1xvv - Revision history

OCA at 06:49, 23 August 2023

OCA — Wed, 23 Aug 2023 06:49:52 GMT

←Older revision		Revision as of 06:49, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1xvv' size='340' side='right'caption='[[1xvv]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1xvv' size='340' side='right'caption='[[1xvv]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xvv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XVV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xvv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XVV FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CCQ:L~~-~~CARNITINYL-COA+INNER+SALT'>CCQ</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1xk6\|1xk6]], [[1xk7\|1xk7]], [[1xvt\|1xvt]], [[1xvu\|1xvu]]~~</~~div~~>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CCQ:L-CARNITINYL-COA+INNER+SALT'>CCQ</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">caiB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xvv OCA], [https://pdbe.org/1xvv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xvv RCSB], [https://www.ebi.ac.uk/pdbsum/1xvv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xvv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xvv OCA], [https://pdbe.org/1xvv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xvv RCSB], [https://www.ebi.ac.uk/pdbsum/1xvv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xvv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CAIB_ECOLI CAIB_ECOLI]] Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA.<ref>PMID:11551212</ref>	+	[https://www.uniprot.org/uniprot/CAIB_ECOLI CAIB_ECOLI] Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA.<ref>PMID:11551212</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cygler, M]]	+	[[Category: Cygler M]]
-	[[Category: Iannuzzi, P]]	+	[[Category: Iannuzzi P]]
-	[[Category: Li, Y]]	+	[[Category: Li Y]]
-	[[Category: Matte, A]]	+	[[Category: Matte A]]
-	[[Category: Rangarajan~~, E S]]~~	+	[[Category: Rangarajan ES]]
-	~~[[Category: Asp mutant]]~~	+
-	~~[[Category: Caib]]~~	+
-	~~[[Category: Carnityl-coa]]~~	+
-	~~[[Category: Coa-transferase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 16:44, 20 October 2021

OCA — Wed, 20 Oct 2021 16:44:55 GMT

←Older revision		Revision as of 16:44, 20 October 2021
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	<StructureSection load='1xvv' size='340' side='right'caption='[[1xvv]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1xvv' size='340' side='right'caption='[[1xvv]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xvv]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1XVV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xvv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XVV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CCQ:L-CARNITINYL-COA+INNER+SALT'>CCQ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CCQ:L-CARNITINYL-COA+INNER+SALT'>CCQ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xk6\|1xk6]], [[1xk7\|1xk7]], [[1xvt\|1xvt]], [[1xvu\|1xvu]]</div></td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xk6\|1xk6]], [[1xk7\|1xk7]], [[1xvt\|1xvt]], [[1xvu\|1xvu]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">caiB ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">caiB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1xvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xvv OCA], [~~http~~://pdbe.org/1xvv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1xvv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1xvv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1xvv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xvv OCA], [https://pdbe.org/1xvv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xvv RCSB], [https://www.ebi.ac.uk/pdbsum/1xvv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xvv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CAIB_ECOLI CAIB_ECOLI]] Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA.<ref>PMID:11551212</ref>	+	[[https://www.uniprot.org/uniprot/CAIB_ECOLI CAIB_ECOLI]] Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA.<ref>PMID:11551212</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:22, 6 January 2021

OCA — Wed, 06 Jan 2021 10:22:51 GMT

←Older revision		Revision as of 10:22, 6 January 2021
Line 1:		Line 1:

	==Crystal Structure of CaiB mutant D169A in complex with carnitinyl-CoA==		==Crystal Structure of CaiB mutant D169A in complex with carnitinyl-CoA==
-	<StructureSection load='1xvv' size='340' side='right' caption='[[1xvv]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='1xvv' size='340' side='right'caption='[[1xvv]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xvv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVV OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1XVV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xvv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1XVV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CCQ:L-CARNITINYL-COA+INNER+SALT'>CCQ</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CCQ:L-CARNITINYL-COA+INNER+SALT'>CCQ</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xk6\|1xk6]], [[1xk7\|1xk7]], [[1xvt\|1xvt]], [[1xvu\|1xvu]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xk6\|1xk6]], [[1xk7\|1xk7]], [[1xvt\|1xvt]], [[1xvu\|1xvu]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">caiB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">caiB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1xvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xvv OCA], [http://pdbe.org/1xvv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xvv RCSB], [http://www.ebi.ac.uk/pdbsum/1xvv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xvv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1xvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xvv OCA], [http://pdbe.org/1xvv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xvv RCSB], [http://www.ebi.ac.uk/pdbsum/1xvv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xvv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Cygler, M]]		[[Category: Cygler, M]]
	[[Category: Iannuzzi, P]]		[[Category: Iannuzzi, P]]

OCA at 06:34, 31 January 2018

OCA — Wed, 31 Jan 2018 06:34:15 GMT

←Older revision		Revision as of 06:34, 31 January 2018
Line 1:		Line 1:
		+
	==Crystal Structure of CaiB mutant D169A in complex with carnitinyl-CoA==		==Crystal Structure of CaiB mutant D169A in complex with carnitinyl-CoA==
	<StructureSection load='1xvv' size='340' side='right' caption='[[1xvv]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1xvv' size='340' side='right' caption='[[1xvv]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xk6\|1xk6]], [[1xk7\|1xk7]], [[1xvt\|1xvt]], [[1xvu\|1xvu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xk6\|1xk6]], [[1xk7\|1xk7]], [[1xvt\|1xvt]], [[1xvu\|1xvu]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">caiB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">caiB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xvv OCA], [http://pdbe.org/1xvv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xvv RCSB], [http://www.ebi.ac.uk/pdbsum/1xvv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xvv OCA], [http://pdbe.org/1xvv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xvv RCSB], [http://www.ebi.ac.uk/pdbsum/1xvv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xvv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xv/1xvv_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xv/1xvv_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 01:06, 8 February 2016

OCA — Mon, 08 Feb 2016 01:06:30 GMT

←Older revision		Revision as of 01:06, 8 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xvv ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:27, 10 September 2015

OCA — Thu, 10 Sep 2015 06:27:50 GMT

←Older revision		Revision as of 06:27, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1xvv' size='340' side='right' caption='[[1xvv]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1xvv' size='340' side='right' caption='[[1xvv]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xvv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XVV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xvv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XVV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CCQ:L-CARNITINYL-COA+INNER+SALT'>CCQ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CCQ:L-CARNITINYL-COA+INNER+SALT'>CCQ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xk6\|1xk6]], [[1xk7\|1xk7]], [[1xvt\|1xvt]], [[1xvu\|1xvu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xk6\|1xk6]], [[1xk7\|1xk7]], [[1xvt\|1xvt]], [[1xvu\|1xvu]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">caiB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">caiB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xvv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xvv RCSB], [http://www.ebi.ac.uk/pdbsum/1xvv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xvv OCA], [http://pdbe.org/1xvv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xvv RCSB], [http://www.ebi.ac.uk/pdbsum/1xvv PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1xvv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Cygler, M]]		[[Category: Cygler, M]]
	[[Category: Iannuzzi, P]]		[[Category: Iannuzzi, P]]

OCA at 19:27, 24 December 2014

OCA — Wed, 24 Dec 2014 19:27:29 GMT

←Older revision		Revision as of 19:27, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xvv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XVV FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xvv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XVV FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CCQ:L-CARNITINYL-COA+INNER+SALT'>CCQ</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CCQ:L-CARNITINYL-COA+INNER+SALT'>CCQ</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xk6\|1xk6]], [[1xk7\|1xk7]], [[1xvt\|1xvt]], [[1xvu\|1xvu]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xk6\|1xk6]], [[1xk7\|1xk7]], [[1xvt\|1xvt]], [[1xvu\|1xvu]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">caiB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">caiB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xvv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xvv RCSB], [http://www.ebi.ac.uk/pdbsum/1xvv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xvv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xvv RCSB], [http://www.ebi.ac.uk/pdbsum/1xvv PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CAIB_ECOLI CAIB_ECOLI]] Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA.<ref>PMID:11551212</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Cygler, M.]]	+	[[Category: Cygler, M]]
-	[[Category: Iannuzzi, P.]]	+	[[Category: Iannuzzi, P]]
-	[[Category: Li, Y.]]	+	[[Category: Li, Y]]
-	[[Category: Matte, A.]]	+	[[Category: Matte, A]]
-	[[Category: Rangarajan, E S.]]	+	[[Category: Rangarajan, E S]]
	[[Category: Asp mutant]]		[[Category: Asp mutant]]
	[[Category: Caib]]		[[Category: Caib]]

OCA at 20:04, 29 September 2014

OCA — Mon, 29 Sep 2014 20:04:14 GMT

←Older revision		Revision as of 20:04, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1xvv.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of CaiB mutant D169A in complex with carnitinyl-CoA==
		+	<StructureSection load='1xvv' size='340' side='right' caption='[[1xvv]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1xvv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XVV FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CCQ:L-CARNITINYL-COA+INNER+SALT'>CCQ</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xk6\|1xk6]], [[1xk7\|1xk7]], [[1xvt\|1xvt]], [[1xvu\|1xvu]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">caiB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xvv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xvv RCSB], [http://www.ebi.ac.uk/pdbsum/1xvv PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xv/1xvv_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	L-Carnitine (R-[-]-3-hydroxy-4-trimethylaminobutyrate) is found in both eukaryotic and prokaryotic cells and participates in diverse processes including long-chain fatty-acid transport and osmoprotection. The enzyme crotonobetainyl/gamma-butyrobetainyl-CoA:carnitine CoA-transferase (CaiB; E.C. 2.8.3.-) catalyzes the first step in carnitine metabolism, leading to the final product gamma-butyrobetaine. The crystal structures of Escherichia coli apo-CaiB, as well as its Asp169Ala mutant bound to CoA and to carnitinyl-CoA, have been determined and refined to 1.6, 2.4, and 2.4 A resolution, respectively. CaiB is composed of two identical circular chains that together form an intertwined dimer. Each monomer consists of a large domain, containing a Rossmann fold, and a small domain. The monomer and dimer resemble those of formyl-CoA transferase from Oxalobacter formigenes, as well as E. coli YfdW, a putative type-III CoA transferase of unknown function. The CoA cofactor-binding site is formed at the interface of the large domain of one monomer and the small domain from the second monomer. Most of the protein-CoA interactions are formed with the Rossmann fold domain. While the location of cofactor binding is similar in the three proteins, the specific CoA-protein interactions vary somewhat between CaiB, formyl-CoA transferase, and YfdW. CoA binding results in a change in the relative positions of the large and small domains compared with apo-CaiB. The observed carnitinyl-CoA product in crystals of the CaiB Asp169Ala mutant cocrystallized with crotonoyl-CoA and carnitine could result from (i) a catalytic mechanism involving a ternary enzyme-substrate complex, independent of a covalent anhydride intermediate with Asp169, (ii) a spontaneous reaction of the substrates in solution, followed by binding to the enzyme, or (iii) an involvement of another residue substituting functionally for Asp169, such as Glu23.

-	~~{{STRUCTURE_1xvv\| PDB=1xvv \| SCENE= }}~~	+	Crystal structure of Escherichia coli crotonobetainyl-CoA: carnitine CoA-transferase (CaiB) and its complexes with CoA and carnitinyl-CoA.,Rangarajan ES, Li Y, Iannuzzi P, Cygler M, Matte A Biochemistry. 2005 Apr 19;44(15):5728-38. PMID:15823031<ref>PMID:15823031</ref>

-	~~===Crystal Structure~~ of ~~CaiB mutant D169A in complex with carnitinyl-CoA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15823031}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1xvv]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1XVV OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015823031<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Cygler, M.]]		[[Category: Cygler, M.]]

OCA: Protected "1xvv" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 13:34:44 GMT

Protected "1xvv" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:34, 5 January 2013

OCA at 13:34, 5 January 2013

OCA — Sat, 05 Jan 2013 13:34:42 GMT

←Older revision		Revision as of 13:34, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1xvv.png\|left\|200px]]		[[Image:1xvv.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1xvv", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1xvv\| PDB=1xvv \| SCENE= }}		{{STRUCTURE_1xvv\| PDB=1xvv \| SCENE= }}

	===Crystal Structure of CaiB mutant D169A in complex with carnitinyl-CoA===		===Crystal Structure of CaiB mutant D169A in complex with carnitinyl-CoA===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15823031}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15823031 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15823031}}		{{ABSTRACT_PUBMED_15823031}}

	==About this Structure==		==About this Structure==
-	~~1XVV~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVV OCA].	+	[[1xvv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVV OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15823031~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015823031</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Cygler, M.]]		[[Category: Cygler, M.]]
Line 34:		Line 22:
	[[Category: Carnityl-coa]]		[[Category: Carnityl-coa]]
	[[Category: Coa-transferase]]		[[Category: Coa-transferase]]
-		+	[[Category: Transferase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 17:41:47 2009''~~	+