1y8s - Revision history

OCA at 16:24, 3 November 2021

OCA — Wed, 03 Nov 2021 16:24:50 GMT

←Older revision		Revision as of 16:24, 3 November 2021
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	<StructureSection load='1y8s' size='340' side='right'caption='[[1y8s]]' scene=''>		<StructureSection load='1y8s' size='340' side='right'caption='[[1y8s]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Y8S FirstGlance]. <br>	+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y8S FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1y8s FirstGlance], [~~http~~://www.ebi.ac.uk/pdbsum/1y8s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1y8s ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y8s FirstGlance], [https://www.ebi.ac.uk/pdbsum/1y8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y8s ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:59, 29 January 2020

OCA — Wed, 29 Jan 2020 16:59:57 GMT

←Older revision		Revision as of 16:59, 29 January 2020
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	==THEORETICAL MODEL OF THE PROTON-PROLINE SYMPORTER PROP==		==THEORETICAL MODEL OF THE PROTON-PROLINE SYMPORTER PROP==
-	<StructureSection load='1y8s' size='340' side='right' caption='[[1y8s]]' scene=''>	+	<StructureSection load='1y8s' size='340' side='right'caption='[[1y8s]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y8S FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y8S FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Theoretical Model]]		[[Category: Theoretical Model]]
		+	[[Category: Large Structures]]
	[[Category: Boggs, J M]]		[[Category: Boggs, J M]]
	[[Category: Culham, D E]]		[[Category: Culham, D E]]

OCA at 06:45, 25 April 2018

OCA — Wed, 25 Apr 2018 06:45:08 GMT

←Older revision		Revision as of 06:45, 25 April 2018
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y8S FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y8S FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y8s FirstGlance], [http://www.ebi.ac.uk/pdbsum/1y8s PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y8s FirstGlance], [http://www.ebi.ac.uk/pdbsum/1y8s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y8s ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:11, 11 February 2016

OCA — Thu, 11 Feb 2016 10:11:04 GMT

←Older revision		Revision as of 10:11, 11 February 2016
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		+	{{Theoretical_model}}
		+
	==THEORETICAL MODEL OF THE PROTON-PROLINE SYMPORTER PROP==		==THEORETICAL MODEL OF THE PROTON-PROLINE SYMPORTER PROP==
	<StructureSection load='1y8s' size='340' side='right' caption='[[1y8s]]' scene=''>		<StructureSection load='1y8s' size='340' side='right' caption='[[1y8s]]' scene=''>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Theoretical Model]]
	[[Category: Boggs, J M]]		[[Category: Boggs, J M]]
	[[Category: Culham, D E]]		[[Category: Culham, D E]]

OCA at 16:50, 11 September 2015

OCA — Fri, 11 Sep 2015 16:50:15 GMT

←Older revision		Revision as of 16:50, 11 September 2015
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1y8s" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:22, 8 January 2015

OCA — Thu, 08 Jan 2015 09:22:23 GMT

←Older revision		Revision as of 09:22, 8 January 2015
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y8S FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y8S FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y8s FirstGlance], [http://www.ebi.ac.uk/pdbsum/1y8s PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y8s FirstGlance], [http://www.ebi.ac.uk/pdbsum/1y8s PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 19:37, 28 September 2014

OCA — Sun, 28 Sep 2014 19:37:06 GMT

←Older revision		Revision as of 19:37, 28 September 2014
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-	~~{{Theoretical_model}}~~	+	==THEORETICAL MODEL OF THE PROTON-PROLINE SYMPORTER PROP==
		+	<StructureSection load='1y8s' size='340' side='right' caption='[[1y8s]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y8S FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y8s FirstGlance], [http://www.ebi.ac.uk/pdbsum/1y8s PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Transporter ProP of Escherichia coli, a member of the major facilitator superfamily (MFS), acts as an osmosensor and an osmoregulator in cells and after purification and reconstitution in proteoliposomes. H(+)-osmoprotectant symport via ProP is activated when medium osmolality is elevated with membrane impermeant osmolytes. The three-dimensional structure of ProP was modeled with the crystal structure of MFS member GlpT as a template. This GlpT structure represents the inward (or cytoplasm)-facing conformation predicted by the alternating access model for transport. LacZ-PhoA fusion analysis and site-directed fluorescence labeling substantiated the membrane topology and orientation predicted by this model and most hydropathy analyses. The model predicts the presence of a proton pathway within the N-terminal six-helix bundle of ProP (as opposed to the corresponding pathway found within the C-terminal helix bundle of its paralogue, LacY). Replacement of residues within the N-terminal helix bundle impaired the osmotic activation of ProP, providing the first indication that residues outside the C-terminal domain are involved in osmosensing. Some residues that were accessible from the periplasmic side, as predicted by the structural model, were more susceptible to covalent labeling in permeabilized membrane fractions than in intact bacteria. These residues may be accessible from the cytoplasmic side in structures not represented by our current model, or their limited exposure in vivo may reflect constraints on transporter structure that are related to its osmosensory mechanism.

-	~~[[Image~~:~~1y8s~~.~~png\|left\|200px]]~~	+	A structural model for the osmosensor, transporter, and osmoregulator ProP of Escherichia coli.,Wood JM, Culham DE, Hillar A, Vernikovska YI, Liu F, Boggs JM, Keates RA Biochemistry. 2005 Apr 19;44(15):5634-46. PMID:15823022<ref>PMID:15823022</ref>

-	~~{{STRUCTURE_1y8s\| PDB=1y8s \| SCENE= }}~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	==~~=THEORETICAL MODEL OF THE PROTON-PROLINE SYMPORTER PROP===~~	+	== References ==
-		+	<references/>
-	~~{{ABSTRACT_PUBMED_15823022}}~~	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	<~~ref group="xtra">PMID:015823022<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Boggs, J M]]		[[Category: Boggs, J M]]
	[[Category: Culham, D E]]		[[Category: Culham, D E]]

OCA: Protected "1y8s" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 09:02:02 GMT

Protected "1y8s" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:02, 21 October 2012

OCA at 09:01, 21 October 2012

OCA — Sun, 21 Oct 2012 09:01:59 GMT

←Older revision		Revision as of 09:01, 21 October 2012
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	{{Theoretical_model}}		{{Theoretical_model}}
-	~~{{Seed}}~~	+
	[[Image:1y8s.png\|left\|200px]]		[[Image:1y8s.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1y8s", creates the "Structure Box" on the page.
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-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_1y8s\| PDB=1y8s \| SCENE= }}		{{STRUCTURE_1y8s\| PDB=1y8s \| SCENE= }}

	===THEORETICAL MODEL OF THE PROTON-PROLINE SYMPORTER PROP===		===THEORETICAL MODEL OF THE PROTON-PROLINE SYMPORTER PROP===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15823022}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15823022 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15823022}}		{{ABSTRACT_PUBMED_15823022}}
-
-	==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y8S OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15823022~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015823022</ref><references group="xtra"/>
	[[Category: Boggs, J M]]		[[Category: Boggs, J M]]
	[[Category: Culham, D E]]		[[Category: Culham, D E]]
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	[[Category: Vernikovska, Y I]]		[[Category: Vernikovska, Y I]]
	[[Category: Wood, J M]]		[[Category: Wood, J M]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 07:31:05 2010''

OCA at 04:31, 8 April 2010

OCA — Thu, 08 Apr 2010 04:31:06 GMT

←Older revision		Revision as of 04:31, 8 April 2010
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-	~~'''Theoretical Model'''~~	+	{{Theoretical_model}}
		+	{{Seed}}
		+	[[Image:1y8s.png\|left\|200px]]

-	The ~~entry 1Y8S~~ is ~~a Theoretical Model titled 'Theoretical model of~~ the ~~proton-proline symporter ProP'~~.	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_1y8s", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_1y8s\| PDB=1y8s \| SCENE= }}

-	~~[[Category:Theoretical Model]]~~	+	===THEORETICAL MODEL OF THE PROTON-PROLINE SYMPORTER PROP===


-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 30 09~~:54:~~55 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_15823022}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 15823022 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_15823022}}
		+
		+	==About this Structure==
		+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y8S OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:15823022</ref><references group="xtra"/>
		+	[[Category: Boggs, J M]]
		+	[[Category: Culham, D E]]
		+	[[Category: Hillar, A]]
		+	[[Category: Keates, R A]]
		+	[[Category: Liu, F]]
		+	[[Category: Vernikovska, Y I]]
		+	[[Category: Wood, J M]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 07:31:05 2010''