1zfs - Revision history

OCA at 08:11, 15 May 2024

OCA — Wed, 15 May 2024 08:11:01 GMT

←Older revision		Revision as of 08:11, 15 May 2024
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	==Solution structure of S100A1 bound to calcium==		==Solution structure of S100A1 bound to calcium==
-	<StructureSection load='1zfs' size='340' side='right'caption='[[1zfs~~]], [[NMR_Ensembles_of_Models \| 19 NMR models~~]]' scene=''>	+	<StructureSection load='1zfs' size='340' side='right'caption='[[1zfs]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zfs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZFS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zfs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZFS FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[1k2h\|1k2h]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">S100a1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfs OCA], [https://pdbe.org/1zfs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zfs RCSB], [https://www.ebi.ac.uk/pdbsum/1zfs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zfs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfs OCA], [https://pdbe.org/1zfs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zfs RCSB], [https://www.ebi.ac.uk/pdbsum/1zfs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zfs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/S10A1_RAT S10A1_RAT]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.	+	[https://www.uniprot.org/uniprot/S10A1_RAT S10A1_RAT] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Varney, K M~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Weber, D J~~]]	+	[[Category: Varney KM]]
-	[[Category: ~~Wright, N T~~]]	+	[[Category: Weber DJ]]
-	[[Category: ~~Calcium binding]]~~	+	[[Category: Wright NT]]
-	~~[[Category: Conformational change]]~~	+
-	~~[[Category: Metal binding protein]]~~	+
-	~~[[Category: Noncovalent homodimer]]~~	+
-	~~[[Category: S100]]~~	+
-	~~[[Category: X-type 4 helix bundle~~]]	+

OCA at 07:17, 2 March 2022

OCA — Wed, 02 Mar 2022 07:17:30 GMT

←Older revision		Revision as of 07:17, 2 March 2022
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	<StructureSection load='1zfs' size='340' side='right'caption='[[1zfs]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>		<StructureSection load='1zfs' size='340' side='right'caption='[[1zfs]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zfs]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1ZFS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zfs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZFS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1k2h\|1k2h]]</div></td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1k2h\|1k2h]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S100a1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S100a1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1zfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfs OCA], [~~http~~://pdbe.org/1zfs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1zfs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1zfs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1zfs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfs OCA], [https://pdbe.org/1zfs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zfs RCSB], [https://www.ebi.ac.uk/pdbsum/1zfs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zfs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/S10A1_RAT S10A1_RAT]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.	+	[[https://www.uniprot.org/uniprot/S10A1_RAT S10A1_RAT]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:03, 20 January 2021

OCA — Wed, 20 Jan 2021 09:03:18 GMT

←Older revision		Revision as of 09:03, 20 January 2021
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	==Solution structure of S100A1 bound to calcium==		==Solution structure of S100A1 bound to calcium==
-	<StructureSection load='1zfs' size='340' side='right' caption='[[1zfs]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>	+	<StructureSection load='1zfs' size='340' side='right'caption='[[1zfs]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zfs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFS OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ZFS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zfs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1ZFS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k2h\|1k2h]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1k2h\|1k2h]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S100a1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S100a1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1zfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfs OCA], [http://pdbe.org/1zfs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zfs RCSB], [http://www.ebi.ac.uk/pdbsum/1zfs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zfs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1zfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfs OCA], [http://pdbe.org/1zfs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zfs RCSB], [http://www.ebi.ac.uk/pdbsum/1zfs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zfs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 1zfs" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1zfs" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[S100 proteins 3D structures\|S100 proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Varney, K M]]		[[Category: Varney, K M]]
	[[Category: Weber, D J]]		[[Category: Weber, D J]]

OCA at 09:00, 2 May 2018

OCA — Wed, 02 May 2018 09:00:19 GMT

←Older revision		Revision as of 09:00, 2 May 2018
Line 1:		Line 1:
		+
	==Solution structure of S100A1 bound to calcium==		==Solution structure of S100A1 bound to calcium==
	<StructureSection load='1zfs' size='340' side='right' caption='[[1zfs]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>		<StructureSection load='1zfs' size='340' side='right' caption='[[1zfs]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k2h\|1k2h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k2h\|1k2h]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S100a1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S100a1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfs OCA], [http://pdbe.org/1zfs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zfs RCSB], [http://www.ebi.ac.uk/pdbsum/1zfs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfs OCA], [http://pdbe.org/1zfs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zfs RCSB], [http://www.ebi.ac.uk/pdbsum/1zfs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zfs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zf/1zfs_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zf/1zfs_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1zfs" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1zfs" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[S100 protein\|S100 protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:04, 8 February 2016

OCA — Mon, 08 Feb 2016 13:04:07 GMT

←Older revision		Revision as of 13:04, 8 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zfs ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:51, 10 September 2015

OCA — Thu, 10 Sep 2015 11:51:17 GMT

←Older revision		Revision as of 11:51, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1zfs' size='340' side='right' caption='[[1zfs]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>		<StructureSection load='1zfs' size='340' side='right' caption='[[1zfs]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zfs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZFS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zfs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZFS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k2h\|1k2h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k2h\|1k2h]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S100a1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S100a1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zfs RCSB], [http://www.ebi.ac.uk/pdbsum/1zfs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfs OCA], [http://pdbe.org/1zfs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zfs RCSB], [http://www.ebi.ac.uk/pdbsum/1zfs PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1zfs" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Varney, K M]]		[[Category: Varney, K M]]
	[[Category: Weber, D J]]		[[Category: Weber, D J]]

OCA at 23:30, 24 December 2014

OCA — Wed, 24 Dec 2014 23:30:47 GMT

←Older revision		Revision as of 23:30, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zfs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZFS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zfs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZFS FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k2h\|1k2h]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k2h\|1k2h]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S100a1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S100a1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zfs RCSB], [http://www.ebi.ac.uk/pdbsum/1zfs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zfs RCSB], [http://www.ebi.ac.uk/pdbsum/1zfs PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/S10A1_RAT S10A1_RAT]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Varney, K M.]]	+	[[Category: Varney, K M]]
-	[[Category: Weber, D J.]]	+	[[Category: Weber, D J]]
-	[[Category: Wright, N T.]]	+	[[Category: Wright, N T]]
	[[Category: Calcium binding]]		[[Category: Calcium binding]]
	[[Category: Conformational change]]		[[Category: Conformational change]]

OCA at 19:30, 29 September 2014

OCA — Mon, 29 Sep 2014 19:30:11 GMT

←Older revision		Revision as of 19:30, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1zfs.~~png~~\|~~left~~\|200px]]	+	==Solution structure of S100A1 bound to calcium==
		+	<StructureSection load='1zfs' size='340' side='right' caption='[[1zfs]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1zfs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZFS FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k2h\|1k2h]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S100a1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zfs RCSB], [http://www.ebi.ac.uk/pdbsum/1zfs PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zf/1zfs_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	S100A1 is an EF-hand-containing Ca(2+)-binding protein that undergoes a conformational change upon binding calcium as is necessary to interact with protein targets and initiate a biological response. To better understand how calcium influences the structure and function of S100A1, the three-dimensional structure of calcium-bound S100A1 was determined by multidimensional NMR spectroscopy and compared to the previously determined structure of apo. In total, 3354 nuclear Overhauser effect-derived distance constraints, 240 dihedral constraints, 160 hydrogen bond constraints, and 362 residual dipolar coupling restraints derived from a series of two-dimensional, three-dimensional, and four-dimensional NMR experiments were used in its structure determination (>21 constraints per residue). As with other dimeric S100 proteins, S100A1 is a symmetric homodimer with helices 1, 1', 4, and 4' associating into an X-type four-helix bundle at the dimer interface. Within each subunit there are four alpha-helices and a short antiparallel beta-sheet typical of two helix-loop-helix EF-hand calcium-binding domains. The addition of calcium did not change the interhelical angle of helices 1 and 2 in the pseudo EF-hand significantly; however, there was a large reorientation of helix 3 in the typical EF-hand. The large conformational change exposes a hydrophobic cleft, defined by residues in the hinge region, the C terminus, and regions of helix 3, which are important for the interaction between S100A1 and a peptide (TRTK-12) derived from the actin-capping protein CapZ.

-	~~{{STRUCTURE_1zfs\| PDB=1zfs \| SCENE= }}~~	+	The three-dimensional solution structure of Ca(2+)-bound S100A1 as determined by NMR spectroscopy.,Wright NT, Varney KM, Ellis KC, Markowitz J, Gitti RK, Zimmer DB, Weber DJ J Mol Biol. 2005 Oct 21;353(2):410-26. PMID:16169012<ref>PMID:16169012</ref>

-	~~===Solution structure~~ of ~~S100A1 bound to calcium===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_16169012}}~~	+	==See Also==
-		+	*[[S100 protein\|S100 protein]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1zfs~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFS OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:016169012<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Varney, K M.]]		[[Category: Varney, K M.]]

OCA: Protected "1zfs" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 17:17:06 GMT

Protected "1zfs" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:17, 5 January 2013

OCA at 17:17, 5 January 2013

OCA — Sat, 05 Jan 2013 17:17:02 GMT

←Older revision		Revision as of 17:17, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1zfs.png\|left\|200px]]		[[Image:1zfs.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1zfs", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1zfs\| PDB=1zfs \| SCENE= }}		{{STRUCTURE_1zfs\| PDB=1zfs \| SCENE= }}

	===Solution structure of S100A1 bound to calcium===		===Solution structure of S100A1 bound to calcium===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16169012}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16169012 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16169012}}		{{ABSTRACT_PUBMED_16169012}}

	==About this Structure==		==About this Structure==
-	~~1ZFS~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFS OCA].	+	[[1zfs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFS OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16169012~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016169012</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Varney, K M.]]		[[Category: Varney, K M.]]
Line 30:		Line 18:
	[[Category: Calcium binding]]		[[Category: Calcium binding]]
	[[Category: Conformational change]]		[[Category: Conformational change]]
		+	[[Category: Metal binding protein]]
	[[Category: Noncovalent homodimer]]		[[Category: Noncovalent homodimer]]
	[[Category: S100]]		[[Category: S100]]
	[[Category: X-type 4 helix bundle]]		[[Category: X-type 4 helix bundle]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 22:14:51 2009''