1z34 - Revision history

OCA at 07:03, 23 August 2023

OCA — Wed, 23 Aug 2023 07:03:16 GMT

←Older revision		Revision as of 07:03, 23 August 2023
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	<StructureSection load='1z34' size='340' side='right'caption='[[1z34]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1z34' size='340' side='right'caption='[[1z34]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1z34]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Triva Triva~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z34 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1z34]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trichomonas_vaginalis Trichomonas vaginalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z34 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=2FD:5-(6-AMINO~~-2~~-FLUORO-PURIN-9-YL)-2-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-OL'>2FD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1z33\|1z33]], [[1z35\|1z35]], [[1z36\|1z36]], [[1z37\|1z37]], [[1z38\|1z38]], [[1z39\|1z39]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2FD:5-(6-AMINO-2-FLUORO-PURIN-9-YL)-2-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-OL'>2FD</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Purine~~-~~nucleoside_phosphorylase Purine~~-~~nucleoside phosphorylase], with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=~~2~~.4.~~2~~.1 2.4.2.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z34 OCA], [https://pdbe.org/1z34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z34 RCSB], [https://www.ebi.ac.uk/pdbsum/1z34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z34 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z34 OCA], [https://pdbe.org/1z34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z34 RCSB], [https://www.ebi.ac.uk/pdbsum/1z34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z34 ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Purine-nucleoside phosphorylase]]~~	+	[[Category: Trichomonas vaginalis]]
-	~~[[Category: Triva~~]]	+	[[Category: Ealick SE]]
-	[[Category: Ealick~~, S E~~]]	+	[[Category: Wang CC]]
-	[[Category: Wang~~, C C~~]]	+	[[Category: Wang WH]]
-	[[Category: Wang~~, W H~~]]	+	[[Category: Wu SW]]
-	[[Category: Wu~~, S W~~]]	+	[[Category: Zhang Y]]
-	[[Category: Zhang, Y]]	+
-	~~[[Category: Alpha-beta-alpha sandwich]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 16:36, 3 November 2021

OCA — Wed, 03 Nov 2021 16:36:21 GMT

←Older revision		Revision as of 16:36, 3 November 2021
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	<StructureSection load='1z34' size='340' side='right'caption='[[1z34]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1z34' size='340' side='right'caption='[[1z34]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1z34]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Triva Triva]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z34 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Z34 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1z34]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Triva Triva]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z34 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2FD:5-(6-AMINO-2-FLUORO-PURIN-9-YL)-2-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-OL'>2FD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2FD:5-(6-AMINO-2-FLUORO-PURIN-9-YL)-2-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-OL'>2FD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z33\|1z33]], [[1z35\|1z35]], [[1z36\|1z36]], [[1z37\|1z37]], [[1z38\|1z38]], [[1z39\|1z39]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1z33\|1z33]], [[1z35\|1z35]], [[1z36\|1z36]], [[1z37\|1z37]], [[1z38\|1z38]], [[1z39\|1z39]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1z34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z34 OCA], [~~http~~://pdbe.org/1z34 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1z34 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1z34 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1z34 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z34 OCA], [https://pdbe.org/1z34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z34 RCSB], [https://www.ebi.ac.uk/pdbsum/1z34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z34 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 16:48, 29 January 2020

OCA — Wed, 29 Jan 2020 16:48:27 GMT

←Older revision		Revision as of 16:48, 29 January 2020
Line 1:		Line 1:

	==Crystal structure of Trichomonas vaginalis purine nucleoside phosphorylase complexed with 2-fluoro-2'-deoxyadenosine==		==Crystal structure of Trichomonas vaginalis purine nucleoside phosphorylase complexed with 2-fluoro-2'-deoxyadenosine==
-	<StructureSection load='1z34' size='340' side='right' caption='[[1z34]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='1z34' size='340' side='right'caption='[[1z34]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1z34]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Triva Triva]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z34 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1z34]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Triva Triva]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z34 FirstGlance]. <br>
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Purine nucleoside phosphorylase\|Purine nucleoside phosphorylase]]	+	*[[Purine nucleoside phosphorylase 3D structures\|Purine nucleoside phosphorylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Purine-nucleoside phosphorylase]]		[[Category: Purine-nucleoside phosphorylase]]
	[[Category: Triva]]		[[Category: Triva]]

OCA at 06:34, 25 April 2018

OCA — Wed, 25 Apr 2018 06:34:02 GMT

←Older revision		Revision as of 06:34, 25 April 2018
Line 1:		Line 1:
		+
	==Crystal structure of Trichomonas vaginalis purine nucleoside phosphorylase complexed with 2-fluoro-2'-deoxyadenosine==		==Crystal structure of Trichomonas vaginalis purine nucleoside phosphorylase complexed with 2-fluoro-2'-deoxyadenosine==
	<StructureSection load='1z34' size='340' side='right' caption='[[1z34]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1z34' size='340' side='right' caption='[[1z34]], [[Resolution\|resolution]] 2.40Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z33\|1z33]], [[1z35\|1z35]], [[1z36\|1z36]], [[1z37\|1z37]], [[1z38\|1z38]], [[1z39\|1z39]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z33\|1z33]], [[1z35\|1z35]], [[1z36\|1z36]], [[1z37\|1z37]], [[1z38\|1z38]], [[1z39\|1z39]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z34 OCA], [http://pdbe.org/1z34 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z34 RCSB], [http://www.ebi.ac.uk/pdbsum/1z34 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z34 OCA], [http://pdbe.org/1z34 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z34 RCSB], [http://www.ebi.ac.uk/pdbsum/1z34 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1z34 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z3/1z34_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z3/1z34_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 02:50, 10 February 2016

OCA — Wed, 10 Feb 2016 02:50:33 GMT

←Older revision		Revision as of 02:50, 10 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z34 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:38, 11 September 2015

OCA — Fri, 11 Sep 2015 04:38:59 GMT

←Older revision		Revision as of 04:38, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1z34' size='340' side='right' caption='[[1z34]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1z34' size='340' side='right' caption='[[1z34]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1z34]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Trichomonas_vaginalis Trichomonas vaginalis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z34 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1z34]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Triva Triva]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z34 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2FD:5-(6-AMINO-2-FLUORO-PURIN-9-YL)-2-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-OL'>2FD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2FD:5-(6-AMINO-2-FLUORO-PURIN-9-YL)-2-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-OL'>2FD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z33\|1z33]], [[1z35\|1z35]], [[1z36\|1z36]], [[1z37\|1z37]], [[1z38\|1z38]], [[1z39\|1z39]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z33\|1z33]], [[1z35\|1z35]], [[1z36\|1z36]], [[1z37\|1z37]], [[1z38\|1z38]], [[1z39\|1z39]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z34 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z34 RCSB], [http://www.ebi.ac.uk/pdbsum/1z34 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z34 OCA], [http://pdbe.org/1z34 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z34 RCSB], [http://www.ebi.ac.uk/pdbsum/1z34 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1z34" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Purine-nucleoside phosphorylase]]		[[Category: Purine-nucleoside phosphorylase]]
-	[[Category: ~~Trichomonas vaginalis~~]]	+	[[Category: Triva]]
	[[Category: Ealick, S E]]		[[Category: Ealick, S E]]
	[[Category: Wang, C C]]		[[Category: Wang, C C]]

OCA at 09:08, 8 January 2015

OCA — Thu, 08 Jan 2015 09:08:41 GMT

←Older revision		Revision as of 09:08, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1z34]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trichomonas_vaginalis Trichomonas vaginalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z34 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1z34]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trichomonas_vaginalis Trichomonas vaginalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z34 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2FD:5-(6-AMINO-2-FLUORO-PURIN-9-YL)-2-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-OL'>2FD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2FD:5-(6-AMINO-2-FLUORO-PURIN-9-YL)-2-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-OL'>2FD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z33\|1z33]], [[1z35\|1z35]], [[1z36\|1z36]], [[1z37\|1z37]], [[1z38\|1z38]], [[1z39\|1z39]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z33\|1z33]], [[1z35\|1z35]], [[1z36\|1z36]], [[1z37\|1z37]], [[1z38\|1z38]], [[1z39\|1z39]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z34 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z34 RCSB], [http://www.ebi.ac.uk/pdbsum/1z34 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z34 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z34 RCSB], [http://www.ebi.ac.uk/pdbsum/1z34 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Purine-nucleoside phosphorylase]]		[[Category: Purine-nucleoside phosphorylase]]
	[[Category: Trichomonas vaginalis]]		[[Category: Trichomonas vaginalis]]
-	[[Category: Ealick, S E.]]	+	[[Category: Ealick, S E]]
-	[[Category: Wang, C C.]]	+	[[Category: Wang, C C]]
-	[[Category: Wang, W H.]]	+	[[Category: Wang, W H]]
-	[[Category: Wu, S W.]]	+	[[Category: Wu, S W]]
-	[[Category: Zhang, Y.]]	+	[[Category: Zhang, Y]]
	[[Category: Alpha-beta-alpha sandwich]]		[[Category: Alpha-beta-alpha sandwich]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 18:27, 29 September 2014

OCA — Mon, 29 Sep 2014 18:27:45 GMT

←Older revision		Revision as of 18:27, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1z34.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of Trichomonas vaginalis purine nucleoside phosphorylase complexed with 2-fluoro-2'-deoxyadenosine==
		+	<StructureSection load='1z34' size='340' side='right' caption='[[1z34]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1z34]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trichomonas_vaginalis Trichomonas vaginalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z34 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2FD:5-(6-AMINO-2-FLUORO-PURIN-9-YL)-2-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-OL'>2FD</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z33\|1z33]], [[1z35\|1z35]], [[1z36\|1z36]], [[1z37\|1z37]], [[1z38\|1z38]], [[1z39\|1z39]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z34 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z34 RCSB], [http://www.ebi.ac.uk/pdbsum/1z34 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z3/1z34_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Trichomonas vaginalis is an anaerobic protozoan parasite that causes trichomoniasis, a common sexually transmitted disease with worldwide impact. One of the pivotal enzymes in its purine salvage pathway, purine nucleoside phosphorylase (PNP), shows physical properties and substrate specificities similar to those of the high molecular mass bacterial PNPs but differing from those of human PNP. While carrying out studies to identify inhibitors of T. vaginalis PNP (TvPNP), we discovered that the nontoxic nucleoside analogue 2-fluoro-2'-deoxyadenosine (F-dAdo) is a "subversive substrate." Phosphorolysis by TvPNP of F-dAdo, which is not a substrate for human PNP, releases highly cytotoxic 2-fluoroadenine (F-Ade). In vitro studies showed that both F-dAdo and F-Ade exert strong inhibition of T. vaginalis growth with estimated IC(50) values of 106 and 84 nm, respectively, suggesting that F-dAdo might be useful as a potential chemotherapeutic agent against T. vaginalis. To understand the basis of TvPNP specificity, the structures of TvPNP complexed with F-dAdo, 2-fluoroadenosine, formycin A, adenosine, inosine, or 2'-deoxyinosine were determined by x-ray crystallography with resolutions ranging from 2.4 to 2.9 A. These studies showed that the quaternary structure, monomer fold, and active site are similar to those of Escherichia coli PNP. The principal active site difference is at Thr-156, which is alanine in E. coli PNP. In the complex of TvPNP with F-dAdo, Thr-156 causes the purine base to tilt and shift by 0.5 A as compared with the binding scheme of F-dAdo in E. coli PNP. The structures of the TvPNP complexes suggest opportunities for further improved subversive substrates beyond F-dAdo.

-	~~{{STRUCTURE_1z34\| PDB=1z34 \| SCENE= }}~~	+	Identification of a subversive substrate of Trichomonas vaginalis purine nucleoside phosphorylase and the crystal structure of the enzyme-substrate complex.,Zang Y, Wang WH, Wu SW, Ealick SE, Wang CC J Biol Chem. 2005 Jun 10;280(23):22318-25. Epub 2005 Apr 7. PMID:15817485<ref>PMID:15817485</ref>

-	~~===Crystal structure~~ of ~~Trichomonas vaginalis purine nucleoside phosphorylase complexed with 2-fluoro-2'-deoxyadenosine===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_15817485}}~~	+	==See Also==
-		+	*[[Purine nucleoside phosphorylase\|Purine nucleoside phosphorylase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1z34~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trichomonas_vaginalis Trichomonas vaginalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z34 OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:015817485<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Purine-nucleoside phosphorylase]]		[[Category: Purine-nucleoside phosphorylase]]
	[[Category: Trichomonas vaginalis]]		[[Category: Trichomonas vaginalis]]

OCA: Protected "1z34" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 17:12:14 GMT

Protected "1z34" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:12, 5 January 2013

OCA at 17:12, 5 January 2013

OCA — Sat, 05 Jan 2013 17:12:13 GMT

←Older revision		Revision as of 17:12, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1z34.png\|left\|200px]]		[[Image:1z34.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1z34", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1z34\| PDB=1z34 \| SCENE= }}		{{STRUCTURE_1z34\| PDB=1z34 \| SCENE= }}

	===Crystal structure of Trichomonas vaginalis purine nucleoside phosphorylase complexed with 2-fluoro-2'-deoxyadenosine===		===Crystal structure of Trichomonas vaginalis purine nucleoside phosphorylase complexed with 2-fluoro-2'-deoxyadenosine===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15817485}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15817485 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15817485}}		{{ABSTRACT_PUBMED_15817485}}

	==About this Structure==		==About this Structure==
-	~~1Z34~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Trichomonas_vaginalis Trichomonas vaginalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z34 OCA].	+	[[1z34]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trichomonas_vaginalis Trichomonas vaginalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z34 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15817485~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015817485</ref><references group="xtra"/>
	[[Category: Purine-nucleoside phosphorylase]]		[[Category: Purine-nucleoside phosphorylase]]
	[[Category: Trichomonas vaginalis]]		[[Category: Trichomonas vaginalis]]
Line 32:		Line 20:
	[[Category: Zhang, Y.]]		[[Category: Zhang, Y.]]
	[[Category: Alpha-beta-alpha sandwich]]		[[Category: Alpha-beta-alpha sandwich]]
-		+	[[Category: Transferase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 14:49:12 2009''~~	+