1y1u - Revision history

OCA at 08:09, 25 October 2023

OCA — Wed, 25 Oct 2023 08:09:53 GMT

←Older revision		Revision as of 08:09, 25 October 2023
Line 3:		Line 3:
	<StructureSection load='1y1u' size='340' side='right'caption='[[1y1u]], [[Resolution\|resolution]] 3.21Å' scene=''>		<StructureSection load='1y1u' size='340' side='right'caption='[[1y1u]], [[Resolution\|resolution]] 3.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y1u]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y1U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y1u]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y1U FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1u OCA], [https://pdbe.org/1y1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y1u RCSB], [https://www.ebi.ac.uk/pdbsum/1y1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y1u ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.21Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1u OCA], [https://pdbe.org/1y1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y1u RCSB], [https://www.ebi.ac.uk/pdbsum/1y1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y1u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/STA5A_MOUSE STA5A_MOUSE]] Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.<ref>PMID:10508857</ref> <ref>PMID:16837552</ref>	+	[https://www.uniprot.org/uniprot/STA5A_MOUSE STA5A_MOUSE] Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.<ref>PMID:10508857</ref> <ref>PMID:16837552</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Becker, S]]	+	[[Category: Becker S]]
-	[[Category: Klumpp, K]]	+	[[Category: Klumpp K]]
-	[[Category: Neculai~~, A M~~]]	+	[[Category: Neculai AM]]
-	[[Category: Neculai, D]]	+	[[Category: Neculai D]]
-	[[Category: Pfitzner, E]]	+	[[Category: Pfitzner E]]
-	[[Category: Straub, K]]	+	[[Category: Straub K]]
-	[[Category: Verrier, S]]	+	[[Category: Verrier S]]
-	~~[[Category: Activator]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Sh2 domain]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Stat]]~~	+
-	~~[[Category: Transcription regulation~~]]	+

OCA at 09:06, 21 April 2021

OCA — Wed, 21 Apr 2021 09:06:40 GMT

←Older revision		Revision as of 09:06, 21 April 2021
Line 3:		Line 3:
	<StructureSection load='1y1u' size='340' side='right'caption='[[1y1u]], [[Resolution\|resolution]] 3.21Å' scene=''>		<StructureSection load='1y1u' size='340' side='right'caption='[[1y1u]], [[Resolution\|resolution]] 3.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y1u]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Y1U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y1u]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y1U FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1y1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1u OCA], [~~http~~://pdbe.org/1y1u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1y1u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1y1u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1y1u ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1u OCA], [https://pdbe.org/1y1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y1u RCSB], [https://www.ebi.ac.uk/pdbsum/1y1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y1u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/STA5A_MOUSE STA5A_MOUSE]] Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.<ref>PMID:10508857</ref> <ref>PMID:16837552</ref>	+	[[https://www.uniprot.org/uniprot/STA5A_MOUSE STA5A_MOUSE]] Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.<ref>PMID:10508857</ref> <ref>PMID:16837552</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:25, 17 July 2019

OCA — Wed, 17 Jul 2019 13:25:14 GMT

←Older revision		Revision as of 13:25, 17 July 2019
Line 1:		Line 1:

	==Structure of unphosphorylated STAT5a==		==Structure of unphosphorylated STAT5a==
-	<StructureSection load='1y1u' size='340' side='right' caption='[[1y1u]], [[Resolution\|resolution]] 3.21Å' scene=''>	+	<StructureSection load='1y1u' size='340' side='right'caption='[[1y1u]], [[Resolution\|resolution]] 3.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1y1u]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y1U FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y1u]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y1U FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y1/1y1u_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y1/1y1u_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Becker, S]]		[[Category: Becker, S]]

OCA at 15:57, 12 October 2017

OCA — Thu, 12 Oct 2017 15:57:54 GMT

←Older revision		Revision as of 15:57, 12 October 2017
Line 1:		Line 1:
		+
	==Structure of unphosphorylated STAT5a==		==Structure of unphosphorylated STAT5a==
	<StructureSection load='1y1u' size='340' side='right' caption='[[1y1u]], [[Resolution\|resolution]] 3.21Å' scene=''>		<StructureSection load='1y1u' size='340' side='right' caption='[[1y1u]], [[Resolution\|resolution]] 3.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1y1u]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y1U FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y1u]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y1U FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1u OCA], [http://pdbe.org/1y1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y1u RCSB], [http://www.ebi.ac.uk/pdbsum/1y1u PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1u OCA], [http://pdbe.org/1y1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y1u RCSB], [http://www.ebi.ac.uk/pdbsum/1y1u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y1u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y1u ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:07, 11 September 2015

OCA — Fri, 11 Sep 2015 13:07:13 GMT

←Older revision		Revision as of 13:07, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1y1u' size='340' side='right' caption='[[1y1u]], [[Resolution\|resolution]] 3.21Å' scene=''>		<StructureSection load='1y1u' size='340' side='right' caption='[[1y1u]], [[Resolution\|resolution]] 3.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y1u]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y1U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y1u]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y1U FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y1u RCSB], [http://www.ebi.ac.uk/pdbsum/1y1u PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1u OCA], [http://pdbe.org/1y1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y1u RCSB], [http://www.ebi.ac.uk/pdbsum/1y1u PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1y1u" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Becker, S]]		[[Category: Becker, S]]
	[[Category: Klumpp, K]]		[[Category: Klumpp, K]]

OCA at 16:51, 25 December 2014

OCA — Thu, 25 Dec 2014 16:51:22 GMT

←Older revision		Revision as of 16:51, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1y1u]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y1U FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y1u]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y1U FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y1u RCSB], [http://www.ebi.ac.uk/pdbsum/1y1u PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y1u RCSB], [http://www.ebi.ac.uk/pdbsum/1y1u PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/STA5A_MOUSE STA5A_MOUSE]] Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.<ref>PMID:10508857</ref> <ref>PMID:16837552</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Becker, S.]]	+	[[Category: Becker, S]]
-	[[Category: Klumpp, K.]]	+	[[Category: Klumpp, K]]
-	[[Category: Neculai, A M.]]	+	[[Category: Neculai, A M]]
-	[[Category: Neculai, D.]]	+	[[Category: Neculai, D]]
-	[[Category: Pfitzner, E.]]	+	[[Category: Pfitzner, E]]
-	[[Category: Straub, K.]]	+	[[Category: Straub, K]]
-	[[Category: Verrier, S.]]	+	[[Category: Verrier, S]]
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]

OCA at 20:04, 29 September 2014

OCA — Mon, 29 Sep 2014 20:04:26 GMT

←Older revision		Revision as of 20:04, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1y1u.~~png\|left~~\|200px]]	+	==Structure of unphosphorylated STAT5a==
		+	<StructureSection load='1y1u' size='340' side='right' caption='[[1y1u]], [[Resolution\|resolution]] 3.21Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1y1u]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y1U FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y1u RCSB], [http://www.ebi.ac.uk/pdbsum/1y1u PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y1/1y1u_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	STAT proteins have the function of signaling from the cell membrane into the nucleus, where they regulate gene transcription. Latent mammalian STAT proteins can form dimers in the cytoplasm even before receptor-mediated activation by specific tyrosine phosphorylation. Here we describe the 3.21-A crystal structure of an unphosphorylated STAT5a homodimer lacking the N-terminal domain as well as the C-terminal transactivation domain. The overall structure of this fragment is very similar to phosphorylated STATs. However, important differences exist in the dimerization mode. Although the interface between phosphorylated STATs is mediated by their Src-homology 2 domains, the unphosphorylated STAT5a fragment dimerizes in a completely different manner via interactions between their beta-barrel and four-helix bundle domains. The STAT4 N-terminal domain dimer can be docked onto this STAT5a core fragment dimer based on shape and charge complementarities. The separation of the dimeric arrangement, taking place upon activation and nuclear translocation of STAT5a, is demonstrated by fluorescence resonance energy transfer experiments in living cells.

-	~~{{STRUCTURE_1y1u\| PDB=1y1u \| SCENE= }}~~	+	Structure of the unphosphorylated STAT5a dimer.,Neculai D, Neculai AM, Verrier S, Straub K, Klumpp K, Pfitzner E, Becker S J Biol Chem. 2005 Dec 9;280(49):40782-7. Epub 2005 Sep 28. PMID:16192273<ref>PMID:16192273</ref>

-	~~===Structure~~ of ~~unphosphorylated STAT5a===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16192273}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1y1u]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1U OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016192273<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Becker, S.]]		[[Category: Becker, S.]]

OCA: Protected "1y1u" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 13:35:05 GMT

Protected "1y1u" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:35, 5 January 2013

OCA at 13:35, 5 January 2013

OCA — Sat, 05 Jan 2013 13:35:02 GMT

←Older revision		Revision as of 13:35, 5 January 2013
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-	{{Seed}}
	[[Image:1y1u.png\|left\|200px]]		[[Image:1y1u.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1y1u", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1y1u\| PDB=1y1u \| SCENE= }}		{{STRUCTURE_1y1u\| PDB=1y1u \| SCENE= }}

	===Structure of unphosphorylated STAT5a===		===Structure of unphosphorylated STAT5a===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16192273}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16192273 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16192273}}		{{ABSTRACT_PUBMED_16192273}}

	==About this Structure==		==About this Structure==
-	~~1Y1U~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1U OCA].	+	[[1y1u]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1U OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16192273~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016192273</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Becker, S.]]		[[Category: Becker, S.]]
Line 35:		Line 23:
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: Sh2 domain]]		[[Category: Sh2 domain]]
		+	[[Category: Signaling protein]]
	[[Category: Stat]]		[[Category: Stat]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:15:15 2009''

OCA at 20:15, 17 February 2009

OCA — Tue, 17 Feb 2009 20:15:18 GMT

←Older revision		Revision as of 20:15, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1Y1U is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1U OCA].	+	1Y1U is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1U OCA].

	==Reference==		==Reference==
-	~~Structure of the unphosphorylated STAT5a dimer., Neculai D, Neculai AM, Verrier S, Straub K, Klumpp K, Pfitzner E, Becker S, J Biol Chem. 2005 Dec 9;280(49):40782-7. Epub 2005 Sep 28.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16192273 16192273]~~	+	<ref group="xtra">PMID:16192273</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Single protein]]
	[[Category: Becker, S.]]		[[Category: Becker, S.]]
	[[Category: Klumpp, K.]]		[[Category: Klumpp, K.]]
Line 39:		Line 38:
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 06~~:31:~~56 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:15:15 2009''