1yp5 - Revision history

OCA at 13:38, 13 March 2024

OCA — Wed, 13 Mar 2024 13:38:22 GMT

←Older revision		Revision as of 13:38, 13 March 2024
Line 3:		Line 3:
	<StructureSection load='1yp5' size='340' side='right'caption='[[1yp5]], [[Resolution\|resolution]] 1.68Å' scene=''>		<StructureSection load='1yp5' size='340' side='right'caption='[[1yp5]], [[Resolution\|resolution]] 1.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yp5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YP5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yp5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YP5 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>~~[[~~1r6s~~\|~~1r6s~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.68Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yp5 OCA], [https://pdbe.org/1yp5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yp5 RCSB], [https://www.ebi.ac.uk/pdbsum/1yp5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yp5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yp5 OCA], [https://pdbe.org/1yp5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yp5 RCSB], [https://www.ebi.ac.uk/pdbsum/1yp5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yp5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MYO5_YEAST MYO5_YEAST]] One of two redundant type-I myosins implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization and for the internalization step in endocytosis. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions redundantly with LAS17 as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Motor domain phosphorylation by PAK kinases CLA4 and STE20 promotes CDC42-regulated actin assembly. Functions together with the NPF PAN1 in late stages of endocytosis. Motor domain phosphorylation by PDK1 kinases PKH1 and PKH2, and by SGK kinases YPK1 and YPK2, promotes ligand-induced, but not constitutive endocytosis of the G protein-coupled receptor STE2.<ref>PMID:8682864</ref> <ref>PMID:8614799</ref> <ref>PMID:9628892</ref> <ref>PMID:10944111</ref> <ref>PMID:10648568</ref> <ref>PMID:10648569</ref> <ref>PMID:12725728</ref> <ref>PMID:12808026</ref> <ref>PMID:16478726</ref>	+	[https://www.uniprot.org/uniprot/MYO5_YEAST MYO5_YEAST] One of two redundant type-I myosins implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization and for the internalization step in endocytosis. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions redundantly with LAS17 as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Motor domain phosphorylation by PAK kinases CLA4 and STE20 promotes CDC42-regulated actin assembly. Functions together with the NPF PAN1 in late stages of endocytosis. Motor domain phosphorylation by PDK1 kinases PKH1 and PKH2, and by SGK kinases YPK1 and YPK2, promotes ligand-induced, but not constitutive endocytosis of the G protein-coupled receptor STE2.<ref>PMID:8682864</ref> <ref>PMID:8614799</ref> <ref>PMID:9628892</ref> <ref>PMID:10944111</ref> <ref>PMID:10648568</ref> <ref>PMID:10648569</ref> <ref>PMID:12725728</ref> <ref>PMID:12808026</ref> <ref>PMID:16478726</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cesareni, G]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: Gonfloni, S]]	+	[[Category: Cesareni G]]
-	[[Category: Kursula, P]]	+	[[Category: Gonfloni S]]
-	[[Category: Sacco, R]]	+	[[Category: Kursula P]]
-	[[Category: Wilmanns, M]]	+	[[Category: Sacco R]]
-	~~[[Category: Contractile protein]]~~	+	[[Category: Wilmanns M]]
-	~~[[Category: Sh3 domain~~]]	+

OCA at 10:53, 6 April 2022

OCA — Wed, 06 Apr 2022 10:53:03 GMT

←Older revision		Revision as of 10:53, 6 April 2022
Line 3:		Line 3:
	<StructureSection load='1yp5' size='340' side='right'caption='[[1yp5]], [[Resolution\|resolution]] 1.68Å' scene=''>		<StructureSection load='1yp5' size='340' side='right'caption='[[1yp5]], [[Resolution\|resolution]] 1.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yp5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YP5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1YP5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yp5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YP5 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r6s\|1r6s]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1r6s\|1r6s]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1yp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yp5 OCA], [~~http~~://pdbe.org/1yp5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1yp5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1yp5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1yp5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yp5 OCA], [https://pdbe.org/1yp5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yp5 RCSB], [https://www.ebi.ac.uk/pdbsum/1yp5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yp5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MYO5_YEAST MYO5_YEAST]] One of two redundant type-I myosins implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization and for the internalization step in endocytosis. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions redundantly with LAS17 as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Motor domain phosphorylation by PAK kinases CLA4 and STE20 promotes CDC42-regulated actin assembly. Functions together with the NPF PAN1 in late stages of endocytosis. Motor domain phosphorylation by PDK1 kinases PKH1 and PKH2, and by SGK kinases YPK1 and YPK2, promotes ligand-induced, but not constitutive endocytosis of the G protein-coupled receptor STE2.<ref>PMID:8682864</ref> <ref>PMID:8614799</ref> <ref>PMID:9628892</ref> <ref>PMID:10944111</ref> <ref>PMID:10648568</ref> <ref>PMID:10648569</ref> <ref>PMID:12725728</ref> <ref>PMID:12808026</ref> <ref>PMID:16478726</ref>	+	[[https://www.uniprot.org/uniprot/MYO5_YEAST MYO5_YEAST]] One of two redundant type-I myosins implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization and for the internalization step in endocytosis. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions redundantly with LAS17 as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Motor domain phosphorylation by PAK kinases CLA4 and STE20 promotes CDC42-regulated actin assembly. Functions together with the NPF PAN1 in late stages of endocytosis. Motor domain phosphorylation by PDK1 kinases PKH1 and PKH2, and by SGK kinases YPK1 and YPK2, promotes ligand-induced, but not constitutive endocytosis of the G protein-coupled receptor STE2.<ref>PMID:8682864</ref> <ref>PMID:8614799</ref> <ref>PMID:9628892</ref> <ref>PMID:10944111</ref> <ref>PMID:10648568</ref> <ref>PMID:10648569</ref> <ref>PMID:12725728</ref> <ref>PMID:12808026</ref> <ref>PMID:16478726</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:02, 1 July 2020

OCA — Wed, 01 Jul 2020 08:02:34 GMT

←Older revision		Revision as of 08:02, 1 July 2020
Line 1:		Line 1:

	==Yeast Myo5 SH3 domain, tetragonal crystal form==		==Yeast Myo5 SH3 domain, tetragonal crystal form==
-	<StructureSection load='1yp5' size='340' side='right' caption='[[1yp5]], [[Resolution\|resolution]] 1.68Å' scene=''>	+	<StructureSection load='1yp5' size='340' side='right'caption='[[1yp5]], [[Resolution\|resolution]] 1.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yp5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YP5 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1YP5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yp5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YP5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1YP5 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r6s\|1r6s]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r6s\|1r6s]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1yp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yp5 OCA], [http://pdbe.org/1yp5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yp5 RCSB], [http://www.ebi.ac.uk/pdbsum/1yp5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1yp5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1yp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yp5 OCA], [http://pdbe.org/1yp5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yp5 RCSB], [http://www.ebi.ac.uk/pdbsum/1yp5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1yp5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Myosin\|Myosin]]	+	*[[Myosin 3D Structures\|Myosin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Cesareni, G]]		[[Category: Cesareni, G]]
	[[Category: Gonfloni, S]]		[[Category: Gonfloni, S]]

OCA at 08:31, 26 September 2018

OCA — Wed, 26 Sep 2018 08:31:39 GMT

←Older revision		Revision as of 08:31, 26 September 2018
Line 28:		Line 28:
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
	[[Category: Cesareni, G]]		[[Category: Cesareni, G]]
-	[[Category: ~~Gonfoni~~, S]]	+	[[Category: Gonfloni, S]]
	[[Category: Kursula, P]]		[[Category: Kursula, P]]
	[[Category: Sacco, R]]		[[Category: Sacco, R]]

OCA at 06:34, 25 April 2018

OCA — Wed, 25 Apr 2018 06:34:44 GMT

←Older revision		Revision as of 06:34, 25 April 2018
Line 1:		Line 1:
		+
	==Yeast Myo5 SH3 domain, tetragonal crystal form==		==Yeast Myo5 SH3 domain, tetragonal crystal form==
	<StructureSection load='1yp5' size='340' side='right' caption='[[1yp5]], [[Resolution\|resolution]] 1.68Å' scene=''>		<StructureSection load='1yp5' size='340' side='right' caption='[[1yp5]], [[Resolution\|resolution]] 1.68Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1yp5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YP5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1yp5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YP5 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r6s\|1r6s]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r6s\|1r6s]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yp5 OCA], [http://pdbe.org/1yp5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yp5 RCSB], [http://www.ebi.ac.uk/pdbsum/1yp5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yp5 OCA], [http://pdbe.org/1yp5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yp5 RCSB], [http://www.ebi.ac.uk/pdbsum/1yp5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1yp5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yp/1yp5_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yp/1yp5_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 16:42, 9 February 2016

OCA — Tue, 09 Feb 2016 16:42:12 GMT

←Older revision		Revision as of 16:42, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yp5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 00:10, 11 September 2015

OCA — Fri, 11 Sep 2015 00:10:22 GMT

←Older revision		Revision as of 00:10, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1yp5' size='340' side='right' caption='[[1yp5]], [[Resolution\|resolution]] 1.68Å' scene=''>		<StructureSection load='1yp5' size='340' side='right' caption='[[1yp5]], [[Resolution\|resolution]] 1.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yp5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YP5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yp5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YP5 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r6s\|1r6s]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r6s\|1r6s]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yp5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yp5 RCSB], [http://www.ebi.ac.uk/pdbsum/1yp5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yp5 OCA], [http://pdbe.org/1yp5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yp5 RCSB], [http://www.ebi.ac.uk/pdbsum/1yp5 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MYO5_YEAST MYO5_YEAST]] One of two redundant type-I myosins implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization and for the internalization step in endocytosis. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions redundantly with LAS17 as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Motor domain phosphorylation by PAK kinases CLA4 and STE20 promotes CDC42-regulated actin assembly. Functions together with the NPF PAN1 in late stages of endocytosis. Motor domain phosphorylation by PDK1 kinases PKH1 and PKH2, and by SGK kinases YPK1 and YPK2, promotes ligand-induced, but not constitutive endocytosis of the G protein-coupled receptor STE2.<ref>PMID:8682864</ref> <ref>PMID:8614799</ref> <ref>PMID:9628892</ref> <ref>PMID:10944111</ref> <ref>PMID:10648568</ref> <ref>PMID:10648569</ref> <ref>PMID:12725728</ref> <ref>PMID:12808026</ref> <ref>PMID:16478726</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 21:
	==See Also==		==See Also==
	*[[Myosin\|Myosin]]		*[[Myosin\|Myosin]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Cesareni, G]]		[[Category: Cesareni, G]]
	[[Category: Gonfoni, S]]		[[Category: Gonfoni, S]]

OCA at 09:09, 8 January 2015

OCA — Thu, 08 Jan 2015 09:09:58 GMT

←Older revision		Revision as of 09:09, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1yp5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YP5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1yp5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YP5 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r6s\|1r6s]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r6s\|1r6s]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yp5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yp5 RCSB], [http://www.ebi.ac.uk/pdbsum/1yp5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yp5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yp5 RCSB], [http://www.ebi.ac.uk/pdbsum/1yp5 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Cesareni, G.]]	+	[[Category: Cesareni, G]]
-	[[Category: Gonfoni, S.]]	+	[[Category: Gonfoni, S]]
-	[[Category: Kursula, P.]]	+	[[Category: Kursula, P]]
-	[[Category: Sacco, R.]]	+	[[Category: Sacco, R]]
-	[[Category: Wilmanns, M.]]	+	[[Category: Wilmanns, M]]
	[[Category: Contractile protein]]		[[Category: Contractile protein]]
	[[Category: Sh3 domain]]		[[Category: Sh3 domain]]

OCA at 20:56, 28 September 2014

OCA — Sun, 28 Sep 2014 20:56:49 GMT

←Older revision		Revision as of 20:56, 28 September 2014
Line 1:		Line 1:
-	~~[[Image:1yp5.png\|left\|200px]]~~	+	==Yeast Myo5 SH3 domain, tetragonal crystal form==
-		+	<StructureSection load='1yp5' size='340' side='right' caption='[[1yp5]], [[Resolution\|resolution]] 1.68Å' scene=''>
-	~~{{STRUCTURE_1yp5\| PDB=1yp5 \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[1yp5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YP5 FirstGlance]. <br>
-	===Yeast Myo5 SH3 domain, tetragonal crystal form===	+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r6s\|1r6s]]</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yp5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yp5 RCSB], [http://www.ebi.ac.uk/pdbsum/1yp5 PDBsum]</span></td></tr>
-		+	<table>
-	==~~About this Structure~~==	+	== Evolutionary Conservation ==
-	[[1yp5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YP5 OCA].	+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yp/1yp5_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Myosin\|Myosin]]		*[[Myosin\|Myosin]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Cesareni, G.]]		[[Category: Cesareni, G.]]

OCA at 14:29, 20 October 2012

OCA — Sat, 20 Oct 2012 14:29:25 GMT

←Older revision		Revision as of 14:29, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[1yp5]] is a 1 chain structure ~~of [[Myosin]]~~ with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YP5 OCA].	+	[[1yp5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YP5 OCA].

	==See Also==		==See Also==