1y18 - Revision history

OCA at 06:51, 23 August 2023

OCA — Wed, 23 Aug 2023 06:51:27 GMT

←Older revision		Revision as of 06:51, 23 August 2023
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	<StructureSection load='1y18' size='340' side='right'caption='[[1y18]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1y18' size='340' side='right'caption='[[1y18]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y18]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y18 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y18]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y18 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HAN:2~~-~~AMINO-5~~,~~6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC+ACID'>HAN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height~~: ~~3em;~~'>~~[[1y0l\|1y0l]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HAN:2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC+ACID'>HAN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y18 OCA], [https://pdbe.org/1y18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y18 RCSB], [https://www.ebi.ac.uk/pdbsum/1y18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y18 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y18 OCA], [https://pdbe.org/1y18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y18 RCSB], [https://www.ebi.ac.uk/pdbsum/1y18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y18 ProSAT]</span></td></tr>
	</table>		</table>
Line 34:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Debler~~, E W~~]]	+	[[Category: Debler EW]]
-	[[Category: Heine, A]]	+	[[Category: Heine A]]
-	[[Category: Ito, S]]	+	[[Category: Ito S]]
-	[[Category: Wilson~~, I A]]~~	+	[[Category: Wilson IA]]
-	~~[[Category: Catalytic antibody]]~~	+
-	~~[[Category: Chimeric fab]]~~	+
-	~~[[Category: Hapten complex]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin~~]]	+

OCA at 06:32, 6 October 2021

OCA — Wed, 06 Oct 2021 06:32:47 GMT

←Older revision		Revision as of 06:32, 6 October 2021
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	<StructureSection load='1y18' size='340' side='right'caption='[[1y18]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1y18' size='340' side='right'caption='[[1y18]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y18]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y18 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Y18 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y18]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y18 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HAN:2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC+ACID'>HAN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HAN:2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC+ACID'>HAN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y0l\|1y0l]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1y0l\|1y0l]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1y18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y18 OCA], [~~http~~://pdbe.org/1y18 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1y18 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1y18 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1y18 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y18 OCA], [https://pdbe.org/1y18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y18 RCSB], [https://www.ebi.ac.uk/pdbsum/1y18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y18 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 11:40, 4 December 2019

OCA — Wed, 04 Dec 2019 11:40:05 GMT

←Older revision		Revision as of 11:40, 4 December 2019
Line 1:		Line 1:

	==Fab fragment of catalytic elimination antibody 34E4 E(H50)D mutant in complex with hapten==		==Fab fragment of catalytic elimination antibody 34E4 E(H50)D mutant in complex with hapten==
-	<StructureSection load='1y18' size='340' side='right' caption='[[1y18]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='1y18' size='340' side='right'caption='[[1y18]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1y18]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y18 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y18]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y18 FirstGlance]. <br>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1y18" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1y18" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Debler, E W]]		[[Category: Debler, E W]]

OCA at 06:34, 31 January 2018

OCA — Wed, 31 Jan 2018 06:34:23 GMT

←Older revision		Revision as of 06:34, 31 January 2018
Line 1:		Line 1:
		+
	==Fab fragment of catalytic elimination antibody 34E4 E(H50)D mutant in complex with hapten==		==Fab fragment of catalytic elimination antibody 34E4 E(H50)D mutant in complex with hapten==
	<StructureSection load='1y18' size='340' side='right' caption='[[1y18]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1y18' size='340' side='right' caption='[[1y18]], [[Resolution\|resolution]] 2.80Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HAN:2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC+ACID'>HAN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HAN:2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC+ACID'>HAN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y0l\|1y0l]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y0l\|1y0l]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y18 OCA], [http://pdbe.org/1y18 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y18 RCSB], [http://www.ebi.ac.uk/pdbsum/1y18 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y18 OCA], [http://pdbe.org/1y18 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y18 RCSB], [http://www.ebi.ac.uk/pdbsum/1y18 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y18 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y1/1y18_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y1/1y18_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 26:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1y18" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1y18" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Monoclonal Antibody\|Monoclonal Antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:29, 7 February 2016

OCA — Sun, 07 Feb 2016 15:29:17 GMT

←Older revision		Revision as of 15:29, 7 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y18 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:48, 10 September 2015

OCA — Thu, 10 Sep 2015 02:48:27 GMT

←Older revision		Revision as of 02:48, 10 September 2015
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	<StructureSection load='1y18' size='340' side='right' caption='[[1y18]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1y18' size='340' side='right' caption='[[1y18]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y18]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y18 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y18]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y18 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HAN:2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC+ACID'>HAN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HAN:2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC+ACID'>HAN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y0l\|1y0l]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y0l\|1y0l]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y18 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y18 RCSB], [http://www.ebi.ac.uk/pdbsum/1y18 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y18 OCA], [http://pdbe.org/1y18 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y18 RCSB], [http://www.ebi.ac.uk/pdbsum/1y18 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1y18" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens]]~~	+	[[Category: Lk3 transgenic mice]]
-	~~[[Category: Mus musculus~~]]	+
	[[Category: Debler, E W]]		[[Category: Debler, E W]]
	[[Category: Heine, A]]		[[Category: Heine, A]]

OCA at 09:37, 8 January 2015

OCA — Thu, 08 Jan 2015 09:37:07 GMT

←Older revision		Revision as of 09:37, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1y18]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y18 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y18]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y18 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HAN:2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC+ACID'>HAN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HAN:2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC+ACID'>HAN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y0l\|1y0l]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y0l\|1y0l]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y18 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y18 RCSB], [http://www.ebi.ac.uk/pdbsum/1y18 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y18 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y18 RCSB], [http://www.ebi.ac.uk/pdbsum/1y18 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Debler, E W.]]	+	[[Category: Debler, E W]]
-	[[Category: Heine, A.]]	+	[[Category: Heine, A]]
-	[[Category: Ito, S.]]	+	[[Category: Ito, S]]
-	[[Category: Wilson, I A.]]	+	[[Category: Wilson, I A]]
	[[Category: Catalytic antibody]]		[[Category: Catalytic antibody]]
	[[Category: Chimeric fab]]		[[Category: Chimeric fab]]

OCA at 21:35, 29 September 2014

OCA — Mon, 29 Sep 2014 21:35:04 GMT

←Older revision		Revision as of 21:35, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1y18.~~png~~\|~~left~~\|200px]]	+	==Fab fragment of catalytic elimination antibody 34E4 E(H50)D mutant in complex with hapten==
		+	<StructureSection load='1y18' size='340' side='right' caption='[[1y18]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1y18]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y18 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HAN:2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC+ACID'>HAN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y0l\|1y0l]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y18 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y18 RCSB], [http://www.ebi.ac.uk/pdbsum/1y18 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y1/1y18_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Antibody 34E4 catalyzes the conversion of benzisoxazoles to salicylonitriles with high rates and multiple turnovers. The crystal structure of its complex with the benzimidazolium hapten at 2.5-angstroms resolution shows that a combination of hydrogen bonding, pi stacking, and van der Waals interactions is exploited to position both the base, Glu(H50), and the substrate for efficient proton transfer. Suboptimal placement of the catalytic carboxylate, as observed in the 2.8-angstroms structure of the Glu(H50)Asp variant, results in substantially reduced catalytic efficiency. In addition to imposing high positional order on the transition state, the antibody pocket provides a highly structured microenvironment for the reaction in which the carboxylate base is activated through partial desolvation, and the highly polarizable transition state is stabilized by dispersion interactions with the aromatic residue Trp(L91) and solvation of the leaving group oxygen by external water. The enzyme-like efficiency of general base catalysis in this system directly reflects the original hapten design, in which a charged guanidinium moiety was strategically used to elicit an accurately positioned functional group in an appropriate reaction environment and suggests that even larger catalytic effects may be achievable by extending this approach to the induction of acid-base pairs capable of bifunctional catalysis.

-	~~{{STRUCTURE_1y18\| PDB=1y18 \| SCENE= }}~~	+	Structural origins of efficient proton abstraction from carbon by a catalytic antibody.,Debler EW, Ito S, Seebeck FP, Heine A, Hilvert D, Wilson IA Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):4984-9. Epub 2005 Mar 23. PMID:15788533<ref>PMID:15788533</ref>

-	~~===Fab fragment~~ of ~~catalytic elimination antibody 34E4 E(H50)D mutant in complex with hapten===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_15788533}}~~	+	==See Also==
-		+	*[[Monoclonal Antibody\|Monoclonal Antibody]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1y18~~]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y18 OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:015788533<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA: Protected "1y18" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 12:54:53 GMT

Protected "1y18" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:54, 5 January 2013

OCA at 12:54, 5 January 2013

OCA — Sat, 05 Jan 2013 12:54:50 GMT

←Older revision		Revision as of 12:54, 5 January 2013
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-	{{Seed}}
	[[Image:1y18.png\|left\|200px]]		[[Image:1y18.png\|left\|200px]]

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	{{STRUCTURE_1y18\| PDB=1y18 \| SCENE= }}		{{STRUCTURE_1y18\| PDB=1y18 \| SCENE= }}

	===Fab fragment of catalytic elimination antibody 34E4 E(H50)D mutant in complex with hapten===		===Fab fragment of catalytic elimination antibody 34E4 E(H50)D mutant in complex with hapten===

-
-	<!--
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	{{ABSTRACT_PUBMED_15788533}}		{{ABSTRACT_PUBMED_15788533}}

	==About this Structure==		==About this Structure==
-	~~1Y18~~ is a 8 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus~~,_homo_sapiens~~ Mus musculus~~, homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y18 OCA].	+	[[1y18]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y18 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15788533~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015788533</ref><references group="xtra"/>
-	[[Category: Mus musculus~~, homo sapiens~~]]	+	[[Category: Homo sapiens]]
		+	[[Category: Mus musculus]]
	[[Category: Debler, E W.]]		[[Category: Debler, E W.]]
	[[Category: Heine, A.]]		[[Category: Heine, A.]]
Line 32:		Line 21:
	[[Category: Chimeric fab]]		[[Category: Chimeric fab]]
	[[Category: Hapten complex]]		[[Category: Hapten complex]]
		+	[[Category: Immune system]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:47:12 2009''