1z81 - Revision history

OCA at 07:05, 23 August 2023

OCA — Wed, 23 Aug 2023 07:05:29 GMT

←Older revision		Revision as of 07:05, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1z81' size='340' side='right'caption='[[1z81]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1z81' size='340' side='right'caption='[[1z81]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1z81]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Playo Playo~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z81 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1z81]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii Plasmodium yoelii yoelii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z81 FirstGlance]. <br>
-	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>[~~https://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase~~]~~, with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.~~2.1.8 ~~5.2.1.8] </span>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z81 OCA], [https://pdbe.org/1z81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z81 RCSB], [https://www.ebi.ac.uk/pdbsum/1z81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z81 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z81 OCA], [https://pdbe.org/1z81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z81 RCSB], [https://www.ebi.ac.uk/pdbsum/1z81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z81 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q7RSH5_PLAYO Q7RSH5_PLAYO]] PPIases accelerate the folding of proteins (By similarity).[RuleBase:RU000493] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).[RuleBase:RU004223]	+	[https://www.uniprot.org/uniprot/Q7RSH5_PLAYO Q7RSH5_PLAYO] PPIases accelerate the folding of proteins (By similarity).[RuleBase:RU000493] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).[RuleBase:RU004223]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Peptidylprolyl isomerase]]~~	+	[[Category: Plasmodium yoelii yoelii]]
-	~~[[Category: Playo~~]]	+	[[Category: Alam Z]]
-	[[Category: Alam, Z]]	+	[[Category: Amani M]]
-	[[Category: Amani, M]]	+	[[Category: Arrowsmith C]]
-	[[Category: Arrowsmith, C]]	+	[[Category: Bochkarev A]]
-	[[Category: Bochkarev, A]]	+	[[Category: Edwards A]]
-	[[Category: Edwards, A]]	+	[[Category: Hui R]]
-	[[Category: Hui, R]]	+	[[Category: Lew J]]
-	[[Category: Lew, J]]	+	[[Category: Mulichak A]]
-	[[Category: Mulichak, A]]	+	[[Category: Sundstrom M]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Vedadi M]]
-	[[Category: Sundstrom, M]]	+	[[Category: Wasney G]]
-	[[Category: Vedadi, M]]	+
-	[[Category: Wasney, G]]	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Sgc~~]]	+

OCA at 08:18, 10 November 2021

OCA — Wed, 10 Nov 2021 08:18:23 GMT

←Older revision		Revision as of 08:18, 10 November 2021
Line 3:		Line 3:
	<StructureSection load='1z81' size='340' side='right'caption='[[1z81]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1z81' size='340' side='right'caption='[[1z81]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1z81]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Playo Playo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z81 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Z81 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1z81]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Playo Playo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z81 FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1z81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z81 OCA], [~~http~~://pdbe.org/1z81 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1z81 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1z81 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1z81 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z81 OCA], [https://pdbe.org/1z81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z81 RCSB], [https://www.ebi.ac.uk/pdbsum/1z81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z81 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/Q7RSH5_PLAYO Q7RSH5_PLAYO]] PPIases accelerate the folding of proteins (By similarity).[RuleBase:RU000493] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).[RuleBase:RU004223]	+	[[https://www.uniprot.org/uniprot/Q7RSH5_PLAYO Q7RSH5_PLAYO]] PPIases accelerate the folding of proteins (By similarity).[RuleBase:RU000493] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).[RuleBase:RU004223]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:53, 5 February 2020

OCA — Wed, 05 Feb 2020 09:53:06 GMT

←Older revision		Revision as of 09:53, 5 February 2020
Line 1:		Line 1:

	==Crystal Structure of cyclophilin from Plasmodium yoelii.==		==Crystal Structure of cyclophilin from Plasmodium yoelii.==
-	<StructureSection load='1z81' size='340' side='right' caption='[[1z81]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='1z81' size='340' side='right'caption='[[1z81]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1z81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Playo Playo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z81 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1z81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Playo Playo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z81 FirstGlance]. <br>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1z81" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1z81" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cyclophilin 3D structures\|Cyclophilin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Playo]]		[[Category: Playo]]

OCA at 09:18, 2 May 2018

OCA — Wed, 02 May 2018 09:18:56 GMT

←Older revision		Revision as of 09:18, 2 May 2018
Line 1:		Line 1:
		+
	==Crystal Structure of cyclophilin from Plasmodium yoelii.==		==Crystal Structure of cyclophilin from Plasmodium yoelii.==
	<StructureSection load='1z81' size='340' side='right' caption='[[1z81]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1z81' size='340' side='right' caption='[[1z81]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1z81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Playo Playo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z81 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1z81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Playo Playo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z81 FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z81 OCA], [http://pdbe.org/1z81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z81 RCSB], [http://www.ebi.ac.uk/pdbsum/1z81 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z81 OCA], [http://pdbe.org/1z81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z81 RCSB], [http://www.ebi.ac.uk/pdbsum/1z81 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1z81 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z8/1z81_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z8/1z81_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z81 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1z81" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1z81" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cyclophilin\|Cyclophilin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:12, 11 September 2015

OCA — Fri, 11 Sep 2015 07:12:04 GMT

←Older revision		Revision as of 07:12, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1z81' size='340' side='right' caption='[[1z81]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1z81' size='340' side='right' caption='[[1z81]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1z81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_yoelii_yoelii Plasmodium yoelii yoelii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z81 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1z81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Playo Playo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z81 FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z81 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z81 RCSB], [http://www.ebi.ac.uk/pdbsum/1z81 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z81 OCA], [http://pdbe.org/1z81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z81 RCSB], [http://www.ebi.ac.uk/pdbsum/1z81 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1z81" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
-	[[Category: ~~Plasmodium yoelii yoelii~~]]	+	[[Category: Playo]]
	[[Category: Alam, Z]]		[[Category: Alam, Z]]
	[[Category: Amani, M]]		[[Category: Amani, M]]

OCA at 13:04, 25 December 2014

OCA — Thu, 25 Dec 2014 13:04:27 GMT

←Older revision		Revision as of 13:04, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1z81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii Plasmodium yoelii yoelii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z81 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1z81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii Plasmodium yoelii yoelii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z81 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z81 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z81 RCSB], [http://www.ebi.ac.uk/pdbsum/1z81 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z81 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z81 RCSB], [http://www.ebi.ac.uk/pdbsum/1z81 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q7RSH5_PLAYO Q7RSH5_PLAYO]] PPIases accelerate the folding of proteins (By similarity).[RuleBase:RU000493] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).[RuleBase:RU004223]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Plasmodium yoelii yoelii]]		[[Category: Plasmodium yoelii yoelii]]
-	[[Category: Alam, Z.]]	+	[[Category: Alam, Z]]
-	[[Category: Amani, M.]]	+	[[Category: Amani, M]]
-	[[Category: Arrowsmith, C.]]	+	[[Category: Arrowsmith, C]]
-	[[Category: Bochkarev, A.]]	+	[[Category: Bochkarev, A]]
-	[[Category: Edwards, A.]]	+	[[Category: Edwards, A]]
-	[[Category: Hui, R.]]	+	[[Category: Hui, R]]
-	[[Category: Lew, J.]]	+	[[Category: Lew, J]]
-	[[Category: Mulichak, A.]]	+	[[Category: Mulichak, A]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Sundstrom, M.]]	+	[[Category: Sundstrom, M]]
-	[[Category: Vedadi, M.]]	+	[[Category: Vedadi, M]]
-	[[Category: Wasney, G.]]	+	[[Category: Wasney, G]]
	[[Category: Isomerase]]		[[Category: Isomerase]]
	[[Category: Sgc]]		[[Category: Sgc]]
-	[[Category: Structural genomic]]
-	[[Category: Structural genomics consortium]]

OCA at 22:01, 28 September 2014

OCA — Sun, 28 Sep 2014 22:01:51 GMT

←Older revision		Revision as of 22:01, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1z81.~~png\|left~~\|200px]]	+	==Crystal Structure of cyclophilin from Plasmodium yoelii.==
		+	<StructureSection load='1z81' size='340' side='right' caption='[[1z81]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1z81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii Plasmodium yoelii yoelii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z81 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z81 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z81 RCSB], [http://www.ebi.ac.uk/pdbsum/1z81 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z8/1z81_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Parasites from the protozoan phylum Apicomplexa are responsible for diseases, such as malaria, toxoplasmosis and cryptosporidiosis, all of which have significantly higher rates of mortality and morbidity in economically underdeveloped regions of the world. Advances in vaccine development and drug discovery are urgently needed to control these diseases and can be facilitated by production of purified recombinant proteins from Apicomplexan genomes and determination of their 3D structures. To date, both heterologous expression and crystallization of Apicomplexan proteins have seen only limited success. In an effort to explore the effectiveness of producing and crystallizing proteins on a genome-scale using a standardized methodology, over 400 distinct Plasmodium falciparum target genes were chosen representing different cellular classes, along with select orthologues from four other Plasmodium species as well as Cryptosporidium parvum and Toxoplasma gondii. From a total of 1008 genes from the seven genomes, 304 (30.2%) produced purified soluble proteins and 97 (9.6%) crystallized, culminating in 36 crystal structures. These results demonstrate that, contrary to previous findings, a standardized platform using Escherichia coli can be effective for genome-scale production and crystallography of Apicomplexan proteins. Predictably, orthologous proteins from different Apicomplexan genomes behaved differently in expression, purification and crystallization, although the overall success rates of Plasmodium orthologues do not differ significantly. Their differences were effectively exploited to elevate the overall productivity to levels comparable to the most successful ongoing structural genomics projects: 229 of the 468 target genes produced purified soluble protein from one or more organisms, with 80 and 32 of the purified targets, respectively, leading to crystals and ultimately structures from one or more orthologues.

-	~~{{STRUCTURE_1z81\| PDB=1z81 \| SCENE= }}~~	+	Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.,Vedadi M, Lew J, Artz J, Amani M, Zhao Y, Dong A, Wasney GA, Gao M, Hills T, Brokx S, Qiu W, Sharma S, Diassiti A, Alam Z, Melone M, Mulichak A, Wernimont A, Bray J, Loppnau P, Plotnikova O, Newberry K, Sundararajan E, Houston S, Walker J, Tempel W, Bochkarev A, Kozieradzki I, Edwards A, Arrowsmith C, Roos D, Kain K, Hui R Mol Biochem Parasitol. 2007 Jan;151(1):100-10. Epub 2006 Nov 13. PMID:17125854<ref>PMID:17125854</ref>

-	~~===Crystal Structure~~ of ~~cyclophilin from Plasmodium yoelii~~.~~===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17125854}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1z81]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Plasmodium_yoelii_yoelii Plasmodium yoelii yoelii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z81 OCA].~~	+

	==See Also==		==See Also==
	*[[Cyclophilin\|Cyclophilin]]		*[[Cyclophilin\|Cyclophilin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017125854<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Plasmodium yoelii yoelii]]		[[Category: Plasmodium yoelii yoelii]]

OCA at 17:00, 20 October 2012

OCA — Sat, 20 Oct 2012 17:00:42 GMT

←Older revision		Revision as of 17:00, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1z81]] is a 1 chain structure ~~of [[Cyclophilin]]~~ with sequence from [http://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii Plasmodium yoelii yoelii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z81 OCA].	+	[[1z81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii Plasmodium yoelii yoelii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z81 OCA].

	==See Also==		==See Also==

OCA at 23:32, 26 July 2012

OCA — Thu, 26 Jul 2012 23:32:47 GMT

←Older revision		Revision as of 23:32, 26 July 2012
Line 1:		Line 1:
	[[Image:1z81.png\|left\|200px]]		[[Image:1z81.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1z81", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1z81\| PDB=1z81 \| SCENE= }}		{{STRUCTURE_1z81\| PDB=1z81 \| SCENE= }}

	===Crystal Structure of cyclophilin from Plasmodium yoelii.===		===Crystal Structure of cyclophilin from Plasmodium yoelii.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17125854}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17125854 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17125854}}		{{ABSTRACT_PUBMED_17125854}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Cyclophilin]]	+	*[[Cyclophilin\|Cyclophilin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17125854~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017125854</ref><references group="xtra"/>
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Plasmodium yoelii yoelii]]		[[Category: Plasmodium yoelii yoelii]]

OCA: Protected "1z81" [edit=sysop:move=sysop]

OCA — Sun, 26 Dec 2010 23:15:50 GMT

Protected "1z81" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:15, 26 December 2010