1yz3 - Revision history

OCA at 08:13, 25 October 2023

OCA — Wed, 25 Oct 2023 08:13:24 GMT

←Older revision		Revision as of 08:13, 25 October 2023
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	<StructureSection load='1yz3' size='340' side='right'caption='[[1yz3]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1yz3' size='340' side='right'caption='[[1yz3]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yz3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YZ3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yz3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YZ3 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SAH:S~~-~~ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SKA:7,8-DICHLORO-1~~,2~~,3,~~4~~-TETRAHYDROISOQUINOLINE'>SKA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1hnn\|1hnn]], [[1n7i\|1n7i]], [[1n7j\|1n7j]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SKA:7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE'>SKA</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phenylethanolamine_N~~-~~methyltransferase Phenylethanolamine N~~-~~methyltransferase]~~, ~~with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=2.1.1.28 2.1.1.28]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yz3 OCA], [https://pdbe.org/1yz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yz3 RCSB], [https://www.ebi.ac.uk/pdbsum/1yz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yz3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yz3 OCA], [https://pdbe.org/1yz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yz3 RCSB], [https://www.ebi.ac.uk/pdbsum/1yz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yz3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PNMT_HUMAN PNMT_HUMAN]] Converts noradrenaline to adrenaline.	+	[https://www.uniprot.org/uniprot/PNMT_HUMAN PNMT_HUMAN] Converts noradrenaline to adrenaline.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Phenylethanolamine N-methyltransferase]]~~	+	[[Category: Gee CL]]
-	[[Category: Gee~~, C L~~]]	+	[[Category: Grunewald GL]]
-	[[Category: Grunewald~~, G L~~]]	+	[[Category: Lin F]]
-	[[Category: Lin, F]]	+	[[Category: Martin JL]]
-	[[Category: Martin~~, J L~~]]	+	[[Category: McLeish MJ]]
-	[[Category: McLeish~~, M J~~]]	+	[[Category: Wu Q]]
-	[[Category: Wu, Q]]	+
-	~~[[Category: Enzyme]]~~	+
-	~~[[Category: Inhibitor complex]]~~	+
-	~~[[Category: Product]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 06:07, 28 April 2021

OCA — Wed, 28 Apr 2021 06:07:23 GMT

←Older revision		Revision as of 06:07, 28 April 2021
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	<StructureSection load='1yz3' size='340' side='right'caption='[[1yz3]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1yz3' size='340' side='right'caption='[[1yz3]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yz3]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YZ3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1YZ3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yz3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YZ3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SKA:7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE'>SKA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SKA:7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE'>SKA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hnn\|1hnn]], [[1n7i\|1n7i]], [[1n7j\|1n7j]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1hnn\|1hnn]], [[1n7i\|1n7i]], [[1n7j\|1n7j]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phenylethanolamine_N-methyltransferase Phenylethanolamine N-methyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.28 2.1.1.28] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phenylethanolamine_N-methyltransferase Phenylethanolamine N-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.28 2.1.1.28] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1yz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yz3 OCA], [~~http~~://pdbe.org/1yz3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1yz3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1yz3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1yz3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yz3 OCA], [https://pdbe.org/1yz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yz3 RCSB], [https://www.ebi.ac.uk/pdbsum/1yz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yz3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PNMT_HUMAN PNMT_HUMAN]] Converts noradrenaline to adrenaline.	+	[[https://www.uniprot.org/uniprot/PNMT_HUMAN PNMT_HUMAN]] Converts noradrenaline to adrenaline.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:22, 24 July 2019

OCA — Wed, 24 Jul 2019 09:22:59 GMT

←Older revision		Revision as of 09:22, 24 July 2019
Line 1:		Line 1:

	==Structure of human pnmt complexed with cofactor product adohcy and inhibitor SK&F 64139==		==Structure of human pnmt complexed with cofactor product adohcy and inhibitor SK&F 64139==
-	<StructureSection load='1yz3' size='340' side='right' caption='[[1yz3]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='1yz3' size='340' side='right'caption='[[1yz3]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1yz3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YZ3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1yz3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YZ3 FirstGlance]. <br>
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yz/1yz3_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yz/1yz3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1yz3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1yz3" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phenylethanolamine N-methyltransferase\|Phenylethanolamine N-methyltransferase]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Phenylethanolamine N-methyltransferase]]		[[Category: Phenylethanolamine N-methyltransferase]]
	[[Category: Gee, C L]]		[[Category: Gee, C L]]

OCA at 15:57, 12 October 2017

OCA — Thu, 12 Oct 2017 15:57:28 GMT

←Older revision		Revision as of 15:57, 12 October 2017
Line 1:		Line 1:
		+
	==Structure of human pnmt complexed with cofactor product adohcy and inhibitor SK&F 64139==		==Structure of human pnmt complexed with cofactor product adohcy and inhibitor SK&F 64139==
	<StructureSection load='1yz3' size='340' side='right' caption='[[1yz3]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1yz3' size='340' side='right' caption='[[1yz3]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hnn\|1hnn]], [[1n7i\|1n7i]], [[1n7j\|1n7j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hnn\|1hnn]], [[1n7i\|1n7i]], [[1n7j\|1n7j]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylethanolamine_N-methyltransferase Phenylethanolamine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.28 2.1.1.28] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylethanolamine_N-methyltransferase Phenylethanolamine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.28 2.1.1.28] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yz3 OCA], [http://pdbe.org/1yz3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yz3 RCSB], [http://www.ebi.ac.uk/pdbsum/1yz3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yz3 OCA], [http://pdbe.org/1yz3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yz3 RCSB], [http://www.ebi.ac.uk/pdbsum/1yz3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1yz3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 1yz3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1yz3" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Phenylethanolamine N-methyltransferase\|Phenylethanolamine N-methyltransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:45, 9 February 2016

OCA — Tue, 09 Feb 2016 04:45:56 GMT

←Older revision		Revision as of 04:45, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yz3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 18:45, 10 September 2015

OCA — Thu, 10 Sep 2015 18:45:24 GMT

←Older revision		Revision as of 18:45, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1yz3' size='340' side='right' caption='[[1yz3]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1yz3' size='340' side='right' caption='[[1yz3]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1yz3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YZ3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1yz3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YZ3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SKA:7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE'>SKA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SKA:7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE'>SKA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hnn\|1hnn]], [[1n7i\|1n7i]], [[1n7j\|1n7j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hnn\|1hnn]], [[1n7i\|1n7i]], [[1n7j\|1n7j]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylethanolamine_N-methyltransferase Phenylethanolamine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.28 2.1.1.28] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylethanolamine_N-methyltransferase Phenylethanolamine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.28 2.1.1.28] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yz3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yz3 RCSB], [http://www.ebi.ac.uk/pdbsum/1yz3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yz3 OCA], [http://pdbe.org/1yz3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yz3 RCSB], [http://www.ebi.ac.uk/pdbsum/1yz3 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1yz3" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Phenylethanolamine N-methyltransferase]]		[[Category: Phenylethanolamine N-methyltransferase]]
	[[Category: Gee, C L]]		[[Category: Gee, C L]]

OCA at 04:31, 25 December 2014

OCA — Thu, 25 Dec 2014 04:31:31 GMT

←Older revision		Revision as of 04:31, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1yz3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YZ3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1yz3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YZ3 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SKA:7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE'>SKA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SKA:7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE'>SKA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hnn\|1hnn]], [[1n7i\|1n7i]], [[1n7j\|1n7j]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hnn\|1hnn]], [[1n7i\|1n7i]], [[1n7j\|1n7j]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylethanolamine_N-methyltransferase Phenylethanolamine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.28 2.1.1.28] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylethanolamine_N-methyltransferase Phenylethanolamine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.28 2.1.1.28] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yz3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yz3 RCSB], [http://www.ebi.ac.uk/pdbsum/1yz3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yz3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yz3 RCSB], [http://www.ebi.ac.uk/pdbsum/1yz3 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PNMT_HUMAN PNMT_HUMAN]] Converts noradrenaline to adrenaline.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phenylethanolamine N-methyltransferase]]		[[Category: Phenylethanolamine N-methyltransferase]]
-	[[Category: Gee, C L.]]	+	[[Category: Gee, C L]]
-	[[Category: Grunewald, G L.]]	+	[[Category: Grunewald, G L]]
-	[[Category: Lin, F.]]	+	[[Category: Lin, F]]
-	[[Category: Martin, J L.]]	+	[[Category: Martin, J L]]
-	[[Category: McLeish, M J.]]	+	[[Category: McLeish, M J]]
-	[[Category: Wu, Q.]]	+	[[Category: Wu, Q]]
	[[Category: Enzyme]]		[[Category: Enzyme]]
	[[Category: Inhibitor complex]]		[[Category: Inhibitor complex]]
	[[Category: Product]]		[[Category: Product]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 21:54, 28 September 2014

OCA — Sun, 28 Sep 2014 21:54:31 GMT

←Older revision		Revision as of 21:54, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1yz3.~~png~~\|~~left~~\|200px]]	+	==Structure of human pnmt complexed with cofactor product adohcy and inhibitor SK&F 64139==
		+	<StructureSection load='1yz3' size='340' side='right' caption='[[1yz3]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1yz3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YZ3 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SKA:7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE'>SKA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hnn\|1hnn]], [[1n7i\|1n7i]], [[1n7j\|1n7j]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylethanolamine_N-methyltransferase Phenylethanolamine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.28 2.1.1.28] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yz3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yz3 RCSB], [http://www.ebi.ac.uk/pdbsum/1yz3 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yz/1yz3_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The X-ray structure of human phenylethanolamine N-methyltransferase (hPNMT) complexed with its product, S-adenosyl-L-homocysteine (4), and the most potent inhibitor reported to date, SK&F 64139 (7), was used to identify the residues involved in inhibitor binding. Four of these residues, Val53, Lys57, Glu219 and Asp267, were replaced, in turn, with alanine. All variants had increased Km values for phenylethanolamine (10), but only D267A showed a noteworthy (20-fold) decrease in its kcat value. Both WT hPNMT and D267A had similar kcat values for a rigid analogue, anti-9-amino-6-(trifluoromethyl)benzonorbornene (12), suggesting that Asp267 plays an important role in positioning the substrate but does not participate directly in catalysis. The Ki values for the binding of inhibitors such as 7 to the E219A and D267A variants increased by 2-3 orders of magnitude. Further, the inhibitors were shown to bind up to 50-fold more tightly in the presence of S-adenosyl-L-methionine (3), suggesting that the binding of the latter brings about a conformational change in the enzyme.

-	~~{{STRUCTURE_1yz3\| PDB=1yz3 \| SCENE= }}~~	+	Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase.,Wu Q, Gee CL, Lin F, Tyndall JD, Martin JL, Grunewald GL, McLeish MJ J Med Chem. 2005 Nov 17;48(23):7243-52. PMID:16279783<ref>PMID:16279783</ref>

-	~~===Structure of human pnmt complexed with cofactor product adohcy and inhibitor SK~~&~~F 64139===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16279783}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1yz3]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1YZ3 OCA].~~	+

	==See Also==		==See Also==
	*[[Phenylethanolamine N-methyltransferase\|Phenylethanolamine N-methyltransferase]]		*[[Phenylethanolamine N-methyltransferase\|Phenylethanolamine N-methyltransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016279783<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phenylethanolamine N-methyltransferase]]		[[Category: Phenylethanolamine N-methyltransferase]]

OCA at 12:41, 20 October 2012

OCA — Sat, 20 Oct 2012 12:41:17 GMT

←Older revision		Revision as of 12:41, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1yz3]] is a 2 chain structure ~~of [[Phenylethanolamine N-methyltransferase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YZ3 OCA].	+	[[1yz3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YZ3 OCA].

	==See Also==		==See Also==

OCA at 09:32, 26 July 2012

OCA — Thu, 26 Jul 2012 09:32:59 GMT

←Older revision		Revision as of 09:32, 26 July 2012
Line 1:		Line 1:
	[[Image:1yz3.png\|left\|200px]]		[[Image:1yz3.png\|left\|200px]]

-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_1yz3\| PDB=1yz3 \| SCENE= }}		{{STRUCTURE_1yz3\| PDB=1yz3 \| SCENE= }}

	===Structure of human pnmt complexed with cofactor product adohcy and inhibitor SK&F 64139===		===Structure of human pnmt complexed with cofactor product adohcy and inhibitor SK&F 64139===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16279783}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16279783 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16279783}}		{{ABSTRACT_PUBMED_16279783}}

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	==See Also==		==See Also==
-	*[[Phenylethanolamine N-methyltransferase]]	+	*[[Phenylethanolamine N-methyltransferase\|Phenylethanolamine N-methyltransferase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16279783~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016279783</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phenylethanolamine N-methyltransferase]]		[[Category: Phenylethanolamine N-methyltransferase]]