1ybt - Revision history

OCA at 08:02, 15 May 2024

OCA — Wed, 15 May 2024 08:02:04 GMT

←Older revision		Revision as of 08:02, 15 May 2024
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	<StructureSection load='1ybt' size='340' side='right'caption='[[1ybt]], [[Resolution\|resolution]] 2.31Å' scene=''>		<StructureSection load='1ybt' size='340' side='right'caption='[[1ybt]], [[Resolution\|resolution]] 2.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ybt]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Mycto Mycto~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YBT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1YBT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ybt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_CDC1551 Mycobacterium tuberculosis CDC1551]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YBT FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.31Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[1ybu\|1ybu]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>Rv1900c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~83331 MYCTO])</td~~><~~/tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ybt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ybt OCA], [https://pdbe.org/1ybt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ybt RCSB], [https://www.ebi.ac.uk/pdbsum/1ybt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ybt ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1ybt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ybt OCA], [~~http~~://pdbe.org/1ybt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ybt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ybt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ybt ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/O07732_MYCTU O07732_MYCTU]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Adenylate cyclase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Mycto~~]]	+	[[Category: Mycobacterium tuberculosis CDC1551]]
-	[[Category: Linder~~, J U~~]]	+	[[Category: Linder JU]]
-	[[Category: Schultz~~, J E~~]]	+	[[Category: Schultz JE]]
-	[[Category: Sinha~~, S C~~]]	+	[[Category: Sinha SC]]
-	[[Category: Sprang~~, S R~~]]	+	[[Category: Sprang SR]]
-	[[Category: Wetterer, M]]	+	[[Category: Wetterer M]]
-	~~[[Category: Chd]]~~	+
-	~~[[Category: Cyclase homology domain]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Rv1900c~~]]	+

OCA at 08:43, 20 January 2021

OCA — Wed, 20 Jan 2021 08:43:12 GMT

←Older revision		Revision as of 08:43, 20 January 2021
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	==MYCOBACTERIUM TUBERCULOSIS ADENYLYL CYCLASE, RV1900C CHD==		==MYCOBACTERIUM TUBERCULOSIS ADENYLYL CYCLASE, RV1900C CHD==
-	<StructureSection load='1ybt' size='340' side='right' caption='[[1ybt]], [[Resolution\|resolution]] 2.31Å' scene=''>	+	<StructureSection load='1ybt' size='340' side='right'caption='[[1ybt]], [[Resolution\|resolution]] 2.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ybt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycto Mycto]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YBT OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1YBT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ybt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycto Mycto]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YBT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1YBT FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ybu\|1ybu]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ybu\|1ybu]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1900c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83331 MYCTO])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1900c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83331 MYCTO])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ybt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ybt OCA], [http://pdbe.org/1ybt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ybt RCSB], [http://www.ebi.ac.uk/pdbsum/1ybt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ybt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1ybt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ybt OCA], [http://pdbe.org/1ybt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ybt RCSB], [http://www.ebi.ac.uk/pdbsum/1ybt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ybt ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Adenylyl cyclase\|Adenylyl cyclase]]	+	*[[3D Adenylyl cyclase 3D structures\|3D Adenylyl cyclase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Adenylate cyclase]]		[[Category: Adenylate cyclase]]
		+	[[Category: Large Structures]]
	[[Category: Mycto]]		[[Category: Mycto]]
	[[Category: Linder, J U]]		[[Category: Linder, J U]]

OCA at 06:48, 25 April 2018

OCA — Wed, 25 Apr 2018 06:48:25 GMT

←Older revision		Revision as of 06:48, 25 April 2018
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		+
	==MYCOBACTERIUM TUBERCULOSIS ADENYLYL CYCLASE, RV1900C CHD==		==MYCOBACTERIUM TUBERCULOSIS ADENYLYL CYCLASE, RV1900C CHD==
	<StructureSection load='1ybt' size='340' side='right' caption='[[1ybt]], [[Resolution\|resolution]] 2.31Å' scene=''>		<StructureSection load='1ybt' size='340' side='right' caption='[[1ybt]], [[Resolution\|resolution]] 2.31Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1900c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83331 MYCTO])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1900c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83331 MYCTO])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ybt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ybt OCA], [http://pdbe.org/1ybt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ybt RCSB], [http://www.ebi.ac.uk/pdbsum/1ybt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ybt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ybt OCA], [http://pdbe.org/1ybt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ybt RCSB], [http://www.ebi.ac.uk/pdbsum/1ybt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ybt ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yb/1ybt_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yb/1ybt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 06:29, 10 February 2016

OCA — Wed, 10 Feb 2016 06:29:24 GMT

←Older revision		Revision as of 06:29, 10 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ybt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:16, 11 September 2015

OCA — Fri, 11 Sep 2015 06:16:54 GMT

←Older revision		Revision as of 06:16, 11 September 2015
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	<StructureSection load='1ybt' size='340' side='right' caption='[[1ybt]], [[Resolution\|resolution]] 2.31Å' scene=''>		<StructureSection load='1ybt' size='340' side='right' caption='[[1ybt]], [[Resolution\|resolution]] 2.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ybt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium tuberculosis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YBT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YBT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ybt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycto Mycto]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YBT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YBT FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ybu\|1ybu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ybu\|1ybu]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1900c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1773 Mycobacterium tuberculosis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1900c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83331 MYCTO])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ybt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ybt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ybt RCSB], [http://www.ebi.ac.uk/pdbsum/1ybt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ybt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ybt OCA], [http://pdbe.org/1ybt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ybt RCSB], [http://www.ebi.ac.uk/pdbsum/1ybt PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ybt" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Adenylate cyclase]]		[[Category: Adenylate cyclase]]
-	[[Category: ~~Mycobacterium tuberculosis~~]]	+	[[Category: Mycto]]
	[[Category: Linder, J U]]		[[Category: Linder, J U]]
	[[Category: Schultz, J E]]		[[Category: Schultz, J E]]

OCA at 09:27, 8 January 2015

OCA — Thu, 08 Jan 2015 09:27:24 GMT

←Older revision		Revision as of 09:27, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ybt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YBT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YBT FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ybt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YBT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YBT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ybu\|1ybu]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ybu\|1ybu]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1900c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1900c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ybt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ybt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ybt RCSB], [http://www.ebi.ac.uk/pdbsum/1ybt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ybt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ybt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ybt RCSB], [http://www.ebi.ac.uk/pdbsum/1ybt PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	[[Category: Adenylate cyclase]]		[[Category: Adenylate cyclase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Linder, J U.]]	+	[[Category: Linder, J U]]
-	[[Category: Schultz, J E.]]	+	[[Category: Schultz, J E]]
-	[[Category: Sinha, S C.]]	+	[[Category: Sinha, S C]]
-	[[Category: Sprang, S R.]]	+	[[Category: Sprang, S R]]
-	[[Category: Wetterer, M.]]	+	[[Category: Wetterer, M]]
	[[Category: Chd]]		[[Category: Chd]]
	[[Category: Cyclase homology domain]]		[[Category: Cyclase homology domain]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Rv1900c]]		[[Category: Rv1900c]]

OCA at 21:07, 28 September 2014

OCA — Sun, 28 Sep 2014 21:07:10 GMT

←Older revision		Revision as of 21:07, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1ybt.~~png~~\|~~left~~\|200px]]	+	==MYCOBACTERIUM TUBERCULOSIS ADENYLYL CYCLASE, RV1900C CHD==
		+	<StructureSection load='1ybt' size='340' side='right' caption='[[1ybt]], [[Resolution\|resolution]] 2.31Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ybt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YBT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YBT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ybu\|1ybu]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1900c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ybt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ybt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ybt RCSB], [http://www.ebi.ac.uk/pdbsum/1ybt PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yb/1ybt_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Rv1900c, a Mycobacterium tuberculosis adenylyl cyclase, is composed of an N-terminal alpha/beta-hydrolase domain and a C-terminal cyclase homology domain. It has an unusual 7% guanylyl cyclase side-activity. A canonical substrate-defining lysine and a catalytic asparagine indispensable for mammalian adenylyl cyclase activity correspond to N342 and H402 in Rv1900c. Mutagenic analysis indicates that these residues are dispensable for activity of Rv1900c. Structures of the cyclase homology domain, solved to 2.4 A both with and without an ATP analog, form isologous, but asymmetric homodimers. The noncanonical N342 and H402 do not interact with the substrate. Subunits of the unliganded open dimer move substantially upon binding substrate, forming a closed dimer similar to the mammalian cyclase heterodimers, in which one interfacial active site is occupied and the quasi-dyad-related active site is occluded. This asymmetry indicates that both active sites cannot simultaneously be catalytically active. Such a mechanism of half-of-sites-reactivity suggests that mammalian heterodimeric adenylyl cyclases may have evolved from gene duplication of a primitive prokaryote-type cyclase, followed by loss of function in one active site.

-	~~{{STRUCTURE_1ybt\| PDB=1ybt \| SCENE= }}~~	+	Origin of asymmetry in adenylyl cyclases: structures of Mycobacterium tuberculosis Rv1900c.,Sinha SC, Wetterer M, Sprang SR, Schultz JE, Linder JU EMBO J. 2005 Feb 23;24(4):663-73. Epub 2005 Jan 27. PMID:15678099<ref>PMID:15678099</ref>

-	~~===MYCOBACTERIUM TUBERCULOSIS ADENYLYL CYCLASE~~, ~~RV1900C CHD===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15678099}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1ybt]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1YBT OCA].~~	+

	==See Also==		==See Also==
	*[[Adenylyl cyclase\|Adenylyl cyclase]]		*[[Adenylyl cyclase\|Adenylyl cyclase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015678099<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Adenylate cyclase]]		[[Category: Adenylate cyclase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]

OCA at 16:39, 20 October 2012

OCA — Sat, 20 Oct 2012 16:39:34 GMT

←Older revision		Revision as of 16:39, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1ybt]] is a 4 chain structure ~~of [[Adenylyl cyclase]]~~ with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YBT OCA].	+	[[1ybt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YBT OCA].

	==See Also==		==See Also==

OCA at 22:24, 26 July 2012

OCA — Thu, 26 Jul 2012 22:24:54 GMT

←Older revision		Revision as of 22:24, 26 July 2012
Line 1:		Line 1:
	[[Image:1ybt.png\|left\|200px]]		[[Image:1ybt.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1ybt", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1ybt\| PDB=1ybt \| SCENE= }}		{{STRUCTURE_1ybt\| PDB=1ybt \| SCENE= }}

	===MYCOBACTERIUM TUBERCULOSIS ADENYLYL CYCLASE, RV1900C CHD===		===MYCOBACTERIUM TUBERCULOSIS ADENYLYL CYCLASE, RV1900C CHD===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15678099}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15678099 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15678099}}		{{ABSTRACT_PUBMED_15678099}}

	==About this Structure==		==About this Structure==
-	[[1ybt]] is a 4 chain structure of [[Adenylyl cyclase]] with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis_cdc1551~~ Mycobacterium tuberculosis ~~cdc1551~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YBT OCA].	+	[[1ybt]] is a 4 chain structure of [[Adenylyl cyclase]] with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YBT OCA].

	==See Also==		==See Also==
-	*[[Adenylyl cyclase]]	+	*[[Adenylyl cyclase\|Adenylyl cyclase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15678099~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015678099</ref><references group="xtra"/>
	[[Category: Adenylate cyclase]]		[[Category: Adenylate cyclase]]
-	[[Category: Mycobacterium tuberculosis ~~cdc1551~~]]	+	[[Category: Mycobacterium tuberculosis]]
	[[Category: Linder, J U.]]		[[Category: Linder, J U.]]
	[[Category: Schultz, J E.]]		[[Category: Schultz, J E.]]

OCA: Protected "1ybt" [edit=sysop:move=sysop]

OCA — Sun, 26 Dec 2010 21:36:01 GMT

Protected "1ybt" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:36, 26 December 2010