1y3s - Revision history

OCA at 08:54, 14 February 2024

OCA — Wed, 14 Feb 2024 08:54:50 GMT

←Older revision		Revision as of 08:54, 14 February 2024
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y3s OCA], [https://pdbe.org/1y3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y3s RCSB], [https://www.ebi.ac.uk/pdbsum/1y3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y3s ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y3s OCA], [https://pdbe.org/1y3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y3s RCSB], [https://www.ebi.ac.uk/pdbsum/1y3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y3s ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	All retroviruses encapsidate their genome as a dimer of homologous single-stranded RNAs. The dimerization initiation site (DIS) of human immunodeficiency virus type 1 (HIV-1) is located in the 5'-untranslated region of the viral genome and consists of a hairpin with a 6 nt self-complementary loop sequence. Genomic RNA dimerization, a crucial step for virion infectivity, is promoted by the formation of a loop-loop complex (or kissing complex) between two DIS hairpins. Crystal structures for the subtypes A, B and F of the HIV-1 DIS kissing complex have now been solved at 2.3 A, 1.9 A and 1.6 A, respectively. They revealed a polymorphism of bulged-out residues showing clearly that their conformation is not a mere consequence of crystal packing. They also provide more insights into ion binding, hydration, and RNA conformation and flexibility. In particular, we observed the binding of spermine to the loop-loop helix, which displaced a magnesium cation important for subtype A DIS dimerization. The excellent agreement between X-ray structures and the results of chemical probing and interference data on larger viral RNA fragments shows that the crystal structures are relevant for the DIS kissing complex present in solution and in viral particles. Accordingly, these structures will be helpful for designing new drugs derived from aminoglycoside antibiotics and targeted against the RNA dimerization step of the viral life-cycle.
-
-	Polymorphism of bulged-out residues in HIV-1 RNA DIS kissing complex and structure comparison with solution studies.,Ennifar E, Dumas P J Mol Biol. 2006 Feb 24;356(3):771-82. Epub 2005 Dec 21. PMID:16403527<ref>PMID:16403527</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1y3s" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:13, 9 August 2023

OCA — Wed, 09 Aug 2023 07:13:24 GMT

←Older revision		Revision as of 07:13, 9 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1y3s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y3S FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y3s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y3S FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=K:POTASSIUM+ION'>K</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.25Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td><~~td class~~=~~"sblockDat"><div style~~=~~'overflow~~: ~~auto; max-height: 3em;~~'>~~[[1xpf\|1xpf]], [[1xpe\|1xpe]], [[1xp7\|1xp7]], [[1y3o\|1y3o]]~~</~~div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y3s OCA], [https://pdbe.org/1y3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y3s RCSB], [https://www.ebi.ac.uk/pdbsum/1y3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y3s ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y3s OCA], [https://pdbe.org/1y3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y3s RCSB], [https://www.ebi.ac.uk/pdbsum/1y3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y3s ProSAT]</span></td></tr>
	</table>		</table>
Line 23:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dumas, P]]	+	[[Category: Dumas P]]
-	[[Category: Ennifar, E]]	+	[[Category: Ennifar E]]
-	~~[[Category: Hiv-1]]~~	+
-	~~[[Category: Loop-loop complex]]~~	+
-	~~[[Category: Rna~~]]	+

OCA at 16:23, 3 November 2021

OCA — Wed, 03 Nov 2021 16:23:30 GMT

←Older revision		Revision as of 16:23, 3 November 2021
Line 3:		Line 3:
	<StructureSection load='1y3s' size='340' side='right'caption='[[1y3s]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='1y3s' size='340' side='right'caption='[[1y3s]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y3s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y3S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Y3S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y3s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y3S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xpf\|1xpf]], [[1xpe\|1xpe]], [[1xp7\|1xp7]], [[1y3o\|1y3o]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xpf\|1xpf]], [[1xpe\|1xpe]], [[1xp7\|1xp7]], [[1y3o\|1y3o]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1y3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y3s OCA], [~~http~~://pdbe.org/1y3s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1y3s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1y3s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1y3s ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y3s OCA], [https://pdbe.org/1y3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y3s RCSB], [https://www.ebi.ac.uk/pdbsum/1y3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y3s ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:46, 29 January 2020

OCA — Wed, 29 Jan 2020 16:46:13 GMT

←Older revision		Revision as of 16:46, 29 January 2020
Line 1:		Line 1:

	==HIV-1 DIS RNA subtype F- MPD form==		==HIV-1 DIS RNA subtype F- MPD form==
-	<StructureSection load='1y3s' size='340' side='right' caption='[[1y3s]], [[Resolution\|resolution]] 2.25Å' scene=''>	+	<StructureSection load='1y3s' size='340' side='right'caption='[[1y3s]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1y3s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y3S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y3S FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y3s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y3S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y3S FirstGlance]. <br>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Dumas, P]]		[[Category: Dumas, P]]
	[[Category: Ennifar, E]]		[[Category: Ennifar, E]]

OCA at 07:06, 18 April 2018

OCA — Wed, 18 Apr 2018 07:06:06 GMT

←Older revision		Revision as of 07:06, 18 April 2018
Line 1:		Line 1:
		+
	==HIV-1 DIS RNA subtype F- MPD form==		==HIV-1 DIS RNA subtype F- MPD form==
	<StructureSection load='1y3s' size='340' side='right' caption='[[1y3s]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='1y3s' size='340' side='right' caption='[[1y3s]], [[Resolution\|resolution]] 2.25Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xpf\|1xpf]], [[1xpe\|1xpe]], [[1xp7\|1xp7]], [[1y3o\|1y3o]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xpf\|1xpf]], [[1xpe\|1xpe]], [[1xp7\|1xp7]], [[1y3o\|1y3o]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y3s OCA], [http://pdbe.org/1y3s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y3s RCSB], [http://www.ebi.ac.uk/pdbsum/1y3s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y3s OCA], [http://pdbe.org/1y3s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y3s RCSB], [http://www.ebi.ac.uk/pdbsum/1y3s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y3s ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:37, 11 September 2015

OCA — Fri, 11 Sep 2015 13:37:56 GMT

←Older revision		Revision as of 13:37, 11 September 2015
Line 6:		Line 6:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xpf\|1xpf]], [[1xpe\|1xpe]], [[1xp7\|1xp7]], [[1y3o\|1y3o]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xpf\|1xpf]], [[1xpe\|1xpe]], [[1xp7\|1xp7]], [[1y3o\|1y3o]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y3s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y3s RCSB], [http://www.ebi.ac.uk/pdbsum/1y3s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y3s OCA], [http://pdbe.org/1y3s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y3s RCSB], [http://www.ebi.ac.uk/pdbsum/1y3s PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1y3s" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:06, 22 December 2014

OCA — Mon, 22 Dec 2014 05:06:16 GMT

←Older revision		Revision as of 05:06, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1y3s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y3S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y3S FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y3s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y3S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y3S FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xpf\|1xpf]], [[1xpe\|1xpe]], [[1xp7\|1xp7]], [[1y3o\|1y3o]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xpf\|1xpf]], [[1xpe\|1xpe]], [[1xp7\|1xp7]], [[1y3o\|1y3o]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y3s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y3s RCSB], [http://www.ebi.ac.uk/pdbsum/1y3s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y3s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y3s RCSB], [http://www.ebi.ac.uk/pdbsum/1y3s PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Dumas, P.]]	+	[[Category: Dumas, P]]
-	[[Category: Ennifar, E.]]	+	[[Category: Ennifar, E]]
	[[Category: Hiv-1]]		[[Category: Hiv-1]]
	[[Category: Loop-loop complex]]		[[Category: Loop-loop complex]]
	[[Category: Rna]]		[[Category: Rna]]

OCA at 06:52, 9 June 2014

OCA — Mon, 09 Jun 2014 06:52:37 GMT

←Older revision		Revision as of 06:52, 9 June 2014
Line 1:		Line 1:
-	[[~~Image:~~1y3s.~~png~~\|~~left~~\|~~200px~~]]	+	==HIV-1 DIS RNA subtype F- MPD form==
		+	<StructureSection load='1y3s' size='340' side='right' caption='[[1y3s]], [[Resolution\|resolution]] 2.25Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1y3s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y3S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y3S FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xpf\|1xpf]], [[1xpe\|1xpe]], [[1xp7\|1xp7]], [[1y3o\|1y3o]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y3s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y3s RCSB], [http://www.ebi.ac.uk/pdbsum/1y3s PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	All retroviruses encapsidate their genome as a dimer of homologous single-stranded RNAs. The dimerization initiation site (DIS) of human immunodeficiency virus type 1 (HIV-1) is located in the 5'-untranslated region of the viral genome and consists of a hairpin with a 6 nt self-complementary loop sequence. Genomic RNA dimerization, a crucial step for virion infectivity, is promoted by the formation of a loop-loop complex (or kissing complex) between two DIS hairpins. Crystal structures for the subtypes A, B and F of the HIV-1 DIS kissing complex have now been solved at 2.3 A, 1.9 A and 1.6 A, respectively. They revealed a polymorphism of bulged-out residues showing clearly that their conformation is not a mere consequence of crystal packing. They also provide more insights into ion binding, hydration, and RNA conformation and flexibility. In particular, we observed the binding of spermine to the loop-loop helix, which displaced a magnesium cation important for subtype A DIS dimerization. The excellent agreement between X-ray structures and the results of chemical probing and interference data on larger viral RNA fragments shows that the crystal structures are relevant for the DIS kissing complex present in solution and in viral particles. Accordingly, these structures will be helpful for designing new drugs derived from aminoglycoside antibiotics and targeted against the RNA dimerization step of the viral life-cycle.

-	~~{{STRUCTURE_1y3s\| PDB=1y3s \| SCENE= }}~~	+	Polymorphism of bulged-out residues in HIV-1 RNA DIS kissing complex and structure comparison with solution studies.,Ennifar E, Dumas P J Mol Biol. 2006 Feb 24;356(3):771-82. Epub 2005 Dec 21. PMID:16403527<ref>PMID:16403527</ref>

-	~~===HIV-1 DIS RNA subtype F- MPD form===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16403527}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1y3s]] is~~ a ~~2 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1Y3S OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016403527<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Dumas, P.]]		[[Category: Dumas, P.]]
	[[Category: Ennifar, E.]]		[[Category: Ennifar, E.]]

OCA: Protected "1y3s" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 15:07:01 GMT

Protected "1y3s" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:07, 14 August 2012

OCA at 15:07, 14 August 2012

OCA — Tue, 14 Aug 2012 15:07:00 GMT

←Older revision		Revision as of 15:07, 14 August 2012
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-	{{Seed}}
	[[Image:1y3s.png\|left\|200px]]		[[Image:1y3s.png\|left\|200px]]

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	{{STRUCTURE_1y3s\| PDB=1y3s \| SCENE= }}		{{STRUCTURE_1y3s\| PDB=1y3s \| SCENE= }}

	===HIV-1 DIS RNA subtype F- MPD form===		===HIV-1 DIS RNA subtype F- MPD form===

-
-	<!--
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	==About this Structure==		==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y3S OCA].	+	[[1y3s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y3S OCA].

	==Reference==		==Reference==
-	~~Polymorphism of bulged-out residues in HIV-1 RNA DIS kissing complex and structure comparison with solution studies., Ennifar E, Dumas P, J Mol Biol. 2006 Feb 24;356(3):771-82. Epub 2005 Dec 21.~~ PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~16403527 16403527]~~	+	<ref group="xtra">PMID:016403527</ref><references group="xtra"/>
	[[Category: Dumas, P.]]		[[Category: Dumas, P.]]
	[[Category: Ennifar, E.]]		[[Category: Ennifar, E.]]
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	[[Category: Loop-loop complex]]		[[Category: Loop-loop complex]]
	[[Category: Rna]]		[[Category: Rna]]
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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:01:05 2008''