1zap - Revision history

OCA at 08:10, 15 May 2024

OCA — Wed, 15 May 2024 08:10:18 GMT

←Older revision		Revision as of 08:10, 15 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zap]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZAP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZAP FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zap]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZAP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZAP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A70:N-ETHYL-N-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-D-PHENYLALANYL-N-[(1S,2S,4R)-4-(BUTYLCARBAMOYL)-1-(CYCLOHEXYLMETHYL)-2-HYDROXY-5-METHYLHEXYL]-L-NORLEUCINAMIDE'>A70</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Candidapepsin Candidapepsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.24 3.4.23.24] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A70:N-ETHYL-N-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-D-PHENYLALANYL-N-[(1S,2S,4R)-4-(BUTYLCARBAMOYL)-1-(CYCLOHEXYLMETHYL)-2-HYDROXY-5-METHYLHEXYL]-L-NORLEUCINAMIDE'>A70</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zap OCA], [https://pdbe.org/1zap PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zap RCSB], [https://www.ebi.ac.uk/pdbsum/1zap PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zap ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zap OCA], [https://pdbe.org/1zap PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zap RCSB], [https://www.ebi.ac.uk/pdbsum/1zap PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zap ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CARP2_CANAX CARP2_CANAX]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[Proteinase\|Proteinase]]
	*[[Proteinase 3D structures\|Proteinase 3D structures]]		*[[Proteinase 3D structures\|Proteinase 3D structures]]
	== References ==		== References ==
Line 36:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Candida albicans]]		[[Category: Candida albicans]]
-	[[Category: Candidapepsin]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Abad-Zapatero, C]]	+	[[Category: Abad-Zapatero C]]
-	[[Category: Muchmore~~, S W]]~~	+	[[Category: Muchmore SW]]
-	~~[[Category: Aspartic protease]]~~	+
-	~~[[Category: Candida albican]]~~	+
-	~~[[Category: Secreted~~]]	+

OCA at 08:18, 10 November 2021

OCA — Wed, 10 Nov 2021 08:18:54 GMT

←Older revision		Revision as of 08:18, 10 November 2021
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	<StructureSection load='1zap' size='340' side='right'caption='[[1zap]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1zap' size='340' side='right'caption='[[1zap]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zap]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZAP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ZAP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zap]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZAP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZAP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A70:N-ETHYL-N-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-D-PHENYLALANYL-N-[(1S,2S,4R)-4-(BUTYLCARBAMOYL)-1-(CYCLOHEXYLMETHYL)-2-HYDROXY-5-METHYLHEXYL]-L-NORLEUCINAMIDE'>A70</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A70:N-ETHYL-N-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-D-PHENYLALANYL-N-[(1S,2S,4R)-4-(BUTYLCARBAMOYL)-1-(CYCLOHEXYLMETHYL)-2-HYDROXY-5-METHYLHEXYL]-L-NORLEUCINAMIDE'>A70</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Candidapepsin Candidapepsin], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.24 3.4.23.24] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Candidapepsin Candidapepsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.24 3.4.23.24] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1zap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zap OCA], [~~http~~://pdbe.org/1zap PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1zap RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1zap PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1zap ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zap OCA], [https://pdbe.org/1zap PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zap RCSB], [https://www.ebi.ac.uk/pdbsum/1zap PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zap ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 09:41, 5 February 2020

OCA — Wed, 05 Feb 2020 09:41:37 GMT

←Older revision		Revision as of 09:41, 5 February 2020
Line 1:		Line 1:

	==SECRETED ASPARTIC PROTEASE FROM C. ALBICANS==		==SECRETED ASPARTIC PROTEASE FROM C. ALBICANS==
-	<StructureSection load='1zap' size='340' side='right' caption='[[1zap]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='1zap' size='340' side='right'caption='[[1zap]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zap]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZAP FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zap]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZAP FirstGlance]. <br>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1zap" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1zap" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Proteinase\|Proteinase]]
		+	*[[Proteinase 3D structures\|Proteinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 37:
	[[Category: Candida albicans]]		[[Category: Candida albicans]]
	[[Category: Candidapepsin]]		[[Category: Candidapepsin]]
		+	[[Category: Large Structures]]
	[[Category: Abad-Zapatero, C]]		[[Category: Abad-Zapatero, C]]
	[[Category: Muchmore, S W]]		[[Category: Muchmore, S W]]

OCA at 09:06, 2 May 2018

OCA — Wed, 02 May 2018 09:06:36 GMT

←Older revision		Revision as of 09:06, 2 May 2018
Line 1:		Line 1:
		+
	==SECRETED ASPARTIC PROTEASE FROM C. ALBICANS==		==SECRETED ASPARTIC PROTEASE FROM C. ALBICANS==
	<StructureSection load='1zap' size='340' side='right' caption='[[1zap]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1zap' size='340' side='right' caption='[[1zap]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A70:N-ETHYL-N-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-D-PHENYLALANYL-N-[(1S,2S,4R)-4-(BUTYLCARBAMOYL)-1-(CYCLOHEXYLMETHYL)-2-HYDROXY-5-METHYLHEXYL]-L-NORLEUCINAMIDE'>A70</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A70:N-ETHYL-N-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-D-PHENYLALANYL-N-[(1S,2S,4R)-4-(BUTYLCARBAMOYL)-1-(CYCLOHEXYLMETHYL)-2-HYDROXY-5-METHYLHEXYL]-L-NORLEUCINAMIDE'>A70</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Candidapepsin Candidapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.24 3.4.23.24] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Candidapepsin Candidapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.24 3.4.23.24] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zap OCA], [http://pdbe.org/1zap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zap RCSB], [http://www.ebi.ac.uk/pdbsum/1zap PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zap OCA], [http://pdbe.org/1zap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zap RCSB], [http://www.ebi.ac.uk/pdbsum/1zap PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zap ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/za/1zap_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/za/1zap_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 26:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1zap" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1zap" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Proteinase\|Proteinase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:17, 9 February 2016

OCA — Tue, 09 Feb 2016 06:17:25 GMT

←Older revision		Revision as of 06:17, 9 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zap ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:25, 10 September 2015

OCA — Thu, 10 Sep 2015 19:25:40 GMT

←Older revision		Revision as of 19:25, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A70:N-ETHYL-N-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-D-PHENYLALANYL-N-[(1S,2S,4R)-4-(BUTYLCARBAMOYL)-1-(CYCLOHEXYLMETHYL)-2-HYDROXY-5-METHYLHEXYL]-L-NORLEUCINAMIDE'>A70</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A70:N-ETHYL-N-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-D-PHENYLALANYL-N-[(1S,2S,4R)-4-(BUTYLCARBAMOYL)-1-(CYCLOHEXYLMETHYL)-2-HYDROXY-5-METHYLHEXYL]-L-NORLEUCINAMIDE'>A70</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Candidapepsin Candidapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.24 3.4.23.24] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Candidapepsin Candidapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.24 3.4.23.24] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zap OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zap RCSB], [http://www.ebi.ac.uk/pdbsum/1zap PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zap OCA], [http://pdbe.org/1zap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zap RCSB], [http://www.ebi.ac.uk/pdbsum/1zap PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1zap" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 09:25, 8 January 2015

OCA — Thu, 08 Jan 2015 09:25:23 GMT

←Older revision		Revision as of 09:25, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zap]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZAP FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zap]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZAP FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A70:N-ETHYL-N-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-D-PHENYLALANYL-N-[(1S,2S,4R)-4-(BUTYLCARBAMOYL)-1-(CYCLOHEXYLMETHYL)-2-HYDROXY-5-METHYLHEXYL]-L-NORLEUCINAMIDE'>A70</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A70:N-ETHYL-N-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-D-PHENYLALANYL-N-[(1S,2S,4R)-4-(BUTYLCARBAMOYL)-1-(CYCLOHEXYLMETHYL)-2-HYDROXY-5-METHYLHEXYL]-L-NORLEUCINAMIDE'>A70</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Candidapepsin Candidapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.24 3.4.23.24] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Candidapepsin Candidapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.24 3.4.23.24] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zap OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zap RCSB], [http://www.ebi.ac.uk/pdbsum/1zap PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zap OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zap RCSB], [http://www.ebi.ac.uk/pdbsum/1zap PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Candida albicans]]		[[Category: Candida albicans]]
	[[Category: Candidapepsin]]		[[Category: Candidapepsin]]
-	[[Category: Abad-Zapatero, C.]]	+	[[Category: Abad-Zapatero, C]]
-	[[Category: Muchmore, S W.]]	+	[[Category: Muchmore, S W]]
	[[Category: Aspartic protease]]		[[Category: Aspartic protease]]
	[[Category: Candida albican]]		[[Category: Candida albican]]
	[[Category: Secreted]]		[[Category: Secreted]]

OCA at 10:23, 3 October 2014

OCA — Fri, 03 Oct 2014 10:23:18 GMT

←Older revision		Revision as of 10:23, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1zap~~\| ~~PDB~~=1zap \| ~~SCENE~~= }}	+	==SECRETED ASPARTIC PROTEASE FROM C. ALBICANS==
-	===~~SECRETED ASPARTIC PROTEASE FROM C~~. ~~ALBICANS~~===	+	<StructureSection load='1zap' size='340' side='right' caption='[[1zap]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_8845753}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1zap]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZAP FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A70:N-ETHYL-N-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-D-PHENYLALANYL-N-[(1S,2S,4R)-4-(BUTYLCARBAMOYL)-1-(CYCLOHEXYLMETHYL)-2-HYDROXY-5-METHYLHEXYL]-L-NORLEUCINAMIDE'>A70</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Candidapepsin Candidapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.24 3.4.23.24] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zap OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zap RCSB], [http://www.ebi.ac.uk/pdbsum/1zap PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/za/1zap_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The three-dimensional structure of a secreted aspartic protease from Candida albicans complexed with a potent inhibitor reveals variations on the classical aspartic protease theme that dramatically alter the specificity of this class of enzymes. The structure presents: (1) an 8-residue insertion near the first disulfide (Cys 45-Cys 50, pepsin numbering) that results in a broad flap extending toward the active site; (2) a 7-residue deletion replacing helix hN2 (Ser 110-Tyr 114), which enlarges the S3 pocket; (3) a short polar connection between the two rigid body domains that alters their relative orientation and provides certain specificity; and (4) an ordered 11-residue addition at the carboxy terminus. The inhibitor binds in an extended conformation and presents a branched structure at the P3 position. The implications of these findings for the design of potent antifungal agents are discussed.

-	~~==About this~~ Structure==	+	Structure of a secreted aspartic protease from C. albicans complexed with a potent inhibitor: implications for the design of antifungal agents.,Abad-Zapatero C, Goldman R, Muchmore SW, Hutchins C, Stewart K, Navaza J, Payne CD, Ray TL Protein Sci. 1996 Apr;5(4):640-52. PMID:8845753<ref>PMID:8845753</ref>
-	~~[[1zap]] is~~ a ~~1 chain structure with sequence~~ from ~~[http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Candida_albicans Candida albicans]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1ZAP OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Proteinase\|Proteinase]]		*[[Proteinase\|Proteinase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:008845753</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Candida albicans]]		[[Category: Candida albicans]]
	[[Category: Candidapepsin]]		[[Category: Candidapepsin]]

OCA at 08:12, 23 April 2014

OCA — Wed, 23 Apr 2014 08:12:21 GMT

←Older revision		Revision as of 08:12, 23 April 2014
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-	[[Image:1zap.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_1zap", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1zap\| PDB=1zap \| SCENE= }}		{{STRUCTURE_1zap\| PDB=1zap \| SCENE= }}
-
	===SECRETED ASPARTIC PROTEASE FROM C. ALBICANS===		===SECRETED ASPARTIC PROTEASE FROM C. ALBICANS===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_8845753}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 8845753 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_8845753}}		{{ABSTRACT_PUBMED_8845753}}

	==About this Structure==		==About this Structure==
	[[1zap]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZAP OCA].		[[1zap]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZAP OCA].
		+
		+	==See Also==
		+	*[[Proteinase\|Proteinase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:008845753</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008845753</ref><references group="xtra"/><references/>
	[[Category: Candida albicans]]		[[Category: Candida albicans]]
	[[Category: Candidapepsin]]		[[Category: Candidapepsin]]

OCA: Protected "1zap" [edit=sysop:move=sysop]

OCA — Wed, 18 Jan 2012 09:30:33 GMT

Protected "1zap" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:30, 18 January 2012