1yn4 - Revision history

OCA at 08:58, 14 February 2024

OCA — Wed, 14 Feb 2024 08:58:24 GMT

←Older revision		Revision as of 08:58, 14 February 2024
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	<StructureSection load='1yn4' size='340' side='right'caption='[[1yn4]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1yn4' size='340' side='right'caption='[[1yn4]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yn4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus~~ aureus~~" (rosenbach 1884) zopf 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YN4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yn4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YN4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yn4 OCA], [https://pdbe.org/1yn4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yn4 RCSB], [https://www.ebi.ac.uk/pdbsum/1yn4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yn4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yn4 OCA], [https://pdbe.org/1yn4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yn4 RCSB], [https://www.ebi.ac.uk/pdbsum/1yn4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yn4 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0H3K0M1_STAAM A0A0H3K0M1_STAAM]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yn4 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yn4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The Eap (extracellular adherence protein) of Staphylococcus aureus functions as a secreted virulence factor by mediating interactions between the bacterial cell surface and several extracellular host proteins. Eap proteins from different Staphylococcal strains consist of four to six tandem repeats of a structurally uncharacterized domain (EAP domain). We have determined the three-dimensional structures of three different EAP domains to 1.8, 2.2, and 1.35 A resolution, respectively. These structures reveal a core fold that is comprised of an alpha-helix lying diagonally across a five-stranded, mixed beta-sheet. Comparison of EAP domains with known structures reveals an unexpected homology with the C-terminal domain of bacterial superantigens. Examination of the structure of the superantigen SEC2 bound to the beta-chain of a T-cell receptor suggests a possible ligand-binding site within the EAP domain (Fields, B. A., Malchiodi, E. L., Li, H., Ysern, X., Stauffacher, C. V., Schlievert, P. M., Karjalainen, K., and Mariuzza, R. (1996) Nature 384, 188-192). These results provide the first structural characterization of EAP domains, relate EAP domains to a large class of bacterial toxins, and will guide the design of future experiments to analyze EAP domain structure/function relationships.
-
-	The crystal structures of EAP domains from Staphylococcus aureus reveal an unexpected homology to bacterial superantigens.,Geisbrecht BV, Hamaoka BY, Perman B, Zemla A, Leahy DJ J Biol Chem. 2005 Apr 29;280(17):17243-50. Epub 2005 Feb 3. PMID:15691839<ref>PMID:15691839</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1yn4" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Geisbrecht, B V]]
-	[[Category: Hamaoka, B Y]]
-	[[Category: Leahy, D J]]
-	[[Category: Perman, B]]
-	[[Category: Zemla, A]]
-	[[Category: Extracellular adherence protein]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
-	[[Category: ~~Toxin~~]]	+	[[Category: Geisbrecht BV]]
-	[[Category: ~~Unknown function~~]]	+	[[Category: Hamaoka BY]]
-	[[Category: ~~Virulence factor~~]]	+	[[Category: Leahy DJ]]
		+	[[Category: Perman B]]
		+	[[Category: Zemla A]]

OCA at 16:30, 3 November 2021

OCA — Wed, 03 Nov 2021 16:30:20 GMT

←Older revision		Revision as of 16:30, 3 November 2021
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	<StructureSection load='1yn4' size='340' side='right'caption='[[1yn4]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1yn4' size='340' side='right'caption='[[1yn4]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yn4]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YN4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1YN4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yn4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YN4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1yn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yn4 OCA], [~~http~~://pdbe.org/1yn4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1yn4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1yn4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1yn4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yn4 OCA], [https://pdbe.org/1yn4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yn4 RCSB], [https://www.ebi.ac.uk/pdbsum/1yn4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yn4 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 16:48, 29 January 2020

OCA — Wed, 29 Jan 2020 16:48:09 GMT

←Older revision		Revision as of 16:48, 29 January 2020
Line 1:		Line 1:

	==Crystal Structures of EAP Domains from Staphylococcus aureus Reveal an Unexpected Homology to Bacterial Superantigens==		==Crystal Structures of EAP Domains from Staphylococcus aureus Reveal an Unexpected Homology to Bacterial Superantigens==
-	<StructureSection load='1yn4' size='340' side='right' caption='[[1yn4]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1yn4' size='340' side='right'caption='[[1yn4]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1yn4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YN4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YN4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1yn4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YN4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YN4 FirstGlance]. <br>
Line 30:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Geisbrecht, B V]]		[[Category: Geisbrecht, B V]]
	[[Category: Hamaoka, B Y]]		[[Category: Hamaoka, B Y]]

OCA at 06:33, 25 April 2018

OCA — Wed, 25 Apr 2018 06:33:51 GMT

←Older revision		Revision as of 06:33, 25 April 2018
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		+
	==Crystal Structures of EAP Domains from Staphylococcus aureus Reveal an Unexpected Homology to Bacterial Superantigens==		==Crystal Structures of EAP Domains from Staphylococcus aureus Reveal an Unexpected Homology to Bacterial Superantigens==
	<StructureSection load='1yn4' size='340' side='right' caption='[[1yn4]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1yn4' size='340' side='right' caption='[[1yn4]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1yn4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YN4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YN4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1yn4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YN4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YN4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yn4 OCA], [http://pdbe.org/1yn4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yn4 RCSB], [http://www.ebi.ac.uk/pdbsum/1yn4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yn4 OCA], [http://pdbe.org/1yn4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yn4 RCSB], [http://www.ebi.ac.uk/pdbsum/1yn4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1yn4 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yn/1yn4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yn/1yn4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 01:15, 10 February 2016

OCA — Wed, 10 Feb 2016 01:15:00 GMT

←Older revision		Revision as of 01:15, 10 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yn4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:54, 11 September 2015

OCA — Fri, 11 Sep 2015 03:54:38 GMT

←Older revision		Revision as of 03:54, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1yn4' size='340' side='right' caption='[[1yn4]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1yn4' size='340' side='right' caption='[[1yn4]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yn4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus~~ aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YN4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YN4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yn4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YN4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YN4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yn4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yn4 RCSB], [http://www.ebi.ac.uk/pdbsum/1yn4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yn4 OCA], [http://pdbe.org/1yn4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yn4 RCSB], [http://www.ebi.ac.uk/pdbsum/1yn4 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1yn4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Staphylococcus aureus]]
	[[Category: Geisbrecht, B V]]		[[Category: Geisbrecht, B V]]
	[[Category: Hamaoka, B Y]]		[[Category: Hamaoka, B Y]]
Line 35:		Line 35:
	[[Category: Zemla, A]]		[[Category: Zemla, A]]
	[[Category: Extracellular adherence protein]]		[[Category: Extracellular adherence protein]]
		+	[[Category: Staphylococcus aureus]]
	[[Category: Toxin]]		[[Category: Toxin]]
	[[Category: Unknown function]]		[[Category: Unknown function]]
	[[Category: Virulence factor]]		[[Category: Virulence factor]]

OCA at 10:45, 25 December 2014

OCA — Thu, 25 Dec 2014 10:45:59 GMT

←Older revision		Revision as of 10:45, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1yn4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YN4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YN4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1yn4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YN4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YN4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yn4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yn4 RCSB], [http://www.ebi.ac.uk/pdbsum/1yn4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yn4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yn4 RCSB], [http://www.ebi.ac.uk/pdbsum/1yn4 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
-	[[Category: Geisbrecht, B V.]]	+	[[Category: Geisbrecht, B V]]
-	[[Category: Hamaoka, B Y.]]	+	[[Category: Hamaoka, B Y]]
-	[[Category: Leahy, D J.]]	+	[[Category: Leahy, D J]]
-	[[Category: Perman, B.]]	+	[[Category: Perman, B]]
-	[[Category: Zemla, A.]]	+	[[Category: Zemla, A]]
	[[Category: Extracellular adherence protein]]		[[Category: Extracellular adherence protein]]
-	[[Category: Staphylococcus aureus]]
	[[Category: Toxin]]		[[Category: Toxin]]
	[[Category: Unknown function]]		[[Category: Unknown function]]
	[[Category: Virulence factor]]		[[Category: Virulence factor]]

OCA at 21:49, 29 September 2014

OCA — Mon, 29 Sep 2014 21:49:20 GMT

←Older revision		Revision as of 21:49, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1yn4.~~png\|left~~\|200px]]	+	==Crystal Structures of EAP Domains from Staphylococcus aureus Reveal an Unexpected Homology to Bacterial Superantigens==
		+	<StructureSection load='1yn4' size='340' side='right' caption='[[1yn4]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1yn4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YN4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YN4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yn4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yn4 RCSB], [http://www.ebi.ac.uk/pdbsum/1yn4 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yn/1yn4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Eap (extracellular adherence protein) of Staphylococcus aureus functions as a secreted virulence factor by mediating interactions between the bacterial cell surface and several extracellular host proteins. Eap proteins from different Staphylococcal strains consist of four to six tandem repeats of a structurally uncharacterized domain (EAP domain). We have determined the three-dimensional structures of three different EAP domains to 1.8, 2.2, and 1.35 A resolution, respectively. These structures reveal a core fold that is comprised of an alpha-helix lying diagonally across a five-stranded, mixed beta-sheet. Comparison of EAP domains with known structures reveals an unexpected homology with the C-terminal domain of bacterial superantigens. Examination of the structure of the superantigen SEC2 bound to the beta-chain of a T-cell receptor suggests a possible ligand-binding site within the EAP domain (Fields, B. A., Malchiodi, E. L., Li, H., Ysern, X., Stauffacher, C. V., Schlievert, P. M., Karjalainen, K., and Mariuzza, R. (1996) Nature 384, 188-192). These results provide the first structural characterization of EAP domains, relate EAP domains to a large class of bacterial toxins, and will guide the design of future experiments to analyze EAP domain structure/function relationships.

-	~~{{STRUCTURE_1yn4\| PDB=1yn4 \| SCENE= }}~~	+	The crystal structures of EAP domains from Staphylococcus aureus reveal an unexpected homology to bacterial superantigens.,Geisbrecht BV, Hamaoka BY, Perman B, Zemla A, Leahy DJ J Biol Chem. 2005 Apr 29;280(17):17243-50. Epub 2005 Feb 3. PMID:15691839<ref>PMID:15691839</ref>

-	~~===Crystal Structures~~ of ~~EAP Domains from Staphylococcus aureus Reveal an Unexpected Homology to Bacterial Superantigens===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15691839}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1yn4]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Staphylococcus_aureus Staphylococcus aureus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1YN4 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015691839<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Geisbrecht, B V.]]		[[Category: Geisbrecht, B V.]]

OCA: Protected "1yn4" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 17:12:02 GMT

Protected "1yn4" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:12, 5 January 2013

OCA at 17:11, 5 January 2013

OCA — Sat, 05 Jan 2013 17:11:56 GMT

←Older revision		Revision as of 17:11, 5 January 2013
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-	{{Seed}}
	[[Image:1yn4.png\|left\|200px]]		[[Image:1yn4.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1yn4\| PDB=1yn4 \| SCENE= }}		{{STRUCTURE_1yn4\| PDB=1yn4 \| SCENE= }}

	===Crystal Structures of EAP Domains from Staphylococcus aureus Reveal an Unexpected Homology to Bacterial Superantigens===		===Crystal Structures of EAP Domains from Staphylococcus aureus Reveal an Unexpected Homology to Bacterial Superantigens===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15691839}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15691839 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_15691839}}		{{ABSTRACT_PUBMED_15691839}}

	==About this Structure==		==About this Structure==
-	~~1YN4~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YN4 OCA].	+	[[1yn4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YN4 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15691839~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015691839</ref><references group="xtra"/>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Geisbrecht, B V.]]		[[Category: Geisbrecht, B V.]]
Line 33:		Line 21:
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Toxin]]		[[Category: Toxin]]
		+	[[Category: Unknown function]]
	[[Category: Virulence factor]]		[[Category: Virulence factor]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:14:18 2009''