1yhk - Revision history

OCA at 08:57, 14 February 2024

OCA — Wed, 14 Feb 2024 08:57:30 GMT

←Older revision		Revision as of 08:57, 14 February 2024
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	<StructureSection load='1yhk' size='340' side='right'caption='[[1yhk]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1yhk' size='340' side='right'caption='[[1yhk]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yhk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Trycr Trycr~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YHK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yhk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YHK FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>[https://en.wikipedia.org/wiki/(2E,6E)-farnesyl_diphosphate_synthase (2E,6E)-farnesyl diphosphate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.10 2.5.1.10] </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yhk OCA], [https://pdbe.org/1yhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yhk RCSB], [https://www.ebi.ac.uk/pdbsum/1yhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yhk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yhk OCA], [https://pdbe.org/1yhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yhk RCSB], [https://www.ebi.ac.uk/pdbsum/1yhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yhk ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8WS26_TRYCR Q8WS26_TRYCR]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yhk ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yhk ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Typanosoma cruzi, the causative agent of Chagas disease, has recently been shown to be sensitive to the action of the bisphosphonates currently used in bone resorption therapy. These compounds target the mevalonate pathway by inhibiting farnesyl diphosphate synthase (farnesyl pyrophosphate synthase, FPPS), the enzyme that condenses the diphosphates of C5 alcohols (isopentenyl and dimethylallyl) to form C10 and C15 diphosphates (geranyl and farnesyl). The structures of the T. cruzi FPPS (TcFPPS) alone and in two complexes with substrates and inhibitors reveal that following binding of the two substrates and three Mg2+ ions, the enzyme undergoes a conformational change consisting of a hinge-like closure of the binding site. In this conformation, it would be possible for the enzyme to bind a bisphosphonate inhibitor that spans the sites usually occupied by dimethylallyl diphosphate (DMAPP) and the homoallyl moiety of isopentenyl diphosphate. This observation may lead to the design of new, more potent anti-trypanosomal bisphosphonates, because existing FPPS inhibitors occupy only the DMAPP site. In addition, the structures provide an important mechanistic insight: after its formation, geranyl diphosphate can swing without leaving the enzyme, from the product site to the substrate site to participate in the synthesis of farnesyl diphosphate.
-
-	Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design.,Gabelli SB, McLellan JS, Montalvetti A, Oldfield E, Docampo R, Amzel LM Proteins. 2006 Jan 1;62(1):80-8. PMID:16288456<ref>PMID:16288456</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1yhk" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Farnesyl diphosphate synthase 3D structures\|Farnesyl diphosphate synthase 3D structures]]		*[[Farnesyl diphosphate synthase 3D structures\|Farnesyl diphosphate synthase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Trycr~~]]	+	[[Category: Trypanosoma cruzi]]
-	[[Category: Amzel~~, L M~~]]	+	[[Category: Amzel LM]]
-	[[Category: Docampo, R]]	+	[[Category: Docampo R]]
-	[[Category: Gabelli~~, S B~~]]	+	[[Category: Gabelli SB]]
-	[[Category: McLellan~~, J S~~]]	+	[[Category: McLellan JS]]
-	[[Category: Montalvetti, A]]	+	[[Category: Montalvetti A]]
-	[[Category: Oldfield, E]]	+	[[Category: Oldfield E]]
-	~~[[Category: Bisphosphonate]]~~	+
-	~~[[Category: Farnesyl disphosphate synthase]]~~	+
-	~~[[Category: Farnesyl pyrophosphate synthase]]~~	+
-	~~[[Category: Fpp]]~~	+
-	~~[[Category: Mevalonate pathway]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 16:28, 3 November 2021

OCA — Wed, 03 Nov 2021 16:28:21 GMT

←Older revision		Revision as of 16:28, 3 November 2021
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	<StructureSection load='1yhk' size='340' side='right'caption='[[1yhk]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1yhk' size='340' side='right'caption='[[1yhk]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yhk]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YHK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1YHK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yhk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YHK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/(2E,6E)-farnesyl_diphosphate_synthase (2E,6E)-farnesyl diphosphate synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.10 2.5.1.10] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/(2E,6E)-farnesyl_diphosphate_synthase (2E,6E)-farnesyl diphosphate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.10 2.5.1.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1yhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yhk OCA], [~~http~~://pdbe.org/1yhk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1yhk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1yhk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1yhk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yhk OCA], [https://pdbe.org/1yhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yhk RCSB], [https://www.ebi.ac.uk/pdbsum/1yhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yhk ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 17:09, 29 January 2020

OCA — Wed, 29 Jan 2020 17:09:29 GMT

←Older revision		Revision as of 17:09, 29 January 2020
Line 1:		Line 1:

	==Trypanosoma cruzi farnesyl diphosphate synthase==		==Trypanosoma cruzi farnesyl diphosphate synthase==
-	<StructureSection load='1yhk' size='340' side='right' caption='[[1yhk]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='1yhk' size='340' side='right'caption='[[1yhk]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1yhk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YHK FirstGlance]. <br>		<table><tr><td colspan='2'>[[1yhk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YHK FirstGlance]. <br>
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[Farnesyl diphosphate synthase\|Farnesyl diphosphate synthase]]	+	*[[Farnesyl diphosphate synthase 3D structures\|Farnesyl diphosphate synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Trycr]]		[[Category: Trycr]]
	[[Category: Amzel, L M]]		[[Category: Amzel, L M]]

OCA at 06:52, 25 April 2018

OCA — Wed, 25 Apr 2018 06:52:10 GMT

←Older revision		Revision as of 06:52, 25 April 2018
Line 1:		Line 1:
		+
	==Trypanosoma cruzi farnesyl diphosphate synthase==		==Trypanosoma cruzi farnesyl diphosphate synthase==
	<StructureSection load='1yhk' size='340' side='right' caption='[[1yhk]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1yhk' size='340' side='right' caption='[[1yhk]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(2E,6E)-farnesyl_diphosphate_synthase (2E,6E)-farnesyl diphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.10 2.5.1.10] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(2E,6E)-farnesyl_diphosphate_synthase (2E,6E)-farnesyl diphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.10 2.5.1.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yhk OCA], [http://pdbe.org/1yhk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yhk RCSB], [http://www.ebi.ac.uk/pdbsum/1yhk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yhk OCA], [http://pdbe.org/1yhk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yhk RCSB], [http://www.ebi.ac.uk/pdbsum/1yhk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1yhk ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yh/1yhk_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yh/1yhk_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yhk ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:12, 11 September 2015

OCA — Fri, 11 Sep 2015 16:12:57 GMT

←Older revision		Revision as of 16:12, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1yhk' size='340' side='right' caption='[[1yhk]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1yhk' size='340' side='right' caption='[[1yhk]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yhk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Trypanosoma_cruzi Trypanosoma cruzi~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YHK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yhk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YHK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Geranyltranstransferase Geranyltranstransferase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.10 2.5.1.10] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(2E,6E)-farnesyl_diphosphate_synthase (2E,6E)-farnesyl diphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.10 2.5.1.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yhk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yhk RCSB], [http://www.ebi.ac.uk/pdbsum/1yhk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yhk OCA], [http://pdbe.org/1yhk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yhk RCSB], [http://www.ebi.ac.uk/pdbsum/1yhk PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1yhk" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Geranyltranstransferase]]~~	+	[[Category: Trycr]]
-	~~[[Category: Trypanosoma cruzi~~]]	+
	[[Category: Amzel, L M]]		[[Category: Amzel, L M]]
	[[Category: Docampo, R]]		[[Category: Docampo, R]]

OCA at 10:26, 8 January 2015

OCA — Thu, 08 Jan 2015 10:26:22 GMT

←Older revision		Revision as of 10:26, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1yhk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YHK FirstGlance]. <br>		<table><tr><td colspan='2'>[[1yhk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YHK FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Geranyltranstransferase Geranyltranstransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.10 2.5.1.10] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Geranyltranstransferase Geranyltranstransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.10 2.5.1.10] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yhk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yhk RCSB], [http://www.ebi.ac.uk/pdbsum/1yhk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yhk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yhk RCSB], [http://www.ebi.ac.uk/pdbsum/1yhk PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Geranyltranstransferase]]		[[Category: Geranyltranstransferase]]
	[[Category: Trypanosoma cruzi]]		[[Category: Trypanosoma cruzi]]
-	[[Category: Amzel, L M.]]	+	[[Category: Amzel, L M]]
-	[[Category: Docampo, R.]]	+	[[Category: Docampo, R]]
-	[[Category: Gabelli, S B.]]	+	[[Category: Gabelli, S B]]
-	[[Category: McLellan, J S.]]	+	[[Category: McLellan, J S]]
-	[[Category: Montalvetti, A.]]	+	[[Category: Montalvetti, A]]
-	[[Category: Oldfield, E.]]	+	[[Category: Oldfield, E]]
	[[Category: Bisphosphonate]]		[[Category: Bisphosphonate]]
	[[Category: Farnesyl disphosphate synthase]]		[[Category: Farnesyl disphosphate synthase]]

OCA at 00:02, 29 September 2014

OCA — Mon, 29 Sep 2014 00:02:38 GMT

←Older revision		Revision as of 00:02, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1yhk.~~png\|left~~\|200px]]	+	==Trypanosoma cruzi farnesyl diphosphate synthase==
		+	<StructureSection load='1yhk' size='340' side='right' caption='[[1yhk]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1yhk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YHK FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Geranyltranstransferase Geranyltranstransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.10 2.5.1.10] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yhk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yhk RCSB], [http://www.ebi.ac.uk/pdbsum/1yhk PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yh/1yhk_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Typanosoma cruzi, the causative agent of Chagas disease, has recently been shown to be sensitive to the action of the bisphosphonates currently used in bone resorption therapy. These compounds target the mevalonate pathway by inhibiting farnesyl diphosphate synthase (farnesyl pyrophosphate synthase, FPPS), the enzyme that condenses the diphosphates of C5 alcohols (isopentenyl and dimethylallyl) to form C10 and C15 diphosphates (geranyl and farnesyl). The structures of the T. cruzi FPPS (TcFPPS) alone and in two complexes with substrates and inhibitors reveal that following binding of the two substrates and three Mg2+ ions, the enzyme undergoes a conformational change consisting of a hinge-like closure of the binding site. In this conformation, it would be possible for the enzyme to bind a bisphosphonate inhibitor that spans the sites usually occupied by dimethylallyl diphosphate (DMAPP) and the homoallyl moiety of isopentenyl diphosphate. This observation may lead to the design of new, more potent anti-trypanosomal bisphosphonates, because existing FPPS inhibitors occupy only the DMAPP site. In addition, the structures provide an important mechanistic insight: after its formation, geranyl diphosphate can swing without leaving the enzyme, from the product site to the substrate site to participate in the synthesis of farnesyl diphosphate.

-	~~{{STRUCTURE_1yhk\| PDB=1yhk \| SCENE= }}~~	+	Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design.,Gabelli SB, McLellan JS, Montalvetti A, Oldfield E, Docampo R, Amzel LM Proteins. 2006 Jan 1;62(1):80-8. PMID:16288456<ref>PMID:16288456</ref>

-	~~===Trypanosoma cruzi farnesyl diphosphate synthase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16288456}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1yhk]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1YHK OCA].~~	+

	==See Also==		==See Also==
	*[[Farnesyl diphosphate synthase\|Farnesyl diphosphate synthase]]		*[[Farnesyl diphosphate synthase\|Farnesyl diphosphate synthase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016288456<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Geranyltranstransferase]]		[[Category: Geranyltranstransferase]]
	[[Category: Trypanosoma cruzi]]		[[Category: Trypanosoma cruzi]]

OCA at 20:12, 20 October 2012

OCA — Sat, 20 Oct 2012 20:12:07 GMT

←Older revision		Revision as of 20:12, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1yhk]] is a 1 chain structure ~~of [[Farnesyl diphosphate synthase]]~~ with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YHK OCA].	+	[[1yhk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YHK OCA].

	==See Also==		==See Also==

OCA at 09:43, 27 July 2012

OCA — Fri, 27 Jul 2012 09:43:00 GMT

←Older revision		Revision as of 09:43, 27 July 2012
Line 1:		Line 1:
	[[Image:1yhk.png\|left\|200px]]		[[Image:1yhk.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1yhk", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1yhk\| PDB=1yhk \| SCENE= }}		{{STRUCTURE_1yhk\| PDB=1yhk \| SCENE= }}

	===Trypanosoma cruzi farnesyl diphosphate synthase===		===Trypanosoma cruzi farnesyl diphosphate synthase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16288456}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16288456 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16288456}}		{{ABSTRACT_PUBMED_16288456}}

OCA: Protected "1yhk" [edit=sysop:move=sysop]

OCA — Sat, 02 Jun 2012 09:13:06 GMT

Protected "1yhk" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:13, 2 June 2012