1ywb - Revision history

OCA at 07:01, 23 August 2023

OCA — Wed, 23 Aug 2023 07:01:42 GMT

←Older revision		Revision as of 07:01, 23 August 2023
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	<StructureSection load='1ywb' size='340' side='right'caption='[[1ywb]], [[Resolution\|resolution]] 0.97Å' scene=''>		<StructureSection load='1ywb' size='340' side='right'caption='[[1ywb]], [[Resolution\|resolution]] 0.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ywb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Rhopr Rhopr~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YWB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ywb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YWB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 0.97Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ywa\|1ywa]], [[1ywc\|1ywc]], [[1ywd\|1ywd]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ywb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ywb OCA], [https://pdbe.org/1ywb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ywb RCSB], [https://www.ebi.ac.uk/pdbsum/1ywb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ywb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ywb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ywb OCA], [https://pdbe.org/1ywb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ywb RCSB], [https://www.ebi.ac.uk/pdbsum/1ywb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ywb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NP4_RHOPR NP4_RHOPR]] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing (By similarity).	+	[https://www.uniprot.org/uniprot/NP4_RHOPR NP4_RHOPR] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Rhopr~~]]	+	[[Category: Rhodnius prolixus]]
-	[[Category: Maes~~, E M~~]]	+	[[Category: Maes EM]]
-	[[Category: Montfort~~, W R~~]]	+	[[Category: Montfort WR]]
-	[[Category: Roberts~~, S A~~]]	+	[[Category: Roberts SA]]
-	[[Category: Weichsel, A]]	+	[[Category: Weichsel A]]
-	~~[[Category: Beta barrel]]~~	+
-	~~[[Category: Blood clotting]]~~	+
-	~~[[Category: Ferrous heme]]~~	+
-	~~[[Category: Ligand binding protein]]~~	+
-	~~[[Category: Lipocalin fold]]~~	+
-	~~[[Category: Nitrogen monoxide complex~~]]	+

OCA at 16:33, 3 November 2021

OCA — Wed, 03 Nov 2021 16:33:42 GMT

←Older revision		Revision as of 16:33, 3 November 2021
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	<StructureSection load='1ywb' size='340' side='right'caption='[[1ywb]], [[Resolution\|resolution]] 0.97Å' scene=''>		<StructureSection load='1ywb' size='340' side='right'caption='[[1ywb]], [[Resolution\|resolution]] 0.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ywb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Rhopr Rhopr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1YWB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ywb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhopr Rhopr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YWB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ywa\|1ywa]], [[1ywc\|1ywc]], [[1ywd\|1ywd]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ywa\|1ywa]], [[1ywc\|1ywc]], [[1ywd\|1ywd]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ywb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ywb OCA], [~~http~~://pdbe.org/1ywb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ywb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ywb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ywb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ywb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ywb OCA], [https://pdbe.org/1ywb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ywb RCSB], [https://www.ebi.ac.uk/pdbsum/1ywb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ywb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NP4_RHOPR NP4_RHOPR]] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing (By similarity).	+	[[https://www.uniprot.org/uniprot/NP4_RHOPR NP4_RHOPR]] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 16:34, 29 January 2020

OCA — Wed, 29 Jan 2020 16:34:50 GMT

←Older revision		Revision as of 16:34, 29 January 2020
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	==0.9 A Structure of NP4 from Rhodnius Prolixus complexed with NO at pH 5.6==		==0.9 A Structure of NP4 from Rhodnius Prolixus complexed with NO at pH 5.6==
-	<StructureSection load='1ywb' size='340' side='right' caption='[[1ywb]], [[Resolution\|resolution]] 0.97Å' scene=''>	+	<StructureSection load='1ywb' size='340' side='right'caption='[[1ywb]], [[Resolution\|resolution]] 0.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ywb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhopr Rhopr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YWB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ywb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhopr Rhopr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YWB FirstGlance]. <br>
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Rhopr]]		[[Category: Rhopr]]
	[[Category: Maes, E M]]		[[Category: Maes, E M]]

OCA at 06:22, 25 April 2018

OCA — Wed, 25 Apr 2018 06:22:50 GMT

←Older revision		Revision as of 06:22, 25 April 2018
Line 1:		Line 1:
		+
	==0.9 A Structure of NP4 from Rhodnius Prolixus complexed with NO at pH 5.6==		==0.9 A Structure of NP4 from Rhodnius Prolixus complexed with NO at pH 5.6==
	<StructureSection load='1ywb' size='340' side='right' caption='[[1ywb]], [[Resolution\|resolution]] 0.97Å' scene=''>		<StructureSection load='1ywb' size='340' side='right' caption='[[1ywb]], [[Resolution\|resolution]] 0.97Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ywa\|1ywa]], [[1ywc\|1ywc]], [[1ywd\|1ywd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ywa\|1ywa]], [[1ywc\|1ywc]], [[1ywd\|1ywd]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ywb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ywb OCA], [http://pdbe.org/1ywb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ywb RCSB], [http://www.ebi.ac.uk/pdbsum/1ywb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ywb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ywb OCA], [http://pdbe.org/1ywb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ywb RCSB], [http://www.ebi.ac.uk/pdbsum/1ywb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ywb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yw/1ywb_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yw/1ywb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1ywb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1ywb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Nitrophorin\|Nitrophorin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:10, 9 February 2016

OCA — Tue, 09 Feb 2016 07:10:37 GMT

←Older revision		Revision as of 07:10, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ywb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:50, 10 September 2015

OCA — Thu, 10 Sep 2015 19:50:05 GMT

←Older revision		Revision as of 19:50, 10 September 2015
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	<StructureSection load='1ywb' size='340' side='right' caption='[[1ywb]], [[Resolution\|resolution]] 0.97Å' scene=''>		<StructureSection load='1ywb' size='340' side='right' caption='[[1ywb]], [[Resolution\|resolution]] 0.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ywb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rhodnius_prolixus Rhodnius prolixus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YWB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ywb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhopr Rhopr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YWB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ywa\|1ywa]], [[1ywc\|1ywc]], [[1ywd\|1ywd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ywa\|1ywa]], [[1ywc\|1ywc]], [[1ywd\|1ywd]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ywb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ywb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ywb RCSB], [http://www.ebi.ac.uk/pdbsum/1ywb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ywb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ywb OCA], [http://pdbe.org/1ywb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ywb RCSB], [http://www.ebi.ac.uk/pdbsum/1ywb PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ywb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rhodnius prolixus~~]]	+	[[Category: Rhopr]]
	[[Category: Maes, E M]]		[[Category: Maes, E M]]
	[[Category: Montfort, W R]]		[[Category: Montfort, W R]]

OCA at 05:15, 25 December 2014

OCA — Thu, 25 Dec 2014 05:15:32 GMT

←Older revision		Revision as of 05:15, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ywb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YWB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ywb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YWB FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ywa\|1ywa]], [[1ywc\|1ywc]], [[1ywd\|1ywd]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ywa\|1ywa]], [[1ywc\|1ywc]], [[1ywd\|1ywd]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ywb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ywb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ywb RCSB], [http://www.ebi.ac.uk/pdbsum/1ywb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ywb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ywb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ywb RCSB], [http://www.ebi.ac.uk/pdbsum/1ywb PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NP4_RHOPR NP4_RHOPR]] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Rhodnius prolixus]]		[[Category: Rhodnius prolixus]]
-	[[Category: Maes, E M.]]	+	[[Category: Maes, E M]]
-	[[Category: Montfort, W R.]]	+	[[Category: Montfort, W R]]
-	[[Category: Roberts, S A.]]	+	[[Category: Roberts, S A]]
-	[[Category: Weichsel, A.]]	+	[[Category: Weichsel, A]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Blood clotting]]		[[Category: Blood clotting]]

OCA at 20:46, 29 September 2014

OCA — Mon, 29 Sep 2014 20:46:07 GMT

←Older revision		Revision as of 20:46, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1ywb.~~png~~\|~~left~~\|200px]]	+	==0.9 A Structure of NP4 from Rhodnius Prolixus complexed with NO at pH 5.6==
		+	<StructureSection load='1ywb' size='340' side='right' caption='[[1ywb]], [[Resolution\|resolution]] 0.97Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ywb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YWB FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ywa\|1ywa]], [[1ywc\|1ywc]], [[1ywd\|1ywd]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ywb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ywb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ywb RCSB], [http://www.ebi.ac.uk/pdbsum/1ywb PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yw/1ywb_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Nitrophorin 4 (NP4), a nitric oxide (NO)-transport protein from the blood-sucking insect Rhodnius prolixus, uses a ferric (Fe3+) heme to deliver NO to its victims. NO binding to NP4 induces a large conformational change and complete desolvation of the distal pocket. The heme is markedly nonplanar, displaying a ruffling distortion postulated to contribute to stabilization of the ferric iron. Here, we report the ferrous (Fe2+) complexes of NP4 with NO, CO, and H2O formed after chemical reduction of the protein and the characterization of these complexes by absorption spectroscopy, flash photolysis, and ultrahigh-resolution crystallography (resolutions vary from 0.9 to 1.08 A). The absorption spectra, both in solution and in the crystal, are typical for six-coordinated ferrous complexes. Closure and desolvation of the distal pocket occurs upon binding CO or NO to the iron regardless of the heme oxidation state, confirming that the conformational change is driven by distal ligand polarity. The degree of heme ruffling is coupled to the nature of the ligand and the iron oxidation state in the following order: (Fe3+)-NO > (Fe2+)-NO > (Fe2+)-CO > (Fe3+)-H2O > (Fe2+)-H2O. The ferrous coordination geometry is as expected, except for the proximal histidine bond, which is shorter than typically found in model compounds. These data are consistent with heme ruffling and coordination geometry serving to stabilize the ferric state of the nitrophorins, a requirement for their physiological function. Possible roles for heme distortion and NO bending in heme protein function are discussed.

-	~~{{STRUCTURE_1ywb\| PDB=1ywb \| SCENE= }}~~	+	Ultrahigh resolution structures of nitrophorin 4: heme distortion in ferrous CO and NO complexes.,Maes EM, Roberts SA, Weichsel A, Montfort WR Biochemistry. 2005 Sep 27;44(38):12690-9. PMID:16171383<ref>PMID:16171383</ref>

-	~~===0~~.~~9 A Structure~~ of ~~NP4 from Rhodnius Prolixus complexed with NO at pH 5~~.~~6===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16171383}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1ywb]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWB OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016171383<~~/~~ref~~><~~ref group="xtra">PMID:019140692</ref><references group="xtra"~~/>	+
	[[Category: Rhodnius prolixus]]		[[Category: Rhodnius prolixus]]
	[[Category: Maes, E M.]]		[[Category: Maes, E M.]]

OCA: Protected "1ywb" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 16:58:56 GMT

Protected "1ywb" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:58, 5 January 2013

OCA at 16:58, 5 January 2013

OCA — Sat, 05 Jan 2013 16:58:54 GMT

←Older revision		Revision as of 16:58, 5 January 2013
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-	{{Seed}}
	[[Image:1ywb.png\|left\|200px]]		[[Image:1ywb.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1ywb", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_1ywb\| PDB=1ywb \| SCENE= }}		{{STRUCTURE_1ywb\| PDB=1ywb \| SCENE= }}

	===0.9 A Structure of NP4 from Rhodnius Prolixus complexed with NO at pH 5.6===		===0.9 A Structure of NP4 from Rhodnius Prolixus complexed with NO at pH 5.6===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16171383}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16171383 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16171383}}		{{ABSTRACT_PUBMED_16171383}}

	==About this Structure==		==About this Structure==
-	~~1YWB~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWB OCA].	+	[[1ywb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWB OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16171383~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016171383</ref><ref group="xtra">PMID:019140692</ref><references group="xtra"/>
	[[Category: Rhodnius prolixus]]		[[Category: Rhodnius prolixus]]
	[[Category: Maes, E M.]]		[[Category: Maes, E M.]]
Line 30:		Line 18:
	[[Category: Weichsel, A.]]		[[Category: Weichsel, A.]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
		+	[[Category: Blood clotting]]
	[[Category: Ferrous heme]]		[[Category: Ferrous heme]]
		+	[[Category: Ligand binding protein]]
	[[Category: Lipocalin fold]]		[[Category: Lipocalin fold]]
	[[Category: Nitrogen monoxide complex]]		[[Category: Nitrogen monoxide complex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 07:50:33 2009''