1zkz - Revision history

OCA at 07:10, 23 August 2023

OCA — Wed, 23 Aug 2023 07:10:04 GMT

←Older revision		Revision as of 07:10, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1zkz' size='340' side='right'caption='[[1zkz]], [[Resolution\|resolution]] 2.33Å' scene=''>		<StructureSection load='1zkz' size='340' side='right'caption='[[1zkz]], [[Resolution\|resolution]] 2.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zkz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZKZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1ZKZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zkz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZKZ FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~GDF2~~, ~~BMP9 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.33Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1zkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zkz OCA], [~~http~~://pdbe.org/1zkz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1zkz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1zkz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1zkz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zkz OCA], [https://pdbe.org/1zkz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zkz RCSB], [https://www.ebi.ac.uk/pdbsum/1zkz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zkz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GDF2_HUMAN GDF2_HUMAN]] Potent circulating inhibitor of angiogenesis. Could be involved in bone formation. Signals through the type I activin receptor ACVRL1 but not other Alks.<ref>PMID:18309101</ref> <ref>PMID:22799562</ref>	+	[https://www.uniprot.org/uniprot/GDF2_HUMAN GDF2_HUMAN] Potent circulating inhibitor of angiogenesis. Could be involved in bone formation. Signals through the type I activin receptor ACVRL1 but not other Alks.<ref>PMID:18309101</ref> <ref>PMID:22799562</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Baker~~, K A~~]]	+	[[Category: Baker KA]]
-	[[Category: Brown~~, M A~~]]	+	[[Category: Brown MA]]
-	[[Category: Chen, C]]	+	[[Category: Chen C]]
-	[[Category: Choe, S]]	+	[[Category: Choe S]]
-	[[Category: Mahoney, A]]	+	[[Category: Mahoney A]]
-	[[Category: Naik, C]]	+	[[Category: Naik C]]
-	[[Category: Parice, Y]]	+	[[Category: Parice Y]]
-	[[Category: Pukac, L]]	+	[[Category: Pukac L]]
-	[[Category: Roschke, V]]	+	[[Category: Roschke V]]
-	[[Category: Sanyal, I]]	+	[[Category: Sanyal I]]
-	[[Category: Singh, M]]	+	[[Category: Singh M]]
-	[[Category: Tsareva, T]]	+	[[Category: Tsareva T]]
-	[[Category: Zhao, Q]]	+	[[Category: Zhao Q]]
-	~~[[Category: Cytokine]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Growth factor]]~~	+
-	~~[[Category: Hormone-growth factor complex~~]]	+

OCA at 09:06, 20 January 2021

OCA — Wed, 20 Jan 2021 09:06:00 GMT

←Older revision		Revision as of 09:06, 20 January 2021
Line 1:		Line 1:

	==Crystal Structure of BMP9==		==Crystal Structure of BMP9==
-	<StructureSection load='1zkz' size='340' side='right' caption='[[1zkz]], [[Resolution\|resolution]] 2.33Å' scene=''>	+	<StructureSection load='1zkz' size='340' side='right'caption='[[1zkz]], [[Resolution\|resolution]] 2.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zkz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZKZ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ZKZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zkz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZKZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1ZKZ FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GDF2, BMP9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GDF2, BMP9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1zkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zkz OCA], [http://pdbe.org/1zkz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zkz RCSB], [http://www.ebi.ac.uk/pdbsum/1zkz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zkz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1zkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zkz OCA], [http://pdbe.org/1zkz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zkz RCSB], [http://www.ebi.ac.uk/pdbsum/1zkz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zkz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zk/1zkz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zk/1zkz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1zkz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1zkz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Growth differentiation factor 3D STRUCTURES\|Growth differentiation factor 3D STRUCTURES]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Baker, K A]]		[[Category: Baker, K A]]
	[[Category: Brown, M A]]		[[Category: Brown, M A]]

OCA at 10:03, 12 October 2017

OCA — Thu, 12 Oct 2017 10:03:07 GMT

←Older revision		Revision as of 10:03, 12 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of BMP9==		==Crystal Structure of BMP9==
	<StructureSection load='1zkz' size='340' side='right' caption='[[1zkz]], [[Resolution\|resolution]] 2.33Å' scene=''>		<StructureSection load='1zkz' size='340' side='right' caption='[[1zkz]], [[Resolution\|resolution]] 2.33Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1zkz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZKZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zkz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZKZ FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GDF2, BMP9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GDF2, BMP9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zkz OCA], [http://pdbe.org/1zkz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zkz RCSB], [http://www.ebi.ac.uk/pdbsum/1zkz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zkz OCA], [http://pdbe.org/1zkz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zkz RCSB], [http://www.ebi.ac.uk/pdbsum/1zkz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zkz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zkz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1zkz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1zkz" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Growth differentiation factor\|Growth differentiation factor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:05, 11 September 2015

OCA — Fri, 11 Sep 2015 11:05:32 GMT

←Older revision		Revision as of 11:05, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1zkz' size='340' side='right' caption='[[1zkz]], [[Resolution\|resolution]] 2.33Å' scene=''>		<StructureSection load='1zkz' size='340' side='right' caption='[[1zkz]], [[Resolution\|resolution]] 2.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zkz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZKZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zkz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZKZ FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GDF2, BMP9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GDF2, BMP9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zkz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zkz RCSB], [http://www.ebi.ac.uk/pdbsum/1zkz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zkz OCA], [http://pdbe.org/1zkz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zkz RCSB], [http://www.ebi.ac.uk/pdbsum/1zkz PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1zkz" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Baker, K A]]		[[Category: Baker, K A]]
	[[Category: Brown, M A]]		[[Category: Brown, M A]]

OCA at 15:36, 25 December 2014

OCA — Thu, 25 Dec 2014 15:36:08 GMT

←Older revision		Revision as of 15:36, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zkz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZKZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zkz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZKZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GDF2, BMP9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GDF2, BMP9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zkz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zkz RCSB], [http://www.ebi.ac.uk/pdbsum/1zkz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zkz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zkz RCSB], [http://www.ebi.ac.uk/pdbsum/1zkz PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GDF2_HUMAN GDF2_HUMAN]] Potent circulating inhibitor of angiogenesis. Could be involved in bone formation. Signals through the type I activin receptor ACVRL1 but not other Alks.<ref>PMID:18309101</ref> <ref>PMID:22799562</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Baker, K A.]]	+	[[Category: Baker, K A]]
-	[[Category: Brown, M A.]]	+	[[Category: Brown, M A]]
-	[[Category: Chen, C.]]	+	[[Category: Chen, C]]
-	[[Category: Choe, S.]]	+	[[Category: Choe, S]]
-	[[Category: Mahoney, A.]]	+	[[Category: Mahoney, A]]
-	[[Category: Naik, C.]]	+	[[Category: Naik, C]]
-	[[Category: Parice, Y.]]	+	[[Category: Parice, Y]]
-	[[Category: Pukac, L.]]	+	[[Category: Pukac, L]]
-	[[Category: Roschke, V.]]	+	[[Category: Roschke, V]]
-	[[Category: Sanyal, I.]]	+	[[Category: Sanyal, I]]
-	[[Category: Singh, M.]]	+	[[Category: Singh, M]]
-	[[Category: Tsareva, T.]]	+	[[Category: Tsareva, T]]
-	[[Category: Zhao, Q.]]	+	[[Category: Zhao, Q]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Growth factor]]		[[Category: Growth factor]]
	[[Category: Hormone-growth factor complex]]		[[Category: Hormone-growth factor complex]]

OCA at 18:48, 29 September 2014

OCA — Mon, 29 Sep 2014 18:48:33 GMT

←Older revision		Revision as of 18:48, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1zkz.~~png\|left~~\|200px]]	+	==Crystal Structure of BMP9==
		+	<StructureSection load='1zkz' size='340' side='right' caption='[[1zkz]], [[Resolution\|resolution]] 2.33Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1zkz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZKZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GDF2, BMP9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zkz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zkz RCSB], [http://www.ebi.ac.uk/pdbsum/1zkz PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zk/1zkz_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bone morphogenetic proteins (BMPs), a subset of the transforming growth factor (TGF)-beta superfamily, regulate a diverse array of cellular functions during development and in the adult. BMP-9 (also known as growth and differentiation factor (GDF)-2) potently induces osteogenesis and chondrogenesis, has been implicated in the differentiation of cholinergic neurons, and may help regulate glucose metabolism. We have determined the structure of BMP-9 to 2.3 A and examined the differences between our model and existing crystal structures of other BMPs, both in isolation and in complex with their receptors. TGF-beta ligands are translated as precursors, with pro-regions that generally dissociate after cleavage from the ligand, but in some cases (including GDF-8 and TGF-beta1, -2, and -3), the pro-region remains associated after secretion from the cell and inhibits binding of the ligand to its receptor. Although the proregion of BMP-9 remains tightly associated after secretion, we find, in several cell-based assays, that the activities of BMP-9 and BMP-9.pro-region complex were equivalent. Activin receptor-like kinase 1 (ALK-1), an orphan receptor in the TGF-beta family, was also identified as a potential receptor for BMP-9 based on surface plasmon resonance studies (BIAcore) and the ability of soluble ALK-1 to block the activity of BMP-9.pro-region complex in cell-based assays.

-	~~{{STRUCTURE_1zkz\| PDB=1zkz \| SCENE= }}~~	+	Crystal structure of BMP-9 and functional interactions with pro-region and receptors.,Brown MA, Zhao Q, Baker KA, Naik C, Chen C, Pukac L, Singh M, Tsareva T, Parice Y, Mahoney A, Roschke V, Sanyal I, Choe S J Biol Chem. 2005 Jul 1;280(26):25111-8. Epub 2005 Apr 25. PMID:15851468<ref>PMID:15851468</ref>

-	~~===Crystal Structure~~ of ~~BMP9===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_15851468}}~~	+	==See Also==
-		+	*[[Growth differentiation factor\|Growth differentiation factor]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1zkz~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZKZ OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:015851468<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Baker, K A.]]		[[Category: Baker, K A.]]

OCA: Protected "1zkz" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 17:53:10 GMT

Protected "1zkz" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:53, 5 January 2013

OCA at 17:53, 5 January 2013

OCA — Sat, 05 Jan 2013 17:53:07 GMT

←Older revision		Revision as of 17:53, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1zkz.png\|left\|200px]]		[[Image:1zkz.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1zkz", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1zkz\| PDB=1zkz \| SCENE= }}		{{STRUCTURE_1zkz\| PDB=1zkz \| SCENE= }}

	===Crystal Structure of BMP9===		===Crystal Structure of BMP9===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15851468}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15851468 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15851468}}		{{ABSTRACT_PUBMED_15851468}}

	==About this Structure==		==About this Structure==
-	~~1ZKZ~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZKZ OCA].	+	[[1zkz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZKZ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15851468~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015851468</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Baker, K A.]]		[[Category: Baker, K A.]]
Line 41:		Line 29:
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Growth factor]]		[[Category: Growth factor]]
-	[[Category: ~~Signal~~]]	+	[[Category: Hormone-growth factor complex]]
-		+
-	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:35:06 2009''~~	+

OCA at 18:35, 17 February 2009

OCA — Tue, 17 Feb 2009 18:35:08 GMT

←Older revision		Revision as of 18:35, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1ZKZ is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZKZ OCA].	+	1ZKZ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZKZ OCA].

	==Reference==		==Reference==
-	Crystal structure of BMP-9 and functional interactions with pro-region and receptors., Brown MA, Zhao Q, Baker KA, Naik C, Chen C, Pukac L, Singh M, Tsareva T, Parice Y, Mahoney A, Roschke V, Sanyal I, Choe S, J Biol Chem. 2005 Jul 1;280(26):25111-8. Epub 2005 Apr 25. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/15851468 15851468]~~	+	<ref group="xtra">PMID:15851468</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Baker, K A.]]		[[Category: Baker, K A.]]
	[[Category: Brown, M A.]]		[[Category: Brown, M A.]]
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	[[Category: Signal]]		[[Category: Signal]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 04~~:28:~~37 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:35:06 2009''

OCA at 01:28, 29 July 2008

OCA — Tue, 29 Jul 2008 01:28:44 GMT

←Older revision		Revision as of 01:28, 29 July 2008
Line 1:		Line 1:
-	[[Image:1zkz.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1zkz.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_1zkz\| PDB=1zkz \| SCENE= }}		{{STRUCTURE_1zkz\| PDB=1zkz \| SCENE= }}

-	~~'''~~Crystal Structure of BMP9~~'''~~	+	===Crystal Structure of BMP9===


-	~~==Overview==~~	+	<!--
-	~~Bone morphogenetic proteins (BMPs), a subset of the transforming growth factor (TGF)~~-~~beta superfamily, regulate a diverse array of cellular functions during development and in the adult. BMP~~-~~9 (also known as growth and differentiation factor (GDF)-2) potently induces osteogenesis and chondrogenesis~~, ~~has been implicated in the differentiation of cholinergic neurons~~, ~~and may help regulate glucose metabolism. We have determined~~ the ~~structure of BMP-9~~ to ~~2.3 A and examined~~ the ~~differences between our model and existing crystal structures of other BMPs, both in isolation and in complex with their receptors. TGF-beta ligands are translated~~ as precursors, with pro-regions that generally dissociate after cleavage from the ligand, but in some cases (including GDF-8 and TGF-beta1, -2, and -3), the pro-region remains associated after secretion from the cell and inhibits binding of the ligand to its receptor. ~~Although the proregion of BMP-9 remains tightly associated after secretion, we find, in several cell-based assays, that the activities of BMP-9 and BMP-9~~.~~pro-region complex were equivalent. Activin receptor-like kinase 1 (ALK-1~~), ~~an orphan receptor in~~ the ~~TGF-beta family, was also identified as a potential receptor for BMP-9 based on surface plasmon resonance studies (BIAcore) and the ability of soluble ALK-1 to block the activity of BMP-9~~.~~pro~~-~~region complex in cell~~-~~based assays.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_15851468}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 15851468 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_15851468}}

	==About this Structure==		==About this Structure==
Line 39:		Line 43:
	[[Category: Growth factor]]		[[Category: Growth factor]]
	[[Category: Signal]]		[[Category: Signal]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 17~~:45:13 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:28:37 2008''