1za3 - Revision history

OCA at 07:06, 23 August 2023

OCA — Wed, 23 Aug 2023 07:06:32 GMT

←Older revision		Revision as of 07:06, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1za3' size='340' side='right'caption='[[1za3]], [[Resolution\|resolution]] 3.35Å' scene=''>		<StructureSection load='1za3' size='340' side='right'caption='[[1za3]], [[Resolution\|resolution]] 3.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1za3]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZA3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1ZA3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1za3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZA3 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1d0g\|1d0g]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.35Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">DR5 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1za3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1za3 OCA], [https://pdbe.org/1za3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1za3 RCSB], [https://www.ebi.ac.uk/pdbsum/1za3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1za3 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1za3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1za3 OCA], [~~http~~://pdbe.org/1za3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1za3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1za3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1za3 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/TR10B_HUMAN TR10B_HUMAN]] Defects in TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:[~~http~~://omim.org/entry/275355 275355]]; also known as squamous cell carcinoma of the head and neck.	+	[https://www.uniprot.org/uniprot/TR10B_HUMAN TR10B_HUMAN] Defects in TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:[https://omim.org/entry/275355 275355]; also known as squamous cell carcinoma of the head and neck.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TR10B_HUMAN TR10B_HUMAN]] Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.<ref>PMID:15322075</ref>	+	[https://www.uniprot.org/uniprot/TR10B_HUMAN TR10B_HUMAN] Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.<ref>PMID:15322075</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 41:		Line 40:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Compaan~~, D M~~]]	+	[[Category: Compaan DM]]
-	[[Category: Fellouse~~, F A~~]]	+	[[Category: Fellouse FA]]
-	[[Category: Hymowitz~~, S G~~]]	+	[[Category: Hymowitz SG]]
-	[[Category: Li, B]]	+	[[Category: Li B]]
-	[[Category: Peden~~, A A~~]]	+	[[Category: Peden AA]]
-	[[Category: Sidhu~~, S S]]~~	+	[[Category: Sidhu SS]]
-	~~[[Category: Antibody library]]~~	+
-	~~[[Category: Combinatorial mutagenesis]]~~	+
-	~~[[Category: Death receptor-5]]~~	+
-	~~[[Category: Immune system-signaling protein complex]]~~	+
-	~~[[Category: Phage display]]~~	+
-	~~[[Category: Protein engineering~~]]	+

OCA at 09:00, 20 January 2021

OCA — Wed, 20 Jan 2021 09:00:54 GMT

←Older revision		Revision as of 09:00, 20 January 2021
Line 1:		Line 1:

	==The crystal structure of the YSd1 Fab bound to DR5==		==The crystal structure of the YSd1 Fab bound to DR5==
-	<StructureSection load='1za3' size='340' side='right' caption='[[1za3]], [[Resolution\|resolution]] 3.35Å' scene=''>	+	<StructureSection load='1za3' size='340' side='right'caption='[[1za3]], [[Resolution\|resolution]] 3.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1za3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZA3 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ZA3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1za3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZA3 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1ZA3 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0g\|1d0g]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1d0g\|1d0g]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DR5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DR5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1za3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1za3 OCA], [http://pdbe.org/1za3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1za3 RCSB], [http://www.ebi.ac.uk/pdbsum/1za3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1za3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1za3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1za3 OCA], [http://pdbe.org/1za3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1za3 RCSB], [http://www.ebi.ac.uk/pdbsum/1za3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1za3 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 31:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 1za3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1za3" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[TRAIL\|TRAIL]]
		+	*[[Tumor necrosis factor receptor 3D structures\|Tumor necrosis factor receptor 3D structures]]
		+	*[[3D structures of human antibody\|3D structures of human antibody]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 42:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Compaan, D M]]		[[Category: Compaan, D M]]
	[[Category: Fellouse, F A]]		[[Category: Fellouse, F A]]

OCA at 08:53, 2 May 2018

OCA — Wed, 02 May 2018 08:53:43 GMT

←Older revision		Revision as of 08:53, 2 May 2018
Line 1:		Line 1:
		+
	==The crystal structure of the YSd1 Fab bound to DR5==		==The crystal structure of the YSd1 Fab bound to DR5==
	<StructureSection load='1za3' size='340' side='right' caption='[[1za3]], [[Resolution\|resolution]] 3.35Å' scene=''>		<StructureSection load='1za3' size='340' side='right' caption='[[1za3]], [[Resolution\|resolution]] 3.35Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0g\|1d0g]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0g\|1d0g]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DR5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DR5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1za3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1za3 OCA], [http://pdbe.org/1za3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1za3 RCSB], [http://www.ebi.ac.uk/pdbsum/1za3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1za3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1za3 OCA], [http://pdbe.org/1za3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1za3 RCSB], [http://www.ebi.ac.uk/pdbsum/1za3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1za3 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/za/1za3_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/za/1za3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 1za3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1za3" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Antibody\|Antibody]]
-	*[[Tumor necrosis factor receptor\|Tumor necrosis factor receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 23:29, 9 February 2016

OCA — Tue, 09 Feb 2016 23:29:44 GMT

←Older revision		Revision as of 23:29, 9 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1za3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:07, 11 September 2015

OCA — Fri, 11 Sep 2015 03:07:13 GMT

←Older revision		Revision as of 03:07, 11 September 2015
Line 5:		Line 5:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0g\|1d0g]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0g\|1d0g]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DR5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DR5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1za3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1za3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1za3 RCSB], [http://www.ebi.ac.uk/pdbsum/1za3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1za3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1za3 OCA], [http://pdbe.org/1za3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1za3 RCSB], [http://www.ebi.ac.uk/pdbsum/1za3 PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1za3" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 09:04, 8 January 2015

OCA — Thu, 08 Jan 2015 09:04:39 GMT

←Older revision		Revision as of 09:04, 8 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_1za3\| PDB=1za3 \| SCENE= }}~~	+	==The crystal structure of the YSd1 Fab bound to DR5==
-	===The crystal structure of the YSd1 Fab bound to DR5===	+	<StructureSection load='1za3' size='340' side='right' caption='[[1za3]], [[Resolution\|resolution]] 3.35Å' scene=''>
-	~~{{ABSTRACT_PUBMED_15854651}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[1za3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZA3 FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d0g\|1d0g]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DR5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1za3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1za3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1za3 RCSB], [http://www.ebi.ac.uk/pdbsum/1za3 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/TR10B_HUMAN TR10B_HUMAN]] Defects in TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:[http://omim.org/entry/275355 275355]]; also known as squamous cell carcinoma of the head and neck.		[[http://www.uniprot.org/uniprot/TR10B_HUMAN TR10B_HUMAN]] Defects in TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:[http://omim.org/entry/275355 275355]]; also known as squamous cell carcinoma of the head and neck.
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/TR10B_HUMAN TR10B_HUMAN]] Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.<ref>PMID:15322075</ref>		[[http://www.uniprot.org/uniprot/TR10B_HUMAN TR10B_HUMAN]] Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.<ref>PMID:15322075</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/za/1za3_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Functional antibodies were obtained from a library of antigen-binding sites generated by a binary code restricted to tyrosine and serine. An antibody raised against human vascular endothelial growth factor recognized the antigen with high affinity (K(D)=60 nM) and high specificity in cell-based assays. The crystal structure of another antigen binding fragment in complex with its antigen (human death receptor DR5) revealed the structural basis for this minimalist mode of molecular recognition. Natural antigen-binding sites are enriched for tyrosine and serine, and we show that these amino acid residues are intrinsically well suited for molecular recognition. Furthermore, these results demonstrate that molecular recognition can evolve from even the simplest chemical diversity.

-	~~==About this Structure==~~	+	Molecular recognition by a binary code.,Fellouse FA, Li B, Compaan DM, Peden AA, Hymowitz SG, Sidhu SS J Mol Biol. 2005 May 20;348(5):1153-62. Epub 2005 Apr 1. PMID:15854651<ref>PMID:15854651</ref>
-	~~[[1za3]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/ ] and [http~~:~~//en~~.~~wikipedia.org/wiki/Human Human]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1ZA3 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Antibody\|Antibody]]		*[[Antibody\|Antibody]]
-		+	*[[Tumor necrosis factor receptor\|Tumor necrosis factor receptor]]
-	==~~Reference~~==	+	== References ==
-	~~<ref group="xtra">PMID:015854651</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Compaan, D M.]]	+	[[Category: Compaan, D M]]
-	[[Category: Fellouse, F A.]]	+	[[Category: Fellouse, F A]]
-	[[Category: Hymowitz, S G.]]	+	[[Category: Hymowitz, S G]]
-	[[Category: Li, B.]]	+	[[Category: Li, B]]
-	[[Category: Peden, A A.]]	+	[[Category: Peden, A A]]
-	[[Category: Sidhu, S S.]]	+	[[Category: Sidhu, S S]]
	[[Category: Antibody library]]		[[Category: Antibody library]]
	[[Category: Combinatorial mutagenesis]]		[[Category: Combinatorial mutagenesis]]

OCA at 08:33, 5 February 2014

OCA — Wed, 05 Feb 2014 08:33:25 GMT

←Older revision		Revision as of 08:33, 5 February 2014
Line 7:		Line 7:

	==Function==		==Function==
-	[[http://www.uniprot.org/uniprot/TR10B_HUMAN TR10B_HUMAN]] Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.<ref>PMID:15322075</ref>	+	[[http://www.uniprot.org/uniprot/TR10B_HUMAN TR10B_HUMAN]] Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.<ref>PMID:15322075</ref>

	==About this Structure==		==About this Structure==
-	[[1za3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZA3 OCA].	+	[[1za3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZA3 OCA].

	==See Also==		==See Also==
Line 17:		Line 17:
	==Reference==		==Reference==
	<ref group="xtra">PMID:015854651</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:015854651</ref><references group="xtra"/><references/>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Compaan, D M.]]		[[Category: Compaan, D M.]]
	[[Category: Fellouse, F A.]]		[[Category: Fellouse, F A.]]

OCA at 20:41, 24 March 2013

OCA — Sun, 24 Mar 2013 20:41:49 GMT

←Older revision		Revision as of 20:41, 24 March 2013
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-	[[Image:1za3.png\|left\|200px]]
-
	{{STRUCTURE_1za3\| PDB=1za3 \| SCENE= }}		{{STRUCTURE_1za3\| PDB=1za3 \| SCENE= }}
-
	===The crystal structure of the YSd1 Fab bound to DR5===		===The crystal structure of the YSd1 Fab bound to DR5===
		+	{{ABSTRACT_PUBMED_15854651}}

-	~~{{ABSTRACT_PUBMED_15854651}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/TR10B_HUMAN TR10B_HUMAN]] Defects in TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:[http://omim.org/entry/275355 275355]]; also known as squamous cell carcinoma of the head and neck.
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/TR10B_HUMAN TR10B_HUMAN]] Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.<ref>PMID:15322075</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:015854651</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015854651</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Compaan, D M.]]		[[Category: Compaan, D M.]]

OCA at 15:31, 20 October 2012

OCA — Sat, 20 Oct 2012 15:31:25 GMT

←Older revision		Revision as of 15:31, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1za3]] is a 6 chain structure ~~of [[Antibody]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZA3 OCA].	+	[[1za3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZA3 OCA].

	==See Also==		==See Also==

OCA: Protected "1za3" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 18:39:05 GMT

Protected "1za3" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:39, 26 July 2012