1yiu - Revision history

OCA at 08:03, 15 May 2024

OCA — Wed, 15 May 2024 08:03:48 GMT

←Older revision		Revision as of 08:03, 15 May 2024
Line 1:		Line 1:

	==Itch E3 ubiquitin ligase WW3 domain==		==Itch E3 ubiquitin ligase WW3 domain==
-	<StructureSection load='1yiu' size='340' side='right'caption='[[1yiu~~]], [[NMR_Ensembles_of_Models \| 8 NMR models~~]]' scene=''>	+	<StructureSection load='1yiu' size='340' side='right'caption='[[1yiu]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yiu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YIU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yiu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YIU FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>Itch E3 WW3 domain ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~10090 LK3 transgenic mice])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yiu OCA], [https://pdbe.org/1yiu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yiu RCSB], [https://www.ebi.ac.uk/pdbsum/1yiu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yiu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yiu OCA], [https://pdbe.org/1yiu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yiu RCSB], [https://www.ebi.ac.uk/pdbsum/1yiu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yiu ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/ITCH_MOUSE ITCH_MOUSE]] Note=Defects in Itch are the cause of the itchy phenotype which is an inflammatory and immunological condition characterized by inflammation in the lung and stomach, hyperplasia in lymphoid and hematopoietic cells and constant itching in the skin.<ref>PMID:9462742</ref>	+	[https://www.uniprot.org/uniprot/ITCH_MOUSE ITCH_MOUSE] Note=Defects in Itch are the cause of the itchy phenotype which is an inflammatory and immunological condition characterized by inflammation in the lung and stomach, hyperplasia in lymphoid and hematopoietic cells and constant itching in the skin.<ref>PMID:9462742</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ITCH_MOUSE ITCH_MOUSE]] Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation. It is involved in the control of inflammatory signaling pathways. Is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of the complex after TNF stimulation. Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1 (By similarity). Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways (By similarity). Regulates the transcriptional activity of several transcription factors involved in immune response. Critical regulator of T-helper (TH2) cytokine development through its ability to induce JUNB ubiquitination and degradation. Ubiquitinates SNX9 (By similarity). Ubiquitinates CXCR4 and HGS/HRS and regulates sorting of CXCR4 to the degradative pathway (By similarity). It is involved in the negative regulation of MAVS-dependent cellular antiviral responses. Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteasomal degradation (By similarity). Involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP (By similarity). Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID. Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination (By similarity).<ref>PMID:11828324</ref> <ref>PMID:15358865</ref> <ref>PMID:17592138</ref> <ref>PMID:18628966</ref> <ref>PMID:20392206</ref>	+	[https://www.uniprot.org/uniprot/ITCH_MOUSE ITCH_MOUSE] Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation. It is involved in the control of inflammatory signaling pathways. Is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of the complex after TNF stimulation. Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1 (By similarity). Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways (By similarity). Regulates the transcriptional activity of several transcription factors involved in immune response. Critical regulator of T-helper (TH2) cytokine development through its ability to induce JUNB ubiquitination and degradation. Ubiquitinates SNX9 (By similarity). Ubiquitinates CXCR4 and HGS/HRS and regulates sorting of CXCR4 to the degradative pathway (By similarity). It is involved in the negative regulation of MAVS-dependent cellular antiviral responses. Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteasomal degradation (By similarity). Involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP (By similarity). Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID. Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination (By similarity).<ref>PMID:11828324</ref> <ref>PMID:15358865</ref> <ref>PMID:17592138</ref> <ref>PMID:18628966</ref> <ref>PMID:20392206</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Macias~~, M J~~]]	+	[[Category: Macias MJ]]
-	[[Category: Martin-Malpartida, P]]	+	[[Category: Martin-Malpartida P]]
-	[[Category: Morales, B]]	+	[[Category: Morales B]]
-	[[Category: Royo, M]]	+	[[Category: Royo M]]
-	[[Category: Shaw~~, A Z~~]]	+	[[Category: Shaw AZ]]
-	[[Category: Yraola, F]]	+	[[Category: Yraola F]]
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Ww domain~~]]	+

OCA at 07:12, 2 March 2022

OCA — Wed, 02 Mar 2022 07:12:23 GMT

←Older revision		Revision as of 07:12, 2 March 2022
Line 3:		Line 3:
	<StructureSection load='1yiu' size='340' side='right'caption='[[1yiu]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>		<StructureSection load='1yiu' size='340' side='right'caption='[[1yiu]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yiu]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1YIU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yiu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YIU FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Itch E3 WW3 domain ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Itch E3 WW3 domain ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1yiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yiu OCA], [~~http~~://pdbe.org/1yiu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1yiu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1yiu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1yiu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yiu OCA], [https://pdbe.org/1yiu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yiu RCSB], [https://www.ebi.ac.uk/pdbsum/1yiu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yiu ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/ITCH_MOUSE ITCH_MOUSE]] Note=Defects in Itch are the cause of the itchy phenotype which is an inflammatory and immunological condition characterized by inflammation in the lung and stomach, hyperplasia in lymphoid and hematopoietic cells and constant itching in the skin.<ref>PMID:9462742</ref>	+	[[https://www.uniprot.org/uniprot/ITCH_MOUSE ITCH_MOUSE]] Note=Defects in Itch are the cause of the itchy phenotype which is an inflammatory and immunological condition characterized by inflammation in the lung and stomach, hyperplasia in lymphoid and hematopoietic cells and constant itching in the skin.<ref>PMID:9462742</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ITCH_MOUSE ITCH_MOUSE]] Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation. It is involved in the control of inflammatory signaling pathways. Is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of the complex after TNF stimulation. Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1 (By similarity). Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways (By similarity). Regulates the transcriptional activity of several transcription factors involved in immune response. Critical regulator of T-helper (TH2) cytokine development through its ability to induce JUNB ubiquitination and degradation. Ubiquitinates SNX9 (By similarity). Ubiquitinates CXCR4 and HGS/HRS and regulates sorting of CXCR4 to the degradative pathway (By similarity). It is involved in the negative regulation of MAVS-dependent cellular antiviral responses. Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteasomal degradation (By similarity). Involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP (By similarity). Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID. Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination (By similarity).<ref>PMID:11828324</ref> <ref>PMID:15358865</ref> <ref>PMID:17592138</ref> <ref>PMID:18628966</ref> <ref>PMID:20392206</ref>	+	[[https://www.uniprot.org/uniprot/ITCH_MOUSE ITCH_MOUSE]] Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation. It is involved in the control of inflammatory signaling pathways. Is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of the complex after TNF stimulation. Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1 (By similarity). Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways (By similarity). Regulates the transcriptional activity of several transcription factors involved in immune response. Critical regulator of T-helper (TH2) cytokine development through its ability to induce JUNB ubiquitination and degradation. Ubiquitinates SNX9 (By similarity). Ubiquitinates CXCR4 and HGS/HRS and regulates sorting of CXCR4 to the degradative pathway (By similarity). It is involved in the negative regulation of MAVS-dependent cellular antiviral responses. Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteasomal degradation (By similarity). Involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP (By similarity). Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID. Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination (By similarity).<ref>PMID:11828324</ref> <ref>PMID:15358865</ref> <ref>PMID:17592138</ref> <ref>PMID:18628966</ref> <ref>PMID:20392206</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:46, 20 January 2021

OCA — Wed, 20 Jan 2021 08:46:34 GMT

←Older revision		Revision as of 08:46, 20 January 2021
Line 1:		Line 1:

	==Itch E3 ubiquitin ligase WW3 domain==		==Itch E3 ubiquitin ligase WW3 domain==
-	<StructureSection load='1yiu' size='340' side='right' caption='[[1yiu]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>	+	<StructureSection load='1yiu' size='340' side='right'caption='[[1yiu]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yiu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIU OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1YIU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yiu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1YIU FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Itch E3 WW3 domain ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Itch E3 WW3 domain ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1yiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yiu OCA], [http://pdbe.org/1yiu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yiu RCSB], [http://www.ebi.ac.uk/pdbsum/1yiu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1yiu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1yiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yiu OCA], [http://pdbe.org/1yiu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yiu RCSB], [http://www.ebi.ac.uk/pdbsum/1yiu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1yiu ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]	+	*[[Ubiquitin protein ligase 3D structures\|Ubiquitin protein ligase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Macias, M J]]		[[Category: Macias, M J]]

OCA at 06:28, 25 April 2018

OCA — Wed, 25 Apr 2018 06:28:07 GMT

←Older revision		Revision as of 06:28, 25 April 2018
Line 1:		Line 1:
		+
	==Itch E3 ubiquitin ligase WW3 domain==		==Itch E3 ubiquitin ligase WW3 domain==
	<StructureSection load='1yiu' size='340' side='right' caption='[[1yiu]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>		<StructureSection load='1yiu' size='340' side='right' caption='[[1yiu]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1yiu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YIU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1yiu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YIU FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Itch E3 WW3 domain ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Itch E3 WW3 domain ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yiu OCA], [http://pdbe.org/1yiu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yiu RCSB], [http://www.ebi.ac.uk/pdbsum/1yiu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yiu OCA], [http://pdbe.org/1yiu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yiu RCSB], [http://www.ebi.ac.uk/pdbsum/1yiu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1yiu ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yi/1yiu_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yi/1yiu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 00:14, 8 February 2016

OCA — Mon, 08 Feb 2016 00:14:03 GMT

←Older revision		Revision as of 00:14, 8 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yiu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 06:07, 10 September 2015

OCA — Thu, 10 Sep 2015 06:07:39 GMT

←Older revision		Revision as of 06:07, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1yiu' size='340' side='right' caption='[[1yiu]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>		<StructureSection load='1yiu' size='340' side='right' caption='[[1yiu]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yiu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YIU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yiu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YIU FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Itch E3 WW3 domain ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Itch E3 WW3 domain ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yiu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yiu RCSB], [http://www.ebi.ac.uk/pdbsum/1yiu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yiu OCA], [http://pdbe.org/1yiu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yiu RCSB], [http://www.ebi.ac.uk/pdbsum/1yiu PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 27:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Macias, M J]]		[[Category: Macias, M J]]
	[[Category: Martin-Malpartida, P]]		[[Category: Martin-Malpartida, P]]

OCA at 10:00, 8 January 2015

OCA — Thu, 08 Jan 2015 10:00:46 GMT

←Older revision		Revision as of 10:00, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1yiu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YIU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1yiu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YIU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Itch E3 WW3 domain ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Itch E3 WW3 domain ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yiu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yiu RCSB], [http://www.ebi.ac.uk/pdbsum/1yiu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yiu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yiu RCSB], [http://www.ebi.ac.uk/pdbsum/1yiu PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/ITCH_MOUSE ITCH_MOUSE]] Note=Defects in Itch are the cause of the itchy phenotype which is an inflammatory and immunological condition characterized by inflammation in the lung and stomach, hyperplasia in lymphoid and hematopoietic cells and constant itching in the skin.<ref>PMID:9462742</ref>		[[http://www.uniprot.org/uniprot/ITCH_MOUSE ITCH_MOUSE]] Note=Defects in Itch are the cause of the itchy phenotype which is an inflammatory and immunological condition characterized by inflammation in the lung and stomach, hyperplasia in lymphoid and hematopoietic cells and constant itching in the skin.<ref>PMID:9462742</ref>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Macias, M J.]]	+	[[Category: Macias, M J]]
-	[[Category: Martin-Malpartida, P.]]	+	[[Category: Martin-Malpartida, P]]
-	[[Category: Morales, B.]]	+	[[Category: Morales, B]]
-	[[Category: Royo, M.]]	+	[[Category: Royo, M]]
-	[[Category: Shaw, A Z.]]	+	[[Category: Shaw, A Z]]
-	[[Category: Yraola, F.]]	+	[[Category: Yraola, F]]
	[[Category: Ligase]]		[[Category: Ligase]]
	[[Category: Ww domain]]		[[Category: Ww domain]]

OCA at 19:51, 29 September 2014

OCA — Mon, 29 Sep 2014 19:51:28 GMT

←Older revision		Revision as of 19:51, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1yiu~~\| ~~PDB~~=1yiu \| ~~SCENE~~= }}	+	==Itch E3 ubiquitin ligase WW3 domain==
-	===Itch E3 ubiquitin ligase ~~WW3 domain~~===	+	<StructureSection load='1yiu' size='340' side='right' caption='[[1yiu]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1yiu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YIU FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Itch E3 WW3 domain ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yiu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yiu RCSB], [http://www.ebi.ac.uk/pdbsum/1yiu PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/ITCH_MOUSE ITCH_MOUSE]] Note=Defects in Itch are the cause of the itchy phenotype which is an inflammatory and immunological condition characterized by inflammation in the lung and stomach, hyperplasia in lymphoid and hematopoietic cells and constant itching in the skin.<ref>PMID:9462742</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ITCH_MOUSE ITCH_MOUSE]] Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation. It is involved in the control of inflammatory signaling pathways. Is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of the complex after TNF stimulation. Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1 (By similarity). Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways (By similarity). Regulates the transcriptional activity of several transcription factors involved in immune response. Critical regulator of T-helper (TH2) cytokine development through its ability to induce JUNB ubiquitination and degradation. Ubiquitinates SNX9 (By similarity). Ubiquitinates CXCR4 and HGS/HRS and regulates sorting of CXCR4 to the degradative pathway (By similarity). It is involved in the negative regulation of MAVS-dependent cellular antiviral responses. Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteasomal degradation (By similarity). Involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP (By similarity). Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID. Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination (By similarity).<ref>PMID:11828324</ref> <ref>PMID:15358865</ref> <ref>PMID:17592138</ref> <ref>PMID:18628966</ref> <ref>PMID:20392206</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yi/1yiu_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

-	==~~Disease~~==	+	==See Also==
-	[[http://www.uniprot.org/uniprot/ITCH_MOUSE ITCH_MOUSE]] Note=Defects in Itch are the cause of the itchy phenotype which is an inflammatory and immunological condition characterized by inflammation in the lung and stomach, hyperplasia in lymphoid and hematopoietic cells and constant itching in the skin.<ref>PMID:9462742</ref>	+	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]
-		+	== References ==
-	~~==Function==~~	+	<references/>
-	~~[[http://www.uniprot.org/uniprot/ITCH_MOUSE ITCH_MOUSE]] Acts as an E3 ubiquitin-~~protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation. It is involved in the control of inflammatory signaling pathways. Is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of the complex after TNF stimulation. Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1 (By similarity). Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways (By similarity). Regulates the transcriptional activity of several transcription factors involved in immune response. Critical regulator of T-helper (TH2) cytokine development through its ability to induce JUNB ubiquitination and degradation. Ubiquitinates SNX9 (By similarity). Ubiquitinates CXCR4 and HGS/HRS and regulates sorting of CXCR4 to the degradative pathway (By similarity). It is involved in the negative regulation of MAVS-dependent cellular antiviral responses. Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteasomal degradation (By similarity). Involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP (By similarity). Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID. Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination (By similarity).<ref>PMID:11828324</ref><ref>PMID:15358865</ref><ref>PMID:17592138</ref><ref>PMID:18628966</ref><ref>PMID:20392206</ref>	+	__TOC__
-		+	</StructureSection>
-	~~==About this Structure==~~	+
-	~~[[1yiu~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIU OCA].	+
-		+
-	==~~Reference~~==	+
-	~~<ref group="xtra">PMID:015971201</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Macias, M J.]]		[[Category: Macias, M J.]]

OCA at 02:08, 25 March 2013

OCA — Mon, 25 Mar 2013 02:08:44 GMT

←Older revision		Revision as of 02:08, 25 March 2013
Line 1:		Line 1:
-	[[Image:1yiu.png\|left\|200px]]
-
	{{STRUCTURE_1yiu\| PDB=1yiu \| SCENE= }}		{{STRUCTURE_1yiu\| PDB=1yiu \| SCENE= }}
		+	===Itch E3 ubiquitin ligase WW3 domain===

-	==~~=Itch E3 ubiquitin ligase WW3 domain~~===	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/ITCH_MOUSE ITCH_MOUSE]] Note=Defects in Itch are the cause of the itchy phenotype which is an inflammatory and immunological condition characterized by inflammation in the lung and stomach, hyperplasia in lymphoid and hematopoietic cells and constant itching in the skin.<ref>PMID:9462742</ref>

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/ITCH_MOUSE ITCH_MOUSE]] Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation. It is involved in the control of inflammatory signaling pathways. Is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of the complex after TNF stimulation. Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1 (By similarity). Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways (By similarity). Regulates the transcriptional activity of several transcription factors involved in immune response. Critical regulator of T-helper (TH2) cytokine development through its ability to induce JUNB ubiquitination and degradation. Ubiquitinates SNX9 (By similarity). Ubiquitinates CXCR4 and HGS/HRS and regulates sorting of CXCR4 to the degradative pathway (By similarity). It is involved in the negative regulation of MAVS-dependent cellular antiviral responses. Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteasomal degradation (By similarity). Involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP (By similarity). Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID. Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination (By similarity).<ref>PMID:11828324</ref><ref>PMID:15358865</ref><ref>PMID:17592138</ref><ref>PMID:18628966</ref><ref>PMID:20392206</ref>

	==About this Structure==		==About this Structure==
Line 10:		Line 12:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:015971201</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015971201</ref><references group="xtra"/><references/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Macias, M J.]]		[[Category: Macias, M J.]]

OCA: Protected "1yiu" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 17:05:04 GMT

Protected "1yiu" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:05, 5 January 2013