1za9 - Revision history

OCA at 08:18, 10 November 2021

OCA — Wed, 10 Nov 2021 08:18:42 GMT

←Older revision		Revision as of 08:18, 10 November 2021
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	<StructureSection load='1za9' size='340' side='right'caption='[[1za9]]' scene=''>		<StructureSection load='1za9' size='340' side='right'caption='[[1za9]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ZA9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZA9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1za9 FirstGlance], [~~http~~://www.ebi.ac.uk/pdbsum/1za9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1za9 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1za9 FirstGlance], [https://www.ebi.ac.uk/pdbsum/1za9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1za9 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:53, 5 February 2020

OCA — Wed, 05 Feb 2020 09:53:31 GMT

←Older revision		Revision as of 09:53, 5 February 2020
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	==3D MODEL OF THE HIV-1 INTEGRATION COMPLEX==		==3D MODEL OF THE HIV-1 INTEGRATION COMPLEX==
-	<StructureSection load='1za9' size='340' side='right' caption='[[1za9]]' scene=''>	+	<StructureSection load='1za9' size='340' side='right'caption='[[1za9]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZA9 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZA9 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Theoretical Model]]		[[Category: Theoretical Model]]
		+	[[Category: Large Structures]]
	[[Category: Chalmers, D K]]		[[Category: Chalmers, D K]]
	[[Category: Crosby, I T]]		[[Category: Crosby, I T]]
	[[Category: Wielens, J]]		[[Category: Wielens, J]]

OCA at 09:19, 2 May 2018

OCA — Wed, 02 May 2018 09:19:16 GMT

←Older revision		Revision as of 09:19, 2 May 2018
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZA9 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZA9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1za9 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1za9 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1za9 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1za9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1za9 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:14, 11 February 2016

OCA — Thu, 11 Feb 2016 10:14:21 GMT

←Older revision		Revision as of 10:14, 11 February 2016
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		+	{{Theoretical_model}}
		+
	==3D MODEL OF THE HIV-1 INTEGRATION COMPLEX==		==3D MODEL OF THE HIV-1 INTEGRATION COMPLEX==
	<StructureSection load='1za9' size='340' side='right' caption='[[1za9]]' scene=''>		<StructureSection load='1za9' size='340' side='right' caption='[[1za9]]' scene=''>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Theoretical Model]]
	[[Category: Chalmers, D K]]		[[Category: Chalmers, D K]]
	[[Category: Crosby, I T]]		[[Category: Crosby, I T]]
	[[Category: Wielens, J]]		[[Category: Wielens, J]]

OCA at 20:26, 10 September 2015

OCA — Thu, 10 Sep 2015 20:26:51 GMT

←Older revision		Revision as of 20:26, 10 September 2015
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1za9" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:35, 8 January 2015

OCA — Thu, 08 Jan 2015 10:35:48 GMT

←Older revision		Revision as of 10:35, 8 January 2015
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZA9 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZA9 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1za9 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1za9 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1za9 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1za9 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 23:01, 28 September 2014

OCA — Sun, 28 Sep 2014 23:01:51 GMT

←Older revision		Revision as of 23:01, 28 September 2014
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-	~~{{Theoretical_model}}~~	+	==3D MODEL OF THE HIV-1 INTEGRATION COMPLEX==
		+	<StructureSection load='1za9' size='340' side='right' caption='[[1za9]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZA9 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1za9 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1za9 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	While the general features of HIV-1 integrase function are understood, there is still uncertainty about the composition of the integration complex and how integrase interacts with viral and host DNA. We propose an improved model of the integration complex based on current experimental evidence including a comparison with the homologous Tn5 transposase containing bound DNA and an analysis of DNA binding sites using Goodford's GRID. Our model comprises a pair of integrase dimers, two strands of DNA to represent the viral DNA ends and a strand of bent DNA representing the host chromosome. In our model, the terminal four base pairs of each of the viral DNA strands interact with the integrase dimer providing the active site, while bases one turn away interact with a flexible loop (residues 186-194) on the second integrase dimer. We propose that residues E152, Q148 and K156 are involved in the specific recognition of the conserved CA dinucleotide and that the active site mobile loop (residues 140-149) stabilises the integration complex by acting as a barrier to separate the two viral DNA ends. In addition, the residues responsible for DNA binding in our model show a high level of amino acid conservation.

-	~~[[Image~~:~~1za9~~.~~png\|left\|200px]]~~	+	A three-dimensional model of the human immunodeficiency virus type 1 integration complex.,Wielens J, Crosby IT, Chalmers DK J Comput Aided Mol Des. 2005 May;19(5):301-17. PMID:16184433<ref>PMID:16184433</ref>

-	~~{{STRUCTURE_1za9\| PDB=1za9 \| SCENE= }}~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	==~~=3D MODEL OF THE HIV-1 INTEGRATION COMPLEX===~~	+	== References ==
-		+	<references/>
-	~~{{ABSTRACT_PUBMED_16184433}}~~	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	<~~ref group="xtra">PMID:016184433<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Chalmers, D K]]		[[Category: Chalmers, D K]]
	[[Category: Crosby, I T]]		[[Category: Crosby, I T]]
	[[Category: Wielens, J]]		[[Category: Wielens, J]]

OCA: Protected "1za9" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 09:58:06 GMT

Protected "1za9" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:58, 21 October 2012

OCA at 09:58, 21 October 2012

OCA — Sun, 21 Oct 2012 09:58:03 GMT

←Older revision		Revision as of 09:58, 21 October 2012
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	{{Theoretical_model}}		{{Theoretical_model}}
-	~~{{Seed}}~~	+
	[[Image:1za9.png\|left\|200px]]		[[Image:1za9.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1za9\| PDB=1za9 \| SCENE= }}		{{STRUCTURE_1za9\| PDB=1za9 \| SCENE= }}

	===3D MODEL OF THE HIV-1 INTEGRATION COMPLEX===		===3D MODEL OF THE HIV-1 INTEGRATION COMPLEX===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16184433}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16184433 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16184433}}		{{ABSTRACT_PUBMED_16184433}}
-
-	==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZA9 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16184433~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016184433</ref><references group="xtra"/>
	[[Category: Chalmers, D K]]		[[Category: Chalmers, D K]]
	[[Category: Crosby, I T]]		[[Category: Crosby, I T]]
	[[Category: Wielens, J]]		[[Category: Wielens, J]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 09:18:18 2010''

OCA at 06:18, 8 April 2010

OCA — Thu, 08 Apr 2010 06:18:18 GMT

←Older revision		Revision as of 06:18, 8 April 2010
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-	~~'''Theoretical Model'''~~	+	{{Theoretical_model}}
		+	{{Seed}}
		+	[[Image:1za9.png\|left\|200px]]

-	The ~~entry 1ZA9~~ is ~~a Theoretical Model titled '3D model of~~ the ~~HIV-1 integration complex'~~.	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_1za9", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_1za9\| PDB=1za9 \| SCENE= }}

-	~~[[Category:Theoretical Model]]~~	+	===3D MODEL OF THE HIV-1 INTEGRATION COMPLEX===


-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 30~~ 09:55:~~08 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_16184433}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 16184433 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_16184433}}
		+
		+	==About this Structure==
		+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZA9 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:16184433</ref><references group="xtra"/>
		+	[[Category: Chalmers, D K]]
		+	[[Category: Crosby, I T]]
		+	[[Category: Wielens, J]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 09:18:18 2010''