1y96 - Revision history

OCA at 08:55, 14 February 2024

OCA — Wed, 14 Feb 2024 08:55:48 GMT

←Older revision		Revision as of 08:55, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='1y96' size='340' side='right'caption='[[1y96]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1y96' size='340' side='right'caption='[[1y96]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y96]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y96 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1Y96 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y96]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y96 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>GEMIN6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~, ~~GEMIN7 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.002Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1y96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y96 OCA], [~~http~~://pdbe.org/1y96 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1y96 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1y96 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1y96 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y96 OCA], [https://pdbe.org/1y96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y96 RCSB], [https://www.ebi.ac.uk/pdbsum/1y96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y96 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GEMI6_HUMAN GEMI6_HUMAN]] The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus.<ref>PMID:11748230</ref> [[http://www.uniprot.org/uniprot/GEMI7_HUMAN GEMI7_HUMAN]] The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus.<ref>PMID:12065586</ref>	+	[https://www.uniprot.org/uniprot/GEMI6_HUMAN GEMI6_HUMAN] The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus.<ref>PMID:11748230</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y96 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y96 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The survival of motor neurons (SMN) protein, product of the disease gene of the common neurodegenerative disease spinal muscular atrophy, is part of the large multiprotein "SMN complex." The SMN complex functions as an assembly machine for small nuclear ribonucleoproteins (snRNPs)-the major components of the spliceosome. Here, we report the crystal structure of two components of the human SMN complex, Gemin6 and Gemin7. Although Gemin6 and Gemin7 have no significant sequence similarity with Sm proteins, both adopt canonical Sm folds. Moreover, Gemin6 and Gemin7 exist as a heterodimer, and interact with each other via an interface similar to that which mediates interactions among the Sm proteins. Together with binding experiments that show that the Gemin6/Gemin7 complex binds to Sm proteins, these findings provide a framework for considering how the SMN complex, with Gemin6 and Gemin7 as tools, might organize Sm proteins for formation of Sm rings on snRNA targets.
-
-	The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure.,Ma Y, Dostie J, Dreyfuss G, Van Duyne GD Structure. 2005 Jun;13(6):883-92. PMID:15939020<ref>PMID:15939020</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1y96" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dostie, J]]	+	[[Category: Dostie J]]
-	[[Category: Dreyfuss, G]]	+	[[Category: Dreyfuss G]]
-	~~[[Category: Duyne, G D.Van~~]]	+	[[Category: Ma Y]]
-	[[Category: Ma, Y]]	+	[[Category: Van Duyne GD]]
-	[[Category: ~~Protein complex]]~~	+
-	~~[[Category: Rna binding protein]]~~	+
-	~~[[Category: Sm fold~~]]	+

OCA at 08:41, 20 January 2021

OCA — Wed, 20 Jan 2021 08:41:50 GMT

←Older revision		Revision as of 08:41, 20 January 2021
Line 1:		Line 1:

	==crystal structure of the Gemin6/Gemin7 heterodimer from the human SMN complex==		==crystal structure of the Gemin6/Gemin7 heterodimer from the human SMN complex==
-	<StructureSection load='1y96' size='340' side='right' caption='[[1y96]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1y96' size='340' side='right'caption='[[1y96]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y96]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y96 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Y96 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y96]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y96 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1Y96 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GEMIN6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GEMIN7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GEMIN6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GEMIN7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1y96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y96 OCA], [http://pdbe.org/1y96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y96 RCSB], [http://www.ebi.ac.uk/pdbsum/1y96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y96 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1y96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y96 OCA], [http://pdbe.org/1y96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y96 RCSB], [http://www.ebi.ac.uk/pdbsum/1y96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y96 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Dostie, J]]		[[Category: Dostie, J]]
	[[Category: Dreyfuss, G]]		[[Category: Dreyfuss, G]]

OCA at 06:38, 25 April 2018

OCA — Wed, 25 Apr 2018 06:38:35 GMT

←Older revision		Revision as of 06:38, 25 April 2018
Line 1:		Line 1:
		+
	==crystal structure of the Gemin6/Gemin7 heterodimer from the human SMN complex==		==crystal structure of the Gemin6/Gemin7 heterodimer from the human SMN complex==
	<StructureSection load='1y96' size='340' side='right' caption='[[1y96]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1y96' size='340' side='right' caption='[[1y96]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1y96]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y96 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y96]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y96 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GEMIN6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GEMIN7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GEMIN6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GEMIN7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y96 OCA], [http://pdbe.org/1y96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y96 RCSB], [http://www.ebi.ac.uk/pdbsum/1y96 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y96 OCA], [http://pdbe.org/1y96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y96 RCSB], [http://www.ebi.ac.uk/pdbsum/1y96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y96 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y9/1y96_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y9/1y96_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y96 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:06, 11 September 2015

OCA — Fri, 11 Sep 2015 12:06:39 GMT

←Older revision		Revision as of 12:06, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1y96' size='340' side='right' caption='[[1y96]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1y96' size='340' side='right' caption='[[1y96]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1y96]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y96 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1y96]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y96 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GEMIN6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), GEMIN7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GEMIN6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GEMIN7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y96 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y96 RCSB], [http://www.ebi.ac.uk/pdbsum/1y96 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y96 OCA], [http://pdbe.org/1y96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y96 RCSB], [http://www.ebi.ac.uk/pdbsum/1y96 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1y96" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Dostie, J]]		[[Category: Dostie, J]]
	[[Category: Dreyfuss, G]]		[[Category: Dreyfuss, G]]

OCA at 16:14, 25 December 2014

OCA — Thu, 25 Dec 2014 16:14:09 GMT

←Older revision		Revision as of 16:14, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1y96]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y96 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1y96]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y96 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GEMIN6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), GEMIN7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GEMIN6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), GEMIN7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y96 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y96 RCSB], [http://www.ebi.ac.uk/pdbsum/1y96 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y96 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y96 RCSB], [http://www.ebi.ac.uk/pdbsum/1y96 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GEMI6_HUMAN GEMI6_HUMAN]] The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus.<ref>PMID:11748230</ref> [[http://www.uniprot.org/uniprot/GEMI7_HUMAN GEMI7_HUMAN]] The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus.<ref>PMID:12065586</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Dostie, J.]]	+	[[Category: Dostie, J]]
-	[[Category: Dreyfuss, G.]]	+	[[Category: Dreyfuss, G]]
-	[[Category: Duyne, G D.Van.]]	+	[[Category: Duyne, G D.Van]]
-	[[Category: Ma, Y.]]	+	[[Category: Ma, Y]]
	[[Category: Protein complex]]		[[Category: Protein complex]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]
	[[Category: Sm fold]]		[[Category: Sm fold]]

OCA at 19:30, 29 September 2014

OCA — Mon, 29 Sep 2014 19:30:00 GMT

←Older revision		Revision as of 19:30, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1y96.~~png\|left~~\|200px]]	+	==crystal structure of the Gemin6/Gemin7 heterodimer from the human SMN complex==
		+	<StructureSection load='1y96' size='340' side='right' caption='[[1y96]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1y96]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y96 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GEMIN6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), GEMIN7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y96 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y96 RCSB], [http://www.ebi.ac.uk/pdbsum/1y96 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y9/1y96_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The survival of motor neurons (SMN) protein, product of the disease gene of the common neurodegenerative disease spinal muscular atrophy, is part of the large multiprotein "SMN complex." The SMN complex functions as an assembly machine for small nuclear ribonucleoproteins (snRNPs)-the major components of the spliceosome. Here, we report the crystal structure of two components of the human SMN complex, Gemin6 and Gemin7. Although Gemin6 and Gemin7 have no significant sequence similarity with Sm proteins, both adopt canonical Sm folds. Moreover, Gemin6 and Gemin7 exist as a heterodimer, and interact with each other via an interface similar to that which mediates interactions among the Sm proteins. Together with binding experiments that show that the Gemin6/Gemin7 complex binds to Sm proteins, these findings provide a framework for considering how the SMN complex, with Gemin6 and Gemin7 as tools, might organize Sm proteins for formation of Sm rings on snRNA targets.

-	~~{{STRUCTURE_1y96\| PDB=1y96 \| SCENE= }}~~	+	The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure.,Ma Y, Dostie J, Dreyfuss G, Van Duyne GD Structure. 2005 Jun;13(6):883-92. PMID:15939020<ref>PMID:15939020</ref>

-	~~===crystal structure~~ of the ~~Gemin6/Gemin7 heterodimer from the human SMN complex===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15939020}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1y96]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1Y96 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015939020<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dostie, J.]]		[[Category: Dostie, J.]]

OCA: Protected "1y96" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 17:16:06 GMT

Protected "1y96" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:16, 5 January 2013

OCA at 17:16, 5 January 2013

OCA — Sat, 05 Jan 2013 17:16:03 GMT

←Older revision		Revision as of 17:16, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1y96.png\|left\|200px]]		[[Image:1y96.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1y96", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1y96\| PDB=1y96 \| SCENE= }}		{{STRUCTURE_1y96\| PDB=1y96 \| SCENE= }}

	===crystal structure of the Gemin6/Gemin7 heterodimer from the human SMN complex===		===crystal structure of the Gemin6/Gemin7 heterodimer from the human SMN complex===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15939020}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15939020 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15939020}}		{{ABSTRACT_PUBMED_15939020}}

	==About this Structure==		==About this Structure==
-	~~1Y96~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y96 OCA].	+	[[1y96]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y96 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15939020~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015939020</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dostie, J.]]		[[Category: Dostie, J.]]
Line 30:		Line 18:
	[[Category: Ma, Y.]]		[[Category: Ma, Y.]]
	[[Category: Protein complex]]		[[Category: Protein complex]]
		+	[[Category: Rna binding protein]]
	[[Category: Sm fold]]		[[Category: Sm fold]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:27:24 2009''

OCA at 19:27, 17 February 2009

OCA — Tue, 17 Feb 2009 19:27:27 GMT

←Older revision		Revision as of 19:27, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1Y96 is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y96 OCA].	+	1Y96 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y96 OCA].

	==Reference==		==Reference==
-	~~The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure., Ma Y, Dostie J, Dreyfuss G, Van Duyne GD, Structure. 2005 Jun;13(6):883-92.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/15939020 15939020]~~	+	<ref group="xtra">PMID:15939020</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Protein complex]]
	[[Category: Dostie, J.]]		[[Category: Dostie, J.]]
	[[Category: Dreyfuss, G.]]		[[Category: Dreyfuss, G.]]
Line 33:		Line 32:
	[[Category: Sm fold]]		[[Category: Sm fold]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 05~~:33:~~57 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:27:24 2009''

OCA at 02:34, 29 July 2008

OCA — Tue, 29 Jul 2008 02:34:04 GMT

←Older revision		Revision as of 02:34, 29 July 2008
Line 1:		Line 1:
-	[[Image:1y96.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1y96.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1y96\| PDB=1y96 \| SCENE= }}		{{STRUCTURE_1y96\| PDB=1y96 \| SCENE= }}

-	~~'''~~crystal structure of the Gemin6/Gemin7 heterodimer from the human SMN complex~~'''~~	+	===crystal structure of the Gemin6/Gemin7 heterodimer from the human SMN complex===


-	~~==Overview==~~	+	<!--
-	The ~~survival of motor neurons (SMN) protein~~, ~~product of~~ the ~~disease gene of~~ the ~~common neurodegenerative disease spinal muscular atrophy, is part of the large multiprotein "SMN complex." The SMN complex functions~~ as ~~an assembly machine for small nuclear ribonucleoproteins (snRNPs)-the major components of the spliceosome~~. ~~Here, we report the crystal structure of two components of the human SMN complex, Gemin6 and Gemin7~~. ~~Although Gemin6 and Gemin7 have no significant sequence similarity with Sm proteins~~, ~~both adopt canonical Sm folds. Moreover, Gemin6 and Gemin7 exist as a heterodimer, and interact with each other via an interface similar to that which mediates interactions among~~ the Sm proteins. Together with binding experiments that show that the Gemin6/Gemin7 complex binds to Sm proteins, these findings provide a framework for considering how the SMN complex, with Gemin6 and Gemin7 as tools, might organize Sm proteins for formation of Sm rings on snRNA targets.	+	The line below this paragraph, {{ABSTRACT_PUBMED_15939020}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 15939020 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_15939020}}

	==About this Structure==		==About this Structure==
Line 28:		Line 32:
	[[Category: Protein complex]]		[[Category: Protein complex]]
	[[Category: Sm fold]]		[[Category: Sm fold]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 16~~:01:52 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:33:57 2008''