], [[1xvg\|1xvg]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methane_monooxygenase_(soluble) Methane monooxygenase (soluble)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.25 1.14.13.25] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methane_monooxygenase_(soluble) Methane monooxygenase (soluble)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.25 1.14.13.25] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xvd OCA], [http://pdbe.org/1xvd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xvd RCSB], [http://www.ebi.ac.uk/pdbsum/1xvd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xvd OCA], [http://pdbe.org/1xvd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xvd RCSB], [http://www.ebi.ac.uk/pdbsum/1xvd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xvd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xv/1xvd_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xv/1xvd_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:45, 8 February 2016

OCA — Mon, 08 Feb 2016 07:45:52 GMT

←Older revision		Revision as of 07:45, 8 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xvd ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:23, 10 September 2015

OCA — Thu, 10 Sep 2015 09:23:09 GMT

←Older revision		Revision as of 09:23, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FPN:4-FLUOROPHENOL'>FPN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FPN:4-FLUOROPHENOL'>FPN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xu3\|1xu3]], [[1xu5\|1xu5]], [[1xvb\|1xvb]], [[1xvc\|1xvc]], [[1xve\|1xve]], [[1xvf\|1xvf]], [[1xvg\|1xvg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xu3\|1xu3]], [[1xu5\|1xu5]], [[1xvb\|1xvb]], [[1xvc\|1xvc]], [[1xve\|1xve]], [[1xvf\|1xvf]], [[1xvg\|1xvg]]</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Methane_monooxygenase~~ Methane monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.25 1.14.13.25] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methane_monooxygenase_(soluble) Methane monooxygenase (soluble)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.25 1.14.13.25] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xvd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xvd RCSB], [http://www.ebi.ac.uk/pdbsum/1xvd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xvd OCA], [http://pdbe.org/1xvd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xvd RCSB], [http://www.ebi.ac.uk/pdbsum/1xvd PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1xvd" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Methane monooxygenase]]
	[[Category: Methylococcus capsulatus]]		[[Category: Methylococcus capsulatus]]
	[[Category: Lippard, S J]]		[[Category: Lippard, S J]]

OCA at 21:44, 24 December 2014

OCA — Wed, 24 Dec 2014 21:44:31 GMT

←Older revision		Revision as of 21:44, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xvd]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylococcus_capsulatus Methylococcus capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XVD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xvd]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylococcus_capsulatus Methylococcus capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XVD FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FPN:4-FLUOROPHENOL'>FPN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FPN:4-FLUOROPHENOL'>FPN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xu3\|1xu3]], [[1xu5\|1xu5]], [[1xvb\|1xvb]], [[1xvc\|1xvc]], [[1xve\|1xve]], [[1xvf\|1xvf]], [[1xvg\|1xvg]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xu3\|1xu3]], [[1xu5\|1xu5]], [[1xvb\|1xvb]], [[1xvc\|1xvc]], [[1xve\|1xve]], [[1xvf\|1xvf]], [[1xvg\|1xvg]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methane_monooxygenase Methane monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.25 1.14.13.25] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methane_monooxygenase Methane monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.25 1.14.13.25] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xvd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xvd RCSB], [http://www.ebi.ac.uk/pdbsum/1xvd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xvd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xvd RCSB], [http://www.ebi.ac.uk/pdbsum/1xvd PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MEMA_METCA MEMA_METCA]] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds. [[http://www.uniprot.org/uniprot/MEMG_METCA MEMG_METCA]] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds. [[http://www.uniprot.org/uniprot/MEMB_METCA MEMB_METCA]] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Methane monooxygenase]]		[[Category: Methane monooxygenase]]
	[[Category: Methylococcus capsulatus]]		[[Category: Methylococcus capsulatus]]
-	[[Category: Lippard, S J.]]	+	[[Category: Lippard, S J]]
-	[[Category: Sazinsky, M H.]]	+	[[Category: Sazinsky, M H]]
	[[Category: Cavity]]		[[Category: Cavity]]
	[[Category: Diiron]]		[[Category: Diiron]]

OCA at 21:53, 29 September 2014

OCA — Mon, 29 Sep 2014 21:53:48 GMT

←Older revision		Revision as of 21:53, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1xvd.~~png~~\|~~left~~\|200px]]	+	==Soluble methane monooxygenase hydroxylase: 4-fluorophenol soaked structure==
		+	<StructureSection load='1xvd' size='340' side='right' caption='[[1xvd]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1xvd]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylococcus_capsulatus Methylococcus capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XVD FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FPN:4-FLUOROPHENOL'>FPN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xu3\|1xu3]], [[1xu5\|1xu5]], [[1xvb\|1xvb]], [[1xvc\|1xvc]], [[1xve\|1xve]], [[1xvf\|1xvf]], [[1xvg\|1xvg]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methane_monooxygenase Methane monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.25 1.14.13.25] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xvd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xvd RCSB], [http://www.ebi.ac.uk/pdbsum/1xvd PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xv/1xvd_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The soluble methane monooxygenase hydroxylase (MMOH) alpha-subunit contains a series of cavities that delineate the route of substrate entrance to and product egress from the buried carboxylate-bridged diiron center. The presence of discrete cavities is a major structural difference between MMOH, which can hydroxylate methane, and toluene/o-xylene monooxygenase hydroxylase (ToMOH), which cannot. To understand better the functions of the cavities and to investigate how an enzyme designed for methane hydroxylation can also accommodate larger substrates such as octane, methylcubane, and trans-1-methyl-2-phenylcyclopropane, MMOH crystals were soaked with an assortment of different alcohols and their X-ray structures were solved to 1.8-2.4 A resolution. The product analogues localize to cavities 1-3 and delineate a path of product exit and/or substrate entrance from the active site to the surface of the protein. The binding of the alcohols to a position bridging the two iron atoms in cavity 1 extends and validates previous crystallographic, spectroscopic, and computational work indicating this site to be where substrates are hydroxylated and products form. The presence of these alcohols induces perturbations in the amino acid side-chain gates linking pairs of cavities, allowing for the formation of a channel similar to one observed in ToMOH. Upon binding of 6-bromohexan-1-ol, the pi helix formed by residues 202-211 in helix E of the alpha-subunit is extended through residue 216, changing the orientations of several amino acid residues in the active site cavity. This remarkable secondary structure rearrangement in the four-helix bundle has several mechanistic implications for substrate accommodation and the function of the effector protein, MMOB.

-	~~{{STRUCTURE_1xvd\| PDB=1xvd \| SCENE= }}~~	+	Product bound structures of the soluble methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath): protein motion in the alpha-subunit.,Sazinsky MH, Lippard SJ J Am Chem Soc. 2005 Apr 27;127(16):5814-25. PMID:15839679<ref>PMID:15839679</ref>

-	~~===Soluble methane monooxygenase hydroxylase: 4-fluorophenol soaked structure===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_15839679}}~~	+	==See Also==
-		+	*[[Methane monooxygenase\|Methane monooxygenase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1xvd~~]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylococcus_capsulatus Methylococcus capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVD OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:015839679<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Methane monooxygenase]]		[[Category: Methane monooxygenase]]
	[[Category: Methylococcus capsulatus]]		[[Category: Methylococcus capsulatus]]

OCA: Protected "1xvd" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 13:28:06 GMT

Protected "1xvd" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:28, 5 January 2013

OCA at 13:28, 5 January 2013

OCA — Sat, 05 Jan 2013 13:28:01 GMT

←Older revision		Revision as of 13:28, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1xvd.png\|left\|200px]]		[[Image:1xvd.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1xvd", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1xvd\| PDB=1xvd \| SCENE= }}		{{STRUCTURE_1xvd\| PDB=1xvd \| SCENE= }}

	===Soluble methane monooxygenase hydroxylase: 4-fluorophenol soaked structure===		===Soluble methane monooxygenase hydroxylase: 4-fluorophenol soaked structure===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15839679}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15839679 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15839679}}		{{ABSTRACT_PUBMED_15839679}}

	==About this Structure==		==About this Structure==
-	~~1XVD~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Methylococcus_capsulatus Methylococcus capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVD OCA].	+	[[1xvd]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylococcus_capsulatus Methylococcus capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVD OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15839679~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015839679</ref><references group="xtra"/>
	[[Category: Methane monooxygenase]]		[[Category: Methane monooxygenase]]
	[[Category: Methylococcus capsulatus]]		[[Category: Methylococcus capsulatus]]
Line 32:		Line 20:
	[[Category: Four-helix bundle]]		[[Category: Four-helix bundle]]
	[[Category: Methane]]		[[Category: Methane]]
		+	[[Category: Oxidoreductase]]
	[[Category: Product binding]]		[[Category: Product binding]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:18:09 2009''