1xw3 - Revision history

OCA at 08:53, 14 February 2024

OCA — Wed, 14 Feb 2024 08:53:37 GMT

←Older revision		Revision as of 08:53, 14 February 2024
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	<StructureSection load='1xw3' size='340' side='right'caption='[[1xw3]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='1xw3' size='340' side='right'caption='[[1xw3]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xw3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XW3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xw3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XW3 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MPD:(4S)~~-~~2-METHYL-2~~,~~4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height~~: ~~3em;~~'>~~[[1xw4\|1xw4]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xw3 OCA], [https://pdbe.org/1xw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xw3 RCSB], [https://www.ebi.ac.uk/pdbsum/1xw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xw3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xw3 OCA], [https://pdbe.org/1xw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xw3 RCSB], [https://www.ebi.ac.uk/pdbsum/1xw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xw3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SRXN1_HUMAN SRXN1_HUMAN]] Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.<ref>PMID:15448164</ref> <ref>PMID:15590625</ref>	+	[https://www.uniprot.org/uniprot/SRXN1_HUMAN SRXN1_HUMAN] Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.<ref>PMID:15448164</ref> <ref>PMID:15590625</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xw3 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xw3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Sufiredoxins (Srx) repair the inactivated forms of typical two-Cys peroxiredoxins (Prx) implicated in hydrogen peroxide-mediated cell signaling. The reduction of the cysteine sulfinic acid moiety within the active site of the Prx by Srx involves novel sulfur chemistry and the use of ATP and Mg(2+). The 1.65 A crystal structure of human Srx (hSrx) exhibits a new protein fold and a unique nucleotide binding motif containing the Gly98-Cys99-His100-Arg101 sequence at the N-terminus of an alpha-helix. HPLC analysis of the reaction products has confirmed that the site of ATP cleavage is between the beta- and gamma-phosphate groups. Cys99 and the gamma-phosphate of ATP, modeled within the active site of the 2.0 A ADP product complex structure, are adjacent to large surface depressions containing additional conserved residues. These features and the necessity for significant remodeling of the Prx structure suggest that the interactions between hSrx and typical two-Cys Prxs are specific. Moreover, the concave shape of the hSrx active site surface appears to be ideally suited to interacting with the convex surface of the toroidal Prx decamer.
-
-	Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin.,Jonsson TJ, Murray MS, Johnson LC, Poole LB, Lowther WT Biochemistry. 2005 Jun 21;44(24):8634-42. PMID:15952770<ref>PMID:15952770</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1xw3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Johnson~~, L C~~]]	+	[[Category: Johnson LC]]
-	[[Category: Jonsson~~, T J~~]]	+	[[Category: Jonsson TJ]]
-	[[Category: Lowther~~, W T~~]]	+	[[Category: Lowther WT]]
-	[[Category: Murray~~, M S~~]]	+	[[Category: Murray MS]]
-	[[Category: Poole~~, L B]]~~	+	[[Category: Poole LB]]
-	~~[[Category: Atp]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Peroxiredoxin]]~~	+
-	~~[[Category: Retroreduction]]~~	+
-	~~[[Category: Sulfinic acid~~]]	+

OCA at 06:06, 28 April 2021

OCA — Wed, 28 Apr 2021 06:06:58 GMT

←Older revision		Revision as of 06:06, 28 April 2021
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	<StructureSection load='1xw3' size='340' side='right'caption='[[1xw3]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='1xw3' size='340' side='right'caption='[[1xw3]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xw3]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XW3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1XW3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xw3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XW3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xw4\|1xw4]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xw4\|1xw4]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1xw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xw3 OCA], [~~http~~://pdbe.org/1xw3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1xw3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1xw3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1xw3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xw3 OCA], [https://pdbe.org/1xw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xw3 RCSB], [https://www.ebi.ac.uk/pdbsum/1xw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xw3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SRXN1_HUMAN SRXN1_HUMAN]] Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.<ref>PMID:15448164</ref> <ref>PMID:15590625</ref>	+	[[https://www.uniprot.org/uniprot/SRXN1_HUMAN SRXN1_HUMAN]] Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.<ref>PMID:15448164</ref> <ref>PMID:15590625</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:08, 24 July 2019

OCA — Wed, 24 Jul 2019 07:08:05 GMT

←Older revision		Revision as of 07:08, 24 July 2019
Line 1:		Line 1:

	==Crystal Structure of Human Sulfiredoxin (Srx)==		==Crystal Structure of Human Sulfiredoxin (Srx)==
-	<StructureSection load='1xw3' size='340' side='right' caption='[[1xw3]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='1xw3' size='340' side='right'caption='[[1xw3]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xw3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XW3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xw3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XW3 FirstGlance]. <br>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Johnson, L C]]		[[Category: Johnson, L C]]
	[[Category: Jonsson, T J]]		[[Category: Jonsson, T J]]

OCA at 07:27, 18 April 2018

OCA — Wed, 18 Apr 2018 07:27:59 GMT

←Older revision		Revision as of 07:27, 18 April 2018
Line 1:		Line 1:
		+
	==Crystal Structure of Human Sulfiredoxin (Srx)==		==Crystal Structure of Human Sulfiredoxin (Srx)==
	<StructureSection load='1xw3' size='340' side='right' caption='[[1xw3]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='1xw3' size='340' side='right' caption='[[1xw3]], [[Resolution\|resolution]] 1.65Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xw4\|1xw4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xw4\|1xw4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xw3 OCA], [http://pdbe.org/1xw3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xw3 RCSB], [http://www.ebi.ac.uk/pdbsum/1xw3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xw3 OCA], [http://pdbe.org/1xw3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xw3 RCSB], [http://www.ebi.ac.uk/pdbsum/1xw3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xw3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xw/1xw3_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xw/1xw3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 38:		Line 39:
	[[Category: Murray, M S]]		[[Category: Murray, M S]]
	[[Category: Poole, L B]]		[[Category: Poole, L B]]
		+	[[Category: Atp]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Peroxiredoxin]]		[[Category: Peroxiredoxin]]
	[[Category: Retroreduction]]		[[Category: Retroreduction]]
	[[Category: Sulfinic acid]]		[[Category: Sulfinic acid]]

OCA at 03:04, 8 February 2016

OCA — Mon, 08 Feb 2016 03:04:59 GMT

←Older revision		Revision as of 03:04, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xw3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:16, 10 September 2015

OCA — Thu, 10 Sep 2015 07:16:14 GMT

←Older revision		Revision as of 07:16, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1xw3' size='340' side='right' caption='[[1xw3]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='1xw3' size='340' side='right' caption='[[1xw3]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xw3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XW3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xw3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XW3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xw4\|1xw4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xw4\|1xw4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xw3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xw3 RCSB], [http://www.ebi.ac.uk/pdbsum/1xw3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xw3 OCA], [http://pdbe.org/1xw3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xw3 RCSB], [http://www.ebi.ac.uk/pdbsum/1xw3 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SRXN1_HUMAN SRXN1_HUMAN]] Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.<ref>PMID:15448164</ref> <ref>PMID:15590625</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1xw3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Johnson, L C]]		[[Category: Johnson, L C]]
	[[Category: Jonsson, T J]]		[[Category: Jonsson, T J]]

OCA at 09:37, 8 January 2015

OCA — Thu, 08 Jan 2015 09:37:14 GMT

←Older revision		Revision as of 09:37, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xw3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XW3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xw3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XW3 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xw4\|1xw4]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xw4\|1xw4]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xw3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xw3 RCSB], [http://www.ebi.ac.uk/pdbsum/1xw3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xw3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xw3 RCSB], [http://www.ebi.ac.uk/pdbsum/1xw3 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Johnson, L C.]]	+	[[Category: Johnson, L C]]
-	[[Category: Jonsson, T J.]]	+	[[Category: Jonsson, T J]]
-	[[Category: Lowther, W T.]]	+	[[Category: Lowther, W T]]
-	[[Category: Murray, M S.]]	+	[[Category: Murray, M S]]
-	[[Category: Poole, L B.]]	+	[[Category: Poole, L B]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Peroxiredoxin]]		[[Category: Peroxiredoxin]]
	[[Category: Retroreduction]]		[[Category: Retroreduction]]
	[[Category: Sulfinic acid]]		[[Category: Sulfinic acid]]

OCA at 20:37, 29 September 2014

OCA — Mon, 29 Sep 2014 20:37:57 GMT

←Older revision		Revision as of 20:37, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1xw3.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of Human Sulfiredoxin (Srx)==
		+	<StructureSection load='1xw3' size='340' side='right' caption='[[1xw3]], [[Resolution\|resolution]] 1.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1xw3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XW3 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xw4\|1xw4]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xw3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xw3 RCSB], [http://www.ebi.ac.uk/pdbsum/1xw3 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xw/1xw3_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Sufiredoxins (Srx) repair the inactivated forms of typical two-Cys peroxiredoxins (Prx) implicated in hydrogen peroxide-mediated cell signaling. The reduction of the cysteine sulfinic acid moiety within the active site of the Prx by Srx involves novel sulfur chemistry and the use of ATP and Mg(2+). The 1.65 A crystal structure of human Srx (hSrx) exhibits a new protein fold and a unique nucleotide binding motif containing the Gly98-Cys99-His100-Arg101 sequence at the N-terminus of an alpha-helix. HPLC analysis of the reaction products has confirmed that the site of ATP cleavage is between the beta- and gamma-phosphate groups. Cys99 and the gamma-phosphate of ATP, modeled within the active site of the 2.0 A ADP product complex structure, are adjacent to large surface depressions containing additional conserved residues. These features and the necessity for significant remodeling of the Prx structure suggest that the interactions between hSrx and typical two-Cys Prxs are specific. Moreover, the concave shape of the hSrx active site surface appears to be ideally suited to interacting with the convex surface of the toroidal Prx decamer.

-	~~{{STRUCTURE_1xw3\| PDB=1xw3 \| SCENE= }}~~	+	Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin.,Jonsson TJ, Murray MS, Johnson LC, Poole LB, Lowther WT Biochemistry. 2005 Jun 21;44(24):8634-42. PMID:15952770<ref>PMID:15952770</ref>

-	~~===Crystal Structure~~ of ~~Human Sulfiredoxin (Srx)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15952770}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1xw3]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1XW3 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015952770<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Johnson, L C.]]		[[Category: Johnson, L C.]]

OCA: Protected "1xw3" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 11:25:01 GMT

Protected "1xw3" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:25, 5 January 2013

OCA at 11:24, 5 January 2013

OCA — Sat, 05 Jan 2013 11:24:57 GMT

←Older revision		Revision as of 11:24, 5 January 2013
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-	{{Seed}}
	[[Image:1xw3.png\|left\|200px]]		[[Image:1xw3.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1xw3", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1xw3\| PDB=1xw3 \| SCENE= }}		{{STRUCTURE_1xw3\| PDB=1xw3 \| SCENE= }}

	===Crystal Structure of Human Sulfiredoxin (Srx)===		===Crystal Structure of Human Sulfiredoxin (Srx)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15952770}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15952770 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15952770}}		{{ABSTRACT_PUBMED_15952770}}

	==About this Structure==		==About this Structure==
-	~~1XW3~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XW3 OCA].	+	[[1xw3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XW3 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15952770~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015952770</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Johnson, L C.]]		[[Category: Johnson, L C.]]
Line 30:		Line 18:
	[[Category: Murray, M S.]]		[[Category: Murray, M S.]]
	[[Category: Poole, L B.]]		[[Category: Poole, L B.]]
-	[[Category: ~~Atp~~]]	+	[[Category: Oxidoreductase]]
	[[Category: Peroxiredoxin]]		[[Category: Peroxiredoxin]]
	[[Category: Retroreduction]]		[[Category: Retroreduction]]
	[[Category: Sulfinic acid]]		[[Category: Sulfinic acid]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:20:46 2009''