1zfu - Revision history

OCA at 11:27, 2 August 2023

OCA — Wed, 02 Aug 2023 11:27:10 GMT

←Older revision		Revision as of 11:27, 2 August 2023
Line 1:		Line 1:

	==Plectasin:A peptide antibiotic with therapeutic potential from a saprophytic fungus==		==Plectasin:A peptide antibiotic with therapeutic potential from a saprophytic fungus==
-	<StructureSection load='1zfu' size='340' side='right'caption='[[1zfu~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='1zfu' size='340' side='right'caption='[[1zfu]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zfu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ebony_cup Ebony cup~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZFU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zfu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudoplectania_nigrella Pseudoplectania nigrella]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZFU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfu OCA], [https://pdbe.org/1zfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zfu RCSB], [https://www.ebi.ac.uk/pdbsum/1zfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zfu ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfu OCA], [https://pdbe.org/1zfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zfu RCSB], [https://www.ebi.ac.uk/pdbsum/1zfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zfu ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/DEFPL_PSENR DEFPL_PSENR] Antimicrobial peptide that potently acts against several species of Gram-positive bacteria (PubMed:16222292, PubMed:19472324). It selectively inhibits peptidoglycan biosynthesis through complex formation with the cell wall precursor lipid II (1:1 molar ratio) thus inhibiting cell wall synthesis (PubMed:20508130). It does not disrupt cell membranes (PubMed:20508130). Is especially active against numerous clinical isolates of S.pneumoniae, including all 90 different serotypes and isolates resistant to clinically used antibiotics (PubMed:16222292). In vitro, shows considerable selectivity for bacteria over mammalian cells (PubMed:16222292). The peptide synthesized in D-amino acids does not show antibacterial activity (PubMed:19472324). In vitro, acts on voltage-gated potassium channels by moderately inhibiting mammalian Kv1.3/KCNA3 (IC(50)=2.8 uM), and moderately inhibiting others potassium channels (PubMed:25568977).<ref>PMID:16222292</ref> <ref>PMID:25568977</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Ebony cup]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Buskov, S]]	+	[[Category: Pseudoplectania nigrella]]
-	[[Category: Christensen, B]]	+	[[Category: Buskov S]]
-	[[Category: Christensen~~, B E~~]]	+	[[Category: Christensen B]]
-	[[Category: Elvig-Jorgensen~~, S G~~]]	+	[[Category: Christensen BE]]
-	[[Category: Fischer~~, R L~~]]	+	[[Category: De Maria L]]
-	[[Category: Frimodt-Moller, N]]	+	[[Category: Elvig-Jorgensen SG]]
-	[[Category: Hansen~~, M T~~]]	+	[[Category: Fischer RL]]
-	[[Category: Kjaerulf, S]]	+	[[Category: Frimodt-Moller N]]
-	[[Category: Kristensen~~, H H~~]]	+	[[Category: Hansen MT]]
-	[[Category: Lehrer~~, R I~~]]	+	[[Category: Kjaerulf S]]
-	[[Category: Ludvigsen, S]]	+	[[Category: Kristensen HH]]
-	~~[[Category: Maria, L De~~]]	+	[[Category: Lehrer RI]]
-	[[Category: Mygind~~, P H~~]]	+	[[Category: Ludvigsen S]]
-	[[Category: Raventos, D]]	+	[[Category: Mygind PH]]
-	[[Category: Schnorr, K]]	+	[[Category: Raventos D]]
-	[[Category: Sonksen~~, C P~~]]	+	[[Category: Schnorr K]]
-	[[Category: Sorensen~~, M V~~]]	+	[[Category: Sonksen CP]]
-	[[Category: Taboureau, O]]	+	[[Category: Sorensen MV]]
-	[[Category: Yaver, D]]	+	[[Category: Taboureau O]]
-	[[Category: Zasloff, M]]	+	[[Category: Yaver D]]
-	~~[[Category: Antimicrobial peptide]]~~	+	[[Category: Zasloff M]]
-	~~[[Category: Antimicrobial protein]]~~	+
-	~~[[Category: Cysteine stabilized alpha-beta motif]]~~	+
-	~~[[Category: Defensin~~]]	+

OCA at 15:45, 27 October 2021

OCA — Wed, 27 Oct 2021 15:45:03 GMT

←Older revision		Revision as of 15:45, 27 October 2021
Line 3:		Line 3:
	<StructureSection load='1zfu' size='340' side='right'caption='[[1zfu]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1zfu' size='340' side='right'caption='[[1zfu]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zfu]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ebony_cup Ebony cup]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ZFU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zfu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebony_cup Ebony cup]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZFU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1zfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfu OCA], [~~http~~://pdbe.org/1zfu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1zfu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1zfu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1zfu ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfu OCA], [https://pdbe.org/1zfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zfu RCSB], [https://www.ebi.ac.uk/pdbsum/1zfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zfu ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:51, 5 February 2020

OCA — Wed, 05 Feb 2020 09:51:59 GMT

←Older revision		Revision as of 09:51, 5 February 2020
Line 1:		Line 1:

	==Plectasin:A peptide antibiotic with therapeutic potential from a saprophytic fungus==		==Plectasin:A peptide antibiotic with therapeutic potential from a saprophytic fungus==
-	<StructureSection load='1zfu' size='340' side='right' caption='[[1zfu]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='1zfu' size='340' side='right'caption='[[1zfu]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zfu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebony_cup Ebony cup]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZFU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zfu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebony_cup Ebony cup]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZFU FirstGlance]. <br>
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Ebony cup]]		[[Category: Ebony cup]]
		+	[[Category: Large Structures]]
	[[Category: Buskov, S]]		[[Category: Buskov, S]]
	[[Category: Christensen, B]]		[[Category: Christensen, B]]

OCA at 09:17, 2 May 2018

OCA — Wed, 02 May 2018 09:17:53 GMT

←Older revision		Revision as of 09:17, 2 May 2018
Line 1:		Line 1:
		+
	==Plectasin:A peptide antibiotic with therapeutic potential from a saprophytic fungus==		==Plectasin:A peptide antibiotic with therapeutic potential from a saprophytic fungus==
	<StructureSection load='1zfu' size='340' side='right' caption='[[1zfu]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1zfu' size='340' side='right' caption='[[1zfu]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zfu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebony_cup Ebony cup]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZFU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zfu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebony_cup Ebony cup]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZFU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfu OCA], [http://pdbe.org/1zfu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zfu RCSB], [http://www.ebi.ac.uk/pdbsum/1zfu PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfu OCA], [http://pdbe.org/1zfu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zfu RCSB], [http://www.ebi.ac.uk/pdbsum/1zfu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zfu ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:00, 11 September 2015

OCA — Fri, 11 Sep 2015 08:00:34 GMT

←Older revision		Revision as of 08:00, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1zfu' size='340' side='right' caption='[[1zfu]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1zfu' size='340' side='right' caption='[[1zfu]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zfu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudoplectania_nigrella Pseudoplectania nigrella~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZFU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zfu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebony_cup Ebony cup]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZFU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zfu RCSB], [http://www.ebi.ac.uk/pdbsum/1zfu PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfu OCA], [http://pdbe.org/1zfu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zfu RCSB], [http://www.ebi.ac.uk/pdbsum/1zfu PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 13:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1zfu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Pseudoplectania nigrella~~]]	+	[[Category: Ebony cup]]
	[[Category: Buskov, S]]		[[Category: Buskov, S]]
	[[Category: Christensen, B]]		[[Category: Christensen, B]]

OCA at 05:54, 22 December 2014

OCA — Mon, 22 Dec 2014 05:54:22 GMT

←Older revision		Revision as of 05:54, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zfu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudoplectania_nigrella Pseudoplectania nigrella]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZFU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zfu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudoplectania_nigrella Pseudoplectania nigrella]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZFU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zfu RCSB], [http://www.ebi.ac.uk/pdbsum/1zfu PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zfu RCSB], [http://www.ebi.ac.uk/pdbsum/1zfu PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	</StructureSection>		</StructureSection>
	[[Category: Pseudoplectania nigrella]]		[[Category: Pseudoplectania nigrella]]
-	[[Category: Buskov, S.]]	+	[[Category: Buskov, S]]
-	[[Category: Christensen, B.]]	+	[[Category: Christensen, B]]
-	[[Category: Christensen, B E.]]	+	[[Category: Christensen, B E]]
-	[[Category: Elvig-Jorgensen, S G.]]	+	[[Category: Elvig-Jorgensen, S G]]
-	[[Category: Fischer, R L.]]	+	[[Category: Fischer, R L]]
-	[[Category: Frimodt-Moller, N.]]	+	[[Category: Frimodt-Moller, N]]
-	[[Category: Hansen, M T.]]	+	[[Category: Hansen, M T]]
-	[[Category: Kjaerulf, S.]]	+	[[Category: Kjaerulf, S]]
-	[[Category: Kristensen, H H.]]	+	[[Category: Kristensen, H H]]
-	[[Category: Lehrer, R I.]]	+	[[Category: Lehrer, R I]]
-	[[Category: Ludvigsen, S.]]	+	[[Category: Ludvigsen, S]]
-	[[Category: Maria, L De.]]	+	[[Category: Maria, L De]]
-	[[Category: Mygind, P H.]]	+	[[Category: Mygind, P H]]
-	[[Category: Raventos, D.]]	+	[[Category: Raventos, D]]
-	[[Category: Schnorr, K.]]	+	[[Category: Schnorr, K]]
-	[[Category: Sonksen, C P.]]	+	[[Category: Sonksen, C P]]
-	[[Category: Sorensen, M V.]]	+	[[Category: Sorensen, M V]]
-	[[Category: Taboureau, O.]]	+	[[Category: Taboureau, O]]
-	[[Category: Yaver, D.]]	+	[[Category: Yaver, D]]
-	[[Category: Zasloff, M.]]	+	[[Category: Zasloff, M]]
	[[Category: Antimicrobial peptide]]		[[Category: Antimicrobial peptide]]
	[[Category: Antimicrobial protein]]		[[Category: Antimicrobial protein]]
	[[Category: Cysteine stabilized alpha-beta motif]]		[[Category: Cysteine stabilized alpha-beta motif]]
	[[Category: Defensin]]		[[Category: Defensin]]

OCA at 07:07, 9 June 2014

OCA — Mon, 09 Jun 2014 07:07:31 GMT

←Older revision		Revision as of 07:07, 9 June 2014
Line 1:		Line 1:
-	[[~~Image~~:1zfu.~~png\|left\|200px~~]]	+	==Plectasin:A peptide antibiotic with therapeutic potential from a saprophytic fungus==
		+	<StructureSection load='1zfu' size='340' side='right' caption='[[1zfu]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1zfu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudoplectania_nigrella Pseudoplectania nigrella]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZFU FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zfu RCSB], [http://www.ebi.ac.uk/pdbsum/1zfu PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Animals and higher plants express endogenous peptide antibiotics called defensins. These small cysteine-rich peptides are active against bacteria, fungi and viruses. Here we describe plectasin-the first defensin to be isolated from a fungus, the saprophytic ascomycete Pseudoplectania nigrella. Plectasin has primary, secondary and tertiary structures that closely resemble those of defensins found in spiders, scorpions, dragonflies and mussels. Recombinant plectasin was produced at a very high, and commercially viable, yield and purity. In vitro, the recombinant peptide was especially active against Streptococcus pneumoniae, including strains resistant to conventional antibiotics. Plectasin showed extremely low toxicity in mice, and cured them of experimental peritonitis and pneumonia caused by S. pneumoniae as efficaciously as vancomycin and penicillin. These findings identify fungi as a novel source of antimicrobial defensins, and show the therapeutic potential of plectasin. They also suggest that the defensins of insects, molluscs and fungi arose from a common ancestral gene.

-	~~{{STRUCTURE_1zfu\| PDB=1zfu \| SCENE= }}~~	+	Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus.,Mygind PH, Fischer RL, Schnorr KM, Hansen MT, Sonksen CP, Ludvigsen S, Raventos D, Buskov S, Christensen B, De Maria L, Taboureau O, Yaver D, Elvig-Jorgensen SG, Sorensen MV, Christensen BE, Kjaerulff S, Frimodt-Moller N, Lehrer RI, Zasloff M, Kristensen HH Nature. 2005 Oct 13;437(7061):975-80. PMID:16222292<ref>PMID:16222292</ref>

-	~~===Plectasin:A peptide antibiotic with therapeutic potential from~~ a ~~saprophytic fungus===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16222292}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1zfu]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Pseudoplectania_nigrella Pseudoplectania nigrella]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFU OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016222292<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Pseudoplectania nigrella]]		[[Category: Pseudoplectania nigrella]]
	[[Category: Buskov, S.]]		[[Category: Buskov, S.]]

OCA: Protected "1zfu" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 16:23:14 GMT

Protected "1zfu" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:23, 14 August 2012

OCA at 16:23, 14 August 2012

OCA — Tue, 14 Aug 2012 16:23:13 GMT

←Older revision		Revision as of 16:23, 14 August 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1zfu.png\|left\|200px]]		[[Image:1zfu.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1zfu", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1zfu\| PDB=1zfu \| SCENE= }}		{{STRUCTURE_1zfu\| PDB=1zfu \| SCENE= }}

	===Plectasin:A peptide antibiotic with therapeutic potential from a saprophytic fungus===		===Plectasin:A peptide antibiotic with therapeutic potential from a saprophytic fungus===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16222292}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16222292 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16222292}}		{{ABSTRACT_PUBMED_16222292}}

	==About this Structure==		==About this Structure==
-	~~1ZFU is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudoplectania_nigrella Pseudoplectania nigrella]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFU OCA].	+	[[1zfu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudoplectania_nigrella Pseudoplectania nigrella]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFU OCA].

	==Reference==		==Reference==
-	Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus., Mygind PH, Fischer RL, Schnorr KM, Hansen MT, Sonksen CP, Ludvigsen S, Raventos D, Buskov S, Christensen B, De Maria L, Taboureau O, Yaver D, Elvig-Jorgensen SG, Sorensen MV, Christensen BE, Kjaerulff S, Frimodt-Moller N, Lehrer RI, Zasloff M, Kristensen HH, Nature. 2005 Oct 13;437(7061):975-80. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~16222292 16222292]~~	+	<ref group="xtra">PMID:016222292</ref><references group="xtra"/>
	[[Category: Pseudoplectania nigrella]]		[[Category: Pseudoplectania nigrella]]
-	[[Category: Single protein]]
	[[Category: Buskov, S.]]		[[Category: Buskov, S.]]
	[[Category: Christensen, B.]]		[[Category: Christensen, B.]]
Line 46:		Line 33:
	[[Category: Yaver, D.]]		[[Category: Yaver, D.]]
	[[Category: Zasloff, M.]]		[[Category: Zasloff, M.]]
-	[[Category: ~~Defensin,antimicrobial~~ peptide~~,cysteine~~ stabilized alpha-beta motif]]	+	[[Category: Antimicrobial peptide]]
-		+	[[Category: Antimicrobial protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Jul 29 00:32:31 2008''~~	+	[[Category: Cysteine stabilized alpha-beta motif]]
		+	[[Category: Defensin]]

OCA at 21:32, 28 July 2008

OCA — Mon, 28 Jul 2008 21:32:42 GMT

←Older revision		Revision as of 21:32, 28 July 2008
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-	[[Image:1zfu.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1zfu.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_1zfu\| PDB=1zfu \| SCENE= }}		{{STRUCTURE_1zfu\| PDB=1zfu \| SCENE= }}

-	~~'''~~Plectasin:A peptide antibiotic with therapeutic potential from a saprophytic fungus~~'''~~	+	===Plectasin:A peptide antibiotic with therapeutic potential from a saprophytic fungus===


-	~~==Overview==~~	+	<!--
-	~~Animals and higher plants express endogenous peptide antibiotics called defensins. These small cysteine-rich peptides are active against bacteria~~, ~~fungi and viruses. Here we describe plectasin-~~the ~~first defensin~~ to ~~be isolated from a fungus,~~ the saprophytic ascomycete Pseudoplectania nigrella. Plectasin has primary, secondary and tertiary structures that closely resemble those of defensins found in spiders, scorpions, dragonflies and mussels. Recombinant plectasin was produced at ~~a very high, and commercially viable, yield and purity~~. ~~In vitro, the recombinant peptide was especially active against Streptococcus pneumoniae, including strains resistant to conventional antibiotics~~. ~~Plectasin showed extremely low toxicity in mice~~, and cured them of experimental peritonitis and pneumonia caused by S. pneumoniae as efficaciously as vancomycin and penicillin. These findings identify fungi as a novel source of antimicrobial defensins, and show the ~~therapeutic potential of plectasin. They also suggest that the defensins of insects, molluscs and fungi arose from a common ancestral gene~~.	+	The line below this paragraph, {{ABSTRACT_PUBMED_16222292}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 16222292 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_16222292}}

	==About this Structure==		==About this Structure==
-	1ZFU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudoplectania_nigrella Pseudoplectania nigrella]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFU OCA].	+	1ZFU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudoplectania_nigrella Pseudoplectania nigrella]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFU OCA].

	==Reference==		==Reference==
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	[[Category: Zasloff, M.]]		[[Category: Zasloff, M.]]
	[[Category: Defensin,antimicrobial peptide,cysteine stabilized alpha-beta motif]]		[[Category: Defensin,antimicrobial peptide,cysteine stabilized alpha-beta motif]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 17~~:34:20 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:32:31 2008''