1xyq - Revision history

OCA at 07:59, 15 May 2024

OCA — Wed, 15 May 2024 07:59:00 GMT

←Older revision		Revision as of 07:59, 15 May 2024
Line 1:		Line 1:

	==NMR structure of the pig prion protein==		==NMR structure of the pig prion protein==
-	<StructureSection load='1xyq' size='340' side='right'caption='[[1xyq~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1xyq' size='340' side='right'caption='[[1xyq]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xyq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Pig Pig~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XYQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xyq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XYQ FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1xyj\|1xyj]], [[1xyk\|1xyk]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Prnp ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xyq OCA], [https://pdbe.org/1xyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xyq RCSB], [https://www.ebi.ac.uk/pdbsum/1xyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xyq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xyq OCA], [https://pdbe.org/1xyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xyq RCSB], [https://www.ebi.ac.uk/pdbsum/1xyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xyq ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/PRIO_PIG PRIO_PIG]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.	+	[https://www.uniprot.org/uniprot/PRIO_PIG PRIO_PIG] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PRIO_PIG PRIO_PIG]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).	+	[https://www.uniprot.org/uniprot/PRIO_PIG PRIO_PIG] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 39:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pig~~]]	+	[[Category: Sus scrofa]]
-	[[Category: Herrmann, T]]	+	[[Category: Herrmann T]]
-	[[Category: Lysek~~, D A~~]]	+	[[Category: Lysek DA]]
-	[[Category: Schorn, C]]	+	[[Category: Schorn C]]
-	[[Category: Wuthrich, K]]	+	[[Category: Wuthrich K]]
-	~~[[Category: Prion]]~~	+
-	~~[[Category: Prp]]~~	+
-	~~[[Category: Scprp]]~~	+
-	~~[[Category: Tse]]~~	+
-	~~[[Category: Unknown function~~]]	+

OCA at 07:10, 2 March 2022

OCA — Wed, 02 Mar 2022 07:10:24 GMT

OCA at 10:26, 6 January 2021

OCA — Wed, 06 Jan 2021 10:26:24 GMT

←Older revision		Revision as of 10:26, 6 January 2021
Line 1:		Line 1:

	==NMR structure of the pig prion protein==		==NMR structure of the pig prion protein==
-	<StructureSection load='1xyq' size='340' side='right' caption='[[1xyq]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1xyq' size='340' side='right'caption='[[1xyq]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xyq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XYQ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1XYQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xyq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XYQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1XYQ FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xyj\|1xyj]], [[1xyk\|1xyk]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xyj\|1xyj]], [[1xyk\|1xyk]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Prnp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Prnp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1xyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xyq OCA], [http://pdbe.org/1xyq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xyq RCSB], [http://www.ebi.ac.uk/pdbsum/1xyq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xyq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1xyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xyq OCA], [http://pdbe.org/1xyq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xyq RCSB], [http://www.ebi.ac.uk/pdbsum/1xyq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xyq ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 33:		Line 33:

	==See Also==		==See Also==
-	*[[Prion\|Prion]]	+	*[[Prion 3D structures\|Prion 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Pig]]		[[Category: Pig]]
	[[Category: Herrmann, T]]		[[Category: Herrmann, T]]

OCA at 07:05, 18 April 2018

OCA — Wed, 18 Apr 2018 07:05:27 GMT

←Older revision		Revision as of 07:05, 18 April 2018
Line 1:		Line 1:
		+
	==NMR structure of the pig prion protein==		==NMR structure of the pig prion protein==
	<StructureSection load='1xyq' size='340' side='right' caption='[[1xyq]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1xyq' size='340' side='right' caption='[[1xyq]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xyj\|1xyj]], [[1xyk\|1xyk]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xyj\|1xyj]], [[1xyk\|1xyk]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Prnp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Prnp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xyq OCA], [http://pdbe.org/1xyq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xyq RCSB], [http://www.ebi.ac.uk/pdbsum/1xyq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xyq OCA], [http://pdbe.org/1xyq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xyq RCSB], [http://www.ebi.ac.uk/pdbsum/1xyq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xyq ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xy/1xyq_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xy/1xyq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xyq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:55, 11 September 2015

OCA — Fri, 11 Sep 2015 22:55:44 GMT

←Older revision		Revision as of 22:55, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1xyq' size='340' side='right' caption='[[1xyq]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1xyq' size='340' side='right' caption='[[1xyq]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xyq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sus_scrofa Sus scrofa~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XYQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xyq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XYQ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xyj\|1xyj]], [[1xyk\|1xyk]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xyj\|1xyj]], [[1xyk\|1xyk]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Prnp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 ~~Sus scrofa~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Prnp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xyq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xyq RCSB], [http://www.ebi.ac.uk/pdbsum/1xyq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xyq OCA], [http://pdbe.org/1xyq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xyq RCSB], [http://www.ebi.ac.uk/pdbsum/1xyq PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1xyq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Sus scrofa~~]]	+	[[Category: Pig]]
	[[Category: Herrmann, T]]		[[Category: Herrmann, T]]
	[[Category: Lysek, D A]]		[[Category: Lysek, D A]]

OCA at 10:04, 8 January 2015

OCA — Thu, 08 Jan 2015 10:04:57 GMT

←Older revision		Revision as of 10:04, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xyq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XYQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xyq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XYQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xyj\|1xyj]], [[1xyk\|1xyk]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xyj\|1xyj]], [[1xyk\|1xyk]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Prnp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 Sus scrofa])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Prnp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 Sus scrofa])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xyq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xyq RCSB], [http://www.ebi.ac.uk/pdbsum/1xyq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xyq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xyq RCSB], [http://www.ebi.ac.uk/pdbsum/1xyq PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/PRIO_PIG PRIO_PIG]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.		[[http://www.uniprot.org/uniprot/PRIO_PIG PRIO_PIG]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
-	[[Category: Herrmann, T.]]	+	[[Category: Herrmann, T]]
-	[[Category: Lysek, D A.]]	+	[[Category: Lysek, D A]]
-	[[Category: Schorn, C.]]	+	[[Category: Schorn, C]]
-	[[Category: Wuthrich, K.]]	+	[[Category: Wuthrich, K]]
	[[Category: Prion]]		[[Category: Prion]]
	[[Category: Prp]]		[[Category: Prp]]

OCA at 19:54, 29 September 2014

OCA — Mon, 29 Sep 2014 19:54:06 GMT

←Older revision		Revision as of 19:54, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1xyq\| PDB~~=1xyq \| ~~SCENE~~= }}	+	==NMR structure of the pig prion protein==
-	===~~NMR~~ structure of the ~~pig prion protein~~===	+	<StructureSection load='1xyq' size='340' side='right' caption='[[1xyq]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_15647367}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[1xyq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XYQ FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xyj\|1xyj]], [[1xyk\|1xyk]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Prnp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 Sus scrofa])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xyq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xyq RCSB], [http://www.ebi.ac.uk/pdbsum/1xyq PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/PRIO_PIG PRIO_PIG]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.		[[http://www.uniprot.org/uniprot/PRIO_PIG PRIO_PIG]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/PRIO_PIG PRIO_PIG]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).		[[http://www.uniprot.org/uniprot/PRIO_PIG PRIO_PIG]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xy/1xyq_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The NMR structures of the recombinant cellular form of the prion proteins (PrPC) of the cat (Felis catus), dog (Canis familiaris), and pig (Sus scrofa), and of two polymorphic forms of the prion protein from sheep (Ovis aries) are presented. In all of these species, PrPC consists of an N-terminal flexibly extended tail with approximately 100 amino acid residues and a C-terminal globular domain of approximately 100 residues with three alpha-helices and a short antiparallel beta-sheet. Although this global architecture coincides with the previously reported murine, Syrian hamster, bovine, and human PrPC structures, there are local differences between the globular domains of the different species. Because the five newly determined PrPC structures originate from species with widely different transmissible spongiform encephalopathy records, the present data indicate previously uncharacterized possible correlations between local features in PrPC three-dimensional structures and susceptibility of different mammalian species to transmissible spongiform encephalopathies.

-	~~==About this Structure==~~	+	Prion protein NMR structures of cats, dogs, pigs, and sheep.,Lysek DA, Schorn C, Nivon LG, Esteve-Moya V, Christen B, Calzolai L, von Schroetter C, Fiorito F, Herrmann T, Guntert P, Wuthrich K Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):640-5. Epub 2005 Jan 12. PMID:15647367<ref>PMID:15647367</ref>
-	~~[[1xyq]] is a 1 chain structure with sequence from [http~~:~~//en~~.~~wikipedia.org/wiki/Sus_scrofa Sus scrofa]~~. ~~Full experimental information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1XYQ OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Prion\|Prion]]		*[[Prion\|Prion]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:015647367</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
	[[Category: Herrmann, T.]]		[[Category: Herrmann, T.]]

OCA at 02:14, 25 March 2013

OCA — Mon, 25 Mar 2013 02:14:28 GMT

←Older revision		Revision as of 02:14, 25 March 2013
Line 1:		Line 1:
-	[[Image:1xyq.png\|left\|200px]]
-
	{{STRUCTURE_1xyq\| PDB=1xyq \| SCENE= }}		{{STRUCTURE_1xyq\| PDB=1xyq \| SCENE= }}
-
	===NMR structure of the pig prion protein===		===NMR structure of the pig prion protein===
		+	{{ABSTRACT_PUBMED_15647367}}

-	~~{{ABSTRACT_PUBMED_15647367}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/PRIO_PIG PRIO_PIG]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/PRIO_PIG PRIO_PIG]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:015647367</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015647367</ref><references group="xtra"/><references/>
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
	[[Category: Herrmann, T.]]		[[Category: Herrmann, T.]]

OCA at 21:10, 20 October 2012

OCA — Sat, 20 Oct 2012 21:10:03 GMT

←Older revision		Revision as of 21:10, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1xyq]] is a 1 chain structure ~~of [[Prion]]~~ with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XYQ OCA].	+	[[1xyq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XYQ OCA].

	==See Also==		==See Also==

OCA: Protected "1xyq" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 12:45:43 GMT

Protected "1xyq" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:45, 27 July 2012

←Older revision		Revision as of 07:10, 2 March 2022
Line 3:		Line 3:
	<StructureSection load='1xyq' size='340' side='right'caption='[[1xyq]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1xyq' size='340' side='right'caption='[[1xyq]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xyq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Pig Pig]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XYQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1XYQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xyq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pig Pig]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XYQ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xyj\|1xyj]], [[1xyk\|1xyk]]</div></td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xyj\|1xyj]], [[1xyk\|1xyk]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Prnp ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Prnp ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1xyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xyq OCA], [~~http~~://pdbe.org/1xyq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1xyq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1xyq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1xyq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xyq OCA], [https://pdbe.org/1xyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xyq RCSB], [https://www.ebi.ac.uk/pdbsum/1xyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xyq ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/PRIO_PIG PRIO_PIG]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.	+	[[https://www.uniprot.org/uniprot/PRIO_PIG PRIO_PIG]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PRIO_PIG PRIO_PIG]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).	+	[[https://www.uniprot.org/uniprot/PRIO_PIG PRIO_PIG]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]