1ysm - Revision history

OCA at 08:05, 15 May 2024

OCA — Wed, 15 May 2024 08:05:44 GMT

←Older revision		Revision as of 08:05, 15 May 2024
Line 1:		Line 1:

	==NMR Structure of N-terminal domain (Residues 1-77) of Siah-Interacting Protein.==		==NMR Structure of N-terminal domain (Residues 1-77) of Siah-Interacting Protein.==
-	<StructureSection load='1ysm' size='340' side='right'caption='[[1ysm~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1ysm' size='340' side='right'caption='[[1ysm]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ysm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YSM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ysm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YSM FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>Cacybp, Sip ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~10090 LK3 transgenic mice])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ysm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ysm OCA], [https://pdbe.org/1ysm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ysm RCSB], [https://www.ebi.ac.uk/pdbsum/1ysm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ysm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ysm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ysm OCA], [https://pdbe.org/1ysm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ysm RCSB], [https://www.ebi.ac.uk/pdbsum/1ysm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ysm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CYBP_MOUSE CYBP_MOUSE]] May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity).	+	[https://www.uniprot.org/uniprot/CYBP_MOUSE CYBP_MOUSE] May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Bhattacharya, S]]	+	[[Category: Bhattacharya S]]
-	[[Category: Chazin~~, W J~~]]	+	[[Category: Chazin WJ]]
-	[[Category: Filipek, A]]	+	[[Category: Filipek A]]
-	[[Category: Jastrzebska, B]]	+	[[Category: Jastrzebska B]]
-	[[Category: Kuznicki, J]]	+	[[Category: Kuznicki J]]
-	[[Category: Lee~~, Y T~~]]	+	[[Category: Lee YT]]
-	[[Category: Michowski, W]]	+	[[Category: Michowski W]]
-	~~[[Category: Helix-turn-helix]]~~	+
-	~~[[Category: Metal binding protein~~]]	+

OCA at 07:13, 2 March 2022

OCA — Wed, 02 Mar 2022 07:13:26 GMT

←Older revision		Revision as of 07:13, 2 March 2022
Line 3:		Line 3:
	<StructureSection load='1ysm' size='340' side='right'caption='[[1ysm]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1ysm' size='340' side='right'caption='[[1ysm]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ysm]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1YSM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ysm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YSM FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cacybp, Sip ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cacybp, Sip ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1ysm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ysm OCA], [~~http~~://pdbe.org/1ysm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ysm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ysm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ysm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ysm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ysm OCA], [https://pdbe.org/1ysm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ysm RCSB], [https://www.ebi.ac.uk/pdbsum/1ysm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ysm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CYBP_MOUSE CYBP_MOUSE]] May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity).	+	[[https://www.uniprot.org/uniprot/CYBP_MOUSE CYBP_MOUSE]] May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:51, 20 January 2021

OCA — Wed, 20 Jan 2021 08:51:38 GMT

←Older revision		Revision as of 08:51, 20 January 2021
Line 1:		Line 1:

	==NMR Structure of N-terminal domain (Residues 1-77) of Siah-Interacting Protein.==		==NMR Structure of N-terminal domain (Residues 1-77) of Siah-Interacting Protein.==
-	<StructureSection load='1ysm' size='340' side='right' caption='[[1ysm]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1ysm' size='340' side='right'caption='[[1ysm]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ysm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSM OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1YSM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ysm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1YSM FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cacybp, Sip ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cacybp, Sip ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ysm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ysm OCA], [http://pdbe.org/1ysm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ysm RCSB], [http://www.ebi.ac.uk/pdbsum/1ysm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ysm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1ysm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ysm OCA], [http://pdbe.org/1ysm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ysm RCSB], [http://www.ebi.ac.uk/pdbsum/1ysm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ysm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Bhattacharya, S]]		[[Category: Bhattacharya, S]]

OCA at 06:44, 25 April 2018

OCA — Wed, 25 Apr 2018 06:44:49 GMT

←Older revision		Revision as of 06:44, 25 April 2018
Line 1:		Line 1:
		+
	==NMR Structure of N-terminal domain (Residues 1-77) of Siah-Interacting Protein.==		==NMR Structure of N-terminal domain (Residues 1-77) of Siah-Interacting Protein.==
	<StructureSection load='1ysm' size='340' side='right' caption='[[1ysm]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1ysm' size='340' side='right' caption='[[1ysm]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1ysm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YSM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ysm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YSM FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cacybp, Sip ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cacybp, Sip ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ysm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ysm OCA], [http://pdbe.org/1ysm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ysm RCSB], [http://www.ebi.ac.uk/pdbsum/1ysm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ysm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ysm OCA], [http://pdbe.org/1ysm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ysm RCSB], [http://www.ebi.ac.uk/pdbsum/1ysm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ysm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ys/1ysm_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ys/1ysm_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:59, 7 February 2016

OCA — Sun, 07 Feb 2016 22:59:33 GMT

←Older revision		Revision as of 22:59, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ysm ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:39, 10 September 2015

OCA — Thu, 10 Sep 2015 05:39:16 GMT

←Older revision		Revision as of 05:39, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1ysm' size='340' side='right' caption='[[1ysm]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1ysm' size='340' side='right' caption='[[1ysm]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ysm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YSM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ysm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YSM FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cacybp, Sip ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cacybp, Sip ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ysm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ysm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ysm RCSB], [http://www.ebi.ac.uk/pdbsum/1ysm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ysm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ysm OCA], [http://pdbe.org/1ysm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ysm RCSB], [http://www.ebi.ac.uk/pdbsum/1ysm PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ysm" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Bhattacharya, S]]		[[Category: Bhattacharya, S]]
	[[Category: Chazin, W J]]		[[Category: Chazin, W J]]

OCA at 18:47, 24 December 2014

OCA — Wed, 24 Dec 2014 18:47:37 GMT

←Older revision		Revision as of 18:47, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ysm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YSM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ysm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YSM FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cacybp, Sip ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cacybp, Sip ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ysm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ysm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ysm RCSB], [http://www.ebi.ac.uk/pdbsum/1ysm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ysm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ysm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ysm RCSB], [http://www.ebi.ac.uk/pdbsum/1ysm PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CYBP_MOUSE CYBP_MOUSE]] May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Bhattacharya, S.]]	+	[[Category: Bhattacharya, S]]
-	[[Category: Chazin, W J.]]	+	[[Category: Chazin, W J]]
-	[[Category: Filipek, A.]]	+	[[Category: Filipek, A]]
-	[[Category: Jastrzebska, B.]]	+	[[Category: Jastrzebska, B]]
-	[[Category: Kuznicki, J.]]	+	[[Category: Kuznicki, J]]
-	[[Category: Lee, Y T.]]	+	[[Category: Lee, Y T]]
-	[[Category: Michowski, W.]]	+	[[Category: Michowski, W]]
	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]
	[[Category: Metal binding protein]]		[[Category: Metal binding protein]]

OCA at 19:32, 29 September 2014

OCA — Mon, 29 Sep 2014 19:32:26 GMT

←Older revision		Revision as of 19:32, 29 September 2014
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-	[[~~Image~~:1ysm.~~png\|left~~\|200px]]	+	==NMR Structure of N-terminal domain (Residues 1-77) of Siah-Interacting Protein.==
		+	<StructureSection load='1ysm' size='340' side='right' caption='[[1ysm]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ysm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YSM FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cacybp, Sip ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ysm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ysm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ysm RCSB], [http://www.ebi.ac.uk/pdbsum/1ysm PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ys/1ysm_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Siah-interacting protein (SIP) was identified as a novel adaptor that physically links the E3 ubiquitin ligase activity of Siah-1 with Skp1 and Ebi F-Box protein in the degradation of beta-catenin, a transcriptional activator of TCF/LEF genes. In this study, we have used solution NMR spectroscopy to characterize the domain structure of SIP, which includes a novel helical hairpin domain at the N-terminus flexibly linked to a CS domain and an unstructured carboxy terminal SGS domain. These studies have been complemented by mapping the sites of functionally important protein-protein interactions involving Siah-1 and Skp1 to individual domains of SIP. NMR-based chemical shift perturbation assays show that Siah-1 interacts with the flexible linker between SIP N and CS domains. This site for interaction in the linker does not perturb residues in the structured region at the N-terminus but does appear to restrict the rotational freedom of the SIP CS domain in the context of the full-length protein. In contrast, Skp1 engages the SIP CS domain exclusively through weak interactions that are not coupled to the other domains. The principal role of the modular structure of SIP appears to be in bringing these two proteins into physical proximity and orchestrating the orientation required for polyubiquitination of beta-catenin in the intact SCF-type complex.

-	~~{{STRUCTURE_1ysm\| PDB=1ysm \| SCENE= }}~~	+	The modular structure of SIP facilitates its role in stabilizing multiprotein assemblies.,Bhattacharya S, Lee YT, Michowski W, Jastrzebska B, Filipek A, Kuznicki J, Chazin WJ Biochemistry. 2005 Jul 12;44(27):9462-71. PMID:15996101<ref>PMID:15996101</ref>

-	~~===NMR Structure~~ of ~~N-terminal domain (Residues 1-77)~~ of ~~Siah-Interacting Protein~~.~~===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15996101}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1ysm]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSM OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015996101<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Bhattacharya, S.]]		[[Category: Bhattacharya, S.]]

OCA: Protected "1ysm" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 17:22:57 GMT

Protected "1ysm" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:22, 5 January 2013

OCA at 17:22, 5 January 2013

OCA — Sat, 05 Jan 2013 17:22:53 GMT

←Older revision		Revision as of 17:22, 5 January 2013
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-	{{Seed}}
	[[Image:1ysm.png\|left\|200px]]		[[Image:1ysm.png\|left\|200px]]

-	<!--
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-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_1ysm\| PDB=1ysm \| SCENE= }}		{{STRUCTURE_1ysm\| PDB=1ysm \| SCENE= }}

	===NMR Structure of N-terminal domain (Residues 1-77) of Siah-Interacting Protein.===		===NMR Structure of N-terminal domain (Residues 1-77) of Siah-Interacting Protein.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15996101}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15996101 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_15996101}}		{{ABSTRACT_PUBMED_15996101}}

	==About this Structure==		==About this Structure==
-	~~1YSM~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSM OCA].	+	[[1ysm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSM OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15996101~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015996101</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Bhattacharya, S.]]		[[Category: Bhattacharya, S.]]
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	[[Category: Michowski, W.]]		[[Category: Michowski, W.]]
	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]
-		+	[[Category: Metal binding protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 17:03:16 2009''~~	+