1zhw - Revision history

OCA at 07:08, 23 August 2023

OCA — Wed, 23 Aug 2023 07:08:50 GMT

←Older revision		Revision as of 07:08, 23 August 2023
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	<StructureSection load='1zhw' size='340' side='right'caption='[[1zhw]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1zhw' size='340' side='right'caption='[[1zhw]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zhw]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZHW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1ZHW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zhw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZHW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZHW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=HC2:20~~-~~HYDROXYCHOLESTEROL'>HC2</scene>~~, ~~<scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1zht\|1zht]], [[1zhx\|1zhx]], [[1zhy\|1zhy]], [[1zhz\|1zhz]], [[1zi7\|1zi7]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HC2:20-HYDROXYCHOLESTEROL'>HC2</scene>, <scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">OSH4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zhw OCA], [https://pdbe.org/1zhw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zhw RCSB], [https://www.ebi.ac.uk/pdbsum/1zhw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zhw ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1zhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zhw OCA], [~~http~~://pdbe.org/1zhw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1zhw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1zhw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1zhw ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KES1_YEAST KES1_YEAST]] Plays a role in ergosterol synthesis.	+	[https://www.uniprot.org/uniprot/KES1_YEAST KES1_YEAST] Plays a role in ergosterol synthesis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Hurley, J H~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Im, Y J~~]]	+	[[Category: Hurley JH]]
-	[[Category: ~~Prinz, W A~~]]	+	[[Category: Im YJ]]
-	[[Category: ~~Raychaudhuri, S~~]]	+	[[Category: Prinz WA]]
-	[[Category: ~~Lipid binding protein]]~~	+	[[Category: Raychaudhuri S]]
-	~~[[Category: Oxysterol]]~~	+
-	~~[[Category: Sterol binding protein~~]]	+

OCA at 09:04, 20 January 2021

OCA — Wed, 20 Jan 2021 09:04:16 GMT

←Older revision		Revision as of 09:04, 20 January 2021
Line 1:		Line 1:

	==Structure of yeast oxysterol binding protein Osh4 in complex with 20-hydroxycholesterol==		==Structure of yeast oxysterol binding protein Osh4 in complex with 20-hydroxycholesterol==
-	<StructureSection load='1zhw' size='340' side='right' caption='[[1zhw]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='1zhw' size='340' side='right'caption='[[1zhw]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zhw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZHW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ZHW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zhw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZHW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1ZHW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HC2:20-HYDROXYCHOLESTEROL'>HC2</scene>, <scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HC2:20-HYDROXYCHOLESTEROL'>HC2</scene>, <scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zht\|1zht]], [[1zhx\|1zhx]], [[1zhy\|1zhy]], [[1zhz\|1zhz]], [[1zi7\|1zi7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zht\|1zht]], [[1zhx\|1zhx]], [[1zhy\|1zhy]], [[1zhz\|1zhz]], [[1zi7\|1zi7]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OSH4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OSH4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1zhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zhw OCA], [http://pdbe.org/1zhw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zhw RCSB], [http://www.ebi.ac.uk/pdbsum/1zhw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zhw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1zhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zhw OCA], [http://pdbe.org/1zhw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zhw RCSB], [http://www.ebi.ac.uk/pdbsum/1zhw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zhw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 1zhw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1zhw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Oxysterol-binding protein homolog\|Oxysterol-binding protein homolog]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Hurley, J H]]		[[Category: Hurley, J H]]
	[[Category: Im, Y J]]		[[Category: Im, Y J]]

OCA at 09:01, 2 May 2018

OCA — Wed, 02 May 2018 09:01:34 GMT

←Older revision		Revision as of 09:01, 2 May 2018
Line 1:		Line 1:
		+
	==Structure of yeast oxysterol binding protein Osh4 in complex with 20-hydroxycholesterol==		==Structure of yeast oxysterol binding protein Osh4 in complex with 20-hydroxycholesterol==
	<StructureSection load='1zhw' size='340' side='right' caption='[[1zhw]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1zhw' size='340' side='right' caption='[[1zhw]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zht\|1zht]], [[1zhx\|1zhx]], [[1zhy\|1zhy]], [[1zhz\|1zhz]], [[1zi7\|1zi7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zht\|1zht]], [[1zhx\|1zhx]], [[1zhy\|1zhy]], [[1zhz\|1zhz]], [[1zi7\|1zi7]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OSH4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OSH4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zhw OCA], [http://pdbe.org/1zhw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zhw RCSB], [http://www.ebi.ac.uk/pdbsum/1zhw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zhw OCA], [http://pdbe.org/1zhw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zhw RCSB], [http://www.ebi.ac.uk/pdbsum/1zhw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zhw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zh/1zhw_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zh/1zhw_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 06:46, 7 February 2016

OCA — Sun, 07 Feb 2016 06:46:50 GMT

←Older revision		Revision as of 06:46, 7 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zhw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:51, 9 September 2015

OCA — Wed, 09 Sep 2015 22:51:44 GMT

←Older revision		Revision as of 22:51, 9 September 2015
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	<StructureSection load='1zhw' size='340' side='right' caption='[[1zhw]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1zhw' size='340' side='right' caption='[[1zhw]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zhw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZHW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zhw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZHW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HC2:20-HYDROXYCHOLESTEROL'>HC2</scene>, <scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HC2:20-HYDROXYCHOLESTEROL'>HC2</scene>, <scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zht\|1zht]], [[1zhx\|1zhx]], [[1zhy\|1zhy]], [[1zhz\|1zhz]], [[1zi7\|1zi7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zht\|1zht]], [[1zhx\|1zhx]], [[1zhy\|1zhy]], [[1zhz\|1zhz]], [[1zi7\|1zi7]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OSH4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OSH4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zhw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zhw RCSB], [http://www.ebi.ac.uk/pdbsum/1zhw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zhw OCA], [http://pdbe.org/1zhw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zhw RCSB], [http://www.ebi.ac.uk/pdbsum/1zhw PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1zhw" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Hurley, J H]]		[[Category: Hurley, J H]]
	[[Category: Im, Y J]]		[[Category: Im, Y J]]

OCA at 08:43, 24 December 2014

OCA — Wed, 24 Dec 2014 08:43:39 GMT

←Older revision		Revision as of 08:43, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zhw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZHW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zhw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZHW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HC2:20-HYDROXYCHOLESTEROL'>HC2</scene>, <scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HC2:20-HYDROXYCHOLESTEROL'>HC2</scene>, <scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zht\|1zht]], [[1zhx\|1zhx]], [[1zhy\|1zhy]], [[1zhz\|1zhz]], [[1zi7\|1zi7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zht\|1zht]], [[1zhx\|1zhx]], [[1zhy\|1zhy]], [[1zhz\|1zhz]], [[1zi7\|1zi7]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OSH4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OSH4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zhw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zhw RCSB], [http://www.ebi.ac.uk/pdbsum/1zhw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zhw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zhw RCSB], [http://www.ebi.ac.uk/pdbsum/1zhw PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KES1_YEAST KES1_YEAST]] Plays a role in ergosterol synthesis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Hurley, J H.]]	+	[[Category: Hurley, J H]]
-	[[Category: Im, Y J.]]	+	[[Category: Im, Y J]]
-	[[Category: Prinz, W A.]]	+	[[Category: Prinz, W A]]
-	[[Category: Raychaudhuri, S.]]	+	[[Category: Raychaudhuri, S]]
	[[Category: Lipid binding protein]]		[[Category: Lipid binding protein]]
	[[Category: Oxysterol]]		[[Category: Oxysterol]]
	[[Category: Sterol binding protein]]		[[Category: Sterol binding protein]]

OCA at 19:30, 29 September 2014

OCA — Mon, 29 Sep 2014 19:30:51 GMT

←Older revision		Revision as of 19:30, 29 September 2014
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-	[[~~Image:~~1zhw.~~png~~\|~~left~~\|200px]]	+	==Structure of yeast oxysterol binding protein Osh4 in complex with 20-hydroxycholesterol==
		+	<StructureSection load='1zhw' size='340' side='right' caption='[[1zhw]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1zhw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZHW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HC2:20-HYDROXYCHOLESTEROL'>HC2</scene>, <scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zht\|1zht]], [[1zhx\|1zhx]], [[1zhy\|1zhy]], [[1zhz\|1zhz]], [[1zi7\|1zi7]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OSH4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zhw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zhw RCSB], [http://www.ebi.ac.uk/pdbsum/1zhw PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zh/1zhw_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The oxysterol-binding-protein (OSBP)-related proteins (ORPs) are conserved from yeast to humans, and are implicated in the regulation of sterol homeostasis and in signal transduction pathways. Here we report the structure of the full-length yeast ORP Osh4 (also known as Kes1) at 1.5-1.9 A resolution in complexes with ergosterol, cholesterol, and 7-, 20- and 25-hydroxycholesterol. We find that a single sterol molecule binds within a hydrophobic tunnel in a manner consistent with a transport function for ORPs. The entrance is blocked by a flexible amino-terminal lid and surrounded by basic residues that are critical for Osh4 function. The structure of the open state of a lid-truncated form of Osh4 was determined at 2.5 A resolution. Structural analysis and limited proteolysis show that sterol binding closes the lid and stabilizes a conformation favouring transport across aqueous barriers and signal transmission. The structure of Osh4 in the absence of ligand exposes potential phospholipid-binding sites that are positioned for membrane docking and sterol exchange. On the basis of these observations, we propose a model in which sterol and membrane binding promote reciprocal conformational changes that facilitate a sterol transfer and signalling cycle.

-	~~{{STRUCTURE_1zhw\| PDB=1zhw \| SCENE= }}~~	+	Structural mechanism for sterol sensing and transport by OSBP-related proteins.,Im YJ, Raychaudhuri S, Prinz WA, Hurley JH Nature. 2005 Sep 1;437(7055):154-8. PMID:16136145<ref>PMID:16136145</ref>

-	~~===Structure~~ of ~~yeast oxysterol binding protein Osh4 in complex with 20-hydroxycholesterol===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16136145}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1zhw]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1ZHW OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016136145<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Hurley, J H.]]		[[Category: Hurley, J H.]]

OCA: Protected "1zhw" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 17:18:47 GMT

Protected "1zhw" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:18, 5 January 2013

OCA at 17:18, 5 January 2013

OCA — Sat, 05 Jan 2013 17:18:45 GMT

←Older revision		Revision as of 17:18, 5 January 2013
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-	{{Seed}}
	[[Image:1zhw.png\|left\|200px]]		[[Image:1zhw.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1zhw", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1zhw\| PDB=1zhw \| SCENE= }}		{{STRUCTURE_1zhw\| PDB=1zhw \| SCENE= }}

	===Structure of yeast oxysterol binding protein Osh4 in complex with 20-hydroxycholesterol===		===Structure of yeast oxysterol binding protein Osh4 in complex with 20-hydroxycholesterol===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16136145}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16136145 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16136145}}		{{ABSTRACT_PUBMED_16136145}}

	==About this Structure==		==About this Structure==
-	~~1ZHW~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZHW OCA].	+	[[1zhw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZHW OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16136145~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016136145</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Hurley, J H.]]		[[Category: Hurley, J H.]]
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	[[Category: Prinz, W A.]]		[[Category: Prinz, W A.]]
	[[Category: Raychaudhuri, S.]]		[[Category: Raychaudhuri, S.]]
		+	[[Category: Lipid binding protein]]
	[[Category: Oxysterol]]		[[Category: Oxysterol]]
	[[Category: Sterol binding protein]]		[[Category: Sterol binding protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:03:19 2009''

OCA at 10:03, 16 February 2009

OCA — Mon, 16 Feb 2009 10:03:21 GMT

←Older revision		Revision as of 10:03, 16 February 2009
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	==About this Structure==		==About this Structure==
-	1ZHW is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZHW OCA].	+	1ZHW is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZHW OCA].

	==Reference==		==Reference==
-	~~Structural mechanism for sterol sensing and transport by OSBP-related proteins., Im YJ, Raychaudhuri S, Prinz WA, Hurley JH, Nature. 2005 Sep 1;437(7055):154-8.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16136145 16136145]~~	+	<ref group="xtra">PMID:16136145</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Single protein]]
	[[Category: Hurley, J H.]]		[[Category: Hurley, J H.]]
	[[Category: Im, Y J.]]		[[Category: Im, Y J.]]
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	[[Category: Sterol binding protein]]		[[Category: Sterol binding protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 14:~~12:~~25 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:03:19 2009''