1z4n - Revision history

OCA at 07:03, 23 August 2023

OCA — Wed, 23 Aug 2023 07:03:34 GMT

←Older revision		Revision as of 07:03, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1z4n' size='340' side='right'caption='[[1z4n]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='1z4n' size='340' side='right'caption='[[1z4n]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1z4n]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacterium_lactis"_lister_1873 "bacterium~~ lactis~~" lister 1873~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1Z4N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1z4n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z4N FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GL1:1~~-~~O-PHOSPHONO-ALPHA-D-GALACTOPYRANOSE'>GL1</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.97Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[1z4o\|1z4o]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GL1:1-O-PHOSPHONO-ALPHA-D-GALACTOPYRANOSE'>GL1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>pgmB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1358~~ "~~Bacterium lactis~~" ~~Lister 1873])</td~~><~~/tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4n OCA], [https://pdbe.org/1z4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z4n RCSB], [https://www.ebi.ac.uk/pdbsum/1z4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z4n ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/Beta-phosphoglucomutase Beta-phosphoglucomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.6 5.4.2.6]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1z4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4n OCA], [~~http~~://pdbe.org/1z4n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1z4n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1z4n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1z4n ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PGMB_LACLA PGMB_LACLA]] Catalyzes the interconversion of D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), forming beta-D-glucose 1,6-(bis)phosphate (beta-G16P) as an intermediate. The beta-phosphoglucomutase (Beta-PGM) acts on the beta-C(1) anomer of G1P. Glucose or lactose are used in preference to maltose, which is only utilized after glucose or lactose has been exhausted. It plays a key role in the regulation of the flow of carbohydrate intermediates in glycolysis and the formation of the sugar nucleotide UDP-glucose.<ref>PMID:9084169</ref> <ref>PMID:15005616</ref>	+	[https://www.uniprot.org/uniprot/PGMB_LACLA PGMB_LACLA] Catalyzes the interconversion of D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), forming beta-D-glucose 1,6-(bis)phosphate (beta-G16P) as an intermediate. The beta-phosphoglucomutase (Beta-PGM) acts on the beta-C(1) anomer of G1P. Glucose or lactose are used in preference to maltose, which is only utilized after glucose or lactose has been exhausted. It plays a key role in the regulation of the flow of carbohydrate intermediates in glycolysis and the formation of the sugar nucleotide UDP-glucose.<ref>PMID:9084169</ref> <ref>PMID:15005616</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacterium~~ lactis ~~lister 1873]]~~	+	[[Category: Lactococcus lactis]]
-	~~[[Category: Beta-phosphoglucomutase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Allen~~, K N~~]]	+	[[Category: Allen KN]]
-	[[Category: Dai, J]]	+	[[Category: Dai J]]
-	[[Category: Dunaway-Mariano, D]]	+	[[Category: Dunaway-Mariano D]]
-	[[Category: Tremblay~~, L W~~]]	+	[[Category: Tremblay LW]]
-	[[Category: Zhang, G]]	+	[[Category: Zhang G]]
-	~~[[Category: Isomerase~~]]	+

OCA at 08:57, 20 January 2021

OCA — Wed, 20 Jan 2021 08:57:48 GMT

←Older revision		Revision as of 08:57, 20 January 2021
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	==Structure of beta-phosphoglucomutase with inhibitor bound alpha-galactose 1-phosphate cocrystallized with Fluoride==		==Structure of beta-phosphoglucomutase with inhibitor bound alpha-galactose 1-phosphate cocrystallized with Fluoride==
-	<StructureSection load='1z4n' size='340' side='right' caption='[[1z4n]], [[Resolution\|resolution]] 1.97Å' scene=''>	+	<StructureSection load='1z4n' size='340' side='right'caption='[[1z4n]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1z4n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_lactis"_lister_1873 "bacterium lactis" lister 1873]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4N OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Z4N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1z4n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_lactis"_lister_1873 "bacterium lactis" lister 1873]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4N OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1Z4N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GL1:1-O-PHOSPHONO-ALPHA-D-GALACTOPYRANOSE'>GL1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GL1:1-O-PHOSPHONO-ALPHA-D-GALACTOPYRANOSE'>GL1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z4o\|1z4o]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1z4o\|1z4o]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pgmB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1358 "Bacterium lactis" Lister 1873])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pgmB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1358 "Bacterium lactis" Lister 1873])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-phosphoglucomutase Beta-phosphoglucomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.6 5.4.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-phosphoglucomutase Beta-phosphoglucomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.6 5.4.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1z4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4n OCA], [http://pdbe.org/1z4n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z4n RCSB], [http://www.ebi.ac.uk/pdbsum/1z4n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1z4n ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1z4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4n OCA], [http://pdbe.org/1z4n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z4n RCSB], [http://www.ebi.ac.uk/pdbsum/1z4n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1z4n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 1z4n" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1z4n" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-phosphoglucomutase 3D structures\|Beta-phosphoglucomutase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 40:
	[[Category: Bacterium lactis lister 1873]]		[[Category: Bacterium lactis lister 1873]]
	[[Category: Beta-phosphoglucomutase]]		[[Category: Beta-phosphoglucomutase]]
		+	[[Category: Large Structures]]
	[[Category: Allen, K N]]		[[Category: Allen, K N]]
	[[Category: Dai, J]]		[[Category: Dai, J]]

OCA at 06:35, 31 January 2018

OCA — Wed, 31 Jan 2018 06:35:36 GMT

←Older revision		Revision as of 06:35, 31 January 2018
Line 1:		Line 1:
		+
	==Structure of beta-phosphoglucomutase with inhibitor bound alpha-galactose 1-phosphate cocrystallized with Fluoride==		==Structure of beta-phosphoglucomutase with inhibitor bound alpha-galactose 1-phosphate cocrystallized with Fluoride==
	<StructureSection load='1z4n' size='340' side='right' caption='[[1z4n]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='1z4n' size='340' side='right' caption='[[1z4n]], [[Resolution\|resolution]] 1.97Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pgmB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1358 "Bacterium lactis" Lister 1873])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pgmB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1358 "Bacterium lactis" Lister 1873])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-phosphoglucomutase Beta-phosphoglucomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.6 5.4.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-phosphoglucomutase Beta-phosphoglucomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.6 5.4.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4n OCA], [http://pdbe.org/1z4n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z4n RCSB], [http://www.ebi.ac.uk/pdbsum/1z4n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4n OCA], [http://pdbe.org/1z4n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z4n RCSB], [http://www.ebi.ac.uk/pdbsum/1z4n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1z4n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z4/1z4n_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z4/1z4n_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z4n ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 30:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 1z4n" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1z4n" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Beta-phosphoglucomutase\|Beta-phosphoglucomutase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:34, 12 September 2015

OCA — Sat, 12 Sep 2015 01:34:11 GMT

←Older revision		Revision as of 01:34, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='1z4n' size='340' side='right' caption='[[1z4n]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='1z4n' size='340' side='right' caption='[[1z4n]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1z4n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Lactococcus_lactis Lactococcus~~ lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z4N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1z4n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_lactis"_lister_1873 "bacterium lactis" lister 1873]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z4N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GL1:1-O-PHOSPHONO-ALPHA-D-GALACTOPYRANOSE'>GL1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GL1:1-O-PHOSPHONO-ALPHA-D-GALACTOPYRANOSE'>GL1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z4o\|1z4o]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z4o\|1z4o]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pgmB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1358 ~~Lactococcus~~ lactis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pgmB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1358 "Bacterium lactis" Lister 1873])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-phosphoglucomutase Beta-phosphoglucomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.6 5.4.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-phosphoglucomutase Beta-phosphoglucomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.6 5.4.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z4n RCSB], [http://www.ebi.ac.uk/pdbsum/1z4n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4n OCA], [http://pdbe.org/1z4n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z4n RCSB], [http://www.ebi.ac.uk/pdbsum/1z4n PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1z4n" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacterium lactis lister 1873]]
	[[Category: Beta-phosphoglucomutase]]		[[Category: Beta-phosphoglucomutase]]
-	[[Category: Lactococcus lactis]]
	[[Category: Allen, K N]]		[[Category: Allen, K N]]
	[[Category: Dai, J]]		[[Category: Dai, J]]

OCA at 22:03, 25 December 2014

OCA — Thu, 25 Dec 2014 22:03:17 GMT

←Older revision		Revision as of 22:03, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1z4n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z4N FirstGlance]. <br>		<table><tr><td colspan='2'>[[1z4n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z4N FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GL1:1-O-PHOSPHONO-ALPHA-D-GALACTOPYRANOSE'>GL1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GL1:1-O-PHOSPHONO-ALPHA-D-GALACTOPYRANOSE'>GL1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z4o\|1z4o]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z4o\|1z4o]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pgmB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1358 Lactococcus lactis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pgmB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1358 Lactococcus lactis])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-phosphoglucomutase Beta-phosphoglucomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.6 5.4.2.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-phosphoglucomutase Beta-phosphoglucomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.6 5.4.2.6] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z4n RCSB], [http://www.ebi.ac.uk/pdbsum/1z4n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z4n RCSB], [http://www.ebi.ac.uk/pdbsum/1z4n PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PGMB_LACLA PGMB_LACLA]] Catalyzes the interconversion of D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), forming beta-D-glucose 1,6-(bis)phosphate (beta-G16P) as an intermediate. The beta-phosphoglucomutase (Beta-PGM) acts on the beta-C(1) anomer of G1P. Glucose or lactose are used in preference to maltose, which is only utilized after glucose or lactose has been exhausted. It plays a key role in the regulation of the flow of carbohydrate intermediates in glycolysis and the formation of the sugar nucleotide UDP-glucose.<ref>PMID:9084169</ref> <ref>PMID:15005616</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Beta-phosphoglucomutase]]		[[Category: Beta-phosphoglucomutase]]
	[[Category: Lactococcus lactis]]		[[Category: Lactococcus lactis]]
-	[[Category: Allen, K N.]]	+	[[Category: Allen, K N]]
-	[[Category: Dai, J.]]	+	[[Category: Dai, J]]
-	[[Category: Dunaway-Mariano, D.]]	+	[[Category: Dunaway-Mariano, D]]
-	[[Category: Tremblay, L W.]]	+	[[Category: Tremblay, L W]]
-	[[Category: Zhang, G~~.]]~~	+	[[Category: Zhang, G]]
-	~~[[Category: Beta-phosphoglucomutase~~]]	+
	[[Category: Isomerase]]		[[Category: Isomerase]]

OCA at 21:26, 29 September 2014

OCA — Mon, 29 Sep 2014 21:26:26 GMT

←Older revision		Revision as of 21:26, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1z4n.~~png~~\|~~left~~\|200px]]	+	==Structure of beta-phosphoglucomutase with inhibitor bound alpha-galactose 1-phosphate cocrystallized with Fluoride==
		+	<StructureSection load='1z4n' size='340' side='right' caption='[[1z4n]], [[Resolution\|resolution]] 1.97Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1z4n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z4N FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GL1:1-O-PHOSPHONO-ALPHA-D-GALACTOPYRANOSE'>GL1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z4o\|1z4o]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pgmB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1358 Lactococcus lactis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-phosphoglucomutase Beta-phosphoglucomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.6 5.4.2.6] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z4n RCSB], [http://www.ebi.ac.uk/pdbsum/1z4n PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z4/1z4n_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	This communication reports the X-ray crystal structure of the alpha-d-galactose-1-phosphate complex with that of Lactococcus lactis beta-phosphoglucomutase (beta-PGM) crystallized in the presence of Mg2+ cofactor and the enzyme-to-phosphorus ratio determined by protein and phosphate analyses of the crystalline complex. The 1:1 ratio determined for this complex was compared to the 1:2 ratio determined for the crystals of beta-PGM grown in the presence of substrate and Mg2+ cofactor. This result verifies the published structure assignment of this latter complex as the phosphorane adduct formed by covalent bonding between the active site Asp8 carboxylate to the C(1)phosphorus of the beta-glucose 1,6-bisphosphate ligand and rules out the proposal of a beta-PGM-glucose-6-phosphate-1-MgF3- complex.

-	~~{{STRUCTURE_1z4n\| PDB=1z4n \| SCENE= }}~~	+	Chemical confirmation of a pentavalent phosphorane in complex with beta-phosphoglucomutase.,Tremblay LW, Zhang G, Dai J, Dunaway-Mariano D, Allen KN J Am Chem Soc. 2005 Apr 20;127(15):5298-9. PMID:15826149<ref>PMID:15826149</ref>

-	~~===Structure~~ of ~~beta-phosphoglucomutase with inhibitor bound alpha-galactose 1-phosphate cocrystallized with Fluoride===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_15826149}}~~	+	==See Also==
-		+	*[[Beta-phosphoglucomutase\|Beta-phosphoglucomutase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1z4n~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4N OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:015826149<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Beta-phosphoglucomutase]]		[[Category: Beta-phosphoglucomutase]]
	[[Category: Lactococcus lactis]]		[[Category: Lactococcus lactis]]

OCA: Protected "1z4n" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 17:19:37 GMT

Protected "1z4n" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:19, 5 January 2013

OCA at 17:19, 5 January 2013

OCA — Sat, 05 Jan 2013 17:19:32 GMT

←Older revision		Revision as of 17:19, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1z4n.png\|left\|200px]]		[[Image:1z4n.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1z4n", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1z4n\| PDB=1z4n \| SCENE= }}		{{STRUCTURE_1z4n\| PDB=1z4n \| SCENE= }}

	===Structure of beta-phosphoglucomutase with inhibitor bound alpha-galactose 1-phosphate cocrystallized with Fluoride===		===Structure of beta-phosphoglucomutase with inhibitor bound alpha-galactose 1-phosphate cocrystallized with Fluoride===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15826149}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15826149 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15826149}}		{{ABSTRACT_PUBMED_15826149}}

	==About this Structure==		==About this Structure==
-	~~1Z4N~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4N OCA].	+	[[1z4n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4N OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15826149~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015826149</ref><references group="xtra"/>
	[[Category: Beta-phosphoglucomutase]]		[[Category: Beta-phosphoglucomutase]]
	[[Category: Lactococcus lactis]]		[[Category: Lactococcus lactis]]
Line 33:		Line 21:
	[[Category: Beta-phosphoglucomutase]]		[[Category: Beta-phosphoglucomutase]]
	[[Category: Isomerase]]		[[Category: Isomerase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:15:26 2009''

OCA at 07:15, 18 February 2009

OCA — Wed, 18 Feb 2009 07:15:29 GMT

←Older revision		Revision as of 07:15, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1Z4N is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4N OCA].	+	1Z4N is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4N OCA].

	==Reference==		==Reference==
-	~~Chemical confirmation of a pentavalent phosphorane in complex with beta-phosphoglucomutase., Tremblay LW, Zhang G, Dai J, Dunaway-Mariano D, Allen KN, J Am Chem Soc. 2005 Apr 20;127(15):5298-9.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/15826149 15826149]~~	+	<ref group="xtra">PMID:15826149</ref><references group="xtra"/>
	[[Category: Beta-phosphoglucomutase]]		[[Category: Beta-phosphoglucomutase]]
	[[Category: Lactococcus lactis]]		[[Category: Lactococcus lactis]]
-	[[Category: Single protein]]
	[[Category: Allen, K N.]]		[[Category: Allen, K N.]]
	[[Category: Dai, J.]]		[[Category: Dai, J.]]
Line 35:		Line 34:
	[[Category: Isomerase]]		[[Category: Isomerase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 15~~:29:~~46 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:15:26 2009''

OCA at 12:29, 29 July 2008

OCA — Tue, 29 Jul 2008 12:29:50 GMT

←Older revision		Revision as of 12:29, 29 July 2008
Line 1:		Line 1:
-	[[Image:1z4n.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1z4n.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1z4n\| PDB=1z4n \| SCENE= }}		{{STRUCTURE_1z4n\| PDB=1z4n \| SCENE= }}

-	~~'''~~Structure of beta-phosphoglucomutase with inhibitor bound alpha-galactose 1-phosphate cocrystallized with Fluoride~~'''~~	+	===Structure of beta-phosphoglucomutase with inhibitor bound alpha-galactose 1-phosphate cocrystallized with Fluoride===


-	~~==Overview==~~	+	<!--
-	~~This communication reports the X~~-~~ray crystal structure of the alpha~~-d-galactose-1-phosphate complex with that of Lactococcus lactis beta-phosphoglucomutase (beta-PGM) crystallized in the presence of Mg2+ cofactor and the enzyme-to-phosphorus ratio determined by protein and phosphate analyses of the crystalline complex. The ~~1:1 ratio determined for~~ this ~~complex was compared~~ to the 1:~~2 ratio determined for the crystals of beta-PGM grown in the presence of substrate and Mg2+ cofactor~~. ~~This result verifies the published structure assignment of this latter complex as the phosphorane adduct formed by covalent bonding between the active site Asp8 carboxylate to the C(1~~)~~phosphorus of the beta-glucose 1~~,~~6-bisphosphate ligand and rules out~~ the ~~proposal of a beta~~-~~PGM~~-~~glucose-6-phosphate-1-MgF3- complex.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_15826149}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 15826149 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_15826149}}

	==About this Structure==		==About this Structure==
Line 30:		Line 34:
	[[Category: Beta-phosphoglucomutase]]		[[Category: Beta-phosphoglucomutase]]
	[[Category: Isomerase]]		[[Category: Isomerase]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 17~~:10:21 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:29:46 2008''