1zg8 - Revision history

OCA at 07:08, 23 August 2023

OCA — Wed, 23 Aug 2023 07:08:14 GMT

←Older revision		Revision as of 07:08, 23 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zg8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZG8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zg8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZG8 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=L98:(2R)~~-~~2-(3-{~~[~~AMINO(IMINO)METHYL~~]~~AMINO}PHENYL)-3-SULFANYLPROPANOIC+ACID'>L98</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;'>~~[~~[1z5r\|1z5r~~]~~], [[1zg7\|1zg7]], [[1zg9\|1zg9]], [[1nsa\|1nsa]], [[1kwm\|1kwm]]</div~~></td><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L98:(2R)-2-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-3-SULFANYLPROPANOIC+ACID'>L98</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zg8 OCA], [https://pdbe.org/1zg8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zg8 RCSB], [https://www.ebi.ac.uk/pdbsum/1zg8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zg8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zg8 OCA], [https://pdbe.org/1zg8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zg8 RCSB], [https://www.ebi.ac.uk/pdbsum/1zg8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zg8 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CBPB1_PIG CBPB1_PIG]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Carboxypeptidase B]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
-	[[Category: Adler, M]]	+	[[Category: Adler M]]
-	[[Category: Bryant, J]]	+	[[Category: Bryant J]]
-	[[Category: Buckman, B]]	+	[[Category: Buckman B]]
-	[[Category: Finster, S]]	+	[[Category: Finster S]]
-	[[Category: Islam, I]]	+	[[Category: Islam I]]
-	[[Category: Kent, L]]	+	[[Category: Kent L]]
-	[[Category: Larsen, B]]	+	[[Category: Larsen B]]
-	[[Category: May, K]]	+	[[Category: May K]]
-	[[Category: Mohan, R]]	+	[[Category: Mohan R]]
-	[[Category: Whitlow, M]]	+	[[Category: Whitlow M]]
-	[[Category: Yuan, S]]	+	[[Category: Yuan S]]
-	~~[[Category: Carboxypeptidase b]]~~	+
-	~~[[Category: Exopeptidase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Thiol based inhibitor~~]]	+

OCA at 08:20, 10 November 2021

OCA — Wed, 10 Nov 2021 08:20:36 GMT

←Older revision		Revision as of 08:20, 10 November 2021
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	<StructureSection load='1zg8' size='340' side='right'caption='[[1zg8]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1zg8' size='340' side='right'caption='[[1zg8]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zg8]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZG8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ZG8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zg8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZG8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=L98:(2R)-2-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-3-SULFANYLPROPANOIC+ACID'>L98</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L98:(2R)-2-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-3-SULFANYLPROPANOIC+ACID'>L98</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg9\|1zg9]], [[1nsa\|1nsa]], [[1kwm\|1kwm]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg9\|1zg9]], [[1nsa\|1nsa]], [[1kwm\|1kwm]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1zg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zg8 OCA], [~~http~~://pdbe.org/1zg8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1zg8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1zg8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1zg8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zg8 OCA], [https://pdbe.org/1zg8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zg8 RCSB], [https://www.ebi.ac.uk/pdbsum/1zg8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zg8 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 09:38, 5 February 2020

OCA — Wed, 05 Feb 2020 09:38:17 GMT

←Older revision		Revision as of 09:38, 5 February 2020
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	==Crystal Structure of (R)-2-(3-{[amino(imino)methyl]amino}phenyl)-3-sulfanylpropanoic acid Bound to Activated Porcine Pancreatic Carboxypeptidase B==		==Crystal Structure of (R)-2-(3-{[amino(imino)methyl]amino}phenyl)-3-sulfanylpropanoic acid Bound to Activated Porcine Pancreatic Carboxypeptidase B==
-	<StructureSection load='1zg8' size='340' side='right' caption='[[1zg8]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1zg8' size='340' side='right'caption='[[1zg8]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zg8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZG8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zg8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZG8 FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 1zg8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1zg8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Carboxypeptidase 3D structures\|Carboxypeptidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Carboxypeptidase B]]		[[Category: Carboxypeptidase B]]
		+	[[Category: Large Structures]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
	[[Category: Adler, M]]		[[Category: Adler, M]]

OCA at 09:03, 2 May 2018

OCA — Wed, 02 May 2018 09:03:50 GMT

←Older revision		Revision as of 09:03, 2 May 2018
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		+
	==Crystal Structure of (R)-2-(3-{[amino(imino)methyl]amino}phenyl)-3-sulfanylpropanoic acid Bound to Activated Porcine Pancreatic Carboxypeptidase B==		==Crystal Structure of (R)-2-(3-{[amino(imino)methyl]amino}phenyl)-3-sulfanylpropanoic acid Bound to Activated Porcine Pancreatic Carboxypeptidase B==
	<StructureSection load='1zg8' size='340' side='right' caption='[[1zg8]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1zg8' size='340' side='right' caption='[[1zg8]], [[Resolution\|resolution]] 2.00Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg9\|1zg9]], [[1nsa\|1nsa]], [[1kwm\|1kwm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg9\|1zg9]], [[1nsa\|1nsa]], [[1kwm\|1kwm]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zg8 OCA], [http://pdbe.org/1zg8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zg8 RCSB], [http://www.ebi.ac.uk/pdbsum/1zg8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zg8 OCA], [http://pdbe.org/1zg8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zg8 RCSB], [http://www.ebi.ac.uk/pdbsum/1zg8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zg8 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zg/1zg8_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zg/1zg8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1zg8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1zg8" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Carboxypeptidase\|Carboxypeptidase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:09, 9 February 2016

OCA — Tue, 09 Feb 2016 06:09:38 GMT

←Older revision		Revision as of 06:09, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zg8 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:22, 10 September 2015

OCA — Thu, 10 Sep 2015 19:22:31 GMT

←Older revision		Revision as of 19:22, 10 September 2015
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg9\|1zg9]], [[1nsa\|1nsa]], [[1kwm\|1kwm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg9\|1zg9]], [[1nsa\|1nsa]], [[1kwm\|1kwm]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zg8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zg8 RCSB], [http://www.ebi.ac.uk/pdbsum/1zg8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zg8 OCA], [http://pdbe.org/1zg8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zg8 RCSB], [http://www.ebi.ac.uk/pdbsum/1zg8 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1zg8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 09:20, 8 January 2015

OCA — Thu, 08 Jan 2015 09:20:49 GMT

←Older revision		Revision as of 09:20, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zg8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZG8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zg8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZG8 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=L98:(2R)-2-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-3-SULFANYLPROPANOIC+ACID'>L98</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=L98:(2R)-2-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-3-SULFANYLPROPANOIC+ACID'>L98</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg9\|1zg9]], [[1nsa\|1nsa]], [[1kwm\|1kwm]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg9\|1zg9]], [[1nsa\|1nsa]], [[1kwm\|1kwm]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zg8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zg8 RCSB], [http://www.ebi.ac.uk/pdbsum/1zg8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zg8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zg8 RCSB], [http://www.ebi.ac.uk/pdbsum/1zg8 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Carboxypeptidase B]]		[[Category: Carboxypeptidase B]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
-	[[Category: Adler, M.]]	+	[[Category: Adler, M]]
-	[[Category: Bryant, J.]]	+	[[Category: Bryant, J]]
-	[[Category: Buckman, B.]]	+	[[Category: Buckman, B]]
-	[[Category: Finster, S.]]	+	[[Category: Finster, S]]
-	[[Category: Islam, I.]]	+	[[Category: Islam, I]]
-	[[Category: Kent, L.]]	+	[[Category: Kent, L]]
-	[[Category: Larsen, B.]]	+	[[Category: Larsen, B]]
-	[[Category: May, K.]]	+	[[Category: May, K]]
-	[[Category: Mohan, R.]]	+	[[Category: Mohan, R]]
-	[[Category: Whitlow, M.]]	+	[[Category: Whitlow, M]]
-	[[Category: Yuan, S.]]	+	[[Category: Yuan, S]]
	[[Category: Carboxypeptidase b]]		[[Category: Carboxypeptidase b]]
	[[Category: Exopeptidase]]		[[Category: Exopeptidase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Thiol based inhibitor]]		[[Category: Thiol based inhibitor]]

OCA at 04:38, 29 September 2014

OCA — Mon, 29 Sep 2014 04:38:16 GMT

←Older revision		Revision as of 04:38, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1zg8.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of (R)-2-(3-{[amino(imino)methyl]amino}phenyl)-3-sulfanylpropanoic acid Bound to Activated Porcine Pancreatic Carboxypeptidase B==
		+	<StructureSection load='1zg8' size='340' side='right' caption='[[1zg8]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1zg8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZG8 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=L98:(2R)-2-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-3-SULFANYLPROPANOIC+ACID'>L98</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg9\|1zg9]], [[1nsa\|1nsa]], [[1kwm\|1kwm]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zg8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zg8 RCSB], [http://www.ebi.ac.uk/pdbsum/1zg8 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zg/1zg8_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	This paper presents the crystal structure of porcine pancreatic carboxypeptidase B (pp-CpB) in complex with a variety of thiol-based inhibitors that were developed as antagonists of activated thrombin-activatable fibrinolysis inhibitor (TAFIa). Recent studies have indicated that a selective inhibitor of TAFIa could enhance the efficacy of existing thrombolytic agents for the treatment of acute myocardial infarction, one of the most prevalent forms of heart attacks. Unfortunately, activated TAFIa rapidly degrades in solution and cannot be used for crystallographic studies. In contrast, porcine pancreatic CpB is stable at room temperature and is available from commercial sources. Both pancreatic CpB and TAFIa are zinc-based exopeptidases, and the proteins share a 47% sequence identity. The homology improves considerably in the active site where nearly all of the residues are conserved. The inhibitors used in this study were designed to mimic a C-terminal arginine residue, one of the natural substrates of TAFIa. The X-ray structures show that the thiol group chelates the active site zinc, the carboxylic acid forms a salt bridge to Arg145, and the guanidine group forms two hydrogen bonds to Asp255. A meta-substituted phenyl was introduced into our inhibitors to reduce conformational freedom. This modification vastly improved the selectivity of compounds against other exopeptidases that cleave basic residues. Comparisons between structures indicate that selectivity derives from the interaction between the guanidine group in the inhibitors and an acidic active site residue. The location of this acidic residue is not conserved in the various carboxypeptidases.

-	~~{{STRUCTURE_1zg8\| PDB=1zg8 \| SCENE= }}~~	+	Crystal structures of potent thiol-based inhibitors bound to carboxypeptidase B.,Adler M, Bryant J, Buckman B, Islam I, Larsen B, Finster S, Kent L, May K, Mohan R, Yuan S, Whitlow M Biochemistry. 2005 Jul 5;44(26):9339-47. PMID:15982000<ref>PMID:15982000</ref>

-	~~===Crystal Structure~~ of ~~(R)-2-(3-{[amino(imino)methyl]amino}phenyl)-3-sulfanylpropanoic acid Bound to Activated Porcine Pancreatic Carboxypeptidase B===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15982000}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1zg8]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Sus_scrofa Sus scrofa]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1ZG8 OCA].~~	+

	==See Also==		==See Also==
	*[[Carboxypeptidase\|Carboxypeptidase]]		*[[Carboxypeptidase\|Carboxypeptidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015982000<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Carboxypeptidase B]]		[[Category: Carboxypeptidase B]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]

OCA at 12:54, 20 October 2012

OCA — Sat, 20 Oct 2012 12:54:45 GMT

←Older revision		Revision as of 12:54, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1zg8]] is a 3 chain structure ~~of [[Carboxypeptidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZG8 OCA].	+	[[1zg8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZG8 OCA].

	==See Also==		==See Also==

OCA: Protected "1zg8" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 10:17:49 GMT

Protected "1zg8" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:17, 26 July 2012