1ywd - Revision history

OCA at 07:01, 23 August 2023

OCA — Wed, 23 Aug 2023 07:01:49 GMT

←Older revision		Revision as of 07:01, 23 August 2023
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	<StructureSection load='1ywd' size='340' side='right'caption='[[1ywd]], [[Resolution\|resolution]] 1.08Å' scene=''>		<StructureSection load='1ywd' size='340' side='right'caption='[[1ywd]], [[Resolution\|resolution]] 1.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ywd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Rhopr Rhopr~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YWD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ywd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YWD FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.08Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1ywa\|1ywa]], [[1ywb\|1ywb]], [[1ywc\|1ywc]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ywd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ywd OCA], [https://pdbe.org/1ywd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ywd RCSB], [https://www.ebi.ac.uk/pdbsum/1ywd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ywd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ywd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ywd OCA], [https://pdbe.org/1ywd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ywd RCSB], [https://www.ebi.ac.uk/pdbsum/1ywd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ywd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NP4_RHOPR NP4_RHOPR]] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing (By similarity).	+	[https://www.uniprot.org/uniprot/NP4_RHOPR NP4_RHOPR] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Rhopr~~]]	+	[[Category: Rhodnius prolixus]]
-	[[Category: Maes~~, E M~~]]	+	[[Category: Maes EM]]
-	[[Category: Montfort~~, W R~~]]	+	[[Category: Montfort WR]]
-	[[Category: Roberts~~, S A~~]]	+	[[Category: Roberts SA]]
-	[[Category: Weichsel, A]]	+	[[Category: Weichsel A]]
-	~~[[Category: Beta barrel]]~~	+
-	~~[[Category: Blood clotting]]~~	+
-	~~[[Category: Ferrous heme]]~~	+
-	~~[[Category: Ligand binding protein]]~~	+
-	~~[[Category: Lipocalin fold~~]]	+

OCA at 16:33, 3 November 2021

OCA — Wed, 03 Nov 2021 16:33:44 GMT

←Older revision		Revision as of 16:33, 3 November 2021
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	<StructureSection load='1ywd' size='340' side='right'caption='[[1ywd]], [[Resolution\|resolution]] 1.08Å' scene=''>		<StructureSection load='1ywd' size='340' side='right'caption='[[1ywd]], [[Resolution\|resolution]] 1.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ywd]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Rhopr Rhopr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1YWD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ywd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhopr Rhopr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YWD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ywa\|1ywa]], [[1ywb\|1ywb]], [[1ywc\|1ywc]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ywa\|1ywa]], [[1ywb\|1ywb]], [[1ywc\|1ywc]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ywd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ywd OCA], [~~http~~://pdbe.org/1ywd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ywd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ywd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ywd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ywd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ywd OCA], [https://pdbe.org/1ywd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ywd RCSB], [https://www.ebi.ac.uk/pdbsum/1ywd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ywd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NP4_RHOPR NP4_RHOPR]] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing (By similarity).	+	[[https://www.uniprot.org/uniprot/NP4_RHOPR NP4_RHOPR]] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 17:22, 29 January 2020

OCA — Wed, 29 Jan 2020 17:22:48 GMT

←Older revision		Revision as of 17:22, 29 January 2020
Line 1:		Line 1:

	==1.08 A Structure of Ferrous NP4 (aquo complex)==		==1.08 A Structure of Ferrous NP4 (aquo complex)==
-	<StructureSection load='1ywd' size='340' side='right' caption='[[1ywd]], [[Resolution\|resolution]] 1.08Å' scene=''>	+	<StructureSection load='1ywd' size='340' side='right'caption='[[1ywd]], [[Resolution\|resolution]] 1.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ywd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhopr Rhopr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YWD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ywd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhopr Rhopr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YWD FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Rhopr]]		[[Category: Rhopr]]
	[[Category: Maes, E M]]		[[Category: Maes, E M]]

OCA at 07:03, 25 April 2018

OCA — Wed, 25 Apr 2018 07:03:50 GMT

←Older revision		Revision as of 07:03, 25 April 2018
Line 1:		Line 1:
		+
	==1.08 A Structure of Ferrous NP4 (aquo complex)==		==1.08 A Structure of Ferrous NP4 (aquo complex)==
	<StructureSection load='1ywd' size='340' side='right' caption='[[1ywd]], [[Resolution\|resolution]] 1.08Å' scene=''>		<StructureSection load='1ywd' size='340' side='right' caption='[[1ywd]], [[Resolution\|resolution]] 1.08Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ywa\|1ywa]], [[1ywb\|1ywb]], [[1ywc\|1ywc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ywa\|1ywa]], [[1ywb\|1ywb]], [[1ywc\|1ywc]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ywd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ywd OCA], [http://pdbe.org/1ywd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ywd RCSB], [http://www.ebi.ac.uk/pdbsum/1ywd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ywd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ywd OCA], [http://pdbe.org/1ywd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ywd RCSB], [http://www.ebi.ac.uk/pdbsum/1ywd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ywd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yw/1ywd_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yw/1ywd_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1ywd" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1ywd" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Nitrophorin\|Nitrophorin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:33, 8 February 2016

OCA — Mon, 08 Feb 2016 08:33:08 GMT

←Older revision		Revision as of 08:33, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ywd ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:45, 10 September 2015

OCA — Thu, 10 Sep 2015 09:45:19 GMT

←Older revision		Revision as of 09:45, 10 September 2015
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	<StructureSection load='1ywd' size='340' side='right' caption='[[1ywd]], [[Resolution\|resolution]] 1.08Å' scene=''>		<StructureSection load='1ywd' size='340' side='right' caption='[[1ywd]], [[Resolution\|resolution]] 1.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ywd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rhodnius_prolixus Rhodnius prolixus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YWD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ywd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhopr Rhopr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YWD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ywa\|1ywa]], [[1ywb\|1ywb]], [[1ywc\|1ywc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ywa\|1ywa]], [[1ywb\|1ywb]], [[1ywc\|1ywc]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ywd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ywd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ywd RCSB], [http://www.ebi.ac.uk/pdbsum/1ywd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ywd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ywd OCA], [http://pdbe.org/1ywd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ywd RCSB], [http://www.ebi.ac.uk/pdbsum/1ywd PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ywd" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rhodnius prolixus~~]]	+	[[Category: Rhopr]]
	[[Category: Maes, E M]]		[[Category: Maes, E M]]
	[[Category: Montfort, W R]]		[[Category: Montfort, W R]]

OCA at 22:00, 24 December 2014

OCA — Wed, 24 Dec 2014 22:00:00 GMT

←Older revision		Revision as of 22:00, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ywd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YWD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ywd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YWD FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ywa\|1ywa]], [[1ywb\|1ywb]], [[1ywc\|1ywc]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ywa\|1ywa]], [[1ywb\|1ywb]], [[1ywc\|1ywc]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ywd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ywd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ywd RCSB], [http://www.ebi.ac.uk/pdbsum/1ywd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ywd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ywd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ywd RCSB], [http://www.ebi.ac.uk/pdbsum/1ywd PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NP4_RHOPR NP4_RHOPR]] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Rhodnius prolixus]]		[[Category: Rhodnius prolixus]]
-	[[Category: Maes, E M.]]	+	[[Category: Maes, E M]]
-	[[Category: Montfort, W R.]]	+	[[Category: Montfort, W R]]
-	[[Category: Roberts, S A.]]	+	[[Category: Roberts, S A]]
-	[[Category: Weichsel, A.]]	+	[[Category: Weichsel, A]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Blood clotting]]		[[Category: Blood clotting]]

OCA at 22:04, 29 September 2014

OCA — Mon, 29 Sep 2014 22:04:28 GMT

←Older revision		Revision as of 22:04, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1ywd.~~png~~\|~~left~~\|200px]]	+	==1.08 A Structure of Ferrous NP4 (aquo complex)==
		+	<StructureSection load='1ywd' size='340' side='right' caption='[[1ywd]], [[Resolution\|resolution]] 1.08Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ywd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YWD FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ywa\|1ywa]], [[1ywb\|1ywb]], [[1ywc\|1ywc]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ywd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ywd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ywd RCSB], [http://www.ebi.ac.uk/pdbsum/1ywd PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yw/1ywd_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Nitrophorin 4 (NP4), a nitric oxide (NO)-transport protein from the blood-sucking insect Rhodnius prolixus, uses a ferric (Fe3+) heme to deliver NO to its victims. NO binding to NP4 induces a large conformational change and complete desolvation of the distal pocket. The heme is markedly nonplanar, displaying a ruffling distortion postulated to contribute to stabilization of the ferric iron. Here, we report the ferrous (Fe2+) complexes of NP4 with NO, CO, and H2O formed after chemical reduction of the protein and the characterization of these complexes by absorption spectroscopy, flash photolysis, and ultrahigh-resolution crystallography (resolutions vary from 0.9 to 1.08 A). The absorption spectra, both in solution and in the crystal, are typical for six-coordinated ferrous complexes. Closure and desolvation of the distal pocket occurs upon binding CO or NO to the iron regardless of the heme oxidation state, confirming that the conformational change is driven by distal ligand polarity. The degree of heme ruffling is coupled to the nature of the ligand and the iron oxidation state in the following order: (Fe3+)-NO > (Fe2+)-NO > (Fe2+)-CO > (Fe3+)-H2O > (Fe2+)-H2O. The ferrous coordination geometry is as expected, except for the proximal histidine bond, which is shorter than typically found in model compounds. These data are consistent with heme ruffling and coordination geometry serving to stabilize the ferric state of the nitrophorins, a requirement for their physiological function. Possible roles for heme distortion and NO bending in heme protein function are discussed.

-	~~{{STRUCTURE_1ywd\| PDB=1ywd \| SCENE= }}~~	+	Ultrahigh resolution structures of nitrophorin 4: heme distortion in ferrous CO and NO complexes.,Maes EM, Roberts SA, Weichsel A, Montfort WR Biochemistry. 2005 Sep 27;44(38):12690-9. PMID:16171383<ref>PMID:16171383</ref>

-	~~===1.08 A Structure~~ of ~~Ferrous NP4 (aquo complex)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16171383}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1ywd]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rhodnius_prolixus Rhodnius prolixus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1YWD OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016171383<~~/~~ref~~><~~ref group="xtra">PMID:019140692</ref><references group="xtra"~~/>	+
	[[Category: Rhodnius prolixus]]		[[Category: Rhodnius prolixus]]
	[[Category: Maes, E M.]]		[[Category: Maes, E M.]]

OCA: Protected "1ywd" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 17:47:51 GMT

Protected "1ywd" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:47, 5 January 2013

OCA at 17:47, 5 January 2013

OCA — Sat, 05 Jan 2013 17:47:47 GMT

←Older revision		Revision as of 17:47, 5 January 2013
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-	{{Seed}}
	[[Image:1ywd.png\|left\|200px]]		[[Image:1ywd.png\|left\|200px]]

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	{{STRUCTURE_1ywd\| PDB=1ywd \| SCENE= }}		{{STRUCTURE_1ywd\| PDB=1ywd \| SCENE= }}

	===1.08 A Structure of Ferrous NP4 (aquo complex)===		===1.08 A Structure of Ferrous NP4 (aquo complex)===

-
-	<!--
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	{{ABSTRACT_PUBMED_16171383}}		{{ABSTRACT_PUBMED_16171383}}

	==About this Structure==		==About this Structure==
-	~~1YWD~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWD OCA].	+	[[1ywd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWD OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16171383~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016171383</ref><ref group="xtra">PMID:019140692</ref><references group="xtra"/>
	[[Category: Rhodnius prolixus]]		[[Category: Rhodnius prolixus]]
	[[Category: Maes, E M.]]		[[Category: Maes, E M.]]
Line 30:		Line 18:
	[[Category: Weichsel, A.]]		[[Category: Weichsel, A.]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
		+	[[Category: Blood clotting]]
	[[Category: Ferrous heme]]		[[Category: Ferrous heme]]
		+	[[Category: Ligand binding protein]]
	[[Category: Lipocalin fold]]		[[Category: Lipocalin fold]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:37:58 2009''