1y6l - Revision history

OCA at 06:53, 23 August 2023

OCA — Wed, 23 Aug 2023 06:53:11 GMT

←Older revision		Revision as of 06:53, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1y6l' size='340' side='right'caption='[[1y6l]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='1y6l' size='340' side='right'caption='[[1y6l]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y6l]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y6L OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1Y6L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y6l]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y6L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y6L FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>UBE2E2, UBCH8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=9606 HUMAN])</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin~~-~~-protein_ligase Ubiquitin--protein ligase]~~, ~~with EC number~~ [~~http://www~~.~~brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span>~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y6l OCA], [https://pdbe.org/1y6l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y6l RCSB], [https://www.ebi.ac.uk/pdbsum/1y6l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y6l ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1y6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y6l OCA], [~~http~~://pdbe.org/1y6l PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1y6l RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1y6l PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1y6l ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/UB2E2_HUMAN UB2E2_HUMAN]] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination.<ref>PMID:9371400</ref> <ref>PMID:20061386</ref>	+	[https://www.uniprot.org/uniprot/UB2E2_HUMAN UB2E2_HUMAN] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination.<ref>PMID:9371400</ref> <ref>PMID:20061386</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 30:

	==See Also==		==See Also==
-	*[[~~Ubiquitin~~ conjugating enzyme\|~~Ubiquitin~~ conjugating enzyme]]	+	*[[3D structures of ubiquitin conjugating enzyme\|3D structures of ubiquitin conjugating enzyme]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Ubiquitin--protein ligase]]~~	+	[[Category: Arrowsmith C]]
-	[[Category: Arrowsmith, C]]	+	[[Category: Avvakumov GV]]
-	[[Category: Avvakumov~~, G V~~]]	+	[[Category: Bochkarev A]]
-	[[Category: Bochkarev, A]]	+	[[Category: Dhe-Paganon S]]
-	[[Category: Dhe-Paganon, S]]	+	[[Category: Edwards A]]
-	[[Category: Edwards, A]]	+	[[Category: Kozieradzki I]]
-	[[Category: Kozieradzki, I]]	+	[[Category: Mackenzie F]]
-	[[Category: Mackenzie, F]]	+	[[Category: Newman EM]]
-	[[Category: Newman~~, E M]]~~	+	[[Category: Sundstrom M]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Walker JR]]
-	[[Category: Sundstrom, M]]	+
-	[[Category: Walker~~, J R]]~~	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Ubiquitin]]~~	+
-	~~[[Category: Ubiquitin-conjugating enzyme~~]]	+

OCA at 10:36, 6 January 2021

OCA — Wed, 06 Jan 2021 10:36:52 GMT

←Older revision		Revision as of 10:36, 6 January 2021
Line 1:		Line 1:

	==Human ubiquitin conjugating enzyme E2E2==		==Human ubiquitin conjugating enzyme E2E2==
-	<StructureSection load='1y6l' size='340' side='right' caption='[[1y6l]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='1y6l' size='340' side='right'caption='[[1y6l]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y6l]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y6L OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Y6L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y6l]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y6L OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1Y6L FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBE2E2, UBCH8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBE2E2, UBCH8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1y6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y6l OCA], [http://pdbe.org/1y6l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y6l RCSB], [http://www.ebi.ac.uk/pdbsum/1y6l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y6l ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1y6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y6l OCA], [http://pdbe.org/1y6l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y6l RCSB], [http://www.ebi.ac.uk/pdbsum/1y6l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y6l ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ubiquitin--protein ligase]]		[[Category: Ubiquitin--protein ligase]]
	[[Category: Arrowsmith, C]]		[[Category: Arrowsmith, C]]

OCA at 06:58, 25 April 2018

OCA — Wed, 25 Apr 2018 06:58:46 GMT

←Older revision		Revision as of 06:58, 25 April 2018
Line 1:		Line 1:
		+
	==Human ubiquitin conjugating enzyme E2E2==		==Human ubiquitin conjugating enzyme E2E2==
	<StructureSection load='1y6l' size='340' side='right' caption='[[1y6l]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='1y6l' size='340' side='right' caption='[[1y6l]], [[Resolution\|resolution]] 1.85Å' scene=''>
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	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBE2E2, UBCH8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBE2E2, UBCH8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y6l OCA], [http://pdbe.org/1y6l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y6l RCSB], [http://www.ebi.ac.uk/pdbsum/1y6l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y6l OCA], [http://pdbe.org/1y6l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y6l RCSB], [http://www.ebi.ac.uk/pdbsum/1y6l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y6l ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y6/1y6l_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y6/1y6l_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 13:43, 7 February 2016

OCA — Sun, 07 Feb 2016 13:43:04 GMT

←Older revision		Revision as of 13:43, 7 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y6l ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:01, 10 September 2015

OCA — Thu, 10 Sep 2015 02:01:38 GMT

←Older revision		Revision as of 02:01, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1y6l' size='340' side='right' caption='[[1y6l]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='1y6l' size='340' side='right' caption='[[1y6l]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y6l]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y6L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y6L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y6l]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y6L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y6L FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBE2E2, UBCH8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBE2E2, UBCH8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y6l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y6l RCSB], [http://www.ebi.ac.uk/pdbsum/1y6l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y6l OCA], [http://pdbe.org/1y6l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y6l RCSB], [http://www.ebi.ac.uk/pdbsum/1y6l PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1y6l" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Ubiquitin--protein ligase]]		[[Category: Ubiquitin--protein ligase]]
	[[Category: Arrowsmith, C]]		[[Category: Arrowsmith, C]]

OCA at 15:30, 24 December 2014

OCA — Wed, 24 Dec 2014 15:30:32 GMT

←Older revision		Revision as of 15:30, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1y6l]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y6L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y6L FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y6l]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y6L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y6L FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBE2E2, UBCH8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBE2E2, UBCH8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y6l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y6l RCSB], [http://www.ebi.ac.uk/pdbsum/1y6l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y6l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y6l RCSB], [http://www.ebi.ac.uk/pdbsum/1y6l PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/UB2E2_HUMAN UB2E2_HUMAN]] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination.<ref>PMID:9371400</ref> <ref>PMID:20061386</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ubiquitin--protein ligase]]		[[Category: Ubiquitin--protein ligase]]
-	[[Category: Arrowsmith, C.]]	+	[[Category: Arrowsmith, C]]
-	[[Category: Avvakumov, G V.]]	+	[[Category: Avvakumov, G V]]
-	[[Category: Bochkarev, A.]]	+	[[Category: Bochkarev, A]]
-	[[Category: Dhe-Paganon, S.]]	+	[[Category: Dhe-Paganon, S]]
-	[[Category: Edwards, A.]]	+	[[Category: Edwards, A]]
-	[[Category: Kozieradzki, I.]]	+	[[Category: Kozieradzki, I]]
-	[[Category: Mackenzie, F.]]	+	[[Category: Mackenzie, F]]
-	[[Category: Newman, E M.]]	+	[[Category: Newman, E M]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Sundstrom, M.]]	+	[[Category: Sundstrom, M]]
-	[[Category: Walker, J R.]]	+	[[Category: Walker, J R]]
	[[Category: Ligase]]		[[Category: Ligase]]
	[[Category: Sgc]]		[[Category: Sgc]]
-	[[Category: Structural genomics consortium]]
	[[Category: Ubiquitin]]		[[Category: Ubiquitin]]
	[[Category: Ubiquitin-conjugating enzyme]]		[[Category: Ubiquitin-conjugating enzyme]]

OCA at 23:00, 28 September 2014

OCA — Sun, 28 Sep 2014 23:00:47 GMT

←Older revision		Revision as of 23:00, 28 September 2014
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-	[[~~Image~~:1y6l.~~png\|left~~\|200px]]	+	==Human ubiquitin conjugating enzyme E2E2==
		+	<StructureSection load='1y6l' size='340' side='right' caption='[[1y6l]], [[Resolution\|resolution]] 1.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1y6l]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y6L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y6L FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBE2E2, UBCH8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y6l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y6l RCSB], [http://www.ebi.ac.uk/pdbsum/1y6l PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y6/1y6l_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Here we describe a systematic structure-function analysis of the human ubiquitin (Ub) E2 conjugating proteins, consisting of the determination of 15 new high-resolution three-dimensional structures of E2 catalytic domains, and autoubiquitylation assays for 26 Ub-loading E2s screened against a panel of nine different HECT (homologous to E6-AP carboxyl terminus) E3 ligase domains. Integration of our structural and biochemical data revealed several E2 surface properties associated with Ub chain building activity; (1) net positive or neutral E2 charge, (2) an "acidic trough" located near the catalytic Cys, surrounded by an extensive basic region, and (3) similarity to the previously described HECT binding signature in UBE2L3 (UbcH7). Mass spectrometry was used to characterize the autoubiquitylation products of a number of functional E2-HECT pairs, and demonstrated that HECT domains from different subfamilies catalyze the formation of very different types of Ub chains, largely independent of the E2 in the reaction. Our data set represents the first comprehensive analysis of E2-HECT E3 interactions, and thus provides a framework for better understanding the molecular mechanisms of ubiquitylation.

-	~~{{STRUCTURE_1y6l\| PDB=1y6l \| SCENE= }}~~	+	A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.,Sheng Y, Hong JH, Doherty R, Srikumar T, Shloush J, Avvakumov GV, Walker JR, Xue S, Neculai D, Wan JW, Kim SK, Arrowsmith CH, Raught B, Dhe-Paganon S Mol Cell Proteomics. 2012 Aug;11(8):329-41. Epub 2012 Apr 10. PMID:22496338<ref>PMID:22496338</ref>

-	~~===Human ubiquitin conjugating enzyme E2E2===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_22496338}}~~	+	==See Also==
-		+	*[[Ubiquitin conjugating enzyme\|Ubiquitin conjugating enzyme]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1y6l~~]] ~~is a 3 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y6L OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ubiquitin--protein ligase]]		[[Category: Ubiquitin--protein ligase]]

OCA: Protected "1y6l" [edit=sysop:move=sysop]

OCA — Wed, 28 Nov 2012 14:22:27 GMT

Protected "1y6l" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:22, 28 November 2012

OCA at 14:22, 28 November 2012

OCA — Wed, 28 Nov 2012 14:22:23 GMT

←Older revision		Revision as of 14:22, 28 November 2012
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-	{{Seed}}
	[[Image:1y6l.png\|left\|200px]]		[[Image:1y6l.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1y6l\| PDB=1y6l \| SCENE= }}		{{STRUCTURE_1y6l\| PDB=1y6l \| SCENE= }}

	===Human ubiquitin conjugating enzyme E2E2===		===Human ubiquitin conjugating enzyme E2E2===

		+	{{ABSTRACT_PUBMED_22496338}}

	==About this Structure==		==About this Structure==
-	~~1Y6L~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y6L OCA].	+	[[1y6l]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y6L OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ubiquitin--protein ligase]]		[[Category: Ubiquitin--protein ligase]]
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	[[Category: Ubiquitin]]		[[Category: Ubiquitin]]
	[[Category: Ubiquitin-conjugating enzyme]]		[[Category: Ubiquitin-conjugating enzyme]]
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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:11:29 2009''

OCA at 12:11, 16 February 2009

OCA — Mon, 16 Feb 2009 12:11:31 GMT

←Older revision		Revision as of 12:11, 16 February 2009
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-	[[Image:1y6l.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1y6l.png\|left\|200px]]

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	{{STRUCTURE_1y6l\| PDB=1y6l \| SCENE= }}		{{STRUCTURE_1y6l\| PDB=1y6l \| SCENE= }}

-	~~'''~~Human ubiquitin conjugating enzyme E2E2~~'''~~	+	===Human ubiquitin conjugating enzyme E2E2===


	==About this Structure==		==About this Structure==
-	1Y6L is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y6L OCA].	+	1Y6L is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y6L OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Ubiquitin--protein ligase]]		[[Category: Ubiquitin--protein ligase]]
	[[Category: Arrowsmith, C.]]		[[Category: Arrowsmith, C.]]
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	[[Category: Ubiquitin]]		[[Category: Ubiquitin]]
	[[Category: Ubiquitin-conjugating enzyme]]		[[Category: Ubiquitin-conjugating enzyme]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 15~~:55:~~57 2008~~''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:11:29 2009''