1yfn - Revision history

OCA at 06:56, 23 August 2023

OCA — Wed, 23 Aug 2023 06:56:44 GMT

←Older revision		Revision as of 06:56, 23 August 2023
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	<StructureSection load='1yfn' size='340' side='right'caption='[[1yfn]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1yfn' size='340' side='right'caption='[[1yfn]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yfn]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YFN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YFN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yfn]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YFN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YFN FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1ou8\|1ou8]]~~, [[~~1ou9~~\|~~1ou9~~]]~~, [[1oul\|1oul]], [[1ox8\|1ox8]], [[1ox9\|1ox9]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yfn OCA], [https://pdbe.org/1yfn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yfn RCSB], [https://www.ebi.ac.uk/pdbsum/1yfn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yfn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yfn OCA], [https://pdbe.org/1yfn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yfn RCSB], [https://www.ebi.ac.uk/pdbsum/1yfn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yfn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SSPB_ECOLI SSPB_ECOLI]] Enhances recognition of ssrA-tagged proteins by the ClpX-ClpP protease; the ssrA degradation tag (AANDENYALAA) is added trans-translationally to proteins that are stalled on the ribosome, freeing the ribosome and targeting stalled peptides for degradation. SspB activates the ATPase activity of ClpX. Seems to act in concert with SspA in the regulation of several proteins during exponential and stationary-phase growth.<ref>PMID:11009422</ref> <ref>PMID:15371343</ref> <ref>PMID:12887894</ref> Also stimulates degradation of the N-terminus of RseA (residues 1-108, alone or in complex with sigma-E) by ClpX-ClpP in a non-ssrA-mediated fashion.<ref>PMID:11009422</ref> <ref>PMID:15371343</ref> <ref>PMID:12887894</ref> ~~[[https://www.uniprot.org/uniprot/RSEA_ECOLI RSEA_ECOLI]] Negative regulator of RpoE.~~	+	[https://www.uniprot.org/uniprot/SSPB_ECOLI SSPB_ECOLI] Enhances recognition of ssrA-tagged proteins by the ClpX-ClpP protease; the ssrA degradation tag (AANDENYALAA) is added trans-translationally to proteins that are stalled on the ribosome, freeing the ribosome and targeting stalled peptides for degradation. SspB activates the ATPase activity of ClpX. Seems to act in concert with SspA in the regulation of several proteins during exponential and stationary-phase growth.<ref>PMID:11009422</ref> <ref>PMID:15371343</ref> <ref>PMID:12887894</ref> Also stimulates degradation of the N-terminus of RseA (residues 1-108, alone or in complex with sigma-E) by ClpX-ClpP in a non-ssrA-mediated fashion.<ref>PMID:11009422</ref> <ref>PMID:15371343</ref> <ref>PMID:12887894</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</div>		</div>
	<div class="pdbe-citations 1yfn" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1yfn" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Stringent starvation protein 3D structures\|Stringent starvation protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Baker~~, T A~~]]	+	[[Category: Baker TA]]
-	[[Category: Flynn~~, J M~~]]	+	[[Category: Flynn JM]]
-	[[Category: Grant~~, R A~~]]	+	[[Category: Grant RA]]
-	[[Category: Levchenko, I]]	+	[[Category: Levchenko I]]
-	[[Category: Sauer~~, R T]]~~	+	[[Category: Sauer RT]]
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Protein-peptide complex]]~~	+
-	~~[[Category: Rsea]]~~	+
-	~~[[Category: Sspb~~]]	+

OCA at 16:27, 3 November 2021

OCA — Wed, 03 Nov 2021 16:27:38 GMT

←Older revision		Revision as of 16:27, 3 November 2021
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	<StructureSection load='1yfn' size='340' side='right'caption='[[1yfn]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1yfn' size='340' side='right'caption='[[1yfn]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yfn]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YFN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1YFN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yfn]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YFN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YFN FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ou8\|1ou8]], [[1ou9\|1ou9]], [[1oul\|1oul]], [[1ox8\|1ox8]], [[1ox9\|1ox9]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ou8\|1ou8]], [[1ou9\|1ou9]], [[1oul\|1oul]], [[1ox8\|1ox8]], [[1ox9\|1ox9]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1yfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yfn OCA], [~~http~~://pdbe.org/1yfn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1yfn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1yfn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1yfn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yfn OCA], [https://pdbe.org/1yfn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yfn RCSB], [https://www.ebi.ac.uk/pdbsum/1yfn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yfn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SSPB_ECOLI SSPB_ECOLI]] Enhances recognition of ssrA-tagged proteins by the ClpX-ClpP protease; the ssrA degradation tag (AANDENYALAA) is added trans-translationally to proteins that are stalled on the ribosome, freeing the ribosome and targeting stalled peptides for degradation. SspB activates the ATPase activity of ClpX. Seems to act in concert with SspA in the regulation of several proteins during exponential and stationary-phase growth.<ref>PMID:11009422</ref> <ref>PMID:15371343</ref> <ref>PMID:12887894</ref> Also stimulates degradation of the N-terminus of RseA (residues 1-108, alone or in complex with sigma-E) by ClpX-ClpP in a non-ssrA-mediated fashion.<ref>PMID:11009422</ref> <ref>PMID:15371343</ref> <ref>PMID:12887894</ref> [[~~http~~://www.uniprot.org/uniprot/RSEA_ECOLI RSEA_ECOLI]] Negative regulator of RpoE.	+	[[https://www.uniprot.org/uniprot/SSPB_ECOLI SSPB_ECOLI]] Enhances recognition of ssrA-tagged proteins by the ClpX-ClpP protease; the ssrA degradation tag (AANDENYALAA) is added trans-translationally to proteins that are stalled on the ribosome, freeing the ribosome and targeting stalled peptides for degradation. SspB activates the ATPase activity of ClpX. Seems to act in concert with SspA in the regulation of several proteins during exponential and stationary-phase growth.<ref>PMID:11009422</ref> <ref>PMID:15371343</ref> <ref>PMID:12887894</ref> Also stimulates degradation of the N-terminus of RseA (residues 1-108, alone or in complex with sigma-E) by ClpX-ClpP in a non-ssrA-mediated fashion.<ref>PMID:11009422</ref> <ref>PMID:15371343</ref> <ref>PMID:12887894</ref> [[https://www.uniprot.org/uniprot/RSEA_ECOLI RSEA_ECOLI]] Negative regulator of RpoE.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 17:17, 29 January 2020

OCA — Wed, 29 Jan 2020 17:17:58 GMT

←Older revision		Revision as of 17:17, 29 January 2020
Line 1:		Line 1:

	==Versatile modes of peptide recognition by the AAA+ adaptor protein SspB- the crystal structure of a SspB-RseA complex==		==Versatile modes of peptide recognition by the AAA+ adaptor protein SspB- the crystal structure of a SspB-RseA complex==
-	<StructureSection load='1yfn' size='340' side='right' caption='[[1yfn]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1yfn' size='340' side='right'caption='[[1yfn]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1yfn]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YFN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YFN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1yfn]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YFN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YFN FirstGlance]. <br>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Baker, T A]]		[[Category: Baker, T A]]
	[[Category: Flynn, J M]]		[[Category: Flynn, J M]]

OCA at 07:00, 25 April 2018

OCA — Wed, 25 Apr 2018 07:00:18 GMT

←Older revision		Revision as of 07:00, 25 April 2018
Line 1:		Line 1:
		+
	==Versatile modes of peptide recognition by the AAA+ adaptor protein SspB- the crystal structure of a SspB-RseA complex==		==Versatile modes of peptide recognition by the AAA+ adaptor protein SspB- the crystal structure of a SspB-RseA complex==
	<StructureSection load='1yfn' size='340' side='right' caption='[[1yfn]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1yfn' size='340' side='right' caption='[[1yfn]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1yfn]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YFN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YFN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1yfn]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YFN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YFN FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ou8\|1ou8]], [[1ou9\|1ou9]], [[1oul\|1oul]], [[1ox8\|1ox8]], [[1ox9\|1ox9]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ou8\|1ou8]], [[1ou9\|1ou9]], [[1oul\|1oul]], [[1ox8\|1ox8]], [[1ox9\|1ox9]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yfn OCA], [http://pdbe.org/1yfn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yfn RCSB], [http://www.ebi.ac.uk/pdbsum/1yfn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yfn OCA], [http://pdbe.org/1yfn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yfn RCSB], [http://www.ebi.ac.uk/pdbsum/1yfn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1yfn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yf/1yfn_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yf/1yfn_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 01:42, 9 February 2016

OCA — Tue, 09 Feb 2016 01:42:25 GMT

←Older revision		Revision as of 01:42, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yfn ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:23, 10 September 2015

OCA — Thu, 10 Sep 2015 17:23:04 GMT

←Older revision		Revision as of 17:23, 10 September 2015
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	<StructureSection load='1yfn' size='340' side='right' caption='[[1yfn]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1yfn' size='340' side='right' caption='[[1yfn]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yfn]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YFN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YFN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yfn]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YFN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YFN FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ou8\|1ou8]], [[1ou9\|1ou9]], [[1oul\|1oul]], [[1ox8\|1ox8]], [[1ox9\|1ox9]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ou8\|1ou8]], [[1ou9\|1ou9]], [[1oul\|1oul]], [[1ox8\|1ox8]], [[1ox9\|1ox9]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yfn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yfn RCSB], [http://www.ebi.ac.uk/pdbsum/1yfn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yfn OCA], [http://pdbe.org/1yfn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yfn RCSB], [http://www.ebi.ac.uk/pdbsum/1yfn PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1yfn" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Baker, T A]]		[[Category: Baker, T A]]
	[[Category: Flynn, J M]]		[[Category: Flynn, J M]]

OCA at 03:33, 25 December 2014

OCA — Thu, 25 Dec 2014 03:33:38 GMT

←Older revision		Revision as of 03:33, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1yfn]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YFN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YFN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1yfn]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YFN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YFN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ou8\|1ou8]], [[1ou9\|1ou9]], [[1oul\|1oul]], [[1ox8\|1ox8]], [[1ox9\|1ox9]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ou8\|1ou8]], [[1ou9\|1ou9]], [[1oul\|1oul]], [[1ox8\|1ox8]], [[1ox9\|1ox9]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yfn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yfn RCSB], [http://www.ebi.ac.uk/pdbsum/1yfn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yfn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yfn RCSB], [http://www.ebi.ac.uk/pdbsum/1yfn PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SSPB_ECOLI SSPB_ECOLI]] Enhances recognition of ssrA-tagged proteins by the ClpX-ClpP protease; the ssrA degradation tag (AANDENYALAA) is added trans-translationally to proteins that are stalled on the ribosome, freeing the ribosome and targeting stalled peptides for degradation. SspB activates the ATPase activity of ClpX. Seems to act in concert with SspA in the regulation of several proteins during exponential and stationary-phase growth.<ref>PMID:11009422</ref> <ref>PMID:15371343</ref> <ref>PMID:12887894</ref> Also stimulates degradation of the N-terminus of RseA (residues 1-108, alone or in complex with sigma-E) by ClpX-ClpP in a non-ssrA-mediated fashion.<ref>PMID:11009422</ref> <ref>PMID:15371343</ref> <ref>PMID:12887894</ref> [[http://www.uniprot.org/uniprot/RSEA_ECOLI RSEA_ECOLI]] Negative regulator of RpoE.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Baker, T A.]]	+	[[Category: Baker, T A]]
-	[[Category: Flynn, J M.]]	+	[[Category: Flynn, J M]]
-	[[Category: Grant, R A.]]	+	[[Category: Grant, R A]]
-	[[Category: Levchenko, I.]]	+	[[Category: Levchenko, I]]
-	[[Category: Sauer, R T.]]	+	[[Category: Sauer, R T]]
	[[Category: Protein binding]]		[[Category: Protein binding]]
	[[Category: Protein-peptide complex]]		[[Category: Protein-peptide complex]]
	[[Category: Rsea]]		[[Category: Rsea]]
	[[Category: Sspb]]		[[Category: Sspb]]

OCA at 19:13, 29 September 2014

OCA — Mon, 29 Sep 2014 19:13:48 GMT

←Older revision		Revision as of 19:13, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1yfn.~~png~~\|~~left~~\|200px]]	+	==Versatile modes of peptide recognition by the AAA+ adaptor protein SspB- the crystal structure of a SspB-RseA complex==
		+	<StructureSection load='1yfn' size='340' side='right' caption='[[1yfn]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1yfn]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YFN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YFN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ou8\|1ou8]], [[1ou9\|1ou9]], [[1oul\|1oul]], [[1ox8\|1ox8]], [[1ox9\|1ox9]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yfn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yfn RCSB], [http://www.ebi.ac.uk/pdbsum/1yfn PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yf/1yfn_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Energy-dependent proteases often rely on adaptor proteins to modulate substrate recognition. The SspB adaptor binds peptide sequences in the stress-response regulator RseA and in ssrA-tagged proteins and delivers these molecules to the AAA+ ClpXP protease for degradation. The structure of SspB bound to an ssrA peptide is known. Here, we report the crystal structure of a complex between SspB and its recognition peptide in RseA. Notably, the RseA sequence is positioned in the peptide-binding groove of SspB in a direction opposite to the ssrA peptide, the two peptides share only one common interaction with the adaptor, and the RseA interaction site is substantially larger than the overlapping ssrA site. This marked diversity in SspB recognition of different target proteins indicates that it is capable of highly flexible and dynamic substrate delivery.

-	~~{{STRUCTURE_1yfn\| PDB=1yfn \| SCENE= }}~~	+	Versatile modes of peptide recognition by the AAA+ adaptor protein SspB.,Levchenko I, Grant RA, Flynn JM, Sauer RT, Baker TA Nat Struct Mol Biol. 2005 Jun;12(6):520-5. Epub 2005 May 8. PMID:15880122<ref>PMID:15880122</ref>

-	~~===Versatile modes~~ of ~~peptide recognition by~~ the ~~AAA+ adaptor protein SspB- the crystal structure of a SspB-RseA complex===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15880122}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1yfn]] is a 8 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1YFN OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015880122<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Baker, T A.]]		[[Category: Baker, T A.]]

OCA: Protected "1yfn" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 17:42:59 GMT

Protected "1yfn" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:42, 5 January 2013

OCA at 17:42, 5 January 2013

OCA — Sat, 05 Jan 2013 17:42:56 GMT

←Older revision		Revision as of 17:42, 5 January 2013
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-	{{Seed}}
	[[Image:1yfn.png\|left\|200px]]		[[Image:1yfn.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1yfn", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1yfn\| PDB=1yfn \| SCENE= }}		{{STRUCTURE_1yfn\| PDB=1yfn \| SCENE= }}

	===Versatile modes of peptide recognition by the AAA+ adaptor protein SspB- the crystal structure of a SspB-RseA complex===		===Versatile modes of peptide recognition by the AAA+ adaptor protein SspB- the crystal structure of a SspB-RseA complex===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15880122}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15880122 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15880122}}		{{ABSTRACT_PUBMED_15880122}}

	==About this Structure==		==About this Structure==
-	~~1YFN~~ is a 8 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YFN OCA].	+	[[1yfn]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YFN OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15880122~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015880122</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Baker, T A.]]		[[Category: Baker, T A.]]
Line 30:		Line 18:
	[[Category: Levchenko, I.]]		[[Category: Levchenko, I.]]
	[[Category: Sauer, R T.]]		[[Category: Sauer, R T.]]
		+	[[Category: Protein binding]]
	[[Category: Protein-peptide complex]]		[[Category: Protein-peptide complex]]
	[[Category: Rsea]]		[[Category: Rsea]]
	[[Category: Sspb]]		[[Category: Sspb]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:26:21 2009''