1y7x - Revision history

OCA at 08:01, 15 May 2024

OCA — Wed, 15 May 2024 08:01:14 GMT

←Older revision		Revision as of 08:01, 15 May 2024
Line 1:		Line 1:

	==Solution structure of a two-repeat fragment of major vault protein==		==Solution structure of a two-repeat fragment of major vault protein==
-	<StructureSection load='1y7x' size='340' side='right'caption='[[1y7x~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1y7x' size='340' side='right'caption='[[1y7x]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y7x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y7X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y7x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y7X FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>MVP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7x OCA], [https://pdbe.org/1y7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y7x RCSB], [https://www.ebi.ac.uk/pdbsum/1y7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7x ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7x OCA], [https://pdbe.org/1y7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y7x RCSB], [https://www.ebi.ac.uk/pdbsum/1y7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7x ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MVP_HUMAN MVP_HUMAN]] Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.<ref>PMID:15133037</ref> <ref>PMID:16441665</ref> <ref>PMID:16418217</ref>	+	[https://www.uniprot.org/uniprot/MVP_HUMAN MVP_HUMAN] Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.<ref>PMID:15133037</ref> <ref>PMID:16441665</ref> <ref>PMID:16418217</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Banville, D]]	+	[[Category: Banville D]]
-	[[Category: Ekiel, I]]	+	[[Category: Ekiel I]]
-	[[Category: Gehring, K]]	+	[[Category: Gehring K]]
-	[[Category: Kozlov, G]]	+	[[Category: Kozlov G]]
-	[[Category: Minailiuc, O]]	+	[[Category: Minailiuc O]]
-	[[Category: Vavelyuk, O]]	+	[[Category: Vavelyuk O]]
-	~~[[Category: Beta-sheet module]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Structural protein]]~~	+
-	~~[[Category: Structural repeat~~]]	+

OCA at 07:11, 2 March 2022

OCA — Wed, 02 Mar 2022 07:11:36 GMT

←Older revision		Revision as of 07:11, 2 March 2022
Line 3:		Line 3:
	<StructureSection load='1y7x' size='340' side='right'caption='[[1y7x]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1y7x' size='340' side='right'caption='[[1y7x]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y7x]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7X OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1Y7X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y7x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y7X FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MVP ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MVP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1y7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7x OCA], [~~http~~://pdbe.org/1y7x PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1y7x RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1y7x PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7x ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7x OCA], [https://pdbe.org/1y7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y7x RCSB], [https://www.ebi.ac.uk/pdbsum/1y7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7x ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MVP_HUMAN MVP_HUMAN]] Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.<ref>PMID:15133037</ref> <ref>PMID:16441665</ref> <ref>PMID:16418217</ref>	+	[[https://www.uniprot.org/uniprot/MVP_HUMAN MVP_HUMAN]] Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.<ref>PMID:15133037</ref> <ref>PMID:16441665</ref> <ref>PMID:16418217</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1y7x" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1y7x" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Major vault protein\|Major vault protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:41, 20 January 2021

OCA — Wed, 20 Jan 2021 08:41:06 GMT

←Older revision		Revision as of 08:41, 20 January 2021
Line 1:		Line 1:

	==Solution structure of a two-repeat fragment of major vault protein==		==Solution structure of a two-repeat fragment of major vault protein==
-	<StructureSection load='1y7x' size='340' side='right' caption='[[1y7x]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1y7x' size='340' side='right'caption='[[1y7x]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y7x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7X OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Y7X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y7x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7X OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1Y7X FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MVP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MVP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1y7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7x OCA], [http://pdbe.org/1y7x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y7x RCSB], [http://www.ebi.ac.uk/pdbsum/1y7x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7x ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1y7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7x OCA], [http://pdbe.org/1y7x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y7x RCSB], [http://www.ebi.ac.uk/pdbsum/1y7x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7x ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Banville, D]]		[[Category: Banville, D]]
	[[Category: Ekiel, I]]		[[Category: Ekiel, I]]

OCA at 06:32, 25 April 2018

OCA — Wed, 25 Apr 2018 06:32:39 GMT

←Older revision		Revision as of 06:32, 25 April 2018
Line 1:		Line 1:
		+
	==Solution structure of a two-repeat fragment of major vault protein==		==Solution structure of a two-repeat fragment of major vault protein==
	<StructureSection load='1y7x' size='340' side='right' caption='[[1y7x]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1y7x' size='340' side='right' caption='[[1y7x]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1y7x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7X FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y7x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7X FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MVP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MVP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7x OCA], [http://pdbe.org/1y7x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y7x RCSB], [http://www.ebi.ac.uk/pdbsum/1y7x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7x OCA], [http://pdbe.org/1y7x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y7x RCSB], [http://www.ebi.ac.uk/pdbsum/1y7x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7x ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y7/1y7x_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y7/1y7x_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y7x ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1y7x" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1y7x" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Major vault protein\|Major vault protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:49, 11 September 2015

OCA — Fri, 11 Sep 2015 09:49:32 GMT

←Older revision		Revision as of 09:49, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1y7x' size='340' side='right' caption='[[1y7x]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1y7x' size='340' side='right' caption='[[1y7x]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y7x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y7x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7X FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MVP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MVP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y7x RCSB], [http://www.ebi.ac.uk/pdbsum/1y7x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7x OCA], [http://pdbe.org/1y7x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y7x RCSB], [http://www.ebi.ac.uk/pdbsum/1y7x PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1y7x" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Banville, D]]		[[Category: Banville, D]]
	[[Category: Ekiel, I]]		[[Category: Ekiel, I]]

OCA at 14:44, 25 December 2014

OCA — Thu, 25 Dec 2014 14:44:23 GMT

←Older revision		Revision as of 14:44, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1y7x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7X FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y7x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7X FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MVP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MVP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y7x RCSB], [http://www.ebi.ac.uk/pdbsum/1y7x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y7x RCSB], [http://www.ebi.ac.uk/pdbsum/1y7x PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MVP_HUMAN MVP_HUMAN]] Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.<ref>PMID:15133037</ref> <ref>PMID:16441665</ref> <ref>PMID:16418217</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Banville, D.]]	+	[[Category: Banville, D]]
-	[[Category: Ekiel, I.]]	+	[[Category: Ekiel, I]]
-	[[Category: Gehring, K.]]	+	[[Category: Gehring, K]]
-	[[Category: Kozlov, G.]]	+	[[Category: Kozlov, G]]
-	[[Category: Minailiuc, O.]]	+	[[Category: Minailiuc, O]]
-	[[Category: Vavelyuk, O.]]	+	[[Category: Vavelyuk, O]]
	[[Category: Beta-sheet module]]		[[Category: Beta-sheet module]]
	[[Category: Protein binding]]		[[Category: Protein binding]]
	[[Category: Structural protein]]		[[Category: Structural protein]]
	[[Category: Structural repeat]]		[[Category: Structural repeat]]

OCA at 21:48, 29 September 2014

OCA — Mon, 29 Sep 2014 21:48:30 GMT

←Older revision		Revision as of 21:48, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1y7x.~~png\|left~~\|200px]]	+	==Solution structure of a two-repeat fragment of major vault protein==
		+	<StructureSection load='1y7x' size='340' side='right' caption='[[1y7x]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1y7x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7X FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MVP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y7x RCSB], [http://www.ebi.ac.uk/pdbsum/1y7x PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y7/1y7x_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Major vault protein (MVP) is the main constituent of vaults, large ribonucleoprotein particles implicated in resistance to cancer therapy and correlated with poor survival prognosis. Here, we report the structure of the main repeat element in human MVP. The approximately 55 amino acid residue MVP domain has a unique, novel fold that consists of a three-stranded antiparallel beta-sheet. The solution NMR structure of a two-domain fragment reveals the interdomain contacts and relative orientations of the two MVP domains. We use these results to model the assembly of 672 MVP domains from 96 MVP molecules into the ribs of the 13MDa vault structure. The unique features include a thin, skin-like structure with polar residues on both the cytoplasmic and internal surface, and a pole-to-pole arrangement of MVP molecules. These studies provide a starting point for understanding the self-assembly of MVP into vaults and their interactions with other proteins. Chemical shift perturbation studies identified the binding site of vault poly(ADP-ribose) polymerase, another component of vault particles, indicating that MVP domains form a new class of interaction-mediating modules.

-	~~{{STRUCTURE_1y7x\| PDB=1y7x \| SCENE= }}~~	+	Solution structure of a two-repeat fragment of major vault protein.,Kozlov G, Vavelyuk O, Minailiuc O, Banville D, Gehring K, Ekiel I J Mol Biol. 2006 Feb 17;356(2):444-52. Epub 2005 Dec 7. PMID:16373071<ref>PMID:16373071</ref>

-	~~===Solution structure of~~ a ~~two-repeat fragment~~ of ~~major vault protein===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16373071}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1y7x]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7X OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016373071<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Banville, D.]]		[[Category: Banville, D.]]

OCA: Protected "1y7x" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 17:10:03 GMT

Protected "1y7x" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:10, 5 January 2013

OCA at 17:10, 5 January 2013

OCA — Sat, 05 Jan 2013 17:10:01 GMT

←Older revision		Revision as of 17:10, 5 January 2013
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-	{{Seed}}
	[[Image:1y7x.png\|left\|200px]]		[[Image:1y7x.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1y7x", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1y7x\| PDB=1y7x \| SCENE= }}		{{STRUCTURE_1y7x\| PDB=1y7x \| SCENE= }}

	===Solution structure of a two-repeat fragment of major vault protein===		===Solution structure of a two-repeat fragment of major vault protein===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16373071}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16373071 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16373071}}		{{ABSTRACT_PUBMED_16373071}}
-
-	==Disease==
-	Known disease associated with this structure: Mitral valve prolapse, myxomatous 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=157700 157700]]

	==About this Structure==		==About this Structure==
-	~~1Y7X~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7X OCA].	+	[[1y7x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7X OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16373071~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016373071</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Banville, D.]]		[[Category: Banville, D.]]
Line 35:		Line 20:
	[[Category: Vavelyuk, O.]]		[[Category: Vavelyuk, O.]]
	[[Category: Beta-sheet module]]		[[Category: Beta-sheet module]]
		+	[[Category: Protein binding]]
		+	[[Category: Structural protein]]
	[[Category: Structural repeat]]		[[Category: Structural repeat]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 19:01:42 2009''

OCA at 17:01, 17 February 2009

OCA — Tue, 17 Feb 2009 17:01:44 GMT

←Older revision		Revision as of 17:01, 17 February 2009
Line 23:		Line 23:

	==About this Structure==		==About this Structure==
-	1Y7X is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7X OCA].	+	1Y7X is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7X OCA].

	==Reference==		==Reference==
-	~~Solution structure of a two-repeat fragment of major vault protein., Kozlov G, Vavelyuk O, Minailiuc O, Banville D, Gehring K, Ekiel I, J Mol Biol. 2006 Feb 17;356(2):444-52. Epub 2005 Dec 7.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16373071 16373071]~~	+	<ref group="xtra">PMID:16373071</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Banville, D.]]		[[Category: Banville, D.]]
	[[Category: Ekiel, I.]]		[[Category: Ekiel, I.]]
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	[[Category: Structural repeat]]		[[Category: Structural repeat]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 03~~:08:~~18 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 19:01:42 2009''