1y2o - Revision history

OCA at 08:00, 15 May 2024

OCA — Wed, 15 May 2024 08:00:05 GMT

←Older revision		Revision as of 08:00, 15 May 2024
Line 3:		Line 3:
	<StructureSection load='1y2o' size='340' side='right'caption='[[1y2o]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1y2o' size='340' side='right'caption='[[1y2o]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y2o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y2O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y2o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y2O FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non~~-~~Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2o OCA], [https://pdbe.org/1y2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y2o RCSB], [https://www.ebi.ac.uk/pdbsum/1y2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y2o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2o OCA], [https://pdbe.org/1y2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y2o RCSB], [https://www.ebi.ac.uk/pdbsum/1y2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y2o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BAIP2_HUMAN BAIP2_HUMAN]] Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.<ref>PMID:11130076</ref> <ref>PMID:11696321</ref> <ref>PMID:14752106</ref> <ref>PMID:19366662</ref>	+	[https://www.uniprot.org/uniprot/BAIP2_HUMAN BAIP2_HUMAN] Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.<ref>PMID:11130076</ref> <ref>PMID:11696321</ref> <ref>PMID:14752106</ref> <ref>PMID:19366662</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bompard, G]]	+	[[Category: Bompard G]]
-	[[Category: Dafforn~~, T R~~]]	+	[[Category: Dafforn TR]]
-	[[Category: Futterer, K]]	+	[[Category: Futterer K]]
-	[[Category: Heung, M Y]]	+	[[Category: Heung M-Y]]
-	[[Category: Machesky~~, L M~~]]	+	[[Category: Machesky LM]]
-	[[Category: Millard~~, T H~~]]	+	[[Category: Millard TH]]
-	[[Category: Scott~~, D J]]~~	+	[[Category: Scott DJ]]
-	~~[[Category: Actin bundling]]~~	+
-	~~[[Category: Cell motility]]~~	+
-	~~[[Category: Filopodia]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 16:23, 3 November 2021

OCA — Wed, 03 Nov 2021 16:23:01 GMT

←Older revision		Revision as of 16:23, 3 November 2021
Line 3:		Line 3:
	<StructureSection load='1y2o' size='340' side='right'caption='[[1y2o]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1y2o' size='340' side='right'caption='[[1y2o]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y2o]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Y2O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y2o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y2O FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1y2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2o OCA], [~~http~~://pdbe.org/1y2o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1y2o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1y2o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1y2o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2o OCA], [https://pdbe.org/1y2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y2o RCSB], [https://www.ebi.ac.uk/pdbsum/1y2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y2o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BAIP2_HUMAN BAIP2_HUMAN]] Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.<ref>PMID:11130076</ref> <ref>PMID:11696321</ref> <ref>PMID:14752106</ref> <ref>PMID:19366662</ref>	+	[[https://www.uniprot.org/uniprot/BAIP2_HUMAN BAIP2_HUMAN]] Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.<ref>PMID:11130076</ref> <ref>PMID:11696321</ref> <ref>PMID:14752106</ref> <ref>PMID:19366662</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 17:22, 29 January 2020

OCA — Wed, 29 Jan 2020 17:22:32 GMT

←Older revision		Revision as of 17:22, 29 January 2020
Line 1:		Line 1:

	==Structure of N-terminal domain IRSp53/BAIAP2==		==Structure of N-terminal domain IRSp53/BAIAP2==
-	<StructureSection load='1y2o' size='340' side='right' caption='[[1y2o]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='1y2o' size='340' side='right'caption='[[1y2o]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1y2o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y2O FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y2o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y2O FirstGlance]. <br>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bompard, G]]		[[Category: Bompard, G]]
	[[Category: Dafforn, T R]]		[[Category: Dafforn, T R]]

OCA at 07:35, 18 April 2018

OCA — Wed, 18 Apr 2018 07:35:26 GMT

←Older revision		Revision as of 07:35, 18 April 2018
Line 1:		Line 1:
		+
	==Structure of N-terminal domain IRSp53/BAIAP2==		==Structure of N-terminal domain IRSp53/BAIAP2==
	<StructureSection load='1y2o' size='340' side='right' caption='[[1y2o]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1y2o' size='340' side='right' caption='[[1y2o]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1y2o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y2O FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y2o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y2O FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2o OCA], [http://pdbe.org/1y2o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y2o RCSB], [http://www.ebi.ac.uk/pdbsum/1y2o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2o OCA], [http://pdbe.org/1y2o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y2o RCSB], [http://www.ebi.ac.uk/pdbsum/1y2o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y2o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y2/1y2o_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y2/1y2o_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 03:21, 8 February 2016

OCA — Mon, 08 Feb 2016 03:21:11 GMT

←Older revision		Revision as of 03:21, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y2o ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:23, 10 September 2015

OCA — Thu, 10 Sep 2015 07:23:04 GMT

←Older revision		Revision as of 07:23, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1y2o' size='340' side='right' caption='[[1y2o]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1y2o' size='340' side='right' caption='[[1y2o]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y2o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y2O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y2o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y2O FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y2o RCSB], [http://www.ebi.ac.uk/pdbsum/1y2o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2o OCA], [http://pdbe.org/1y2o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y2o RCSB], [http://www.ebi.ac.uk/pdbsum/1y2o PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1y2o" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bompard, G]]		[[Category: Bompard, G]]
	[[Category: Dafforn, T R]]		[[Category: Dafforn, T R]]

OCA at 20:12, 24 December 2014

OCA — Wed, 24 Dec 2014 20:12:50 GMT

←Older revision		Revision as of 20:12, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1y2o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y2O FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y2o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y2O FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y2o RCSB], [http://www.ebi.ac.uk/pdbsum/1y2o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y2o RCSB], [http://www.ebi.ac.uk/pdbsum/1y2o PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BAIP2_HUMAN BAIP2_HUMAN]] Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.<ref>PMID:11130076</ref> <ref>PMID:11696321</ref> <ref>PMID:14752106</ref> <ref>PMID:19366662</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bompard, G.]]	+	[[Category: Bompard, G]]
-	[[Category: Dafforn, T R.]]	+	[[Category: Dafforn, T R]]
-	[[Category: Futterer, K.]]	+	[[Category: Futterer, K]]
-	[[Category: Heung, M Y.]]	+	[[Category: Heung, M Y]]
-	[[Category: Machesky, L M.]]	+	[[Category: Machesky, L M]]
-	[[Category: Millard, T H.]]	+	[[Category: Millard, T H]]
-	[[Category: Scott, D J.]]	+	[[Category: Scott, D J]]
	[[Category: Actin bundling]]		[[Category: Actin bundling]]
	[[Category: Cell motility]]		[[Category: Cell motility]]
	[[Category: Filopodia]]		[[Category: Filopodia]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 20:41, 29 September 2014

OCA — Mon, 29 Sep 2014 20:41:54 GMT

←Older revision		Revision as of 20:41, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1y2o.~~png\|left~~\|200px]]	+	==Structure of N-terminal domain IRSp53/BAIAP2==
		+	<StructureSection load='1y2o' size='340' side='right' caption='[[1y2o]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1y2o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y2O FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y2o RCSB], [http://www.ebi.ac.uk/pdbsum/1y2o PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y2/1y2o_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The scaffolding protein insulin receptor tyrosine kinase substrate p53 (IRSp53), a ubiquitous regulator of the actin cytoskeleton, mediates filopodia formation under the control of Rho-family GTPases. IRSp53 comprises a central SH3 domain, which binds to proline-rich regions of a wide range of actin regulators, and a conserved N-terminal IRSp53/MIM homology domain (IMD) that harbours F-actin-bundling activity. Here, we present the crystal structure of this novel actin-bundling domain revealing a coiled-coil domain that self-associates into a 180 A-long zeppelin-shaped dimer. Sedimentation velocity experiments confirm the presence of a single molecular species of twice the molecular weight of the monomer in solution. Mutagenesis of conserved basic residues at the extreme ends of the dimer abrogated actin bundling in vitro and filopodia formation in vivo, demonstrating that IMD-mediated actin bundling is required for IRSp53-induced filopodia formation. This study promotes an expanded view of IRSp53 as an actin regulator that integrates scaffolding and effector functions.

-	~~{{STRUCTURE_1y2o\| PDB=1y2o \| SCENE= }}~~	+	Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53.,Millard TH, Bompard G, Heung MY, Dafforn TR, Scott DJ, Machesky LM, Futterer K EMBO J. 2005 Jan 26;24(2):240-50. Epub 2005 Jan 6. PMID:15635447<ref>PMID:15635447</ref>

-	~~===Structure of N-terminal domain IRSp53~~/~~BAIAP2===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15635447}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1y2o]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2O OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015635447<~~/~~ref~~><~~ref group="xtra">PMID:018216767</ref><references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bompard, G.]]		[[Category: Bompard, G.]]

OCA: Protected "1y2o" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 11:30:55 GMT

Protected "1y2o" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:30, 5 January 2013

OCA at 11:30, 5 January 2013

OCA — Sat, 05 Jan 2013 11:30:51 GMT

←Older revision		Revision as of 11:30, 5 January 2013
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-	{{Seed}}
	[[Image:1y2o.png\|left\|200px]]		[[Image:1y2o.png\|left\|200px]]

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	{{STRUCTURE_1y2o\| PDB=1y2o \| SCENE= }}		{{STRUCTURE_1y2o\| PDB=1y2o \| SCENE= }}

	===Structure of N-terminal domain IRSp53/BAIAP2===		===Structure of N-terminal domain IRSp53/BAIAP2===

-
-	<!--
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	{{ABSTRACT_PUBMED_15635447}}		{{ABSTRACT_PUBMED_15635447}}

	==About this Structure==		==About this Structure==
-	~~1Y2O~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2O OCA].	+	[[1y2o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2O OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15635447~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015635447</ref><ref group="xtra">PMID:018216767</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bompard, G.]]		[[Category: Bompard, G.]]
Line 35:		Line 23:
	[[Category: Cell motility]]		[[Category: Cell motility]]
	[[Category: Filopodia]]		[[Category: Filopodia]]
-		+	[[Category: Signaling protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 18:26:12 2009''~~	+