1y2f - Revision history

OCA at 06:51, 23 August 2023

OCA — Wed, 23 Aug 2023 06:51:47 GMT

←Older revision		Revision as of 06:51, 23 August 2023
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	<StructureSection load='1y2f' size='340' side='right'caption='[[1y2f]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1y2f' size='340' side='right'caption='[[1y2f]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y2F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y2F FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=WAI:4-{2~~-[~~4-(2-AMINOETHYL)PIPERAZIN-1-YL~~]~~PYRIDIN-4-YL}-N-(3-CHLORO-4-METHYLPHENYL)PYRIMIDIN-~~2~~-AMINE'>WAI</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1y2g\|1y2g]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WAI:4-{2-[4-(2-AMINOETHYL)PIPERAZIN-1-YL]PYRIDIN-4-YL}-N-(3-CHLORO-4-METHYLPHENYL)PYRIMIDIN-2-AMINE'>WAI</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2f OCA], [https://pdbe.org/1y2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y2f RCSB], [https://www.ebi.ac.uk/pdbsum/1y2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y2f ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2f OCA], [https://pdbe.org/1y2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y2f RCSB], [https://www.ebi.ac.uk/pdbsum/1y2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y2f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ZIPA_ECOLI ZIPA_ECOLI]] Interacts directly with the cell division protein FtsZ. Probable receptor for the septal ring structure, may anchor it to the inner-membrane.[HAMAP-Rule:MF_00509]	+	[https://www.uniprot.org/uniprot/ZIPA_ECOLI ZIPA_ECOLI] Interacts directly with the cell division protein FtsZ. Probable receptor for the septal ring structure, may anchor it to the inner-membrane.[HAMAP-Rule:MF_00509]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Mosyak, L]]	+	[[Category: Mosyak L]]
-	[[Category: Rush~~, T S]]~~	+	[[Category: Rush TS]]
-	~~[[Category: Cell cycle~~]]	+

OCA at 16:22, 3 November 2021

OCA — Wed, 03 Nov 2021 16:22:55 GMT

←Older revision		Revision as of 16:22, 3 November 2021
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	<StructureSection load='1y2f' size='340' side='right'caption='[[1y2f]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1y2f' size='340' side='right'caption='[[1y2f]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y2f]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2F OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Y2F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y2F FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=WAI:4-{2-[4-(2-AMINOETHYL)PIPERAZIN-1-YL]PYRIDIN-4-YL}-N-(3-CHLORO-4-METHYLPHENYL)PYRIMIDIN-2-AMINE'>WAI</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WAI:4-{2-[4-(2-AMINOETHYL)PIPERAZIN-1-YL]PYRIDIN-4-YL}-N-(3-CHLORO-4-METHYLPHENYL)PYRIMIDIN-2-AMINE'>WAI</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y2g\|1y2g]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1y2g\|1y2g]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1y2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2f OCA], [~~http~~://pdbe.org/1y2f PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1y2f RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1y2f PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1y2f ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2f OCA], [https://pdbe.org/1y2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y2f RCSB], [https://www.ebi.ac.uk/pdbsum/1y2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y2f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ZIPA_ECOLI ZIPA_ECOLI]] Interacts directly with the cell division protein FtsZ. Probable receptor for the septal ring structure, may anchor it to the inner-membrane.[HAMAP-Rule:MF_00509]	+	[[https://www.uniprot.org/uniprot/ZIPA_ECOLI ZIPA_ECOLI]] Interacts directly with the cell division protein FtsZ. Probable receptor for the septal ring structure, may anchor it to the inner-membrane.[HAMAP-Rule:MF_00509]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 17:11, 29 January 2020

OCA — Wed, 29 Jan 2020 17:11:43 GMT

←Older revision		Revision as of 17:11, 29 January 2020
Line 1:		Line 1:

	==Crystal Structure of ZipA with an inhibitor==		==Crystal Structure of ZipA with an inhibitor==
-	<StructureSection load='1y2f' size='340' side='right' caption='[[1y2f]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1y2f' size='340' side='right'caption='[[1y2f]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1y2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y2F FirstGlance]. <br>
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Cell division protein\|Cell division protein]]	+	*[[Cell division protein 3D structures\|Cell division protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Mosyak, L]]		[[Category: Mosyak, L]]
	[[Category: Rush, T S]]		[[Category: Rush, T S]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]

OCA at 07:25, 18 April 2018

OCA — Wed, 18 Apr 2018 07:25:43 GMT

←Older revision		Revision as of 07:25, 18 April 2018
Line 1:		Line 1:
		+
	==Crystal Structure of ZipA with an inhibitor==		==Crystal Structure of ZipA with an inhibitor==
	<StructureSection load='1y2f' size='340' side='right' caption='[[1y2f]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1y2f' size='340' side='right' caption='[[1y2f]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=WAI:4-{2-[4-(2-AMINOETHYL)PIPERAZIN-1-YL]PYRIDIN-4-YL}-N-(3-CHLORO-4-METHYLPHENYL)PYRIMIDIN-2-AMINE'>WAI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=WAI:4-{2-[4-(2-AMINOETHYL)PIPERAZIN-1-YL]PYRIDIN-4-YL}-N-(3-CHLORO-4-METHYLPHENYL)PYRIMIDIN-2-AMINE'>WAI</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y2g\|1y2g]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y2g\|1y2g]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2f OCA], [http://pdbe.org/1y2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y2f RCSB], [http://www.ebi.ac.uk/pdbsum/1y2f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2f OCA], [http://pdbe.org/1y2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y2f RCSB], [http://www.ebi.ac.uk/pdbsum/1y2f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y2f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y2/1y2f_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y2/1y2f_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 1y2f" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1y2f" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cell division protein\|Cell division protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:33, 8 February 2016

OCA — Mon, 08 Feb 2016 20:33:53 GMT

←Older revision		Revision as of 20:33, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y2f ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:10, 10 September 2015

OCA — Thu, 10 Sep 2015 15:10:00 GMT

←Older revision		Revision as of 15:10, 10 September 2015
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	<StructureSection load='1y2f' size='340' side='right' caption='[[1y2f]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1y2f' size='340' side='right' caption='[[1y2f]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y2F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y2F FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=WAI:4-{2-[4-(2-AMINOETHYL)PIPERAZIN-1-YL]PYRIDIN-4-YL}-N-(3-CHLORO-4-METHYLPHENYL)PYRIMIDIN-2-AMINE'>WAI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=WAI:4-{2-[4-(2-AMINOETHYL)PIPERAZIN-1-YL]PYRIDIN-4-YL}-N-(3-CHLORO-4-METHYLPHENYL)PYRIMIDIN-2-AMINE'>WAI</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y2g\|1y2g]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y2g\|1y2g]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y2f RCSB], [http://www.ebi.ac.uk/pdbsum/1y2f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2f OCA], [http://pdbe.org/1y2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y2f RCSB], [http://www.ebi.ac.uk/pdbsum/1y2f PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1y2f" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Mosyak, L]]		[[Category: Mosyak, L]]
	[[Category: Rush, T S]]		[[Category: Rush, T S]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]

OCA at 01:58, 25 December 2014

OCA — Thu, 25 Dec 2014 01:58:23 GMT

←Older revision		Revision as of 01:58, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1y2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y2F FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=WAI:4-{2-[4-(2-AMINOETHYL)PIPERAZIN-1-YL]PYRIDIN-4-YL}-N-(3-CHLORO-4-METHYLPHENYL)PYRIMIDIN-2-AMINE'>WAI</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=WAI:4-{2-[4-(2-AMINOETHYL)PIPERAZIN-1-YL]PYRIDIN-4-YL}-N-(3-CHLORO-4-METHYLPHENYL)PYRIMIDIN-2-AMINE'>WAI</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y2g\|1y2g]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y2g\|1y2g]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y2f RCSB], [http://www.ebi.ac.uk/pdbsum/1y2f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y2f RCSB], [http://www.ebi.ac.uk/pdbsum/1y2f PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ZIPA_ECOLI ZIPA_ECOLI]] Interacts directly with the cell division protein FtsZ. Probable receptor for the septal ring structure, may anchor it to the inner-membrane.[HAMAP-Rule:MF_00509]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Mosyak, L.]]	+	[[Category: Mosyak, L]]
-	[[Category: Rush, T S.]]	+	[[Category: Rush, T S]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]

OCA at 21:33, 29 September 2014

OCA — Mon, 29 Sep 2014 21:33:35 GMT

←Older revision		Revision as of 21:33, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1y2f.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of ZipA with an inhibitor==
		+	<StructureSection load='1y2f' size='340' side='right' caption='[[1y2f]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1y2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y2F FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=WAI:4-{2-[4-(2-AMINOETHYL)PIPERAZIN-1-YL]PYRIDIN-4-YL}-N-(3-CHLORO-4-METHYLPHENYL)PYRIMIDIN-2-AMINE'>WAI</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y2g\|1y2g]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y2f RCSB], [http://www.ebi.ac.uk/pdbsum/1y2f PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y2/1y2f_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In this paper, we describe the first prospective application of the shape-comparison program ROCS (Rapid Overlay of Chemical Structures) to find new scaffolds for small molecule inhibitors of the ZipA-FtsZ protein-protein interaction, a proposed antibacterial target. The shape comparisons are made relative to the crystallographically determined, bioactive conformation of a high-throughput screening (HTS) hit. The use of ROCS led to the identification of a set of novel, weakly binding inhibitors with scaffolds presenting synthetic opportunities to further optimize biological affinity and lacking development issues associated with the HTS lead. These ROCS-identified scaffolds would have been missed using other structural similarity approaches such as ISIS 2D fingerprints. X-ray crystallographic analysis of one of the new inhibitors bound to ZipA reveals that the shape comparison approach very accurately predicted the binding mode. These experimental results validate this use of ROCS for chemotype switching or "lead hopping" and suggest that it is of general interest for lead identification in drug discovery endeavors.

-	~~{{STRUCTURE_1y2f\| PDB=1y2f \| SCENE= }}~~	+	A shape-based 3-D scaffold hopping method and its application to a bacterial protein-protein interaction.,Rush TS 3rd, Grant JA, Mosyak L, Nicholls A J Med Chem. 2005 Mar 10;48(5):1489-95. PMID:15743191<ref>PMID:15743191</ref>

-	~~===Crystal Structure~~ of ~~ZipA with an inhibitor===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15743191}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1y2f]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2F OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015743191<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Mosyak, L.]]		[[Category: Mosyak, L.]]
	[[Category: Rush, T S.]]		[[Category: Rush, T S.]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]

OCA: Protected "1y2f" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 12:52:25 GMT

Protected "1y2f" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:52, 5 January 2013

OCA at 12:52, 5 January 2013

OCA — Sat, 05 Jan 2013 12:52:22 GMT

←Older revision		Revision as of 12:52, 5 January 2013
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-	{{Seed}}
	[[Image:1y2f.png\|left\|200px]]		[[Image:1y2f.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1y2f", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1y2f\| PDB=1y2f \| SCENE= }}		{{STRUCTURE_1y2f\| PDB=1y2f \| SCENE= }}

	===Crystal Structure of ZipA with an inhibitor===		===Crystal Structure of ZipA with an inhibitor===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15743191}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15743191 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15743191}}		{{ABSTRACT_PUBMED_15743191}}

	==About this Structure==		==About this Structure==
-	~~1Y2F~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2F OCA].	+	[[1y2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2F OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15743191~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015743191</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Mosyak, L.]]		[[Category: Mosyak, L.]]
	[[Category: Rush, T S.]]		[[Category: Rush, T S.]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 02:54:14 2009''