1yc7 - Revision history

OCA at 08:02, 15 May 2024

OCA — Wed, 15 May 2024 08:02:12 GMT

←Older revision		Revision as of 08:02, 15 May 2024
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	<StructureSection load='1yc7' size='340' side='right'caption='[[1yc7]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='1yc7' size='340' side='right'caption='[[1yc7]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yc7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Arabian_camel Arabian camel~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YC7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yc7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YC7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yc7 OCA], [https://pdbe.org/1yc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yc7 RCSB], [https://www.ebi.ac.uk/pdbsum/1yc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yc7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yc7 OCA], [https://pdbe.org/1yc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yc7 RCSB], [https://www.ebi.ac.uk/pdbsum/1yc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yc7 ProSAT]</span></td></tr>
	</table>		</table>
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arabian camel~~]]	+	[[Category: Camelus dromedarius]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Conrath, K]]	+	[[Category: Conrath K]]
-	[[Category: Loris, R]]	+	[[Category: Loris R]]
-	[[Category: Muyldermans, S]]	+	[[Category: Muyldermans S]]
-	[[Category: Schymkowitz, J]]	+	[[Category: Schymkowitz J]]
-	[[Category: Stijlemans, B]]	+	[[Category: Stijlemans B]]
-	[[Category: Vincke, C]]	+	[[Category: Vincke C]]
-	[[Category: Wyns, L]]	+	[[Category: Wyns L]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Camel antibody]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 16:26, 3 November 2021

OCA — Wed, 03 Nov 2021 16:26:01 GMT

←Older revision		Revision as of 16:26, 3 November 2021
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	<StructureSection load='1yc7' size='340' side='right'caption='[[1yc7]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='1yc7' size='340' side='right'caption='[[1yc7]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yc7]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Arabian_camel Arabian camel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YC7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1YC7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yc7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabian_camel Arabian camel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YC7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1yc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yc7 OCA], [~~http~~://pdbe.org/1yc7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1yc7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1yc7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1yc7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yc7 OCA], [https://pdbe.org/1yc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yc7 RCSB], [https://www.ebi.ac.uk/pdbsum/1yc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yc7 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 29:		Line 29:
	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:16, 29 January 2020

OCA — Wed, 29 Jan 2020 17:16:17 GMT

←Older revision		Revision as of 17:16, 29 January 2020
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	==cAbAn33 VHH fragment against VSG==		==cAbAn33 VHH fragment against VSG==
-	<StructureSection load='1yc7' size='340' side='right' caption='[[1yc7]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='1yc7' size='340' side='right'caption='[[1yc7]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1yc7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabian_camel Arabian camel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YC7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1yc7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabian_camel Arabian camel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YC7 FirstGlance]. <br>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Arabian camel]]		[[Category: Arabian camel]]
		+	[[Category: Large Structures]]
	[[Category: Conrath, K]]		[[Category: Conrath, K]]
	[[Category: Loris, R]]		[[Category: Loris, R]]

OCA at 06:59, 25 April 2018

OCA — Wed, 25 Apr 2018 06:59:02 GMT

←Older revision		Revision as of 06:59, 25 April 2018
Line 1:		Line 1:
		+
	==cAbAn33 VHH fragment against VSG==		==cAbAn33 VHH fragment against VSG==
	<StructureSection load='1yc7' size='340' side='right' caption='[[1yc7]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='1yc7' size='340' side='right' caption='[[1yc7]], [[Resolution\|resolution]] 1.60Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1yc7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabian_camel Arabian camel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YC7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1yc7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabian_camel Arabian camel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YC7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yc7 OCA], [http://pdbe.org/1yc7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yc7 RCSB], [http://www.ebi.ac.uk/pdbsum/1yc7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yc7 OCA], [http://pdbe.org/1yc7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yc7 RCSB], [http://www.ebi.ac.uk/pdbsum/1yc7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1yc7 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yc/1yc7_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yc/1yc7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 25:		Line 26:
	</div>		</div>
	<div class="pdbe-citations 1yc7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1yc7" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:45, 9 February 2016

OCA — Tue, 09 Feb 2016 17:45:28 GMT

←Older revision		Revision as of 17:45, 9 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yc7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:33, 11 September 2015

OCA — Fri, 11 Sep 2015 00:33:37 GMT

←Older revision		Revision as of 00:33, 11 September 2015
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	<StructureSection load='1yc7' size='340' side='right' caption='[[1yc7]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='1yc7' size='340' side='right' caption='[[1yc7]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yc7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Camelus_dromedarius Camelus dromedarius~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YC7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yc7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabian_camel Arabian camel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YC7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yc7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yc7 RCSB], [http://www.ebi.ac.uk/pdbsum/1yc7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yc7 OCA], [http://pdbe.org/1yc7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yc7 RCSB], [http://www.ebi.ac.uk/pdbsum/1yc7 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1yc7" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Camelus dromedarius~~]]	+	[[Category: Arabian camel]]
	[[Category: Conrath, K]]		[[Category: Conrath, K]]
	[[Category: Loris, R]]		[[Category: Loris, R]]

OCA at 09:39, 8 January 2015

OCA — Thu, 08 Jan 2015 09:39:25 GMT

←Older revision		Revision as of 09:39, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1yc7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YC7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1yc7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YC7 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yc7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yc7 RCSB], [http://www.ebi.ac.uk/pdbsum/1yc7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yc7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yc7 RCSB], [http://www.ebi.ac.uk/pdbsum/1yc7 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Camelus dromedarius]]		[[Category: Camelus dromedarius]]
-	[[Category: Conrath, K.]]	+	[[Category: Conrath, K]]
-	[[Category: Loris, R.]]	+	[[Category: Loris, R]]
-	[[Category: Muyldermans, S.]]	+	[[Category: Muyldermans, S]]
-	[[Category: Schymkowitz, J.]]	+	[[Category: Schymkowitz, J]]
-	[[Category: Stijlemans, B.]]	+	[[Category: Stijlemans, B]]
-	[[Category: Vincke, C.]]	+	[[Category: Vincke, C]]
-	[[Category: Wyns, L.]]	+	[[Category: Wyns, L]]
	[[Category: Antibody]]		[[Category: Antibody]]
	[[Category: Camel antibody]]		[[Category: Camel antibody]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 19:41, 29 September 2014

OCA — Mon, 29 Sep 2014 19:41:37 GMT

←Older revision		Revision as of 19:41, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1yc7.~~png\|left~~\|200px]]	+	==cAbAn33 VHH fragment against VSG==
		+	<StructureSection load='1yc7' size='340' side='right' caption='[[1yc7]], [[Resolution\|resolution]] 1.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1yc7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YC7 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yc7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yc7 RCSB], [http://www.ebi.ac.uk/pdbsum/1yc7 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yc/1yc7_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Heavy chain only antibodies of camelids bind their antigens with a single domain, the VHH, which acquired adaptations relative to classical VHs to function in the absence of a VL partner. Additional CDR loop conformations, outside the canonical loop structures of VHs, broaden the repertoire of the antigen-binding site. The combined effects of part of the CDR3 that folds over the "former" VL binding site and framework-2 mutations to more hydrophilic amino acids, enhance the solubility of VHH domains and prevent VL pairing. cAbAn33, a VHH domain specific for the carbohydrate moiety of the variant surface glycoprotein of trypanosomes, has a short CDR3 loop that does not cover the former VL binding site as well as a VH-specific Trp47 instead of the VHH-specific Gly47. Resurfacing its framework-2 region (mutations Tyr37Val, Glu44Gly and Arg45Leu) to mimic that of a human VH restores the VL binding capacity. In solution, the humanised VHH behaves as a soluble, monomeric entity, albeit with reduced thermodynamic stability and affinity for its antigen. Comparison of the crystal structures of cAbAn33 and its humanised derivative reveals steric hindrance exerted by VHH-specific residues Tyr37 and Arg45 that prevent the VL domain pairing, whereas Glu44 and Arg45 are key elements to avoid insolubility of the domain.

-	~~{{STRUCTURE_1yc7\| PDB=1yc7 \| SCENE= }}~~	+	Antigen binding and solubility effects upon the veneering of a camel VHH in framework-2 to mimic a VH.,Conrath K, Vincke C, Stijlemans B, Schymkowitz J, Decanniere K, Wyns L, Muyldermans S, Loris R J Mol Biol. 2005 Jul 1;350(1):112-25. PMID:15913651<ref>PMID:15913651</ref>

-	~~===cAbAn33 VHH fragment against VSG===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15913651}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1yc7]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Camelus_dromedarius Camelus dromedarius]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1YC7 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015913651<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Camelus dromedarius]]		[[Category: Camelus dromedarius]]
	[[Category: Conrath, K.]]		[[Category: Conrath, K.]]

OCA: Protected "1yc7" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 17:41:26 GMT

Protected "1yc7" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:41, 5 January 2013

OCA at 17:41, 5 January 2013

OCA — Sat, 05 Jan 2013 17:41:22 GMT

←Older revision		Revision as of 17:41, 5 January 2013
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-	{{Seed}}
	[[Image:1yc7.png\|left\|200px]]		[[Image:1yc7.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1yc7\| PDB=1yc7 \| SCENE= }}		{{STRUCTURE_1yc7\| PDB=1yc7 \| SCENE= }}

	===cAbAn33 VHH fragment against VSG===		===cAbAn33 VHH fragment against VSG===

-
-	<!--
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	{{ABSTRACT_PUBMED_15913651}}		{{ABSTRACT_PUBMED_15913651}}

	==About this Structure==		==About this Structure==
-	~~1YC7~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YC7 OCA].	+	[[1yc7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YC7 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15913651~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015913651</ref><references group="xtra"/>
	[[Category: Camelus dromedarius]]		[[Category: Camelus dromedarius]]
	[[Category: Conrath, K.]]		[[Category: Conrath, K.]]
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	[[Category: Antibody]]		[[Category: Antibody]]
	[[Category: Camel antibody]]		[[Category: Camel antibody]]
-		+	[[Category: Immune system]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 11:33:39 2009''~~	+