1yiy - Revision history

OCA at 06:57, 23 August 2023

OCA — Wed, 23 Aug 2023 06:57:30 GMT

←Older revision		Revision as of 06:57, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1yiy' size='340' side='right'caption='[[1yiy]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1yiy' size='340' side='right'caption='[[1yiy]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yiy]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Aedae Aedae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1YIY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yiy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YIY FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>~~, ~~<scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1yiz\|1yiz]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">KAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 AEDAE])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yiy OCA], [https://pdbe.org/1yiy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yiy RCSB], [https://www.ebi.ac.uk/pdbsum/1yiy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yiy ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1yiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yiy OCA], [~~http~~://pdbe.org/1yiy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1yiy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1yiy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1yiy ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/KAT_AEDAE KAT_AEDAE] Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA) (PubMed:12110301, PubMed:15556614). Also catalyzes the irreversible transamination of several amino acids including cysteine, tyrosine, glutamine, methionine, histidine and phenylalanine (PubMed:15556614). Can use various keto-acids as the amino group acceptor (PubMed:15556614, PubMed:12110301).<ref>PMID:12110301</ref> <ref>PMID:15556614</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aedae~~]]	+	[[Category: Aedes aegypti]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ding, H]]	+	[[Category: Ding H]]
-	[[Category: Gao~~, Y G~~]]	+	[[Category: Gao YG]]
-	[[Category: Han, Q]]	+	[[Category: Han Q]]
-	[[Category: Li, J]]	+	[[Category: Li J]]
-	[[Category: Robinson, H]]	+	[[Category: Robinson H]]
-	[[Category: Wilson, S]]	+	[[Category: Wilson S]]
-	~~[[Category: Aede]]~~	+
-	~~[[Category: Kynurenic acid]]~~	+
-	~~[[Category: Kynurenine]]~~	+
-	~~[[Category: Kynurenine aminotrasferase]]~~	+
-	~~[[Category: Mosquito]]~~	+
-	~~[[Category: Plp-enzyme]]~~	+
-	~~[[Category: Pmp]]~~	+
-	~~[[Category: Pyridoxamine phosphate]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:46, 20 January 2021

OCA — Wed, 20 Jan 2021 08:46:37 GMT

←Older revision		Revision as of 08:46, 20 January 2021
Line 1:		Line 1:

	==Aedes aegypti kynurenine aminotransferase==		==Aedes aegypti kynurenine aminotransferase==
-	<StructureSection load='1yiy' size='340' side='right' caption='[[1yiy]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='1yiy' size='340' side='right'caption='[[1yiy]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yiy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aedae Aedae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1YIY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yiy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aedae Aedae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1YIY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yiz\|1yiz]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1yiz\|1yiz]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 AEDAE])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 AEDAE])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1yiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yiy OCA], [http://pdbe.org/1yiy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yiy RCSB], [http://www.ebi.ac.uk/pdbsum/1yiy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1yiy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1yiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yiy OCA], [http://pdbe.org/1yiy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yiy RCSB], [http://www.ebi.ac.uk/pdbsum/1yiy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1yiy ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Aedae]]		[[Category: Aedae]]
		+	[[Category: Large Structures]]
	[[Category: Ding, H]]		[[Category: Ding, H]]
	[[Category: Gao, Y G]]		[[Category: Gao, Y G]]

OCA at 06:54, 25 April 2018

OCA — Wed, 25 Apr 2018 06:54:57 GMT

←Older revision		Revision as of 06:54, 25 April 2018
Line 1:		Line 1:
		+
	==Aedes aegypti kynurenine aminotransferase==		==Aedes aegypti kynurenine aminotransferase==
	<StructureSection load='1yiy' size='340' side='right' caption='[[1yiy]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1yiy' size='340' side='right' caption='[[1yiy]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yiz\|1yiz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yiz\|1yiz]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 AEDAE])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 AEDAE])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yiy OCA], [http://pdbe.org/1yiy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yiy RCSB], [http://www.ebi.ac.uk/pdbsum/1yiy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yiy OCA], [http://pdbe.org/1yiy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yiy RCSB], [http://www.ebi.ac.uk/pdbsum/1yiy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1yiy ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yi/1yiy_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yi/1yiy_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 11:29, 7 February 2016

OCA — Sun, 07 Feb 2016 11:29:52 GMT

←Older revision		Revision as of 11:29, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yiy ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:03, 10 September 2015

OCA — Thu, 10 Sep 2015 01:03:54 GMT

←Older revision		Revision as of 01:03, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1yiy' size='340' side='right' caption='[[1yiy]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1yiy' size='340' side='right' caption='[[1yiy]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yiy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Aedes_aegypti Aedes aegypti~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YIY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yiy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aedae Aedae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YIY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yiz\|1yiz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yiz\|1yiz]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 ~~Aedes aegypti~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 AEDAE])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yiy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yiy RCSB], [http://www.ebi.ac.uk/pdbsum/1yiy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yiy OCA], [http://pdbe.org/1yiy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yiy RCSB], [http://www.ebi.ac.uk/pdbsum/1yiy PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1yiy" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aedes aegypti~~]]	+	[[Category: Aedae]]
	[[Category: Ding, H]]		[[Category: Ding, H]]
	[[Category: Gao, Y G]]		[[Category: Gao, Y G]]

OCA at 09:34, 8 January 2015

OCA — Thu, 08 Jan 2015 09:34:53 GMT

←Older revision		Revision as of 09:34, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1yiy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YIY FirstGlance]. <br>		<table><tr><td colspan='2'>[[1yiy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YIY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yiz\|1yiz]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yiz\|1yiz]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 Aedes aegypti])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 Aedes aegypti])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yiy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yiy RCSB], [http://www.ebi.ac.uk/pdbsum/1yiy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yiy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yiy RCSB], [http://www.ebi.ac.uk/pdbsum/1yiy PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Aedes aegypti]]		[[Category: Aedes aegypti]]
-	[[Category: Ding, H.]]	+	[[Category: Ding, H]]
-	[[Category: Gao, Y G.]]	+	[[Category: Gao, Y G]]
-	[[Category: Han, Q.]]	+	[[Category: Han, Q]]
-	[[Category: Li, J.]]	+	[[Category: Li, J]]
-	[[Category: Robinson, H.]]	+	[[Category: Robinson, H]]
-	[[Category: Wilson, S.]]	+	[[Category: Wilson, S]]
	[[Category: Aede]]		[[Category: Aede]]
	[[Category: Kynurenic acid]]		[[Category: Kynurenic acid]]

OCA at 20:36, 29 September 2014

OCA — Mon, 29 Sep 2014 20:36:52 GMT

←Older revision		Revision as of 20:36, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1yiy.~~png~~\|~~left~~\|200px]]	+	==Aedes aegypti kynurenine aminotransferase==
		+	<StructureSection load='1yiy' size='340' side='right' caption='[[1yiy]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1yiy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YIY FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yiz\|1yiz]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 Aedes aegypti])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yiy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yiy RCSB], [http://www.ebi.ac.uk/pdbsum/1yiy PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yi/1yiy_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aedes aegypti kynurenine aminotransferase (AeKAT) catalyzes the irreversible transamination of kynurenine to kynurenic acid, the natural antagonist of NMDA and 7-nicotinic acetycholine receptors. Here, we report the crystal structure of AeKAT in its PMP and PLP forms at 1.90 and 1.55 A, respectively. The structure was solved by a combination of single-wavelength anomalous dispersion and molecular replacement approaches. The initial search model in the molecular replacement method was built with the result of single-wavelength anomalous dispersion data from the Br-AeKAT crystal in combination with homology modeling. The solved structure shows that the enzyme is a homodimer, and that the two subunits are stabilized by a number of hydrogen bonds, salts bridges, and hydrophobic interactions. Each subunit is divided into an N-terminal arm and small and large domains. Based on its folding, the enzyme belongs to the prototypical fold type, aminotransferase subgroup I. The three-dimensional structure shows a strictly conserved 'PLP-phosphate binding cup' featuring PLP-dependent enzymes. The interaction between Cys284 (A) and Cys284 (B) is unique in AeKAT, which might explain the cysteine effect of AeKAT activity. Further mutation experiments of this residue are needed to eventually understand the mechanism of the enzyme modulation by cysteine.

-	~~{{STRUCTURE_1yiy\| PDB=1yiy \| SCENE= }}~~	+	Crystal structures of Aedes aegypti kynurenine aminotransferase.,Han Q, Gao YG, Robinson H, Ding H, Wilson S, Li J FEBS J. 2005 May;272(9):2198-206. PMID:15853804<ref>PMID:15853804</ref>

-	~~===Aedes aegypti kynurenine aminotransferase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15853804}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1yiy]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Aedes_aegypti Aedes aegypti]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1YIY OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015853804<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Aedes aegypti]]		[[Category: Aedes aegypti]]
	[[Category: Ding, H.]]		[[Category: Ding, H.]]

OCA: Protected "1yiy" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 17:36:08 GMT

Protected "1yiy" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:36, 5 January 2013

OCA at 17:36, 5 January 2013

OCA — Sat, 05 Jan 2013 17:36:07 GMT

←Older revision		Revision as of 17:36, 5 January 2013
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-	{{Seed}}
	[[Image:1yiy.png\|left\|200px]]		[[Image:1yiy.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1yiy", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_1yiy\| PDB=1yiy \| SCENE= }}		{{STRUCTURE_1yiy\| PDB=1yiy \| SCENE= }}

	===Aedes aegypti kynurenine aminotransferase===		===Aedes aegypti kynurenine aminotransferase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15853804}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15853804 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15853804}}		{{ABSTRACT_PUBMED_15853804}}

	==About this Structure==		==About this Structure==
-	~~1YIY~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIY OCA].	+	[[1yiy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIY OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15853804~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015853804</ref><references group="xtra"/>
	[[Category: Aedes aegypti]]		[[Category: Aedes aegypti]]
	[[Category: Ding, H.]]		[[Category: Ding, H.]]
Line 40:		Line 28:
	[[Category: Pyridoxamine phosphate]]		[[Category: Pyridoxamine phosphate]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:30:26 2009''

OCA at 11:30, 16 February 2009

OCA — Mon, 16 Feb 2009 11:30:28 GMT

←Older revision		Revision as of 11:30, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1YIY is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIY OCA].	+	1YIY is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIY OCA].

	==Reference==		==Reference==
-	~~Crystal structures of Aedes aegypti kynurenine aminotransferase., Han Q, Gao YG, Robinson H, Ding H, Wilson S, Li J, FEBS J. 2005 May;272(9):2198-206.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/15853804 15853804]~~	+	<ref group="xtra">PMID:15853804</ref><references group="xtra"/>
	[[Category: Aedes aegypti]]		[[Category: Aedes aegypti]]
-	[[Category: Single protein]]
	[[Category: Ding, H.]]		[[Category: Ding, H.]]
	[[Category: Gao, Y G.]]		[[Category: Gao, Y G.]]
Line 42:		Line 41:
	[[Category: Transferase]]		[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 15~~:56:~~23 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:30:26 2009''