1y0l - Revision history

OCA at 06:51, 23 August 2023

OCA — Wed, 23 Aug 2023 06:51:21 GMT

←Older revision		Revision as of 06:51, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1y0l' size='340' side='right'caption='[[1y0l]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1y0l' size='340' side='right'caption='[[1y0l]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y0l]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y0L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y0l]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y0L FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=HAN:~~2~~-AMINO-~~5~~,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC+ACID'>HAN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height~~: ~~3em;~~'>~~[[1y18\|1y18]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HAN:2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC+ACID'>HAN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y0l OCA], [https://pdbe.org/1y0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y0l RCSB], [https://www.ebi.ac.uk/pdbsum/1y0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y0l ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y0l OCA], [https://pdbe.org/1y0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y0l RCSB], [https://www.ebi.ac.uk/pdbsum/1y0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y0l ProSAT]</span></td></tr>
	</table>		</table>
Line 34:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Debler~~, E W~~]]	+	[[Category: Debler EW]]
-	[[Category: Heine, A]]	+	[[Category: Heine A]]
-	[[Category: Ito, S]]	+	[[Category: Ito S]]
-	[[Category: Wilson~~, I A]]~~	+	[[Category: Wilson IA]]
-	~~[[Category: Catalytic antibody]]~~	+
-	~~[[Category: Chimeric fab]]~~	+
-	~~[[Category: Hapten complex]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin~~]]	+

OCA at 16:22, 3 November 2021

OCA — Wed, 03 Nov 2021 16:22:15 GMT

←Older revision		Revision as of 16:22, 3 November 2021
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	<StructureSection load='1y0l' size='340' side='right'caption='[[1y0l]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1y0l' size='340' side='right'caption='[[1y0l]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y0l]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y0L OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Y0L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y0l]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y0L FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HAN:2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC+ACID'>HAN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HAN:2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC+ACID'>HAN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y18\|1y18]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1y18\|1y18]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1y0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y0l OCA], [~~http~~://pdbe.org/1y0l PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1y0l RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1y0l PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1y0l ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y0l OCA], [https://pdbe.org/1y0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y0l RCSB], [https://www.ebi.ac.uk/pdbsum/1y0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y0l ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 17:19, 29 January 2020

OCA — Wed, 29 Jan 2020 17:19:48 GMT

←Older revision		Revision as of 17:19, 29 January 2020
Line 1:		Line 1:

	==Catalytic elimination antibody 34E4 in complex with hapten==		==Catalytic elimination antibody 34E4 in complex with hapten==
-	<StructureSection load='1y0l' size='340' side='right' caption='[[1y0l]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='1y0l' size='340' side='right'caption='[[1y0l]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1y0l]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y0L FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y0l]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y0L FirstGlance]. <br>
Line 34:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Debler, E W]]		[[Category: Debler, E W]]

OCA at 07:33, 18 April 2018

OCA — Wed, 18 Apr 2018 07:33:11 GMT

←Older revision		Revision as of 07:33, 18 April 2018
Line 1:		Line 1:
		+
	==Catalytic elimination antibody 34E4 in complex with hapten==		==Catalytic elimination antibody 34E4 in complex with hapten==
	<StructureSection load='1y0l' size='340' side='right' caption='[[1y0l]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1y0l' size='340' side='right' caption='[[1y0l]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HAN:2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC+ACID'>HAN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HAN:2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC+ACID'>HAN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y18\|1y18]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y18\|1y18]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y0l OCA], [http://pdbe.org/1y0l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y0l RCSB], [http://www.ebi.ac.uk/pdbsum/1y0l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y0l OCA], [http://pdbe.org/1y0l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y0l RCSB], [http://www.ebi.ac.uk/pdbsum/1y0l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y0l ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y0/1y0l_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y0/1y0l_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:

	==See Also==		==See Also==
-	*[[Monoclonal ~~Antibody~~\|Monoclonal ~~Antibody~~]]	+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:34, 8 February 2016

OCA — Mon, 08 Feb 2016 15:34:27 GMT

←Older revision		Revision as of 15:34, 8 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y0l ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:00, 10 September 2015

OCA — Thu, 10 Sep 2015 13:00:11 GMT

←Older revision		Revision as of 13:00, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1y0l' size='340' side='right' caption='[[1y0l]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1y0l' size='340' side='right' caption='[[1y0l]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y0l]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y0L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y0l]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y0L FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HAN:2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC+ACID'>HAN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HAN:2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC+ACID'>HAN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y18\|1y18]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y18\|1y18]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y0l RCSB], [http://www.ebi.ac.uk/pdbsum/1y0l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y0l OCA], [http://pdbe.org/1y0l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y0l RCSB], [http://www.ebi.ac.uk/pdbsum/1y0l PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1y0l" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens]]~~	+	[[Category: Lk3 transgenic mice]]
-	~~[[Category: Mus musculus~~]]	+
	[[Category: Debler, E W]]		[[Category: Debler, E W]]
	[[Category: Heine, A]]		[[Category: Heine, A]]

OCA at 10:37, 8 January 2015

OCA — Thu, 08 Jan 2015 10:37:13 GMT

←Older revision		Revision as of 10:37, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1y0l]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y0L FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y0l]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y0L FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HAN:2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC+ACID'>HAN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HAN:2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC+ACID'>HAN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y18\|1y18]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y18\|1y18]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y0l RCSB], [http://www.ebi.ac.uk/pdbsum/1y0l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y0l RCSB], [http://www.ebi.ac.uk/pdbsum/1y0l PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Debler, E W.]]	+	[[Category: Debler, E W]]
-	[[Category: Heine, A.]]	+	[[Category: Heine, A]]
-	[[Category: Ito, S.]]	+	[[Category: Ito, S]]
-	[[Category: Wilson, I A.]]	+	[[Category: Wilson, I A]]
	[[Category: Catalytic antibody]]		[[Category: Catalytic antibody]]
	[[Category: Chimeric fab]]		[[Category: Chimeric fab]]

OCA at 22:04, 28 September 2014

OCA — Sun, 28 Sep 2014 22:04:21 GMT

←Older revision		Revision as of 22:04, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1y0l.~~png~~\|~~left~~\|200px]]	+	==Catalytic elimination antibody 34E4 in complex with hapten==
		+	<StructureSection load='1y0l' size='340' side='right' caption='[[1y0l]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1y0l]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y0L FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HAN:2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC+ACID'>HAN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y18\|1y18]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y0l RCSB], [http://www.ebi.ac.uk/pdbsum/1y0l PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y0/1y0l_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Antibody 34E4 catalyzes the conversion of benzisoxazoles to salicylonitriles with high rates and multiple turnovers. The crystal structure of its complex with the benzimidazolium hapten at 2.5-angstroms resolution shows that a combination of hydrogen bonding, pi stacking, and van der Waals interactions is exploited to position both the base, Glu(H50), and the substrate for efficient proton transfer. Suboptimal placement of the catalytic carboxylate, as observed in the 2.8-angstroms structure of the Glu(H50)Asp variant, results in substantially reduced catalytic efficiency. In addition to imposing high positional order on the transition state, the antibody pocket provides a highly structured microenvironment for the reaction in which the carboxylate base is activated through partial desolvation, and the highly polarizable transition state is stabilized by dispersion interactions with the aromatic residue Trp(L91) and solvation of the leaving group oxygen by external water. The enzyme-like efficiency of general base catalysis in this system directly reflects the original hapten design, in which a charged guanidinium moiety was strategically used to elicit an accurately positioned functional group in an appropriate reaction environment and suggests that even larger catalytic effects may be achievable by extending this approach to the induction of acid-base pairs capable of bifunctional catalysis.

-	~~{{STRUCTURE_1y0l\| PDB=1y0l \| SCENE= }}~~	+	Structural origins of efficient proton abstraction from carbon by a catalytic antibody.,Debler EW, Ito S, Seebeck FP, Heine A, Hilvert D, Wilson IA Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):4984-9. Epub 2005 Mar 23. PMID:15788533<ref>PMID:15788533</ref>

-	~~===Catalytic elimination antibody 34E4 in complex with hapten===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15788533}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1y0l]] is~~ a ~~8 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens] and [http://en~~.~~wikipedia.org~~/~~wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y0L OCA].~~	+

	==See Also==		==See Also==
-	*[[Antibody\|Antibody]]	+	*[[Monoclonal Antibody\|Monoclonal Antibody]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015788533<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 10:37, 20 October 2012

OCA — Sat, 20 Oct 2012 10:37:19 GMT

←Older revision		Revision as of 10:37, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1y0l]] is a 8 chain structure ~~of [[Antibody]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus~~,_homo_sapiens~~ Mus musculus~~, homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y0L OCA].	+	[[1y0l]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y0L OCA].

	==See Also==		==See Also==
Line 15:		Line 15:
	==Reference==		==Reference==
	<ref group="xtra">PMID:015788533</ref><references group="xtra"/>		<ref group="xtra">PMID:015788533</ref><references group="xtra"/>
-	[[Category: Mus musculus~~, homo sapiens~~]]	+	[[Category: Homo sapiens]]
		+	[[Category: Mus musculus]]
	[[Category: Debler, E W.]]		[[Category: Debler, E W.]]
	[[Category: Heine, A.]]		[[Category: Heine, A.]]

OCA: Protected "1y0l" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 02:44:25 GMT

Protected "1y0l" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:44, 26 July 2012