1z5l - Revision history

OCA at 07:04, 23 August 2023

OCA — Wed, 23 Aug 2023 07:04:09 GMT

←Older revision		Revision as of 07:04, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1z5l' size='340' side='right'caption='[[1z5l]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1z5l' size='340' side='right'caption='[[1z5l]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1z5l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z5L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z5L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1z5l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z5L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z5L FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PBS:(2S,3S,4R)-N-OCTANOYL-1-[(ALPHA-D-GALACTOPYRANOSYL)OXY]-2-AMINO-OCTADECANE-3,4-DIOL'>PBS</scene>, <scene name='pdbligand=R16:HEXADECANE'>R16</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1cd1\|1cd1]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PBS:(2S,3S,4R)-N-OCTANOYL-1-[(ALPHA-D-GALACTOPYRANOSYL)OXY]-2-AMINO-OCTADECANE-3,4-DIOL'>PBS</scene>, <scene name='pdbligand=R16:HEXADECANE'>R16</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z5l OCA], [https://pdbe.org/1z5l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z5l RCSB], [https://www.ebi.ac.uk/pdbsum/1z5l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z5l ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z5l OCA], [https://pdbe.org/1z5l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z5l RCSB], [https://www.ebi.ac.uk/pdbsum/1z5l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z5l ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CD1D1_MOUSE CD1D1_MOUSE] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:11754812</ref> <ref>PMID:16314439</ref> <ref>PMID:16007091</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Bendelac, A]]	+	[[Category: Bendelac A]]
-	[[Category: Cantu, C]]	+	[[Category: Cantu C]]
-	[[Category: Mattner, J]]	+	[[Category: Mattner J]]
-	[[Category: Savage~~, P B~~]]	+	[[Category: Savage PB]]
-	[[Category: Teyton, L]]	+	[[Category: Teyton L]]
-	[[Category: Wilson~~, I A~~]]	+	[[Category: Wilson IA]]
-	[[Category: Zajonc~~, D M~~]]	+	[[Category: Zajonc DM]]
-	[[Category: Zhou, D]]	+	[[Category: Zhou D]]
-	~~[[Category: Ig fold]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Mhc fold~~]]	+

OCA at 08:17, 10 November 2021

OCA — Wed, 10 Nov 2021 08:17:40 GMT

←Older revision		Revision as of 08:17, 10 November 2021
Line 3:		Line 3:
	<StructureSection load='1z5l' size='340' side='right'caption='[[1z5l]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1z5l' size='340' side='right'caption='[[1z5l]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1z5l]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z5L OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Z5L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1z5l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z5L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z5L FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PBS:(2S,3S,4R)-N-OCTANOYL-1-[(ALPHA-D-GALACTOPYRANOSYL)OXY]-2-AMINO-OCTADECANE-3,4-DIOL'>PBS</scene>, <scene name='pdbligand=R16:HEXADECANE'>R16</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PBS:(2S,3S,4R)-N-OCTANOYL-1-[(ALPHA-D-GALACTOPYRANOSYL)OXY]-2-AMINO-OCTADECANE-3,4-DIOL'>PBS</scene>, <scene name='pdbligand=R16:HEXADECANE'>R16</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cd1\|1cd1]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1cd1\|1cd1]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1z5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z5l OCA], [~~http~~://pdbe.org/1z5l PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1z5l RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1z5l PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1z5l ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z5l OCA], [https://pdbe.org/1z5l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z5l RCSB], [https://www.ebi.ac.uk/pdbsum/1z5l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z5l ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 09:35, 5 February 2020

OCA — Wed, 05 Feb 2020 09:35:34 GMT

←Older revision		Revision as of 09:35, 5 February 2020
Line 1:		Line 1:

	==Structure of a highly potent short-chain galactosyl ceramide agonist bound to CD1D==		==Structure of a highly potent short-chain galactosyl ceramide agonist bound to CD1D==
-	<StructureSection load='1z5l' size='340' side='right' caption='[[1z5l]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='1z5l' size='340' side='right'caption='[[1z5l]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1z5l]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z5L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z5L FirstGlance]. <br>		<table><tr><td colspan='2'>[[1z5l]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z5L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z5L FirstGlance]. <br>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1z5l" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1z5l" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
		+	*[[CD1\|CD1]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Bendelac, A]]		[[Category: Bendelac, A]]

OCA at 09:00, 2 May 2018

OCA — Wed, 02 May 2018 09:00:56 GMT

←Older revision		Revision as of 09:00, 2 May 2018
Line 1:		Line 1:
		+
	==Structure of a highly potent short-chain galactosyl ceramide agonist bound to CD1D==		==Structure of a highly potent short-chain galactosyl ceramide agonist bound to CD1D==
	<StructureSection load='1z5l' size='340' side='right' caption='[[1z5l]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1z5l' size='340' side='right' caption='[[1z5l]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PBS:(2S,3S,4R)-N-OCTANOYL-1-[(ALPHA-D-GALACTOPYRANOSYL)OXY]-2-AMINO-OCTADECANE-3,4-DIOL'>PBS</scene>, <scene name='pdbligand=R16:HEXADECANE'>R16</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PBS:(2S,3S,4R)-N-OCTANOYL-1-[(ALPHA-D-GALACTOPYRANOSYL)OXY]-2-AMINO-OCTADECANE-3,4-DIOL'>PBS</scene>, <scene name='pdbligand=R16:HEXADECANE'>R16</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cd1\|1cd1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cd1\|1cd1]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z5l OCA], [http://pdbe.org/1z5l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z5l RCSB], [http://www.ebi.ac.uk/pdbsum/1z5l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z5l OCA], [http://pdbe.org/1z5l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z5l RCSB], [http://www.ebi.ac.uk/pdbsum/1z5l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1z5l ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z5/1z5l_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z5/1z5l_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 26:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1z5l" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1z5l" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
-	*[[CD1\|CD1]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:26, 8 February 2016

OCA — Mon, 08 Feb 2016 09:26:11 GMT

←Older revision		Revision as of 09:26, 8 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z5l ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:11, 10 September 2015

OCA — Thu, 10 Sep 2015 10:11:11 GMT

←Older revision		Revision as of 10:11, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1z5l' size='340' side='right' caption='[[1z5l]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1z5l' size='340' side='right' caption='[[1z5l]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1z5l]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z5L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z5L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1z5l]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z5L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z5L FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PBS:(2S,3S,4R)-N-OCTANOYL-1-[(ALPHA-D-GALACTOPYRANOSYL)OXY]-2-AMINO-OCTADECANE-3,4-DIOL'>PBS</scene>, <scene name='pdbligand=R16:HEXADECANE'>R16</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PBS:(2S,3S,4R)-N-OCTANOYL-1-[(ALPHA-D-GALACTOPYRANOSYL)OXY]-2-AMINO-OCTADECANE-3,4-DIOL'>PBS</scene>, <scene name='pdbligand=R16:HEXADECANE'>R16</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cd1\|1cd1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cd1\|1cd1]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z5l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z5l RCSB], [http://www.ebi.ac.uk/pdbsum/1z5l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z5l OCA], [http://pdbe.org/1z5l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z5l RCSB], [http://www.ebi.ac.uk/pdbsum/1z5l PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1z5l" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Bendelac, A]]		[[Category: Bendelac, A]]
	[[Category: Cantu, C]]		[[Category: Cantu, C]]

OCA at 09:16, 8 January 2015

OCA — Thu, 08 Jan 2015 09:16:11 GMT

←Older revision		Revision as of 09:16, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1z5l]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z5L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z5L FirstGlance]. <br>		<table><tr><td colspan='2'>[[1z5l]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z5L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z5L FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PBS:(2S,3S,4R)-N-OCTANOYL-1-[(ALPHA-D-GALACTOPYRANOSYL)OXY]-2-AMINO-OCTADECANE-3,4-DIOL'>PBS</scene>, <scene name='pdbligand=R16:HEXADECANE'>R16</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PBS:(2S,3S,4R)-N-OCTANOYL-1-[(ALPHA-D-GALACTOPYRANOSYL)OXY]-2-AMINO-OCTADECANE-3,4-DIOL'>PBS</scene>, <scene name='pdbligand=R16:HEXADECANE'>R16</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cd1\|1cd1]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cd1\|1cd1]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z5l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z5l RCSB], [http://www.ebi.ac.uk/pdbsum/1z5l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z5l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z5l RCSB], [http://www.ebi.ac.uk/pdbsum/1z5l PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Bendelac, A.]]	+	[[Category: Bendelac, A]]
-	[[Category: Cantu, C.]]	+	[[Category: Cantu, C]]
-	[[Category: Mattner, J.]]	+	[[Category: Mattner, J]]
-	[[Category: Savage, P B.]]	+	[[Category: Savage, P B]]
-	[[Category: Teyton, L.]]	+	[[Category: Teyton, L]]
-	[[Category: Wilson, I A.]]	+	[[Category: Wilson, I A]]
-	[[Category: Zajonc, D M.]]	+	[[Category: Zajonc, D M]]
-	[[Category: Zhou, D.]]	+	[[Category: Zhou, D]]
	[[Category: Ig fold]]		[[Category: Ig fold]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Mhc fold]]		[[Category: Mhc fold]]

OCA at 19:32, 28 September 2014

OCA — Sun, 28 Sep 2014 19:32:55 GMT

←Older revision		Revision as of 19:32, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1z5l.~~png~~\|~~left~~\|200px]]	+	==Structure of a highly potent short-chain galactosyl ceramide agonist bound to CD1D==
		+	<StructureSection load='1z5l' size='340' side='right' caption='[[1z5l]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1z5l]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z5L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z5L FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PBS:(2S,3S,4R)-N-OCTANOYL-1-[(ALPHA-D-GALACTOPYRANOSYL)OXY]-2-AMINO-OCTADECANE-3,4-DIOL'>PBS</scene>, <scene name='pdbligand=R16:HEXADECANE'>R16</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cd1\|1cd1]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z5l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z5l RCSB], [http://www.ebi.ac.uk/pdbsum/1z5l PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z5/1z5l_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Natural killer T cells express a conserved, semi-invariant alphabeta T cell receptor that has specificity for self glycosphingolipids and microbial cell wall alpha-glycuronosylceramide antigens presented by CD1d molecules. Here we report the crystal structure of CD1d in complex with a short-chain synthetic variant of alpha-galactosylceramide at a resolution of 2.2 A. This structure elucidates the basis for the high specificity of these microbial ligands and explains the restriction of the alpha-linkage as a unique pathogen-specific pattern-recognition motif. Comparison of the binding of altered lipid ligands to CD1d and T cell receptors suggested that the differential T helper type 1-like and T helper type 2-like properties of natural killer T cells may originate largely from differences in their 'loading' in different cell types and hence in their tissue distribution in vivo.

-	~~{{STRUCTURE_1z5l\| PDB=1z5l \| SCENE= }}~~	+	Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor.,Zajonc DM, Cantu C 3rd, Mattner J, Zhou D, Savage PB, Bendelac A, Wilson IA, Teyton L Nat Immunol. 2005 Aug;6(8):810-8. Epub 2005 Jul 10. PMID:16007091<ref>PMID:16007091</ref>

-	~~===Structure~~ of ~~a highly potent short-chain galactosyl ceramide agonist bound to CD1D===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16007091}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1z5l]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1Z5L OCA].~~	+

	==See Also==		==See Also==
	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]		*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
-		+	*[[CD1\|CD1]]
-	==~~Reference~~==	+	== References ==
-	<~~ref group="xtra">PMID:016007091<~~/~~ref~~><~~references group="xtra"~~/>	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Bendelac, A.]]		[[Category: Bendelac, A.]]

OCA at 09:41, 20 October 2012

OCA — Sat, 20 Oct 2012 09:41:59 GMT

←Older revision		Revision as of 09:41, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1z5l]] is a 4 chain structure ~~of [[Beta-2 microglobulin]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z5L OCA].	+	[[1z5l]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z5L OCA].

	==See Also==		==See Also==

OCA: Protected "1z5l" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 23:41:46 GMT

Protected "1z5l" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:41, 25 July 2012