1y1c - Revision history

OCA at 07:59, 15 May 2024

OCA — Wed, 15 May 2024 07:59:43 GMT

←Older revision		Revision as of 07:59, 15 May 2024
Line 1:		Line 1:

	==Solution structure of Anemonia elastase inhibitor analogue==		==Solution structure of Anemonia elastase inhibitor analogue==
-	<StructureSection load='1y1c' size='340' side='right'caption='[[1y1c~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1y1c' size='340' side='right'caption='[[1y1c]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y1c]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y1C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y1c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Anemonia_sulcata Anemonia sulcata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y1C FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[1y1b\|1y1b]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1c OCA], [https://pdbe.org/1y1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y1c RCSB], [https://www.ebi.ac.uk/pdbsum/1y1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y1c ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1c OCA], [https://pdbe.org/1y1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y1c RCSB], [https://www.ebi.ac.uk/pdbsum/1y1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y1c ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IELA_ANESU IELA_ANESU]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Anemonia sulcata]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hemmi, H]]	+	[[Category: Hemmi H]]
-	[[Category: Kobayashi, Y]]	+	[[Category: Kobayashi Y]]
-	[[Category: Kumazaki, T]]	+	[[Category: Kumazaki T]]
-	[[Category: Nishiuchi, Y]]	+	[[Category: Nishiuchi Y]]
-	[[Category: Ohkubo, T]]	+	[[Category: Ohkubo T]]
-	[[Category: Yoshida, T]]	+	[[Category: Yoshida T]]
-	[[Category: Yoshizawa-Kumagaye, K]]	+	[[Category: Yoshizawa-Kumagaye K]]
-	~~[[Category: Csh motif]]~~	+
-	~~[[Category: Hydrolase inhibitor]]~~	+
-	~~[[Category: Kazal-type]]~~	+
-	~~[[Category: Non-classical]]~~	+
-	~~[[Category: Protease inhibitor~~]]	+

OCA at 16:22, 3 November 2021

OCA — Wed, 03 Nov 2021 16:22:31 GMT

←Older revision		Revision as of 16:22, 3 November 2021
Line 3:		Line 3:
	<StructureSection load='1y1c' size='340' side='right'caption='[[1y1c]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1y1c' size='340' side='right'caption='[[1y1c]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y1c]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1C OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Y1C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y1c]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y1C FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y1b\|1y1b]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1y1b\|1y1b]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1y1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1c OCA], [~~http~~://pdbe.org/1y1c PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1y1c RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1y1c PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1y1c ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1c OCA], [https://pdbe.org/1y1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y1c RCSB], [https://www.ebi.ac.uk/pdbsum/1y1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y1c ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 16:52, 29 January 2020

OCA — Wed, 29 Jan 2020 16:52:05 GMT

←Older revision		Revision as of 16:52, 29 January 2020
Line 1:		Line 1:

	==Solution structure of Anemonia elastase inhibitor analogue==		==Solution structure of Anemonia elastase inhibitor analogue==
-	<StructureSection load='1y1c' size='340' side='right' caption='[[1y1c]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1y1c' size='340' side='right'caption='[[1y1c]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1y1c]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y1C FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y1c]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y1C FirstGlance]. <br>
Line 30:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Hemmi, H]]		[[Category: Hemmi, H]]
	[[Category: Kobayashi, Y]]		[[Category: Kobayashi, Y]]

OCA at 07:11, 18 April 2018

OCA — Wed, 18 Apr 2018 07:11:03 GMT

←Older revision		Revision as of 07:11, 18 April 2018
Line 1:		Line 1:
		+
	==Solution structure of Anemonia elastase inhibitor analogue==		==Solution structure of Anemonia elastase inhibitor analogue==
	<StructureSection load='1y1c' size='340' side='right' caption='[[1y1c]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1y1c' size='340' side='right' caption='[[1y1c]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1y1c]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y1C FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y1c]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y1C FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y1b\|1y1b]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y1b\|1y1b]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1c OCA], [http://pdbe.org/1y1c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y1c RCSB], [http://www.ebi.ac.uk/pdbsum/1y1c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1c OCA], [http://pdbe.org/1y1c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y1c RCSB], [http://www.ebi.ac.uk/pdbsum/1y1c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y1c ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y1/1y1c_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y1/1y1c_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:54, 10 February 2016

OCA — Wed, 10 Feb 2016 07:54:05 GMT

←Older revision		Revision as of 07:54, 10 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y1c ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:52, 11 September 2015

OCA — Fri, 11 Sep 2015 06:52:50 GMT

←Older revision		Revision as of 06:52, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1y1c]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y1C FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y1c]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y1C FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y1b\|1y1b]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y1b\|1y1b]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y1c RCSB], [http://www.ebi.ac.uk/pdbsum/1y1c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1c OCA], [http://pdbe.org/1y1c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y1c RCSB], [http://www.ebi.ac.uk/pdbsum/1y1c PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1y1c" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:12, 8 January 2015

OCA — Thu, 08 Jan 2015 10:12:07 GMT

←Older revision		Revision as of 10:12, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1y1c]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y1C FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y1c]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y1C FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y1b\|1y1b]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y1b\|1y1b]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y1c RCSB], [http://www.ebi.ac.uk/pdbsum/1y1c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y1c RCSB], [http://www.ebi.ac.uk/pdbsum/1y1c PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Hemmi, H.]]	+	[[Category: Hemmi, H]]
-	[[Category: Kobayashi, Y.]]	+	[[Category: Kobayashi, Y]]
-	[[Category: Kumazaki, T.]]	+	[[Category: Kumazaki, T]]
-	[[Category: Nishiuchi, Y.]]	+	[[Category: Nishiuchi, Y]]
-	[[Category: Ohkubo, T.]]	+	[[Category: Ohkubo, T]]
-	[[Category: Yoshida, T.]]	+	[[Category: Yoshida, T]]
-	[[Category: Yoshizawa-Kumagaye, K.]]	+	[[Category: Yoshizawa-Kumagaye, K]]
	[[Category: Csh motif]]		[[Category: Csh motif]]
	[[Category: Hydrolase inhibitor]]		[[Category: Hydrolase inhibitor]]

OCA at 19:57, 29 September 2014

OCA — Mon, 29 Sep 2014 19:57:31 GMT

←Older revision		Revision as of 19:57, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1y1c.~~png~~\|~~left~~\|200px]]	+	==Solution structure of Anemonia elastase inhibitor analogue==
		+	<StructureSection load='1y1c' size='340' side='right' caption='[[1y1c]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1y1c]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y1C FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y1b\|1y1b]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y1c RCSB], [http://www.ebi.ac.uk/pdbsum/1y1c PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y1/1y1c_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Anemonia elastase inhibitor (AEI) is a "nonclassical" Kazal-type elastase inhibitor from Anemonia sulcata. Unlike many nonclassical inhibitors, AEI does not have a cystine-stabilized alpha-helical (CSH) motif in the sequence. We chemically synthesized AEI and determined its three-dimensional solution structure by two-dimensional NMR spectroscopy. The resulting structure of AEI was characterized by a central alpha-helix and a three-stranded antiparallel beta-sheet of a typical Kazal-type inhibitor such as silver pheasant ovomucoid third domain (OMSVP3), even though the first and fifth half-cystine residues forming a disulfide bond in AEI are shifted both toward the C-terminus in comparison with those of OMSVP3. Synthesized AEI exhibited unexpected strong inhibition toward Streptomyces griseus protease B (SGPB). Our previous study [Hemmi, H., et al. (2003) Biochemistry 42, 2524-2534] demonstrated that the site-specific introduction of the engineered disulfide bond into the OMSVP3 molecule to form the CSH motif could produce an inhibitor with a narrower specificity. Thus, the CSH motif-containing derivative of AEI (AEI analogue) was chemically synthesized when a Cys(4)-Cys(34) bond was changed to a Cys(6)-Cys(31) bond. The AEI analogue scarcely inhibited porcine pancreatic elastase (PPE), even though it exhibited almost the same potent inhibitory activity toward SGPB. For the molecular scaffold, essentially no structural difference was detected between the two, but the N-terminal loop from Pro(5) to Ile(7) near the putative reactive site (Met(10)-Gln(11)) in the analogue moved by 3.7 A toward the central helix to form the introduced Cys(6)-Cys(31) bond. Such a conformational change in the restricted region correlates with the specificity change of the inhibitor.

-	~~{{STRUCTURE_1y1c\| PDB=1y1c \| SCENE= }}~~	+	Structural and functional study of an Anemonia elastase inhibitor, a "nonclassical" Kazal-type inhibitor from Anemonia sulcata.,Hemmi H, Kumazaki T, Yoshizawa-Kumagaye K, Nishiuchi Y, Yoshida T, Ohkubo T, Kobayashi Y Biochemistry. 2005 Jul 19;44(28):9626-36. PMID:16008348<ref>PMID:16008348</ref>

-	~~===Solution structure~~ of ~~Anemonia elastase inhibitor analogue===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16008348}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1y1c]] is a 1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1Y1C OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016008348<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Hemmi, H.]]		[[Category: Hemmi, H.]]
	[[Category: Kobayashi, Y.]]		[[Category: Kobayashi, Y.]]

OCA: Protected "1y1c" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 13:23:46 GMT

Protected "1y1c" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:23, 5 January 2013

OCA at 13:23, 5 January 2013

OCA — Sat, 05 Jan 2013 13:23:42 GMT

←Older revision		Revision as of 13:23, 5 January 2013
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	[[Image:1y1c.png\|left\|200px]]		[[Image:1y1c.png\|left\|200px]]

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	{{STRUCTURE_1y1c\| PDB=1y1c \| SCENE= }}		{{STRUCTURE_1y1c\| PDB=1y1c \| SCENE= }}

	===Solution structure of Anemonia elastase inhibitor analogue===		===Solution structure of Anemonia elastase inhibitor analogue===

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	{{ABSTRACT_PUBMED_16008348}}		{{ABSTRACT_PUBMED_16008348}}

	==About this Structure==		==About this Structure==
-	~~1Y1C~~ is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1C OCA].	+	[[1y1c]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1C OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16008348~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016008348</ref><references group="xtra"/>
	[[Category: Hemmi, H.]]		[[Category: Hemmi, H.]]
	[[Category: Kobayashi, Y.]]		[[Category: Kobayashi, Y.]]
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	[[Category: Yoshizawa-Kumagaye, K.]]		[[Category: Yoshizawa-Kumagaye, K.]]
	[[Category: Csh motif]]		[[Category: Csh motif]]
		+	[[Category: Hydrolase inhibitor]]
	[[Category: Kazal-type]]		[[Category: Kazal-type]]
	[[Category: Non-classical]]		[[Category: Non-classical]]
	[[Category: Protease inhibitor]]		[[Category: Protease inhibitor]]
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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:39:15 2009''