1xxb - Revision history

OCA at 08:53, 14 February 2024

OCA — Wed, 14 Feb 2024 08:53:45 GMT

←Older revision		Revision as of 08:53, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='1xxb' size='340' side='right'caption='[[1xxb]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1xxb' size='340' side='right'caption='[[1xxb]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xxb]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1XXB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xxb]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XXB FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ARG:ARGININE'>ARG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~T7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=83333 ECOLI])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1xxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxb OCA], [~~http~~://pdbe.org/1xxb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1xxb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1xxb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1xxb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxb OCA], [https://pdbe.org/1xxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xxb RCSB], [https://www.ebi.ac.uk/pdbsum/1xxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xxb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ARGR_ECOLI ARGR_ECOLI]] Negatively controls the expression of the four operons of arginine biosynthesis in addition to the carAB operon. Predominantly interacts with A/T residues in ARG boxes. It also binds to a specific site in cer locus. Thus it is essential for cer-mediated site-specific recombination in ColE1. It is necessary for monomerization of the plasmid ColE1.	+	[https://www.uniprot.org/uniprot/ARGR_ECOLI ARGR_ECOLI] Negatively controls the expression of the four operons of arginine biosynthesis in addition to the carAB operon. Predominantly interacts with A/T residues in ARG boxes. It also binds to a specific site in cer locus. Thus it is essential for cer-mediated site-specific recombination in ColE1. It is necessary for monomerization of the plasmid ColE1.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xxb ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xxb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The structure of the oligomerization and L-arginine binding domain of the Escherichia coli arginine repressor (ArgR) has been determined using X-ray diffraction methods at 2.2 A resolution with bound arginine and at 2.8 A in the unliganded form. The oligomeric core is a 3-fold rotationally symmetric hexamer formed from six identical subunits corresponding to the 77 C-terminal residues (80 to 156) of ArgR. Each subunit has an alpha/beta fold containing a four-stranded antiparallel beta-sheet and two antiparallel alpha-helices. The hexamer is formed from two trimers, each with tightly packed hydrophobic cores. In the absence of arginine, the trimers stack back-to-back through a dyad-symmetric, sparsely packed hydrophobic interface. Six molecules of arginine bind at the trimer-trimer interface, each making ten hydrogen bonds to the protein including a direct ion pair that crosslinks the two protein trimers. Solution experiments with wild-type ArgR and oligomerization domain indicate that the hexameric form is greatly stabilized upon arginine binding. The crystal structures and solution experiments together suggest possible mechanisms of how arginine activates ArgR to bind to its DNA targets and provides a stereochemical basis for interpreting the results of mutagenesis and biochemical experiments with ArgR.
-
-	Structure of the oligomerization and L-arginine binding domain of the arginine repressor of Escherichia coli.,Van Duyne GD, Ghosh G, Maas WK, Sigler PB J Mol Biol. 1996 Feb 23;256(2):377-91. PMID:8594204<ref>PMID:8594204</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1xxb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Arginine repressor\|Arginine repressor]]		*[[Arginine repressor\|Arginine repressor]]
	*[[Arginine repressor 3D structures\|Arginine repressor 3D structures]]		*[[Arginine repressor 3D structures\|Arginine repressor 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli~~]]	+	[[Category: Escherichia coli K-12]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Duyne,~~ G ~~D.Van~~]]	+	[[Category: Ghosh G]]
-	[[Category: ~~Ghosh, G~~]]	+	[[Category: Maas WK]]
-	[[Category: ~~Maas, W K~~]]	+	[[Category: Sigler PB]]
-	[[Category: ~~Sigler, P B~~]]	+	[[Category: Van Duyne GD]]

OCA at 10:24, 6 January 2021

OCA — Wed, 06 Jan 2021 10:24:46 GMT

←Older revision		Revision as of 10:24, 6 January 2021
Line 1:		Line 1:

	==C-TERMINAL DOMAIN OF ESCHERICHIA COLI ARGININE REPRESSOR/ L-ARGININE COMPLEX==		==C-TERMINAL DOMAIN OF ESCHERICHIA COLI ARGININE REPRESSOR/ L-ARGININE COMPLEX==
-	<StructureSection load='1xxb' size='340' side='right' caption='[[1xxb]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='1xxb' size='340' side='right'caption='[[1xxb]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xxb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXB OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1XXB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xxb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1XXB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">T7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">T7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1xxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxb OCA], [http://pdbe.org/1xxb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xxb RCSB], [http://www.ebi.ac.uk/pdbsum/1xxb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xxb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1xxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxb OCA], [http://pdbe.org/1xxb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xxb RCSB], [http://www.ebi.ac.uk/pdbsum/1xxb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xxb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 32:		Line 32:
	==See Also==		==See Also==
	*[[Arginine repressor\|Arginine repressor]]		*[[Arginine repressor\|Arginine repressor]]
		+	*[[Arginine repressor 3D structures\|Arginine repressor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Ecoli]]		[[Category: Ecoli]]
		+	[[Category: Large Structures]]
	[[Category: Duyne, G D.Van]]		[[Category: Duyne, G D.Van]]
	[[Category: Ghosh, G]]		[[Category: Ghosh, G]]
	[[Category: Maas, W K]]		[[Category: Maas, W K]]
	[[Category: Sigler, P B]]		[[Category: Sigler, P B]]

OCA at 07:14, 18 April 2018

OCA — Wed, 18 Apr 2018 07:14:36 GMT

←Older revision		Revision as of 07:14, 18 April 2018
Line 1:		Line 1:
		+
	==C-TERMINAL DOMAIN OF ESCHERICHIA COLI ARGININE REPRESSOR/ L-ARGININE COMPLEX==		==C-TERMINAL DOMAIN OF ESCHERICHIA COLI ARGININE REPRESSOR/ L-ARGININE COMPLEX==
	<StructureSection load='1xxb' size='340' side='right' caption='[[1xxb]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1xxb' size='340' side='right' caption='[[1xxb]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">T7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">T7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxb OCA], [http://pdbe.org/1xxb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xxb RCSB], [http://www.ebi.ac.uk/pdbsum/1xxb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxb OCA], [http://pdbe.org/1xxb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xxb RCSB], [http://www.ebi.ac.uk/pdbsum/1xxb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xxb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xx/1xxb_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xx/1xxb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xxb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:53, 11 September 2015

OCA — Fri, 11 Sep 2015 23:53:38 GMT

←Older revision		Revision as of 23:53, 11 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">T7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">T7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xxb RCSB], [http://www.ebi.ac.uk/pdbsum/1xxb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxb OCA], [http://pdbe.org/1xxb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xxb RCSB], [http://www.ebi.ac.uk/pdbsum/1xxb PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1xxb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 21:04, 25 December 2014

OCA — Thu, 25 Dec 2014 21:04:43 GMT

←Older revision		Revision as of 21:04, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xxb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XXB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xxb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XXB FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">T7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">T7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xxb RCSB], [http://www.ebi.ac.uk/pdbsum/1xxb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xxb RCSB], [http://www.ebi.ac.uk/pdbsum/1xxb PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ARGR_ECOLI ARGR_ECOLI]] Negatively controls the expression of the four operons of arginine biosynthesis in addition to the carAB operon. Predominantly interacts with A/T residues in ARG boxes. It also binds to a specific site in cer locus. Thus it is essential for cer-mediated site-specific recombination in ColE1. It is necessary for monomerization of the plasmid ColE1.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Ecoli]]		[[Category: Ecoli]]
-	[[Category: Duyne, G D.Van.]]	+	[[Category: Duyne, G D.Van]]
-	[[Category: Ghosh, G.]]	+	[[Category: Ghosh, G]]
-	[[Category: Maas, W K.]]	+	[[Category: Maas, W K]]
-	[[Category: Sigler, P B.]]	+	[[Category: Sigler, P B]]

OCA at 10:21, 3 October 2014

OCA — Fri, 03 Oct 2014 10:21:11 GMT

←Older revision		Revision as of 10:21, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1xxb\| PDB=1xxb \| SCENE= }}~~	+	==C-TERMINAL DOMAIN OF ESCHERICHIA COLI ARGININE REPRESSOR/ L-ARGININE COMPLEX==
-	===C-TERMINAL DOMAIN OF ESCHERICHIA COLI ARGININE REPRESSOR/ L-ARGININE COMPLEX===	+	<StructureSection load='1xxb' size='340' side='right' caption='[[1xxb]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_8594204}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1xxb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XXB FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">T7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xxb RCSB], [http://www.ebi.ac.uk/pdbsum/1xxb PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xx/1xxb_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structure of the oligomerization and L-arginine binding domain of the Escherichia coli arginine repressor (ArgR) has been determined using X-ray diffraction methods at 2.2 A resolution with bound arginine and at 2.8 A in the unliganded form. The oligomeric core is a 3-fold rotationally symmetric hexamer formed from six identical subunits corresponding to the 77 C-terminal residues (80 to 156) of ArgR. Each subunit has an alpha/beta fold containing a four-stranded antiparallel beta-sheet and two antiparallel alpha-helices. The hexamer is formed from two trimers, each with tightly packed hydrophobic cores. In the absence of arginine, the trimers stack back-to-back through a dyad-symmetric, sparsely packed hydrophobic interface. Six molecules of arginine bind at the trimer-trimer interface, each making ten hydrogen bonds to the protein including a direct ion pair that crosslinks the two protein trimers. Solution experiments with wild-type ArgR and oligomerization domain indicate that the hexameric form is greatly stabilized upon arginine binding. The crystal structures and solution experiments together suggest possible mechanisms of how arginine activates ArgR to bind to its DNA targets and provides a stereochemical basis for interpreting the results of mutagenesis and biochemical experiments with ArgR.

-	~~==Function==~~	+	Structure of the oligomerization and L-arginine binding domain of the arginine repressor of Escherichia coli.,Van Duyne GD, Ghosh G, Maas WK, Sigler PB J Mol Biol. 1996 Feb 23;256(2):377-91. PMID:8594204<ref>PMID:8594204</ref>
-	~~[[http://www.uniprot.org/uniprot/ARGR_ECOLI ARGR_ECOLI]] Negatively controls~~ the ~~expression~~ of the ~~four operons~~ of ~~arginine biosynthesis in addition to the carAB operon~~. ~~Predominantly interacts with A/T residues in ARG boxes~~. ~~It also binds to a specific site in cer locus. Thus it is essential for cer~~-~~mediated site-specific recombination in ColE1. It is necessary for monomerization of the plasmid ColE1~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[1xxb]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Ecoli Ecoli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1XXB OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Arginine repressor\|Arginine repressor]]		*[[Arginine repressor\|Arginine repressor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:008594204</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Ecoli]]		[[Category: Ecoli]]
	[[Category: Duyne, G D.Van.]]		[[Category: Duyne, G D.Van.]]

OCA at 08:48, 23 April 2014

OCA — Wed, 23 Apr 2014 08:48:25 GMT

←Older revision		Revision as of 08:48, 23 April 2014
Line 1:		Line 1:
-	[[Image:1xxb.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_1xxb", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1xxb\| PDB=1xxb \| SCENE= }}		{{STRUCTURE_1xxb\| PDB=1xxb \| SCENE= }}
-
	===C-TERMINAL DOMAIN OF ESCHERICHIA COLI ARGININE REPRESSOR/ L-ARGININE COMPLEX===		===C-TERMINAL DOMAIN OF ESCHERICHIA COLI ARGININE REPRESSOR/ L-ARGININE COMPLEX===
		+	{{ABSTRACT_PUBMED_8594204}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/ARGR_ECOLI ARGR_ECOLI]] Negatively controls the expression of the four operons of arginine biosynthesis in addition to the carAB operon. Predominantly interacts with A/T residues in ARG boxes. It also binds to a specific site in cer locus. Thus it is essential for cer-mediated site-specific recombination in ColE1. It is necessary for monomerization of the plasmid ColE1.

-	~~<!--~~	+	==About this Structure==
-	~~The line below~~ this ~~paragraph, {{ABSTRACT_PUBMED_8594204}}, adds the Publication Abstract to the page~~	+	[[1xxb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXB OCA].
-	~~(as it appears on PubMed at~~ http://~~www~~.~~pubmed~~.~~gov), where 8594204~~ is ~~the PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_8594204}}~~	+

-	==~~About this Structure~~==	+	==See Also==
-	[[~~1xxb~~]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k12 Escherichia coli k12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXB OCA].	+	*[[Arginine repressor\|Arginine repressor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:008594204</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008594204</ref><references group="xtra"/><references/>
-	[[Category: ~~Escherichia coli k12~~]]	+	[[Category: Ecoli]]
	[[Category: Duyne, G D.Van.]]		[[Category: Duyne, G D.Van.]]
	[[Category: Ghosh, G.]]		[[Category: Ghosh, G.]]
	[[Category: Maas, W K.]]		[[Category: Maas, W K.]]
	[[Category: Sigler, P B.]]		[[Category: Sigler, P B.]]

OCA: Protected "1xxb" [edit=sysop:move=sysop]

OCA — Wed, 16 Nov 2011 10:27:37 GMT

Protected "1xxb" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:27, 16 November 2011

OCA at 10:27, 16 November 2011

OCA — Wed, 16 Nov 2011 10:27:35 GMT

←Older revision		Revision as of 10:27, 16 November 2011
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-	{{Seed}}
	[[Image:1xxb.png\|left\|200px]]		[[Image:1xxb.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~1XXB~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/~~Escherichia_coli~~ Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXB OCA].	+	[[1xxb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k12 Escherichia coli k12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXB OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~8594204~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008594204</ref><references group="xtra"/>
-	[[Category: Escherichia coli]]	+	[[Category: Escherichia coli k12]]
	[[Category: Duyne, G D.Van.]]		[[Category: Duyne, G D.Van.]]
	[[Category: Ghosh, G.]]		[[Category: Ghosh, G.]]
	[[Category: Maas, W K.]]		[[Category: Maas, W K.]]
	[[Category: Sigler, P B.]]		[[Category: Sigler, P B.]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 07:21:03 2009''

OCA at 05:21, 18 February 2009

OCA — Wed, 18 Feb 2009 05:21:09 GMT

←Older revision		Revision as of 05:21, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1XXB is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXB OCA].	+	1XXB is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXB OCA].

	==Reference==		==Reference==
-	~~Structure of the oligomerization and L-arginine binding domain of the arginine repressor of Escherichia coli., Van Duyne GD, Ghosh G, Maas WK, Sigler PB, J Mol Biol. 1996 Feb 23;256(2):377-91.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/8594204 8594204]~~	+	<ref group="xtra">PMID:8594204</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Single protein]]
	[[Category: Duyne, G D.Van.]]		[[Category: Duyne, G D.Van.]]
	[[Category: Ghosh, G.]]		[[Category: Ghosh, G.]]
Line 31:		Line 30:
	[[Category: Sigler, P B.]]		[[Category: Sigler, P B.]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 13~~:59:~~18 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 07:21:03 2009''