1znw - Revision history

OCA at 08:15, 25 October 2023

OCA — Wed, 25 Oct 2023 08:15:12 GMT

←Older revision		Revision as of 08:15, 25 October 2023
Line 3:		Line 3:
	<StructureSection load='1znw' size='340' side='right'caption='[[1znw]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1znw' size='340' side='right'caption='[[1znw]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1znw]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus~~ tuberculosis~~" (zopf 1883) klein 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZNW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1ZNW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1znw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZNW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZNW FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1znx\|1znx]], [[1zny\|1zny]], [[1znz\|1znz]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">gmk (RV1389) ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1znw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1znw OCA], [https://pdbe.org/1znw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1znw RCSB], [https://www.ebi.ac.uk/pdbsum/1znw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1znw ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1znw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1znw OCA], [~~http~~://pdbe.org/1znw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1znw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1znw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1znw ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KGUA_MYCTU KGUA_MYCTU]] Essential for recycling GMP and indirectly, cGMP (By similarity).[HAMAP-Rule:MF_00328]	+	[https://www.uniprot.org/uniprot/KGUA_MYCTU KGUA_MYCTU] Essential for recycling GMP and indirectly, cGMP (By similarity).[HAMAP-Rule:MF_00328]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Guanylate kinase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cherfils, J]]	+	[[Category: Mycobacterium tuberculosis]]
-	[[Category: Christova, P]]	+	[[Category: Cherfils J]]
-	[[Category: Girard, E]]	+	[[Category: Christova P]]
-	[[Category: Hible, G]]	+	[[Category: Girard E]]
-	[[Category: Munier-Lehmann, H]]	+	[[Category: Hible G]]
-	[[Category: Renault, L]]	+	[[Category: Munier-Lehmann H]]
-	[[Category: Seclaman, E]]	+	[[Category: Renault L]]
-	[[Category: Thompson, A]]	+	[[Category: Seclaman E]]
-	~~[[Category: Atp:gmp-phosphotransferase]]~~	+	[[Category: Thompson A]]
-	~~[[Category: Gmp kinase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 09:07, 20 January 2021

OCA — Wed, 20 Jan 2021 09:07:44 GMT

←Older revision		Revision as of 09:07, 20 January 2021
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	==Crystal Structure Of Unliganded Form Of Mycobacterium tuberculosis Guanylate Kinase==		==Crystal Structure Of Unliganded Form Of Mycobacterium tuberculosis Guanylate Kinase==
-	<StructureSection load='1znw' size='340' side='right' caption='[[1znw]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='1znw' size='340' side='right'caption='[[1znw]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1znw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZNW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ZNW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1znw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZNW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1ZNW FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1znx\|1znx]], [[1zny\|1zny]], [[1znz\|1znz]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1znx\|1znx]], [[1zny\|1zny]], [[1znz\|1znz]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gmk (RV1389) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gmk (RV1389) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1znw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1znw OCA], [http://pdbe.org/1znw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1znw RCSB], [http://www.ebi.ac.uk/pdbsum/1znw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1znw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1znw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1znw OCA], [http://pdbe.org/1znw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1znw RCSB], [http://www.ebi.ac.uk/pdbsum/1znw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1znw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 1znw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1znw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Guanylate kinase 3D structures\|Guanylate kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Guanylate kinase]]		[[Category: Guanylate kinase]]
		+	[[Category: Large Structures]]
	[[Category: Cherfils, J]]		[[Category: Cherfils, J]]
	[[Category: Christova, P]]		[[Category: Christova, P]]

OCA at 08:48, 2 May 2018

OCA — Wed, 02 May 2018 08:48:22 GMT

←Older revision		Revision as of 08:48, 2 May 2018
Line 1:		Line 1:
		+
	==Crystal Structure Of Unliganded Form Of Mycobacterium tuberculosis Guanylate Kinase==		==Crystal Structure Of Unliganded Form Of Mycobacterium tuberculosis Guanylate Kinase==
	<StructureSection load='1znw' size='340' side='right' caption='[[1znw]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1znw' size='340' side='right' caption='[[1znw]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gmk (RV1389) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gmk (RV1389) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1znw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1znw OCA], [http://pdbe.org/1znw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1znw RCSB], [http://www.ebi.ac.uk/pdbsum/1znw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1znw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1znw OCA], [http://pdbe.org/1znw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1znw RCSB], [http://www.ebi.ac.uk/pdbsum/1znw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1znw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zn/1znw_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zn/1znw_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1znw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1znw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1znw" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Guanylate kinase\|Guanylate kinase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:03, 12 September 2015

OCA — Sat, 12 Sep 2015 02:03:20 GMT

←Older revision		Revision as of 02:03, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='1znw' size='340' side='right' caption='[[1znw]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1znw' size='340' side='right' caption='[[1znw]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1znw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium~~ tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZNW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1znw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZNW FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1znx\|1znx]], [[1zny\|1zny]], [[1znz\|1znz]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1znx\|1znx]], [[1zny\|1zny]], [[1znz\|1znz]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gmk (RV1389) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 ~~Mycobacterium~~ tuberculosis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gmk (RV1389) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1znw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1znw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1znw RCSB], [http://www.ebi.ac.uk/pdbsum/1znw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1znw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1znw OCA], [http://pdbe.org/1znw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1znw RCSB], [http://www.ebi.ac.uk/pdbsum/1znw PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1znw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Guanylate kinase]]		[[Category: Guanylate kinase]]
-	[[Category: Mycobacterium tuberculosis]]
	[[Category: Cherfils, J]]		[[Category: Cherfils, J]]
	[[Category: Christova, P]]		[[Category: Christova, P]]

OCA at 22:24, 25 December 2014

OCA — Thu, 25 Dec 2014 22:24:53 GMT

←Older revision		Revision as of 22:24, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1znw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZNW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1znw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZNW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1znx\|1znx]], [[1zny\|1zny]], [[1znz\|1znz]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1znx\|1znx]], [[1zny\|1zny]], [[1znz\|1znz]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gmk (RV1389) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gmk (RV1389) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1znw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1znw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1znw RCSB], [http://www.ebi.ac.uk/pdbsum/1znw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1znw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1znw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1znw RCSB], [http://www.ebi.ac.uk/pdbsum/1znw PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KGUA_MYCTU KGUA_MYCTU]] Essential for recycling GMP and indirectly, cGMP (By similarity).[HAMAP-Rule:MF_00328]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Guanylate kinase]]		[[Category: Guanylate kinase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Cherfils, J.]]	+	[[Category: Cherfils, J]]
-	[[Category: Christova, P.]]	+	[[Category: Christova, P]]
-	[[Category: Girard, E.]]	+	[[Category: Girard, E]]
-	[[Category: Hible, G.]]	+	[[Category: Hible, G]]
-	[[Category: Munier-Lehmann, H.]]	+	[[Category: Munier-Lehmann, H]]
-	[[Category: Renault, L.]]	+	[[Category: Renault, L]]
-	[[Category: Seclaman, E.]]	+	[[Category: Seclaman, E]]
-	[[Category: Thompson, A.]]	+	[[Category: Thompson, A]]
	[[Category: Atp:gmp-phosphotransferase]]		[[Category: Atp:gmp-phosphotransferase]]
	[[Category: Gmp kinase]]		[[Category: Gmp kinase]]
-	[[Category: Guanylate kinase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 09:32, 29 September 2014

OCA — Mon, 29 Sep 2014 09:32:35 GMT

←Older revision		Revision as of 09:32, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1znw.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure Of Unliganded Form Of Mycobacterium tuberculosis Guanylate Kinase==
		+	<StructureSection load='1znw' size='340' side='right' caption='[[1znw]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1znw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZNW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1znx\|1znx]], [[1zny\|1zny]], [[1znz\|1znz]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gmk (RV1389) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1znw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1znw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1znw RCSB], [http://www.ebi.ac.uk/pdbsum/1znw PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zn/1znw_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacterial nucleoside monophosphate (NMP) kinases, which convert NMPs to nucleoside diphosphates (NDP), are investigated as potential antibacterial targets against pathogenic bacteria. Herein, we report the biochemical and structural characterization of GMP kinase from Mycobacterium tuberculosis (GMPKMt). GMPKMt is a monomer with an unusual specificity for ATP as a phosphate donor, a lower catalytic efficiency compared with eukaryotic GMPKs, and it carries two redox-sensitive cysteines in the central CORE domain. These properties were analyzed in the light of the high-resolution crystal structures of unbound, GMP-bound, and GDP-bound GMPKMt. The latter structure was obtained in both an oxidized form, in which the cysteines form a disulfide bridge, and a reduced form which is expected to correspond to the physiological enzyme. GMPKMt has a modular domain structure as most NMP kinases. However, it departs from eukaryotic GMPKs by the unusual conformation of its CORE domain, and by its partially open LID and GMP-binding domains which are the same in the apo-, GMP-bound, and GDP-bound forms. GMPKMt also features a unique GMP binding site which is less close-packed than that of mammalian GMPKs, and in which the replacement of a critical tyrosine by a serine removes a catalytic interaction. In contrast, the specificity of GMPKMt for ATP may be a general feature of GMPKs because of an invariant structural motif that recognizes the adenine base. Altogether, differences in domain dynamics and GMP binding between GMPKMt and mammalian GMPKs should reveal clues for the design of GMPKMt-specific inhibitors.

-	~~{{STRUCTURE_1znw\| PDB=1znw \| SCENE= }}~~	+	Unique GMP-binding site in Mycobacterium tuberculosis guanosine monophosphate kinase.,Hible G, Christova P, Renault L, Seclaman E, Thompson A, Girard E, Munier-Lehmann H, Cherfils J Proteins. 2006 Feb 1;62(2):489-500. PMID:16288457<ref>PMID:16288457</ref>

-	~~===Crystal Structure Of Unliganded Form Of Mycobacterium tuberculosis Guanylate Kinase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16288457}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1znw]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1ZNW OCA].~~	+

	==See Also==		==See Also==
	*[[Guanylate kinase\|Guanylate kinase]]		*[[Guanylate kinase\|Guanylate kinase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016288457<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Guanylate kinase]]		[[Category: Guanylate kinase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]

OCA at 22:21, 20 October 2012

OCA — Sat, 20 Oct 2012 22:21:49 GMT

←Older revision		Revision as of 22:21, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1znw]] is a 1 chain structure ~~of [[Guanylate kinase]]~~ with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZNW OCA].	+	[[1znw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZNW OCA].

	==See Also==		==See Also==

OCA: Protected "1znw" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 16:03:14 GMT

Protected "1znw" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:03, 27 July 2012

OCA at 16:03, 27 July 2012

OCA — Fri, 27 Jul 2012 16:03:12 GMT

←Older revision		Revision as of 16:03, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1znw.png\|left\|200px]]		[[Image:1znw.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1znw", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1znw\| PDB=1znw \| SCENE= }}		{{STRUCTURE_1znw\| PDB=1znw \| SCENE= }}

	===Crystal Structure Of Unliganded Form Of Mycobacterium tuberculosis Guanylate Kinase===		===Crystal Structure Of Unliganded Form Of Mycobacterium tuberculosis Guanylate Kinase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16288457}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16288457 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16288457}}		{{ABSTRACT_PUBMED_16288457}}

	==About this Structure==		==About this Structure==
-	~~1ZNW~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZNW OCA].	+	[[1znw]] is a 1 chain structure of [[Guanylate kinase]] with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZNW OCA].
		+
		+	==See Also==
		+	*[[Guanylate kinase\|Guanylate kinase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16288457~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016288457</ref><references group="xtra"/>
	[[Category: Guanylate kinase]]		[[Category: Guanylate kinase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
Line 37:		Line 28:
	[[Category: Gmp kinase]]		[[Category: Gmp kinase]]
	[[Category: Guanylate kinase]]		[[Category: Guanylate kinase]]
-		+	[[Category: Transferase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 09:40:53 2009''~~	+

OCA at 07:40, 18 February 2009

OCA — Wed, 18 Feb 2009 07:40:55 GMT

←Older revision		Revision as of 07:40, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1ZNW is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZNW OCA].	+	1ZNW is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZNW OCA].

	==Reference==		==Reference==
-	Unique GMP-binding site in Mycobacterium tuberculosis guanosine monophosphate kinase., Hible G, Christova P, Renault L, Seclaman E, Thompson A, Girard E, Munier-Lehmann H, Cherfils J, Proteins. 2006 Feb 1;62(2):489-500. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16288457 16288457]~~	+	<ref group="xtra">PMID:16288457</ref><references group="xtra"/>
	[[Category: Guanylate kinase]]		[[Category: Guanylate kinase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Single protein]]
	[[Category: Cherfils, J.]]		[[Category: Cherfils, J.]]
	[[Category: Christova, P.]]		[[Category: Christova, P.]]
Line 39:		Line 38:
	[[Category: Guanylate kinase]]		[[Category: Guanylate kinase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 15~~:58:~~45 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:40:53 2009''