1zlm - Revision history

OCA at 07:10, 23 August 2023

OCA — Wed, 23 Aug 2023 07:10:32 GMT

←Older revision		Revision as of 07:10, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1zlm' size='340' side='right'caption='[[1zlm]], [[Resolution\|resolution]] 1.07Å' scene=''>		<StructureSection load='1zlm' size='340' side='right'caption='[[1zlm]], [[Resolution\|resolution]] 1.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zlm]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1ZLM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zlm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZLM FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~OSTF1 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.07Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1zlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zlm OCA], [~~http~~://pdbe.org/1zlm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1zlm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1zlm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1zlm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zlm OCA], [https://pdbe.org/1zlm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zlm RCSB], [https://www.ebi.ac.uk/pdbsum/1zlm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zlm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/OSTF1_HUMAN OSTF1_HUMAN]] Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.<ref>PMID:10092216</ref>	+	[https://www.uniprot.org/uniprot/OSTF1_HUMAN OSTF1_HUMAN] Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.<ref>PMID:10092216</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, L]]	+	[[Category: Chen L]]
-	[[Category: DiGiammarino, E]]	+	[[Category: DiGiammarino E]]
-	[[Category: Harold, H]]	+	[[Category: Harold H]]
-	[[Category: Meehan~~, E J~~]]	+	[[Category: Meehan EJ]]
-	[[Category: Toh, D]]	+	[[Category: Toh D]]
-	[[Category: Wang, Y]]	+	[[Category: Wang Y]]
-	[[Category: Wells, D]]	+	[[Category: Wells D]]
-	[[Category: Zhou, J]]	+	[[Category: Zhou J]]
-	~~[[Category: Beta barrel]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 09:06, 20 January 2021

OCA — Wed, 20 Jan 2021 09:06:21 GMT

←Older revision		Revision as of 09:06, 20 January 2021
Line 1:		Line 1:

	==Crystal structure of the SH3 domain of human osteoclast stimulating factor==		==Crystal structure of the SH3 domain of human osteoclast stimulating factor==
-	<StructureSection load='1zlm' size='340' side='right' caption='[[1zlm]], [[Resolution\|resolution]] 1.07Å' scene=''>	+	<StructureSection load='1zlm' size='340' side='right'caption='[[1zlm]], [[Resolution\|resolution]] 1.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zlm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLM OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ZLM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zlm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1ZLM FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OSTF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OSTF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1zlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zlm OCA], [http://pdbe.org/1zlm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zlm RCSB], [http://www.ebi.ac.uk/pdbsum/1zlm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zlm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1zlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zlm OCA], [http://pdbe.org/1zlm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zlm RCSB], [http://www.ebi.ac.uk/pdbsum/1zlm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zlm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chen, L]]		[[Category: Chen, L]]
	[[Category: DiGiammarino, E]]		[[Category: DiGiammarino, E]]

OCA at 09:02, 2 May 2018

OCA — Wed, 02 May 2018 09:02:36 GMT

←Older revision		Revision as of 09:02, 2 May 2018
Line 1:		Line 1:
		+
	==Crystal structure of the SH3 domain of human osteoclast stimulating factor==		==Crystal structure of the SH3 domain of human osteoclast stimulating factor==
	<StructureSection load='1zlm' size='340' side='right' caption='[[1zlm]], [[Resolution\|resolution]] 1.07Å' scene=''>		<StructureSection load='1zlm' size='340' side='right' caption='[[1zlm]], [[Resolution\|resolution]] 1.07Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1zlm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZLM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zlm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZLM FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OSTF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OSTF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zlm OCA], [http://pdbe.org/1zlm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zlm RCSB], [http://www.ebi.ac.uk/pdbsum/1zlm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zlm OCA], [http://pdbe.org/1zlm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zlm RCSB], [http://www.ebi.ac.uk/pdbsum/1zlm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zlm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zl/1zlm_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zl/1zlm_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:44, 8 February 2016

OCA — Mon, 08 Feb 2016 07:44:53 GMT

←Older revision		Revision as of 07:44, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zlm ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:22, 10 September 2015

OCA — Thu, 10 Sep 2015 09:22:49 GMT

←Older revision		Revision as of 09:22, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1zlm' size='340' side='right' caption='[[1zlm]], [[Resolution\|resolution]] 1.07Å' scene=''>		<StructureSection load='1zlm' size='340' side='right' caption='[[1zlm]], [[Resolution\|resolution]] 1.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zlm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZLM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zlm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZLM FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OSTF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OSTF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zlm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zlm RCSB], [http://www.ebi.ac.uk/pdbsum/1zlm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zlm OCA], [http://pdbe.org/1zlm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zlm RCSB], [http://www.ebi.ac.uk/pdbsum/1zlm PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1zlm" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chen, L]]		[[Category: Chen, L]]
	[[Category: DiGiammarino, E]]		[[Category: DiGiammarino, E]]

OCA at 21:44, 24 December 2014

OCA — Wed, 24 Dec 2014 21:44:21 GMT

←Older revision		Revision as of 21:44, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zlm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZLM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zlm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZLM FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OSTF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OSTF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zlm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zlm RCSB], [http://www.ebi.ac.uk/pdbsum/1zlm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zlm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zlm RCSB], [http://www.ebi.ac.uk/pdbsum/1zlm PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/OSTF1_HUMAN OSTF1_HUMAN]] Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.<ref>PMID:10092216</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Chen, L.]]	+	[[Category: Chen, L]]
-	[[Category: DiGiammarino, E.]]	+	[[Category: DiGiammarino, E]]
-	[[Category: Harold, H.]]	+	[[Category: Harold, H]]
-	[[Category: Meehan, E J.]]	+	[[Category: Meehan, E J]]
-	[[Category: Toh, D.]]	+	[[Category: Toh, D]]
-	[[Category: Wang, Y.]]	+	[[Category: Wang, Y]]
-	[[Category: Wells, D.]]	+	[[Category: Wells, D]]
-	[[Category: Zhou, J.]]	+	[[Category: Zhou, J]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 21:53, 29 September 2014

OCA — Mon, 29 Sep 2014 21:53:36 GMT

←Older revision		Revision as of 21:53, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1zlm.~~png\|left~~\|200px]]	+	==Crystal structure of the SH3 domain of human osteoclast stimulating factor==
		+	<StructureSection load='1zlm' size='340' side='right' caption='[[1zlm]], [[Resolution\|resolution]] 1.07Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1zlm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZLM FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OSTF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zlm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zlm RCSB], [http://www.ebi.ac.uk/pdbsum/1zlm PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zl/1zlm_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Osteoclast-stimulating factor (OSF) is an intracellular signaling protein, produced by osteoclasts themselves, that enhances osteoclast formation and bone resorption. It is thought to act via an Src-related signaling pathway and contains SH3 and ankyrin-repeat domains which are involved in protein-protein interactions. As part of a structure-based anti-bone-loss drug-design program, the atomic resolution X-ray structure of the recombinant human OSF SH3 domain (hOSF-SH3) has been determined. The domain, residues 12-72, yielded crystals that diffracted to the ultrahigh resolution of 1.07 A. The overall structure shows a characteristic SH3 fold consisting of two perpendicular beta-sheets that form a beta-barrel. Structure-based sequence alignment reveals that the putative proline-rich peptide-binding site of hOSF-SH3 consists of (i) residues that are highly conserved in the SH3-domain family, including residues Tyr21, Phe23, Trp49, Pro62, Asn64 and Tyr65, and (ii) residues that are less conserved and/or even specific to hOSF, including Thr22, Arg26, Thr27, Glu30, Asp46, Thr47, Asn48 and Leu60, which might be key to designing specific inhibitors for hOSF to fight osteoporosis and related bone-loss diseases. There are a total of 13 well defined water molecules forming hydrogen bonds with the above residues in and around the peptide-binding pocket. Some of those water molecules might be important for drug-design approaches. The hOSF-SH3 structure at atomic resolution provides an accurate framework for structure-based design of its inhibitors.

-	~~{{STRUCTURE_1zlm\| PDB=1zlm \| SCENE= }}~~	+	Structure of the SH3 domain of human osteoclast-stimulating factor at atomic resolution.,Chen L, Wang Y, Wells D, Toh D, Harold H, Zhou J, DiGiammarino E, Meehan EJ Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Sep 1;62(Pt, 9):844-8. Epub 2006 Aug 18. PMID:16946461<ref>PMID:16946461</ref>

-	~~===Crystal structure~~ of the ~~SH3 domain of human osteoclast stimulating factor===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16946461}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1zlm]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLM OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016946461<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, L.]]		[[Category: Chen, L.]]

OCA: Protected "1zlm" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 17:20:21 GMT

Protected "1zlm" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:20, 5 January 2013

OCA at 17:20, 5 January 2013

OCA — Sat, 05 Jan 2013 17:20:19 GMT

←Older revision		Revision as of 17:20, 5 January 2013
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-	{{Seed}}
	[[Image:1zlm.png\|left\|200px]]		[[Image:1zlm.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1zlm", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_1zlm\| PDB=1zlm \| SCENE= }}		{{STRUCTURE_1zlm\| PDB=1zlm \| SCENE= }}

	===Crystal structure of the SH3 domain of human osteoclast stimulating factor===		===Crystal structure of the SH3 domain of human osteoclast stimulating factor===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16946461}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16946461 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16946461}}		{{ABSTRACT_PUBMED_16946461}}

	==About this Structure==		==About this Structure==
-	~~1ZLM~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLM OCA].	+	[[1zlm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLM OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16946461~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016946461</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, L.]]		[[Category: Chen, L.]]
Line 34:		Line 22:
	[[Category: Zhou, J.]]		[[Category: Zhou, J.]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
-		+	[[Category: Signaling protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 20:17:44 2009''~~	+

OCA at 18:17, 16 February 2009

OCA — Mon, 16 Feb 2009 18:17:45 GMT

←Older revision		Revision as of 18:17, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1ZLM is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLM OCA].	+	1ZLM is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLM OCA].

	==Reference==		==Reference==
-	Structure of the SH3 domain of human osteoclast-stimulating factor at atomic resolution., Chen L, Wang Y, Wells D, Toh D, Harold H, Zhou J, DiGiammarino E, Meehan EJ, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Sep 1;62(Pt, 9):844-8. Epub 2006 Aug 18. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16946461 16946461]~~	+	<ref group="xtra">PMID:16946461</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Chen, L.]]		[[Category: Chen, L.]]
	[[Category: DiGiammarino, E.]]		[[Category: DiGiammarino, E.]]
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	[[Category: Beta barrel]]		[[Category: Beta barrel]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon ~~Jul 28 00~~:26:~~30 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:17:44 2009''