1yvg - Revision history

OCA at 07:01, 23 August 2023

OCA — Wed, 23 Aug 2023 07:01:27 GMT

←Older revision		Revision as of 07:01, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1yvg' size='340' side='right'caption='[[1yvg]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1yvg' size='340' side='right'caption='[[1yvg]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yvg]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_tetani"_flugge_1886 "bacillus~~ tetani~~" flugge 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YVG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1YVG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yvg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YVG FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>tetX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1513~~ "~~Bacillus tetani~~" ~~Flugge 1886])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yvg OCA], [https://pdbe.org/1yvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yvg RCSB], [https://www.ebi.ac.uk/pdbsum/1yvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yvg ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1yvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yvg OCA], [~~http~~://pdbe.org/1yvg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1yvg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1yvg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1yvg ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE]] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-\|-Phe-77' bond of synaptobrevin-2.	+	[https://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-\|-Phe-77' bond of synaptobrevin-2.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ tetani ~~flugge 1886~~]]	+	[[Category: Clostridium tetani]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Tentoxilysin]]~~	+	[[Category: Binz T]]
-	[[Category: Binz, T]]	+	[[Category: Kumaran D]]
-	[[Category: Kumaran, D]]	+	[[Category: Rao KN]]
-	[[Category: Rao~~, K N~~]]	+	[[Category: Swaminathan S]]
-	[[Category: Swaminathan, S]]	+
-	~~[[Category: Clostridium neurotoxin]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Tetanus neurotoxin]]~~	+
-	~~[[Category: Zinc metalloprotease~~]]	+

OCA at 08:53, 20 January 2021

OCA — Wed, 20 Jan 2021 08:53:30 GMT

←Older revision		Revision as of 08:53, 20 January 2021
Line 1:		Line 1:

	==Structural analysis of the catalytic domain of tetanus neurotoxin==		==Structural analysis of the catalytic domain of tetanus neurotoxin==
-	<StructureSection load='1yvg' size='340' side='right' caption='[[1yvg]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='1yvg' size='340' side='right'caption='[[1yvg]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yvg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tetani"_flugge_1886 "bacillus tetani" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YVG OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1YVG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yvg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tetani"_flugge_1886 "bacillus tetani" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YVG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1YVG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tetX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1513 "Bacillus tetani" Flugge 1886])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tetX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1513 "Bacillus tetani" Flugge 1886])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1yvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yvg OCA], [http://pdbe.org/1yvg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yvg RCSB], [http://www.ebi.ac.uk/pdbsum/1yvg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1yvg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1yvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yvg OCA], [http://pdbe.org/1yvg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yvg RCSB], [http://www.ebi.ac.uk/pdbsum/1yvg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1yvg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus tetani flugge 1886]]		[[Category: Bacillus tetani flugge 1886]]
		+	[[Category: Large Structures]]
	[[Category: Tentoxilysin]]		[[Category: Tentoxilysin]]
	[[Category: Binz, T]]		[[Category: Binz, T]]

OCA at 06:29, 25 April 2018

OCA — Wed, 25 Apr 2018 06:29:11 GMT

←Older revision		Revision as of 06:29, 25 April 2018
Line 1:		Line 1:
		+
	==Structural analysis of the catalytic domain of tetanus neurotoxin==		==Structural analysis of the catalytic domain of tetanus neurotoxin==
	<StructureSection load='1yvg' size='340' side='right' caption='[[1yvg]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1yvg' size='340' side='right' caption='[[1yvg]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tetX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1513 "Bacillus tetani" Flugge 1886])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tetX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1513 "Bacillus tetani" Flugge 1886])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yvg OCA], [http://pdbe.org/1yvg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yvg RCSB], [http://www.ebi.ac.uk/pdbsum/1yvg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yvg OCA], [http://pdbe.org/1yvg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yvg RCSB], [http://www.ebi.ac.uk/pdbsum/1yvg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1yvg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yv/1yvg_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yv/1yvg_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 05:34, 8 February 2016

OCA — Mon, 08 Feb 2016 05:34:57 GMT

←Older revision		Revision as of 05:34, 8 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yvg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:24, 10 September 2015

OCA — Thu, 10 Sep 2015 08:24:18 GMT

←Older revision		Revision as of 08:24, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1yvg' size='340' side='right' caption='[[1yvg]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1yvg' size='340' side='right' caption='[[1yvg]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yvg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Clostridium_tetani Clostridium~~ tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YVG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YVG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yvg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tetani"_flugge_1886 "bacillus tetani" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YVG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YVG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tetX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1513 ~~Clostridium~~ tetani])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tetX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1513 "Bacillus tetani" Flugge 1886])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yvg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yvg RCSB], [http://www.ebi.ac.uk/pdbsum/1yvg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yvg OCA], [http://pdbe.org/1yvg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yvg RCSB], [http://www.ebi.ac.uk/pdbsum/1yvg PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1yvg" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Clostridium~~ tetani]]	+	[[Category: Bacillus tetani flugge 1886]]
	[[Category: Tentoxilysin]]		[[Category: Tentoxilysin]]
	[[Category: Binz, T]]		[[Category: Binz, T]]

OCA at 21:00, 24 December 2014

OCA — Wed, 24 Dec 2014 21:00:26 GMT

←Older revision		Revision as of 21:00, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1yvg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YVG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YVG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1yvg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YVG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YVG FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tetX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1513 Clostridium tetani])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tetX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1513 Clostridium tetani])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yvg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yvg RCSB], [http://www.ebi.ac.uk/pdbsum/1yvg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yvg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yvg RCSB], [http://www.ebi.ac.uk/pdbsum/1yvg PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE]] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-\|-Phe-77' bond of synaptobrevin-2.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Clostridium tetani]]		[[Category: Clostridium tetani]]
	[[Category: Tentoxilysin]]		[[Category: Tentoxilysin]]
-	[[Category: Binz, T.]]	+	[[Category: Binz, T]]
-	[[Category: Kumaran, D.]]	+	[[Category: Kumaran, D]]
-	[[Category: Rao, K N.]]	+	[[Category: Rao, K N]]
-	[[Category: Swaminathan, S.]]	+	[[Category: Swaminathan, S]]
	[[Category: Clostridium neurotoxin]]		[[Category: Clostridium neurotoxin]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Tetanus neurotoxin]]		[[Category: Tetanus neurotoxin]]
	[[Category: Zinc metalloprotease]]		[[Category: Zinc metalloprotease]]

OCA at 23:14, 28 September 2014

OCA — Sun, 28 Sep 2014 23:14:28 GMT

←Older revision		Revision as of 23:14, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1yvg.~~png~~\|~~left~~\|200px]]	+	==Structural analysis of the catalytic domain of tetanus neurotoxin==
		+	<StructureSection load='1yvg' size='340' side='right' caption='[[1yvg]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1yvg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YVG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YVG FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tetX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1513 Clostridium tetani])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yvg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yvg RCSB], [http://www.ebi.ac.uk/pdbsum/1yvg PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yv/1yvg_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Clostridium neurotoxins, comprising the tetanus neurotoxin and the seven antigenically distinct botulinum neurotoxins (BoNT/A-G), are among the known most potent bacterial protein toxins to humans. Although they have similar function, sequences and three-dimensional structures, the substrate specificity and the selectivity of peptide bond cleavage are different and unique. Tetanus and botulinum type B neurotoxins enzymatically cleave the same substrate, vesicle-associated membrane protein, at the same peptide bond though the optimum length of substrate peptide required for cleavage by them is different. Here, we present the first experimentally determined three-dimensional structure of the catalytic domain of tetanus neurotoxin and analyze its active site. The structure provides insight into the active site of tetanus toxin's proteolytic activity and the importance of the nucleophilic water and the role of the zinc ion. The probable reason for different modes of binding of vesicle-associated membrane protein to botulinum neurotoxin type B and the tetanus toxin is discussed. The structure provides a basis for designing a novel recombinant vaccine or structure-based drugs for tetanus.

-	~~{{STRUCTURE_1yvg\| PDB=1yvg \| SCENE= }}~~	+	Structural analysis of the catalytic domain of tetanus neurotoxin.,Rao KN, Kumaran D, Binz T, Swaminathan S Toxicon. 2005 Jun 1;45(7):929-39. Epub 2005 Apr 13. PMID:15904688<ref>PMID:15904688</ref>

-	~~===Structural analysis~~ of the ~~catalytic domain of tetanus neurotoxin===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15904688}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1yvg]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Clostridium_tetani Clostridium tetani]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1YVG OCA].~~	+

	==See Also==		==See Also==
	*[[Tetanus toxin\|Tetanus toxin]]		*[[Tetanus toxin\|Tetanus toxin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015904688<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Clostridium tetani]]		[[Category: Clostridium tetani]]
	[[Category: Tentoxilysin]]		[[Category: Tentoxilysin]]

OCA at 09:05, 20 October 2012

OCA — Sat, 20 Oct 2012 09:05:06 GMT

←Older revision		Revision as of 09:05, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1yvg]] is a 1 chain structure ~~of [[Tetanus toxin]]~~ with sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YVG OCA].	+	[[1yvg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YVG OCA].

	==See Also==		==See Also==

OCA at 21:43, 25 July 2012

OCA — Wed, 25 Jul 2012 21:43:16 GMT

←Older revision		Revision as of 21:43, 25 July 2012
Line 1:		Line 1:
	[[Image:1yvg.png\|left\|200px]]		[[Image:1yvg.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1yvg", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1yvg\| PDB=1yvg \| SCENE= }}		{{STRUCTURE_1yvg\| PDB=1yvg \| SCENE= }}

	===Structural analysis of the catalytic domain of tetanus neurotoxin===		===Structural analysis of the catalytic domain of tetanus neurotoxin===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15904688}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15904688 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15904688}}		{{ABSTRACT_PUBMED_15904688}}

	==About this Structure==		==About this Structure==
-	[[1yvg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YVG OCA].	+	[[1yvg]] is a 1 chain structure of [[Tetanus toxin]] with sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YVG OCA].
		+
		+	==See Also==
		+	*[[Tetanus toxin\|Tetanus toxin]]

	==Reference==		==Reference==

OCA: Protected "1yvg" [edit=sysop:move=sysop]

OCA — Wed, 16 Nov 2011 09:57:39 GMT

Protected "1yvg" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:57, 16 November 2011