1xy4 - Revision history

OCA at 07:12, 9 August 2023

OCA — Wed, 09 Aug 2023 07:12:59 GMT

←Older revision		Revision as of 07:12, 9 August 2023
Line 1:		Line 1:

	==NMR strcutre of sst1-selective somatostatin (SRIF) analog 1==		==NMR strcutre of sst1-selective somatostatin (SRIF) analog 1==
-	<StructureSection load='1xy4' size='340' side='right'caption='[[1xy4~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='1xy4' size='340' side='right'caption='[[1xy4]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xy4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XY4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xy4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XY4 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene>, <scene name='pdbligand=IAM:4-[(ISOPROPYLAMINO)METHYL]PHENYLALANINE'>IAM</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1xxz\|1xxz]]~~, [~~[1xy5\|1xy5]], [[1xy6\|1xy6]], [[1xy8\|1xy8]], [[1xy9\|1xy9]~~]</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene>, <scene name='pdbligand=IAM:4-[(ISOPROPYLAMINO)METHYL]PHENYLALANINE'>IAM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xy4 OCA], [https://pdbe.org/1xy4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xy4 RCSB], [https://www.ebi.ac.uk/pdbsum/1xy4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xy4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xy4 OCA], [https://pdbe.org/1xy4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xy4 RCSB], [https://www.ebi.ac.uk/pdbsum/1xy4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xy4 ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Durrer, L]]	+	[[Category: Durrer L]]
-	[[Category: Erchegyi, J]]	+	[[Category: Erchegyi J]]
-	[[Category: Grace~~, C R.R~~]]	+	[[Category: Grace CRR]]
-	[[Category: Koerber~~, S C~~]]	+	[[Category: Koerber SC]]
-	[[Category: Reubi~~, J C~~]]	+	[[Category: Reubi JC]]
-	[[Category: Riek, R]]	+	[[Category: Riek R]]
-	[[Category: Rivier~~, J E]]~~	+	[[Category: Rivier JE]]
-	~~[[Category: Gamma turn]]~~	+
-	~~[[Category: Hormone-growth factor complex~~]]	+

OCA at 16:21, 3 November 2021

OCA — Wed, 03 Nov 2021 16:21:24 GMT

←Older revision		Revision as of 16:21, 3 November 2021
Line 3:		Line 3:
	<StructureSection load='1xy4' size='340' side='right'caption='[[1xy4]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1xy4' size='340' side='right'caption='[[1xy4]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xy4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XY4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1XY4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xy4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XY4 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene>, <scene name='pdbligand=IAM:4-[(ISOPROPYLAMINO)METHYL]PHENYLALANINE'>IAM</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene>, <scene name='pdbligand=IAM:4-[(ISOPROPYLAMINO)METHYL]PHENYLALANINE'>IAM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xxz\|1xxz]], [[1xy5\|1xy5]], [[1xy6\|1xy6]], [[1xy8\|1xy8]], [[1xy9\|1xy9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xxz\|1xxz]], [[1xy5\|1xy5]], [[1xy6\|1xy6]], [[1xy8\|1xy8]], [[1xy9\|1xy9]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1xy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xy4 OCA], [~~http~~://pdbe.org/1xy4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1xy4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1xy4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1xy4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xy4 OCA], [https://pdbe.org/1xy4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xy4 RCSB], [https://www.ebi.ac.uk/pdbsum/1xy4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xy4 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:32, 29 January 2020

OCA — Wed, 29 Jan 2020 16:32:58 GMT

←Older revision		Revision as of 16:32, 29 January 2020
Line 1:		Line 1:

	==NMR strcutre of sst1-selective somatostatin (SRIF) analog 1==		==NMR strcutre of sst1-selective somatostatin (SRIF) analog 1==
-	<StructureSection load='1xy4' size='340' side='right' caption='[[1xy4]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='1xy4' size='340' side='right'caption='[[1xy4]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xy4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XY4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XY4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xy4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XY4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XY4 FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Durrer, L]]		[[Category: Durrer, L]]
	[[Category: Erchegyi, J]]		[[Category: Erchegyi, J]]

OCA at 06:53, 18 April 2018

OCA — Wed, 18 Apr 2018 06:53:51 GMT

←Older revision		Revision as of 06:53, 18 April 2018
Line 1:		Line 1:
		+
	==NMR strcutre of sst1-selective somatostatin (SRIF) analog 1==		==NMR strcutre of sst1-selective somatostatin (SRIF) analog 1==
	<StructureSection load='1xy4' size='340' side='right' caption='[[1xy4]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1xy4' size='340' side='right' caption='[[1xy4]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene>, <scene name='pdbligand=IAM:4-[(ISOPROPYLAMINO)METHYL]PHENYLALANINE'>IAM</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene>, <scene name='pdbligand=IAM:4-[(ISOPROPYLAMINO)METHYL]PHENYLALANINE'>IAM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xxz\|1xxz]], [[1xy5\|1xy5]], [[1xy6\|1xy6]], [[1xy8\|1xy8]], [[1xy9\|1xy9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xxz\|1xxz]], [[1xy5\|1xy5]], [[1xy6\|1xy6]], [[1xy8\|1xy8]], [[1xy9\|1xy9]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xy4 OCA], [http://pdbe.org/1xy4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xy4 RCSB], [http://www.ebi.ac.uk/pdbsum/1xy4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xy4 OCA], [http://pdbe.org/1xy4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xy4 RCSB], [http://www.ebi.ac.uk/pdbsum/1xy4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xy4 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:57, 11 September 2015

OCA — Fri, 11 Sep 2015 08:57:07 GMT

←Older revision		Revision as of 08:57, 11 September 2015
Line 5:		Line 5:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene>, <scene name='pdbligand=IAM:4-[(ISOPROPYLAMINO)METHYL]PHENYLALANINE'>IAM</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene>, <scene name='pdbligand=IAM:4-[(ISOPROPYLAMINO)METHYL]PHENYLALANINE'>IAM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xxz\|1xxz]], [[1xy5\|1xy5]], [[1xy6\|1xy6]], [[1xy8\|1xy8]], [[1xy9\|1xy9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xxz\|1xxz]], [[1xy5\|1xy5]], [[1xy6\|1xy6]], [[1xy8\|1xy8]], [[1xy9\|1xy9]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xy4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xy4 RCSB], [http://www.ebi.ac.uk/pdbsum/1xy4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xy4 OCA], [http://pdbe.org/1xy4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xy4 RCSB], [http://www.ebi.ac.uk/pdbsum/1xy4 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1xy4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:44, 22 December 2014

OCA — Mon, 22 Dec 2014 04:44:17 GMT

←Older revision		Revision as of 04:44, 22 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1xy4\| PDB=1xy4 \| SCENE= }}~~	+	==NMR strcutre of sst1-selective somatostatin (SRIF) analog 1==
-	===NMR strcutre of sst1-selective somatostatin (SRIF) analog 1===	+	<StructureSection load='1xy4' size='340' side='right' caption='[[1xy4]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_15658866}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1xy4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XY4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XY4 FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene>, <scene name='pdbligand=IAM:4-[(ISOPROPYLAMINO)METHYL]PHENYLALANINE'>IAM</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xxz\|1xxz]], [[1xy5\|1xy5]], [[1xy6\|1xy6]], [[1xy8\|1xy8]], [[1xy9\|1xy9]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xy4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xy4 RCSB], [http://www.ebi.ac.uk/pdbsum/1xy4 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The three-dimensional NMR structures of six analogues of somatostatin (SRIF) are described. These analogues with the amino acid 4-(N-isopropyl)-aminomethylphenylalanine (IAmp) at position 9 exhibit potent and highly selective binding to human SRIF subtype 1 receptors (sst(1)). The conformations reveal that the backbones of these analogues have a hairpin-like structure similar to the sst(2)-subtype-selective analogues. This structure serves as a scaffold for retaining a unique arrangement of the side chains of d-Trp(8), IAmp(9), Phe(7), and Phe(11) or m-I-Tyr(11) (m-I-Tyr = mono-iodo-tyrosine). The conformational preferences and results from biological analyses of these analogues(1,2) allow a detailed study of the structure-activity relationship of SRIF. The proposed consensus pharmacophore of the sst(1)-selective analogues requires a unique set of distances between an indole/2-naphthyl ring, an IAmp side chain, and two aromatic rings. This motif is necessary and sufficient to explain the binding affinities of all of the analogues studied and is distinct from the existing models suggested for sst(4) as well as sst(2)/sst(5) selectivity.

-	~~==About this Structure==~~	+	Somatostatin receptor 1 selective analogues: 4. Three-dimensional consensus structure by NMR.,Grace CR, Durrer L, Koerber SC, Erchegyi J, Reubi JC, Rivier JE, Riek R J Med Chem. 2005 Jan 27;48(2):523-33. PMID:15658866<ref>PMID:15658866</ref>
-	~~[[1xy4]] is a~~ 1 ~~chain structure. Full experimental information is available from [http~~:~~//oca~~.~~weizmann~~.ac.~~il/oca~~-~~bin/ocashort?id=1XY4 OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:015658866</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Durrer, L.]]	+	== References ==
-	[[Category: Erchegyi, J.]]	+	<references/>
-	[[Category: Grace, C R.R.]]	+	__TOC__
-	[[Category: Koerber, S C.]]	+	</StructureSection>
-	[[Category: Reubi, J C.]]	+	[[Category: Durrer, L]]
-	[[Category: Riek, R.]]	+	[[Category: Erchegyi, J]]
-	[[Category: Rivier, J E.]]	+	[[Category: Grace, C R.R]]
		+	[[Category: Koerber, S C]]
		+	[[Category: Reubi, J C]]
		+	[[Category: Riek, R]]
		+	[[Category: Rivier, J E]]
	[[Category: Gamma turn]]		[[Category: Gamma turn]]
	[[Category: Hormone-growth factor complex]]		[[Category: Hormone-growth factor complex]]

OCA at 08:11, 23 April 2014

OCA — Wed, 23 Apr 2014 08:11:35 GMT

←Older revision		Revision as of 08:11, 23 April 2014
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-	[[Image:1xy4.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_1xy4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1xy4\| PDB=1xy4 \| SCENE= }}		{{STRUCTURE_1xy4\| PDB=1xy4 \| SCENE= }}
-
	===NMR strcutre of sst1-selective somatostatin (SRIF) analog 1===		===NMR strcutre of sst1-selective somatostatin (SRIF) analog 1===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15658866}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15658866 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_15658866}}		{{ABSTRACT_PUBMED_15658866}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:015658866</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015658866</ref><references group="xtra"/><references/>
	[[Category: Durrer, L.]]		[[Category: Durrer, L.]]
	[[Category: Erchegyi, J.]]		[[Category: Erchegyi, J.]]

OCA: Protected "1xy4" [edit=sysop:move=sysop]

OCA — Wed, 28 Sep 2011 04:42:18 GMT

Protected "1xy4" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:42, 28 September 2011

OCA at 04:42, 28 September 2011

OCA — Wed, 28 Sep 2011 04:42:16 GMT

←Older revision		Revision as of 04:42, 28 September 2011
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1xy4.png\|left\|200px]]		[[Image:1xy4.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XY4 OCA].	+	[[1xy4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XY4 OCA].

	==Reference==		==Reference==
-	Somatostatin receptor 1 selective analogues: 4. Three-dimensional consensus structure by NMR., Grace CR, Durrer L, Koerber SC, Erchegyi J, Reubi JC, Rivier JE, Riek R, J Med Chem. 2005 Jan 27;48(2):523-33. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~15658866 15658866]~~	+	<ref group="xtra">PMID:015658866</ref><references group="xtra"/>
	[[Category: Durrer, L.]]		[[Category: Durrer, L.]]
	[[Category: Erchegyi, J.]]		[[Category: Erchegyi, J.]]
Line 32:		Line 31:
	[[Category: Rivier, J E.]]		[[Category: Rivier, J E.]]
	[[Category: Gamma turn]]		[[Category: Gamma turn]]
-		+	[[Category: Hormone-growth factor complex]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Jul 29 02:13:48 2008''~~	+

OCA at 23:13, 28 July 2008

OCA — Mon, 28 Jul 2008 23:13:51 GMT

←Older revision		Revision as of 23:13, 28 July 2008
Line 1:		Line 1:
-	[[Image:1xy4.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1xy4.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1xy4\| PDB=1xy4 \| SCENE= }}		{{STRUCTURE_1xy4\| PDB=1xy4 \| SCENE= }}

-	~~'''~~NMR strcutre of sst1-selective somatostatin (SRIF) analog 1~~'''~~	+	===NMR strcutre of sst1-selective somatostatin (SRIF) analog 1===


-	~~==Overview==~~	+	<!--
-	~~The three~~-~~dimensional NMR structures of six analogues of somatostatin (SRIF) are described. These analogues with the amino acid 4~~-~~(N-isopropyl)-aminomethylphenylalanine (IAmp) at position 9 exhibit potent and highly selective binding to human SRIF subtype 1 receptors (sst(1)).~~ The ~~conformations reveal that~~ the ~~backbones of these analogues have a hairpin-like structure similar~~ to the ~~sst~~(~~2)-subtype-selective analogues. This structure serves~~ as ~~a scaffold for retaining a unique arrangement of the side chains of d-Trp(8), IAmp(9), Phe(7), and Phe(11) or m-I-Tyr(11) (m-I-Tyr = mono-iodo-tyrosine)~~. ~~The conformational preferences and results from biological analyses of these analogues(1,2) allow a detailed study of the structure-activity relationship of SRIF~~. ~~The proposed consensus pharmacophore of the sst(1~~)~~-selective analogues requires a unique set of distances between an indole/2-naphthyl ring~~, ~~an IAmp side chain, and two aromatic rings. This motif~~ is ~~necessary and sufficient to explain~~ the ~~binding affinities of all of the analogues studied and is distinct from the existing models suggested for sst(4) as well as sst(2)/sst(5) selectivity~~.	+	The line below this paragraph, {{ABSTRACT_PUBMED_15658866}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 15658866 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_15658866}}

	==About this Structure==		==About this Structure==
-	Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XY4 OCA].	+	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XY4 OCA].

	==Reference==		==Reference==
Line 28:		Line 32:
	[[Category: Rivier, J E.]]		[[Category: Rivier, J E.]]
	[[Category: Gamma turn]]		[[Category: Gamma turn]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 15~~:39:21 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:13:48 2008''