1z7d - Revision history

OCA at 07:05, 23 August 2023

OCA — Wed, 23 Aug 2023 07:05:11 GMT

←Older revision		Revision as of 07:05, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1z7d' size='340' side='right'caption='[[1z7d]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1z7d' size='340' side='right'caption='[[1z7d]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1z7d]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Playo Playo~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z7D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1z7d]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii Plasmodium yoelii yoelii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z7D FirstGlance]. <br>
-	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>[~~https://en.wikipedia.org/wiki/Ornithine_aminotransferase Ornithine aminotransferase~~]~~, with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=~~2.6.1~~.13 2.6.1.13] </span>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7d OCA], [https://pdbe.org/1z7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z7d RCSB], [https://www.ebi.ac.uk/pdbsum/1z7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z7d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7d OCA], [https://pdbe.org/1z7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z7d RCSB], [https://www.ebi.ac.uk/pdbsum/1z7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z7d ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/OAT_PLAYO OAT_PLAYO]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Ornithine aminotransferase]]~~	+	[[Category: Plasmodium yoelii yoelii]]
-	~~[[Category: Playo~~]]	+	[[Category: Alam Z]]
-	[[Category: Alam, Z]]	+	[[Category: Amani M]]
-	[[Category: Amani, M]]	+	[[Category: Arrowsmith C]]
-	[[Category: Arrowsmith, C]]	+	[[Category: Bochkarev A]]
-	[[Category: Bochkarev, A]]	+	[[Category: Boulanger K]]
-	[[Category: Boulanger, K]]	+	[[Category: Edwards A]]
-	[[Category: Edwards, A]]	+	[[Category: Hui R]]
-	[[Category: Hui, R]]	+	[[Category: Lew J]]
-	[[Category: Lew, J]]	+	[[Category: Sundstrom M]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Vedadi M]]
-	[[Category: Sundstrom, M]]	+	[[Category: Walker JR]]
-	[[Category: Vedadi, M]]	+	[[Category: Wasney G]]
-	[[Category: Walker~~, J R~~]]	+	[[Category: Weigelt J]]
-	[[Category: Wasney, G]]	+
-	[[Category: Weigelt, J]]	+
-	~~[[Category: Malaria]]~~	+
-	~~[[Category: Plasmodium yoelii]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:18, 10 November 2021

OCA — Wed, 10 Nov 2021 08:18:12 GMT

←Older revision		Revision as of 08:18, 10 November 2021
Line 3:		Line 3:
	<StructureSection load='1z7d' size='340' side='right'caption='[[1z7d]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1z7d' size='340' side='right'caption='[[1z7d]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1z7d]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Playo Playo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Z7D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1z7d]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Playo Playo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z7D FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Ornithine_aminotransferase Ornithine aminotransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.13 2.6.1.13] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ornithine_aminotransferase Ornithine aminotransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.13 2.6.1.13] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1z7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7d OCA], [~~http~~://pdbe.org/1z7d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1z7d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1z7d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1z7d ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7d OCA], [https://pdbe.org/1z7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z7d RCSB], [https://www.ebi.ac.uk/pdbsum/1z7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z7d ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 09:35, 5 February 2020

OCA — Wed, 05 Feb 2020 09:35:16 GMT

←Older revision		Revision as of 09:35, 5 February 2020
Line 1:		Line 1:

	==Ornithine aminotransferase PY00104 from Plasmodium Yoelii==		==Ornithine aminotransferase PY00104 from Plasmodium Yoelii==
-	<StructureSection load='1z7d' size='340' side='right' caption='[[1z7d]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='1z7d' size='340' side='right'caption='[[1z7d]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1z7d]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Playo Playo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z7D FirstGlance]. <br>		<table><tr><td colspan='2'>[[1z7d]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Playo Playo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z7D FirstGlance]. <br>
Line 30:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Ornithine aminotransferase]]		[[Category: Ornithine aminotransferase]]
	[[Category: Playo]]		[[Category: Playo]]

OCA at 09:00, 2 May 2018

OCA — Wed, 02 May 2018 09:00:44 GMT

←Older revision		Revision as of 09:00, 2 May 2018
Line 1:		Line 1:
		+
	==Ornithine aminotransferase PY00104 from Plasmodium Yoelii==		==Ornithine aminotransferase PY00104 from Plasmodium Yoelii==
	<StructureSection load='1z7d' size='340' side='right' caption='[[1z7d]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1z7d' size='340' side='right' caption='[[1z7d]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1z7d]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Playo Playo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z7D FirstGlance]. <br>		<table><tr><td colspan='2'>[[1z7d]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Playo Playo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z7D FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ornithine_aminotransferase Ornithine aminotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.13 2.6.1.13] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ornithine_aminotransferase Ornithine aminotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.13 2.6.1.13] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7d OCA], [http://pdbe.org/1z7d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z7d RCSB], [http://www.ebi.ac.uk/pdbsum/1z7d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7d OCA], [http://pdbe.org/1z7d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z7d RCSB], [http://www.ebi.ac.uk/pdbsum/1z7d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1z7d ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z7/1z7d_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z7/1z7d_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z7d ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 14:31, 11 September 2015

OCA — Fri, 11 Sep 2015 14:31:08 GMT

←Older revision		Revision as of 14:31, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1z7d' size='340' side='right' caption='[[1z7d]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1z7d' size='340' side='right' caption='[[1z7d]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1z7d]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_yoelii_yoelii Plasmodium yoelii yoelii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z7D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1z7d]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Playo Playo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z7D FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ornithine_aminotransferase Ornithine aminotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.13 2.6.1.13] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ornithine_aminotransferase Ornithine aminotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.13 2.6.1.13] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z7d RCSB], [http://www.ebi.ac.uk/pdbsum/1z7d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7d OCA], [http://pdbe.org/1z7d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z7d RCSB], [http://www.ebi.ac.uk/pdbsum/1z7d PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1z7d" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Ornithine aminotransferase]]		[[Category: Ornithine aminotransferase]]
-	[[Category: ~~Plasmodium yoelii yoelii~~]]	+	[[Category: Playo]]
	[[Category: Alam, Z]]		[[Category: Alam, Z]]
	[[Category: Amani, M]]		[[Category: Amani, M]]

OCA at 10:13, 8 January 2015

OCA — Thu, 08 Jan 2015 10:13:57 GMT

←Older revision		Revision as of 10:13, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1z7d]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii Plasmodium yoelii yoelii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z7D FirstGlance]. <br>		<table><tr><td colspan='2'>[[1z7d]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii Plasmodium yoelii yoelii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z7D FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ornithine_aminotransferase Ornithine aminotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.13 2.6.1.13] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ornithine_aminotransferase Ornithine aminotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.13 2.6.1.13] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z7d RCSB], [http://www.ebi.ac.uk/pdbsum/1z7d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z7d RCSB], [http://www.ebi.ac.uk/pdbsum/1z7d PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	[[Category: Ornithine aminotransferase]]		[[Category: Ornithine aminotransferase]]
	[[Category: Plasmodium yoelii yoelii]]		[[Category: Plasmodium yoelii yoelii]]
-	[[Category: Alam, Z.]]	+	[[Category: Alam, Z]]
-	[[Category: Amani, M.]]	+	[[Category: Amani, M]]
-	[[Category: Arrowsmith, C.]]	+	[[Category: Arrowsmith, C]]
-	[[Category: Bochkarev, A.]]	+	[[Category: Bochkarev, A]]
-	[[Category: Boulanger, K.]]	+	[[Category: Boulanger, K]]
-	[[Category: Edwards, A.]]	+	[[Category: Edwards, A]]
-	[[Category: Hui, R.]]	+	[[Category: Hui, R]]
-	[[Category: Lew, J.]]	+	[[Category: Lew, J]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Sundstrom, M.]]	+	[[Category: Sundstrom, M]]
-	[[Category: Vedadi, M.]]	+	[[Category: Vedadi, M]]
-	[[Category: Walker, J R.]]	+	[[Category: Walker, J R]]
-	[[Category: Wasney, G.]]	+	[[Category: Wasney, G]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
	[[Category: Malaria]]		[[Category: Malaria]]
-	[[Category: Ornithine aminotransferase]]
	[[Category: Plasmodium yoelii]]		[[Category: Plasmodium yoelii]]
	[[Category: Sgc]]		[[Category: Sgc]]
-	[[Category: Structural genomics consortium]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 20:55, 29 September 2014

OCA — Mon, 29 Sep 2014 20:55:27 GMT

←Older revision		Revision as of 20:55, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1z7d.~~png\|left~~\|200px]]	+	==Ornithine aminotransferase PY00104 from Plasmodium Yoelii==
		+	<StructureSection load='1z7d' size='340' side='right' caption='[[1z7d]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1z7d]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii Plasmodium yoelii yoelii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z7D FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ornithine_aminotransferase Ornithine aminotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.13 2.6.1.13] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z7d RCSB], [http://www.ebi.ac.uk/pdbsum/1z7d PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z7/1z7d_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Parasites from the protozoan phylum Apicomplexa are responsible for diseases, such as malaria, toxoplasmosis and cryptosporidiosis, all of which have significantly higher rates of mortality and morbidity in economically underdeveloped regions of the world. Advances in vaccine development and drug discovery are urgently needed to control these diseases and can be facilitated by production of purified recombinant proteins from Apicomplexan genomes and determination of their 3D structures. To date, both heterologous expression and crystallization of Apicomplexan proteins have seen only limited success. In an effort to explore the effectiveness of producing and crystallizing proteins on a genome-scale using a standardized methodology, over 400 distinct Plasmodium falciparum target genes were chosen representing different cellular classes, along with select orthologues from four other Plasmodium species as well as Cryptosporidium parvum and Toxoplasma gondii. From a total of 1008 genes from the seven genomes, 304 (30.2%) produced purified soluble proteins and 97 (9.6%) crystallized, culminating in 36 crystal structures. These results demonstrate that, contrary to previous findings, a standardized platform using Escherichia coli can be effective for genome-scale production and crystallography of Apicomplexan proteins. Predictably, orthologous proteins from different Apicomplexan genomes behaved differently in expression, purification and crystallization, although the overall success rates of Plasmodium orthologues do not differ significantly. Their differences were effectively exploited to elevate the overall productivity to levels comparable to the most successful ongoing structural genomics projects: 229 of the 468 target genes produced purified soluble protein from one or more organisms, with 80 and 32 of the purified targets, respectively, leading to crystals and ultimately structures from one or more orthologues.

-	~~{{STRUCTURE_1z7d\| PDB=1z7d \| SCENE= }}~~	+	Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.,Vedadi M, Lew J, Artz J, Amani M, Zhao Y, Dong A, Wasney GA, Gao M, Hills T, Brokx S, Qiu W, Sharma S, Diassiti A, Alam Z, Melone M, Mulichak A, Wernimont A, Bray J, Loppnau P, Plotnikova O, Newberry K, Sundararajan E, Houston S, Walker J, Tempel W, Bochkarev A, Kozieradzki I, Edwards A, Arrowsmith C, Roos D, Kain K, Hui R Mol Biochem Parasitol. 2007 Jan;151(1):100-10. Epub 2006 Nov 13. PMID:17125854<ref>PMID:17125854</ref>

-	~~===Ornithine aminotransferase PY00104 from Plasmodium Yoelii===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17125854}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1z7d]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Plasmodium_yoelii_yoelii Plasmodium yoelii yoelii]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7D OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017125854<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Ornithine aminotransferase]]		[[Category: Ornithine aminotransferase]]
	[[Category: Plasmodium yoelii yoelii]]		[[Category: Plasmodium yoelii yoelii]]

OCA: Protected "1z7d" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 17:17:38 GMT

Protected "1z7d" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:17, 5 January 2013

OCA at 17:17, 5 January 2013

OCA — Sat, 05 Jan 2013 17:17:37 GMT

←Older revision		Revision as of 17:17, 5 January 2013
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-	{{Seed}}
	[[Image:1z7d.png\|left\|200px]]		[[Image:1z7d.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1z7d", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1z7d\| PDB=1z7d \| SCENE= }}		{{STRUCTURE_1z7d\| PDB=1z7d \| SCENE= }}

	===Ornithine aminotransferase PY00104 from Plasmodium Yoelii===		===Ornithine aminotransferase PY00104 from Plasmodium Yoelii===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17125854}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17125854 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17125854}}		{{ABSTRACT_PUBMED_17125854}}

	==About this Structure==		==About this Structure==
-	~~1Z7D~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii Plasmodium yoelii yoelii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7D OCA].	+	[[1z7d]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii Plasmodium yoelii yoelii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7D OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17125854~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017125854</ref><references group="xtra"/>
	[[Category: Ornithine aminotransferase]]		[[Category: Ornithine aminotransferase]]
	[[Category: Plasmodium yoelii yoelii]]		[[Category: Plasmodium yoelii yoelii]]
Line 45:		Line 33:
	[[Category: Sgc]]		[[Category: Sgc]]
	[[Category: Structural genomics consortium]]		[[Category: Structural genomics consortium]]
-		+	[[Category: Transferase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 00:35:15 2009''~~	+

OCA at 22:35, 17 February 2009

OCA — Tue, 17 Feb 2009 22:35:15 GMT

←Older revision		Revision as of 22:35, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1Z7D is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii Plasmodium yoelii yoelii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7D OCA].	+	1Z7D is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii Plasmodium yoelii yoelii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7D OCA].

	==Reference==		==Reference==
-	Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms., Vedadi M, Lew J, Artz J, Amani M, Zhao Y, Dong A, Wasney GA, Gao M, Hills T, Brokx S, Qiu W, Sharma S, Diassiti A, Alam Z, Melone M, Mulichak A, Wernimont A, Bray J, Loppnau P, Plotnikova O, Newberry K, Sundararajan E, Houston S, Walker J, Tempel W, Bochkarev A, Kozieradzki I, Edwards A, Arrowsmith C, Roos D, Kain K, Hui R, Mol Biochem Parasitol. 2007 Jan;151(1):100-10. Epub 2006 Nov 13. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17125854 17125854]~~	+	<ref group="xtra">PMID:17125854</ref><references group="xtra"/>
	[[Category: Ornithine aminotransferase]]		[[Category: Ornithine aminotransferase]]
	[[Category: Plasmodium yoelii yoelii]]		[[Category: Plasmodium yoelii yoelii]]
-	[[Category: Single protein]]
	[[Category: Alam, Z.]]		[[Category: Alam, Z.]]
	[[Category: Amani, M.]]		[[Category: Amani, M.]]
Line 47:		Line 46:
	[[Category: Structural genomics consortium]]		[[Category: Structural genomics consortium]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 07~~:59:~~34 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:35:15 2009''