1z12 - Revision history

OCA at 07:02, 23 August 2023

OCA — Wed, 23 Aug 2023 07:02:50 GMT

←Older revision		Revision as of 07:02, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1z12' size='340' side='right'caption='[[1z12]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1z12' size='340' side='right'caption='[[1z12]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1z12]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bovin Bovin~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z12 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1Z12 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1z12]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z12 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[1dg9\|1dg9]], [[3pnt\|3pnt]], [[1z13\|1z13]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">ACP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z12 OCA], [https://pdbe.org/1z12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z12 RCSB], [https://www.ebi.ac.uk/pdbsum/1z12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z12 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1z12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z12 OCA], [~~http~~://pdbe.org/1z12 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1z12 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1z12 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1z12 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PPAC_BOVIN PPAC_BOVIN]] Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.	+	[https://www.uniprot.org/uniprot/PPAC_BOVIN PPAC_BOVIN] Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bovin~~]]	+	[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Etten, R L.Van~~]]	+	[[Category: Stauffacher CV]]
-	[[Category: ~~Stauffacher, C V~~]]	+	[[Category: Van Etten RL]]
-	[[Category: Zhang, M]]	+	[[Category: Zhang M]]
-	[[Category: Zhou, M]]	+	[[Category: Zhou M]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Ptpase]]~~	+
-	~~[[Category: Vanadate complex~~]]	+

OCA at 08:56, 20 January 2021

OCA — Wed, 20 Jan 2021 08:56:45 GMT

←Older revision		Revision as of 08:56, 20 January 2021
Line 1:		Line 1:

	==Crystal Structure of Bovine Low Molecular Weight PTPase Complexed with Vanadate==		==Crystal Structure of Bovine Low Molecular Weight PTPase Complexed with Vanadate==
-	<StructureSection load='1z12' size='340' side='right' caption='[[1z12]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='1z12' size='340' side='right'caption='[[1z12]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1z12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z12 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Z12 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1z12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z12 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1Z12 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dg9\|1dg9]], [[3pnt\|3pnt]], [[1z13\|1z13]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1dg9\|1dg9]], [[3pnt\|3pnt]], [[1z13\|1z13]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1z12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z12 OCA], [http://pdbe.org/1z12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z12 RCSB], [http://www.ebi.ac.uk/pdbsum/1z12 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1z12 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1z12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z12 OCA], [http://pdbe.org/1z12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z12 RCSB], [http://www.ebi.ac.uk/pdbsum/1z12 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1z12 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Acid phosphatase\|Acid phosphatase]]	+	*[[Acid phosphatase 3D structures\|Acid phosphatase 3D structures]]
-	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]	+	*[[Tyrosine phosphatase 3D structures\|Tyrosine phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Bovin]]		[[Category: Bovin]]
		+	[[Category: Large Structures]]
	[[Category: Etten, R L.Van]]		[[Category: Etten, R L.Van]]
	[[Category: Stauffacher, C V]]		[[Category: Stauffacher, C V]]

OCA at 06:38, 25 April 2018

OCA — Wed, 25 Apr 2018 06:38:00 GMT

←Older revision		Revision as of 06:38, 25 April 2018
Line 1:		Line 1:
		+
	==Crystal Structure of Bovine Low Molecular Weight PTPase Complexed with Vanadate==		==Crystal Structure of Bovine Low Molecular Weight PTPase Complexed with Vanadate==
	<StructureSection load='1z12' size='340' side='right' caption='[[1z12]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1z12' size='340' side='right' caption='[[1z12]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dg9\|1dg9]], [[3pnt\|3pnt]], [[1z13\|1z13]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dg9\|1dg9]], [[3pnt\|3pnt]], [[1z13\|1z13]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z12 OCA], [http://pdbe.org/1z12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z12 RCSB], [http://www.ebi.ac.uk/pdbsum/1z12 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z12 OCA], [http://pdbe.org/1z12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z12 RCSB], [http://www.ebi.ac.uk/pdbsum/1z12 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1z12 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z1/1z12_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z1/1z12_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z12 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:50, 11 September 2015

OCA — Fri, 11 Sep 2015 23:50:15 GMT

←Older revision		Revision as of 23:50, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1z12' size='340' side='right' caption='[[1z12]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1z12' size='340' side='right' caption='[[1z12]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1z12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z12 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1z12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z12 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dg9\|1dg9]], [[3pnt\|3pnt]], [[1z13\|1z13]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dg9\|1dg9]], [[3pnt\|3pnt]], [[1z13\|1z13]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 ~~Bos taurus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z12 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z12 RCSB], [http://www.ebi.ac.uk/pdbsum/1z12 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z12 OCA], [http://pdbe.org/1z12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z12 RCSB], [http://www.ebi.ac.uk/pdbsum/1z12 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1z12" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bos taurus~~]]	+	[[Category: Bovin]]
	[[Category: Etten, R L.Van]]		[[Category: Etten, R L.Van]]
	[[Category: Stauffacher, C V]]		[[Category: Stauffacher, C V]]

OCA at 21:02, 25 December 2014

OCA — Thu, 25 Dec 2014 21:02:32 GMT

←Older revision		Revision as of 21:02, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1z12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z12 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1z12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z12 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dg9\|1dg9]], [[3pnt\|3pnt]], [[1z13\|1z13]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dg9\|1dg9]], [[3pnt\|3pnt]], [[1z13\|1z13]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z12 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z12 RCSB], [http://www.ebi.ac.uk/pdbsum/1z12 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z12 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z12 RCSB], [http://www.ebi.ac.uk/pdbsum/1z12 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PPAC_BOVIN PPAC_BOVIN]] Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: Etten, R L.Van.]]	+	[[Category: Etten, R L.Van]]
-	[[Category: Stauffacher, C V.]]	+	[[Category: Stauffacher, C V]]
-	[[Category: Zhang, M.]]	+	[[Category: Zhang, M]]
-	[[Category: Zhou, M.]]	+	[[Category: Zhou, M]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Ptpase]]		[[Category: Ptpase]]
	[[Category: Vanadate complex]]		[[Category: Vanadate complex]]

OCA at 22:20, 28 September 2014

OCA — Sun, 28 Sep 2014 22:20:11 GMT

←Older revision		Revision as of 22:20, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1z12.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of Bovine Low Molecular Weight PTPase Complexed with Vanadate==
		+	<StructureSection load='1z12' size='340' side='right' caption='[[1z12]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1z12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z12 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dg9\|1dg9]], [[3pnt\|3pnt]], [[1z13\|1z13]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z12 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z12 RCSB], [http://www.ebi.ac.uk/pdbsum/1z12 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z1/1z12_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The early transition metal oxoanions vanadate, molybdate, and tungstate are widely used inhibitors for phosphatase enzymes. These oxoanions could inhibit such enzymes by simply mimicking the tetrahedral geometry of phosphate ion. However, in some cases, the enzyme-inhibitor dissociation constants (Ki) for these oxoanions are much lower than that for phosphate. Such observations gave rise to the hypothesis that in some cases these transition metal oxoanions may inhibit phosphomonoesterases by forming complexes that resemble the trigonal bipyramidal geometry of the SN2(P) transition state. As a test of this, the crystal structures of a low molecular weight protein tyrosine phosphatase at pH 7.5 complexed with the inhibitors vanadate and molybdate were solved at 2.2 A resolution and compared to a newly refined 1.9 A structure of the enzyme. Geometric restraints on the oxoanions were relaxed during refinement in order to minimize model bias. Both inhibitors were bound at the active site, and the overall protein structures were left unchanged, although some small but significant side chain movements at the active site were observed. Vanadate ion formed a covalent linkage with the nucleophile Cys12 at the active site and exhibited a trigonal bipyramidal geometry. In contrast, simple tetrahedral geometry was observed for the weaker molybdate complex. These studies are consistent with the conclusion that vanadate inhibits tyrosine phosphatases by acting as a transition state analog. The structure of the vanadate complex may be expected to closely resemble the transition state for reactions catalyzed by protein tyrosine phosphatases.

-	~~{{STRUCTURE_1z12\| PDB=1z12 \| SCENE= }}~~	+	Crystal structure of bovine low molecular weight phosphotyrosyl phosphatase complexed with the transition state analog vanadate.,Zhang M, Zhou M, Van Etten RL, Stauffacher CV Biochemistry. 1997 Jan 7;36(1):15-23. PMID:8993313<ref>PMID:8993313</ref>

-	~~===Crystal Structure~~ of ~~Bovine Low Molecular Weight PTPase Complexed with Vanadate===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_8993313}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1z12]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1Z12 OCA].~~	+

	==See Also==		==See Also==
	*[[Acid phosphatase\|Acid phosphatase]]		*[[Acid phosphatase\|Acid phosphatase]]
	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]		*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:008993313<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Etten, R L.Van.]]		[[Category: Etten, R L.Van.]]

OCA at 21:36, 20 October 2012

OCA — Sat, 20 Oct 2012 21:36:48 GMT

←Older revision		Revision as of 21:36, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1z12]] is a 1 chain structure ~~of [[Acid phosphatase]] and [[Tyrosine phosphatase]]~~ with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z12 OCA].	+	[[1z12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z12 OCA].

	==See Also==		==See Also==

OCA: Protected "1z12" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 13:45:33 GMT

Protected "1z12" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:45, 27 July 2012

OCA at 13:45, 27 July 2012

OCA — Fri, 27 Jul 2012 13:45:32 GMT

←Older revision		Revision as of 13:45, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1z12.png\|left\|200px]]		[[Image:1z12.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1z12", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_1z12\| PDB=1z12 \| SCENE= }}		{{STRUCTURE_1z12\| PDB=1z12 \| SCENE= }}

	===Crystal Structure of Bovine Low Molecular Weight PTPase Complexed with Vanadate===		===Crystal Structure of Bovine Low Molecular Weight PTPase Complexed with Vanadate===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_8993313}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 8993313 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_8993313}}		{{ABSTRACT_PUBMED_8993313}}

	==About this Structure==		==About this Structure==
-	~~1Z12~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z12 OCA].	+	[[1z12]] is a 1 chain structure of [[Acid phosphatase]] and [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z12 OCA].
		+
		+	==See Also==
		+	*[[Acid phosphatase\|Acid phosphatase]]
		+	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~8993313~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008993313</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Etten, R L.Van.]]		[[Category: Etten, R L.Van.]]
Line 32:		Line 24:
	[[Category: Ptpase]]		[[Category: Ptpase]]
	[[Category: Vanadate complex]]		[[Category: Vanadate complex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 07:12:42 2009''

OCA at 05:12, 18 February 2009

OCA — Wed, 18 Feb 2009 05:12:43 GMT

←Older revision		Revision as of 05:12, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1Z12 is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z12 OCA].	+	1Z12 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z12 OCA].

	==Reference==		==Reference==
-	Crystal structure of bovine low molecular weight phosphotyrosyl phosphatase complexed with the transition state analog vanadate., Zhang M, Zhou M, Van Etten RL, Stauffacher CV, Biochemistry. 1997 Jan 7;36(1):15-23. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/8993313 8993313]~~	+	<ref group="xtra">PMID:8993313</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: Single protein]]
	[[Category: Etten, R L.Van.]]		[[Category: Etten, R L.Van.]]
	[[Category: Stauffacher, C V.]]		[[Category: Stauffacher, C V.]]
Line 34:		Line 33:
	[[Category: Vanadate complex]]		[[Category: Vanadate complex]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 13~~:55:~~36 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 07:12:42 2009''