1z7z - Revision history

OCA at 08:09, 15 May 2024

OCA — Wed, 15 May 2024 08:09:42 GMT

←Older revision		Revision as of 08:09, 15 May 2024
Line 3:		Line 3:
	<SX load='1z7z' size='340' side='right' viewer='molstar' caption='[[1z7z]], [[Resolution\|resolution]] 8.00Å' scene=''>		<SX load='1z7z' size='340' side='right' viewer='molstar' caption='[[1z7z]], [[Resolution\|resolution]] 8.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1z7z]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [https://en.wikipedia.org/wiki/~~Human_coxsackievirus_a21 Human coxsackievirus a21~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z7Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1z7z]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus_A21 Coxsackievirus A21] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z7Z FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1iam\|1iam]], [[1z7s\|1z7s]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7z OCA], [https://pdbe.org/1z7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z7z RCSB], [https://www.ebi.ac.uk/pdbsum/1z7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z7z ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7z OCA], [https://pdbe.org/1z7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z7z RCSB], [https://www.ebi.ac.uk/pdbsum/1z7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z7z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~ICAM1_HUMAN ICAM1_HUMAN~~]] ~~ICAM~~ proteins are ~~ligands for~~ the ~~leukocyte adhesion~~ protein ~~LFA~~-1 (~~integrin~~ alpha-~~L/beta-2~~). ~~During leukocyte trans-endothelial migration~~, ~~ICAM1 engagement promotes~~ the ~~assembly~~ of ~~endothelial apical cups~~ through ~~ARHGEF26/SGEF~~ and ~~RHOG activation~~. In ~~case~~ of ~~rhinovirus infection acts~~ as a ~~cellular receptor for~~ the ~~virus~~.~~<ref>PMID~~:~~2538243</ref> <ref>PMID~~:~~1968231</ref> <ref>PMID~~:~~11173916</ref> <ref>PMID~~:~~17875742</ref>~~	+	[https://www.uniprot.org/uniprot/Q7T7N6_9ENTO Q7T7N6_9ENTO] Capsid protein VP0: Component of immature procapsids, which is cleaved into capsid proteins VP4 and VP2 after maturation. Allows the capsid to remain inactive before the maturation step.[RuleBase:RU364118] Capsid protein VP1: Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome. Capsid protein VP1 mainly forms the vertices of the capsid. Capsid protein VP1 interacts with host cell receptor to provide virion attachment to target host cells. This attachment induces virion internalization. Tyrosine kinases are probably involved in the entry process. After binding to its receptor, the capsid undergoes conformational changes. Capsid protein VP1 N-terminus (that contains an amphipathic alpha-helix) and capsid protein VP4 are externalized. Together, they shape a pore in the host membrane through which viral genome is translocated to host cell cytoplasm. After genome has been released, the channel shrinks.[RuleBase:RU364118] Capsid protein VP2: Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome.[RuleBase:RU364118] Capsid protein VP3: Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome.[RuleBase:RU364118] Capsid protein VP4: Lies on the inner surface of the capsid shell. After binding to the host receptor, the capsid undergoes conformational changes. Capsid protein VP4 is released, Capsid protein VP1 N-terminus is externalized, and together, they shape a pore in the host membrane through which the viral genome is translocated into the host cell cytoplasm.[RuleBase:RU364118] Protease 2A: Cysteine protease that cleaves viral polyprotein and specific host proteins.[RuleBase:RU364118] Protease 3C: Major viral protease that mediates proteolytic processing of the polyprotein. Cleaves host EIF5B, contributing to host translation shutoff. Cleaves also host PABPC1, contributing to host translation shutoff.[RuleBase:RU364118] Protein 2B: Plays an essential role in the virus replication cycle by acting as a viroporin. Creates a pore in the host reticulum endoplasmic and as a consequence releases Ca2+ in the cytoplasm of infected cell. In turn, high levels of cytoplasmic calcium may trigger membrane trafficking and transport of viral ER-associated proteins to viroplasms, sites of viral genome replication.[RuleBase:RU364118] Protein 2C: Induces and associates with structural rearrangements of intracellular membranes. Displays RNA-binding, nucleotide binding and NTPase activities. May play a role in virion morphogenesis and viral RNA encapsidation by interacting with the capsid protein VP3.[RuleBase:RU364118] Protein 3A: Localizes the viral replication complex to the surface of membranous vesicles. It inhibits host cell endoplasmic reticulum-to-Golgi apparatus transport and causes the disassembly of the Golgi complex, possibly through GBF1 interaction. This would result in depletion of MHC, trail receptors and IFN receptors at the host cell surface.[RuleBase:RU364118] Protein 3AB: Localizes the viral replication complex to the surface of membranous vesicles. Together with protein 3CD binds the Cis-Active RNA Element (CRE) which is involved in RNA synthesis initiation. Acts as a cofactor to stimulate the activity of 3D polymerase, maybe through a nucleid acid chaperone activity.[RuleBase:RU364118] Protein 3CD: Involved in the viral replication complex and viral polypeptide maturation. It exhibits protease activity with a specificity and catalytic efficiency that is different from protease 3C. Protein 3CD lacks polymerase activity. Protein 3CD binds to the 5'UTR of the viral genome.[RuleBase:RU364118] RNA-directed RNA polymerase: Replicates the viral genomic RNA on the surface of intracellular membranes. May form linear arrays of subunits that propagate along a strong head-to-tail interaction called interface-I. Covalently attaches UMP to a tyrosine of VPg, which is used to prime RNA synthesis. The positive stranded RNA genome is first replicated at virus induced membranous vesicles, creating a dsRNA genomic replication form. This dsRNA is then used as template to synthesize positive stranded RNA genomes. ss(+)RNA genomes are either translated, replicated or encapsidated.[RuleBase:RU364118] Viral protein genome-linked: acts as a primer for viral RNA replication and remains covalently bound to viral genomic RNA. VPg is uridylylated prior to priming replication into VPg-pUpU. The oriI viral genomic sequence may act as a template for this. The VPg-pUpU is then used as primer on the genomic RNA poly(A) by the RNA-dependent RNA polymerase to replicate the viral genome.[RuleBase:RU364118]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</SX>		</SX>
		+	[[Category: Coxsackievirus A21]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Human coxsackievirus a21]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bator-Kelly~~, C M~~]]	+	[[Category: Bator-Kelly CM]]
-	[[Category: Chipman~~, P R~~]]	+	[[Category: Chipman PR]]
-	[[Category: Craig, A]]	+	[[Category: Craig A]]
-	[[Category: Kuhn~~, R J~~]]	+	[[Category: Kuhn RJ]]
-	[[Category: Rieder, E]]	+	[[Category: Rieder E]]
-	[[Category: Rossmann~~, M G~~]]	+	[[Category: Rossmann MG]]
-	[[Category: Wimmer, E]]	+	[[Category: Wimmer E]]
-	[[Category: Xiao, C]]	+	[[Category: Xiao C]]
-	~~[[Category: Cd54]]~~	+
-	~~[[Category: Icam-1]]~~	+
-	~~[[Category: Icosahedral virus]]~~	+
-	~~[[Category: Kilifi]]~~	+
-	~~[[Category: Virus-receptor complex~~]]	+

OCA at 16:58, 20 October 2021

OCA — Wed, 20 Oct 2021 16:58:02 GMT

←Older revision		Revision as of 16:58, 20 October 2021
Line 3:		Line 3:
	<SX load='1z7z' size='340' side='right' viewer='molstar' caption='[[1z7z]], [[Resolution\|resolution]] 8.00Å' scene=''>		<SX load='1z7z' size='340' side='right' viewer='molstar' caption='[[1z7z]], [[Resolution\|resolution]] 8.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1z7z]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [~~http~~://en.wikipedia.org/wiki/Human_coxsackievirus_a21 Human coxsackievirus a21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1Z7Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1z7z]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_coxsackievirus_a21 Human coxsackievirus a21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z7Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG~~</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iam\|1iam]], [[1z7s\|1z7s]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1iam\|1iam]], [[1z7s\|1z7s]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1z7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7z OCA], [~~http~~://pdbe.org/1z7z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1z7z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1z7z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1z7z ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7z OCA], [https://pdbe.org/1z7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z7z RCSB], [https://www.ebi.ac.uk/pdbsum/1z7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z7z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ICAM1_HUMAN ICAM1_HUMAN]] ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.<ref>PMID:2538243</ref> <ref>PMID:1968231</ref> <ref>PMID:11173916</ref> <ref>PMID:17875742</ref>	+	[[https://www.uniprot.org/uniprot/ICAM1_HUMAN ICAM1_HUMAN]] ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.<ref>PMID:2538243</ref> <ref>PMID:1968231</ref> <ref>PMID:11173916</ref> <ref>PMID:17875742</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Intercellular adhesion molecule\|Intercellular adhesion molecule]]		*[[Intercellular adhesion molecule\|Intercellular adhesion molecule]]
		+	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:44, 10 April 2020

OCA — Fri, 10 Apr 2020 16:44:08 GMT

←Older revision		Revision as of 16:44, 10 April 2020
Line 3:		Line 3:
	<SX load='1z7z' size='340' side='right' viewer='molstar' caption='[[1z7z]], [[Resolution\|resolution]] 8.00Å' scene=''>		<SX load='1z7z' size='340' side='right' viewer='molstar' caption='[[1z7z]], [[Resolution\|resolution]] 8.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1z7z]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_coxsackievirus_a21 Human coxsackievirus a21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7Z OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Z7Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1z7z]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_coxsackievirus_a21 Human coxsackievirus a21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7Z OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1Z7Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iam\|1iam]], [[1z7s\|1z7s]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iam\|1iam]], [[1z7s\|1z7s]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1z7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7z OCA], [http://pdbe.org/1z7z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z7z RCSB], [http://www.ebi.ac.uk/pdbsum/1z7z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1z7z ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1z7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7z OCA], [http://pdbe.org/1z7z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z7z RCSB], [http://www.ebi.ac.uk/pdbsum/1z7z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1z7z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 16:51, 6 March 2020

OCA — Fri, 06 Mar 2020 16:51:01 GMT

←Older revision		Revision as of 16:51, 6 March 2020
Line 1:		Line 1:

	==Cryo-em structure of human coxsackievirus A21 complexed with five domain icam-1kilifi==		==Cryo-em structure of human coxsackievirus A21 complexed with five domain icam-1kilifi==
-	<~~StructureSection~~ load='1z7z' size='340' side='right'caption='[[1z7z]], [[Resolution\|resolution]] 8.00Å' scene=''>	+	<SX load='1z7z' size='340' side='right' viewer='molstar' caption='[[1z7z]], [[Resolution\|resolution]] 8.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1z7z]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_coxsackievirus_a21 Human coxsackievirus a21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z7Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[1z7z]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_coxsackievirus_a21 Human coxsackievirus a21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z7Z FirstGlance]. <br>
Line 35:		Line 35:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Human coxsackievirus a21]]		[[Category: Human coxsackievirus a21]]

OCA at 08:04, 18 December 2019

OCA — Wed, 18 Dec 2019 08:04:55 GMT

←Older revision		Revision as of 08:04, 18 December 2019
Line 1:		Line 1:

	==Cryo-em structure of human coxsackievirus A21 complexed with five domain icam-1kilifi==		==Cryo-em structure of human coxsackievirus A21 complexed with five domain icam-1kilifi==
-	<StructureSection load='1z7z' size='340' side='right' caption='[[1z7z]], [[Resolution\|resolution]] 8.00Å' scene=''>	+	<StructureSection load='1z7z' size='340' side='right'caption='[[1z7z]], [[Resolution\|resolution]] 8.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1z7z]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_coxsackievirus_a21 Human coxsackievirus a21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z7Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[1z7z]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_coxsackievirus_a21 Human coxsackievirus a21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z7Z FirstGlance]. <br>
Line 38:		Line 38:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Human coxsackievirus a21]]		[[Category: Human coxsackievirus a21]]
		+	[[Category: Large Structures]]
	[[Category: Bator-Kelly, C M]]		[[Category: Bator-Kelly, C M]]
	[[Category: Chipman, P R]]		[[Category: Chipman, P R]]

OCA at 07:52, 18 July 2018

OCA — Wed, 18 Jul 2018 07:52:02 GMT

←Older revision		Revision as of 07:52, 18 July 2018
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1z7z" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1z7z" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Intercellular adhesion molecule\|Intercellular adhesion molecule]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:54, 2 May 2018

OCA — Wed, 02 May 2018 08:54:16 GMT

←Older revision		Revision as of 08:54, 2 May 2018
Line 1:		Line 1:
		+
	==Cryo-em structure of human coxsackievirus A21 complexed with five domain icam-1kilifi==		==Cryo-em structure of human coxsackievirus A21 complexed with five domain icam-1kilifi==
	<StructureSection load='1z7z' size='340' side='right' caption='[[1z7z]], [[Resolution\|resolution]] 8.00Å' scene=''>		<StructureSection load='1z7z' size='340' side='right' caption='[[1z7z]], [[Resolution\|resolution]] 8.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1z7z]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Cv-a21 Cv-a21~~] and [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z7Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1z7z]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_coxsackievirus_a21 Human coxsackievirus a21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z7Z FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iam\|1iam]], [[1z7s\|1z7s]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iam\|1iam]], [[1z7s\|1z7s]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7z OCA], [http://pdbe.org/1z7z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z7z RCSB], [http://www.ebi.ac.uk/pdbsum/1z7z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7z OCA], [http://pdbe.org/1z7z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z7z RCSB], [http://www.ebi.ac.uk/pdbsum/1z7z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1z7z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z7/1z7z_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z7/1z7z_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1z7z" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1z7z" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Intercellular adhesion molecule\|Intercellular adhesion molecule]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cv-a21]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Human coxsackievirus a21]]
	[[Category: Bator-Kelly, C M]]		[[Category: Bator-Kelly, C M]]
	[[Category: Chipman, P R]]		[[Category: Chipman, P R]]
Line 46:		Line 44:
	[[Category: Xiao, C]]		[[Category: Xiao, C]]
	[[Category: Cd54]]		[[Category: Cd54]]
-	[[Category: Cryo-electron microscopy]]
-	[[Category: Human coxsackievirus a21]]
	[[Category: Icam-1]]		[[Category: Icam-1]]
	[[Category: Icosahedral virus]]		[[Category: Icosahedral virus]]
	[[Category: Kilifi]]		[[Category: Kilifi]]
	[[Category: Virus-receptor complex]]		[[Category: Virus-receptor complex]]

OCA at 16:29, 7 February 2016

OCA — Sun, 07 Feb 2016 16:29:47 GMT

←Older revision		Revision as of 16:29, 7 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z7z ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:15, 10 September 2015

OCA — Thu, 10 Sep 2015 03:15:01 GMT

←Older revision		Revision as of 03:15, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1z7z' size='340' side='right' caption='[[1z7z]], [[Resolution\|resolution]] 8.00Å' scene=''>		<StructureSection load='1z7z' size='340' side='right' caption='[[1z7z]], [[Resolution\|resolution]] 8.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1z7z]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Human_coxsackievirus_a21 Human coxsackievirus a21~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z7Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1z7z]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Cv-a21 Cv-a21] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z7Z FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iam\|1iam]], [[1z7s\|1z7s]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iam\|1iam]], [[1z7s\|1z7s]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z7z RCSB], [http://www.ebi.ac.uk/pdbsum/1z7z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7z OCA], [http://pdbe.org/1z7z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z7z RCSB], [http://www.ebi.ac.uk/pdbsum/1z7z PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ICAM1_HUMAN ICAM1_HUMAN]] ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.<ref>PMID:2538243</ref> <ref>PMID:1968231</ref> <ref>PMID:11173916</ref> <ref>PMID:17875742</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1z7z" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cv-a21]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Human coxsackievirus a21]]
	[[Category: Bator-Kelly, C M]]		[[Category: Bator-Kelly, C M]]
	[[Category: Chipman, P R]]		[[Category: Chipman, P R]]
Line 44:		Line 47:
	[[Category: Cd54]]		[[Category: Cd54]]
	[[Category: Cryo-electron microscopy]]		[[Category: Cryo-electron microscopy]]
		+	[[Category: Human coxsackievirus a21]]
	[[Category: Icam-1]]		[[Category: Icam-1]]
	[[Category: Icosahedral virus]]		[[Category: Icosahedral virus]]
	[[Category: Kilifi]]		[[Category: Kilifi]]
	[[Category: Virus-receptor complex]]		[[Category: Virus-receptor complex]]

OCA at 10:06, 8 January 2015

OCA — Thu, 08 Jan 2015 10:06:06 GMT

←Older revision		Revision as of 10:06, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1z7z]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_coxsackievirus_a21 Human coxsackievirus a21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z7Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[1z7z]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_coxsackievirus_a21 Human coxsackievirus a21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z7Z FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iam\|1iam]], [[1z7s\|1z7s]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iam\|1iam]], [[1z7s\|1z7s]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z7z RCSB], [http://www.ebi.ac.uk/pdbsum/1z7z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z7z RCSB], [http://www.ebi.ac.uk/pdbsum/1z7z PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Human coxsackievirus a21]]		[[Category: Human coxsackievirus a21]]
-	[[Category: Bator-Kelly, C M.]]	+	[[Category: Bator-Kelly, C M]]
-	[[Category: Chipman, P R.]]	+	[[Category: Chipman, P R]]
-	[[Category: Craig, A.]]	+	[[Category: Craig, A]]
-	[[Category: Kuhn, R J.]]	+	[[Category: Kuhn, R J]]
-	[[Category: Rieder, E.]]	+	[[Category: Rieder, E]]
-	[[Category: Rossmann, M G.]]	+	[[Category: Rossmann, M G]]
-	[[Category: Wimmer, E.]]	+	[[Category: Wimmer, E]]
-	[[Category: Xiao, C.]]	+	[[Category: Xiao, C]]
	[[Category: Cd54]]		[[Category: Cd54]]
	[[Category: Cryo-electron microscopy]]		[[Category: Cryo-electron microscopy]]
-	[[Category: Human coxsackievirus a21]]
	[[Category: Icam-1]]		[[Category: Icam-1]]
	[[Category: Icosahedral virus]]		[[Category: Icosahedral virus]]
	[[Category: Kilifi]]		[[Category: Kilifi]]
	[[Category: Virus-receptor complex]]		[[Category: Virus-receptor complex]]