1zqh - Revision history

OCA at 11:05, 2 August 2023

OCA — Wed, 02 Aug 2023 11:05:25 GMT

←Older revision		Revision as of 11:05, 2 August 2023
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	<StructureSection load='1zqh' size='340' side='right'caption='[[1zqh]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='1zqh' size='340' side='right'caption='[[1zqh]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zqh]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZQH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zqh]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZQH FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>[[7ice\|7ice]], [[7icf\|7icf]], [[7icg\|7icg]], [[7ich\|7ich]], [[7ici\|7ici]], [[7icj\|7icj]], [[7ick\|7ick]], [[7icl\|7icl]], [[7icm\|7icm]], [[7icn\|7icn]], [[7ico\|7ico]], [[7icp\|7icp]], [[7icq\|7icq]], [[7icr\|7icr]], [[7ics\|7ics]], [[7ict\|7ict]], [[7icu\|7icu]], [[7icv\|7icv]], [[8ica\|8ica]], [[8icb\|8icb]], [[8icc\|8icc]], [[8ice\|8ice]], [[8icf\|8icf]], [[8icg\|8icg]], [[8ich\|8ich]], [[8ici\|8ici]], [[8icj\|8icj]], [[8ick\|8ick]], [[8icl\|8icl]], [[8icm\|8icm]], [[8icn\|8icn]], [[8ico\|8ico]], [[8icp\|8icp]], [[8icq\|8icq]], [[8icr\|8icr]], [[8ics\|8ics]], [[8ict\|8ict]], [[8icu\|8icu]], [[8icv\|8icv]], [[8icw\|8icw]], [[8icx\|8icx]], [[8icy\|8icy]], [[8icz\|8icz]], [[9ica\|9ica]], [[9icb\|9icb]], [[9icc\|9icc]], [[9ice\|9ice]], [[9icf\|9icf]], [[9icg\|9icg]], [[9ich\|9ich]], [[9ici\|9ici]], [[9icj\|9icj]], [[9ick\|9ick]], [[9icl\|9icl]], [[9icm\|9icm]], [[9icn\|9icn]], [[9ico\|9ico]], [[9icp\|9icp]], [[9icq\|9icq]], [[9icr\|9icr]], [[9ics\|9ics]], [[9ict\|9ict]], [[9icu\|9icu]], [[9icv\|9icv]], [[9icw\|9icw]], [[9icx\|9icx]], [[9icy\|9icy]], [[1zqa\|1zqa]], [[1zqb\|1zqb]], [[1zqc\|1zqc]], [[1zqd\|1zqd]], [[1zqe\|1zqe]], [[1zqf\|1zqf]], [[1zqg\|1zqg]], [[1zqi\|1zqi]], [[1zqj\|1zqj]], [[1zqk\|1zqk]], [[1zql\|1zql]], [[1zqm\|1zqm]], [[1zqn\|1zqn]], [[1zqo\|1zqo]], [[1zqp\|1zqp]], [[1zqq\|1zqq]], [[1zqr\|1zqr]], [[1zqs\|1zqs]], [[1zqt\|1zqt]]</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zqh OCA], [https://pdbe.org/1zqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zqh RCSB], [https://www.ebi.ac.uk/pdbsum/1zqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zqh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zqh OCA], [https://pdbe.org/1zqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zqh RCSB], [https://www.ebi.ac.uk/pdbsum/1zqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zqh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>	+	[https://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</div>		</div>
	<div class="pdbe-citations 1zqh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1zqh" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[DNA polymerase 3D structures\|DNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Pelletier, H]]	+	[[Category: Pelletier H]]
-	[[Category: Sawaya~~, M R]]~~	+	[[Category: Sawaya MR]]
-	~~[[Category: Dna repair]]~~	+
-	~~[[Category: Dna replication]]~~	+
-	~~[[Category: Dna-directed dna polymerase]]~~	+
-	~~[[Category: Nucleotidyltransferase]]~~	+
-	~~[[Category: Transferase-dna complex~~]]	+

OCA at 08:23, 10 November 2021

OCA — Wed, 10 Nov 2021 08:23:45 GMT

←Older revision		Revision as of 08:23, 10 November 2021
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	<StructureSection load='1zqh' size='340' side='right'caption='[[1zqh]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='1zqh' size='340' side='right'caption='[[1zqh]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zqh]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZQH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ZQH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zqh]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZQH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[7ice\|7ice]], [[7icf\|7icf]], [[7icg\|7icg]], [[7ich\|7ich]], [[7ici\|7ici]], [[7icj\|7icj]], [[7ick\|7ick]], [[7icl\|7icl]], [[7icm\|7icm]], [[7icn\|7icn]], [[7ico\|7ico]], [[7icp\|7icp]], [[7icq\|7icq]], [[7icr\|7icr]], [[7ics\|7ics]], [[7ict\|7ict]], [[7icu\|7icu]], [[7icv\|7icv]], [[8ica\|8ica]], [[8icb\|8icb]], [[8icc\|8icc]], [[8ice\|8ice]], [[8icf\|8icf]], [[8icg\|8icg]], [[8ich\|8ich]], [[8ici\|8ici]], [[8icj\|8icj]], [[8ick\|8ick]], [[8icl\|8icl]], [[8icm\|8icm]], [[8icn\|8icn]], [[8ico\|8ico]], [[8icp\|8icp]], [[8icq\|8icq]], [[8icr\|8icr]], [[8ics\|8ics]], [[8ict\|8ict]], [[8icu\|8icu]], [[8icv\|8icv]], [[8icw\|8icw]], [[8icx\|8icx]], [[8icy\|8icy]], [[8icz\|8icz]], [[9ica\|9ica]], [[9icb\|9icb]], [[9icc\|9icc]], [[9ice\|9ice]], [[9icf\|9icf]], [[9icg\|9icg]], [[9ich\|9ich]], [[9ici\|9ici]], [[9icj\|9icj]], [[9ick\|9ick]], [[9icl\|9icl]], [[9icm\|9icm]], [[9icn\|9icn]], [[9ico\|9ico]], [[9icp\|9icp]], [[9icq\|9icq]], [[9icr\|9icr]], [[9ics\|9ics]], [[9ict\|9ict]], [[9icu\|9icu]], [[9icv\|9icv]], [[9icw\|9icw]], [[9icx\|9icx]], [[9icy\|9icy]], [[1zqa\|1zqa]], [[1zqb\|1zqb]], [[1zqc\|1zqc]], [[1zqd\|1zqd]], [[1zqe\|1zqe]], [[1zqf\|1zqf]], [[1zqg\|1zqg]], [[1zqi\|1zqi]], [[1zqj\|1zqj]], [[1zqk\|1zqk]], [[1zql\|1zql]], [[1zqm\|1zqm]], [[1zqn\|1zqn]], [[1zqo\|1zqo]], [[1zqp\|1zqp]], [[1zqq\|1zqq]], [[1zqr\|1zqr]], [[1zqs\|1zqs]], [[1zqt\|1zqt]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7ice\|7ice]], [[7icf\|7icf]], [[7icg\|7icg]], [[7ich\|7ich]], [[7ici\|7ici]], [[7icj\|7icj]], [[7ick\|7ick]], [[7icl\|7icl]], [[7icm\|7icm]], [[7icn\|7icn]], [[7ico\|7ico]], [[7icp\|7icp]], [[7icq\|7icq]], [[7icr\|7icr]], [[7ics\|7ics]], [[7ict\|7ict]], [[7icu\|7icu]], [[7icv\|7icv]], [[8ica\|8ica]], [[8icb\|8icb]], [[8icc\|8icc]], [[8ice\|8ice]], [[8icf\|8icf]], [[8icg\|8icg]], [[8ich\|8ich]], [[8ici\|8ici]], [[8icj\|8icj]], [[8ick\|8ick]], [[8icl\|8icl]], [[8icm\|8icm]], [[8icn\|8icn]], [[8ico\|8ico]], [[8icp\|8icp]], [[8icq\|8icq]], [[8icr\|8icr]], [[8ics\|8ics]], [[8ict\|8ict]], [[8icu\|8icu]], [[8icv\|8icv]], [[8icw\|8icw]], [[8icx\|8icx]], [[8icy\|8icy]], [[8icz\|8icz]], [[9ica\|9ica]], [[9icb\|9icb]], [[9icc\|9icc]], [[9ice\|9ice]], [[9icf\|9icf]], [[9icg\|9icg]], [[9ich\|9ich]], [[9ici\|9ici]], [[9icj\|9icj]], [[9ick\|9ick]], [[9icl\|9icl]], [[9icm\|9icm]], [[9icn\|9icn]], [[9ico\|9ico]], [[9icp\|9icp]], [[9icq\|9icq]], [[9icr\|9icr]], [[9ics\|9ics]], [[9ict\|9ict]], [[9icu\|9icu]], [[9icv\|9icv]], [[9icw\|9icw]], [[9icx\|9icx]], [[9icy\|9icy]], [[1zqa\|1zqa]], [[1zqb\|1zqb]], [[1zqc\|1zqc]], [[1zqd\|1zqd]], [[1zqe\|1zqe]], [[1zqf\|1zqf]], [[1zqg\|1zqg]], [[1zqi\|1zqi]], [[1zqj\|1zqj]], [[1zqk\|1zqk]], [[1zql\|1zql]], [[1zqm\|1zqm]], [[1zqn\|1zqn]], [[1zqo\|1zqo]], [[1zqp\|1zqp]], [[1zqq\|1zqq]], [[1zqr\|1zqr]], [[1zqs\|1zqs]], [[1zqt\|1zqt]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1zqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zqh OCA], [~~http~~://pdbe.org/1zqh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1zqh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1zqh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1zqh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zqh OCA], [https://pdbe.org/1zqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zqh RCSB], [https://www.ebi.ac.uk/pdbsum/1zqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zqh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>	+	[[https://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</div>		</div>
	<div class="pdbe-citations 1zqh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1zqh" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[DNA polymerase 3D structures\|DNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:45, 5 February 2020

OCA — Wed, 05 Feb 2020 09:45:36 GMT

←Older revision		Revision as of 09:45, 5 February 2020
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	==DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF A SODIUM-FREE ARTIFICIAL MOTHER LIQUOR AT PH 7.5==		==DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF A SODIUM-FREE ARTIFICIAL MOTHER LIQUOR AT PH 7.5==
-	<StructureSection load='1zqh' size='340' side='right' caption='[[1zqh]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<StructureSection load='1zqh' size='340' side='right'caption='[[1zqh]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zqh]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZQH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZQH FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zqh]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZQH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZQH FirstGlance]. <br>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1zqh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1zqh" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[DNA polymerase 3D structures\|DNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Pelletier, H]]		[[Category: Pelletier, H]]
	[[Category: Sawaya, M R]]		[[Category: Sawaya, M R]]

OCA at 09:11, 2 May 2018

OCA — Wed, 02 May 2018 09:11:18 GMT

←Older revision		Revision as of 09:11, 2 May 2018
Line 1:		Line 1:
		+
	==DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF A SODIUM-FREE ARTIFICIAL MOTHER LIQUOR AT PH 7.5==		==DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF A SODIUM-FREE ARTIFICIAL MOTHER LIQUOR AT PH 7.5==
	<StructureSection load='1zqh' size='340' side='right' caption='[[1zqh]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='1zqh' size='340' side='right' caption='[[1zqh]], [[Resolution\|resolution]] 3.10Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[7ice\|7ice]], [[7icf\|7icf]], [[7icg\|7icg]], [[7ich\|7ich]], [[7ici\|7ici]], [[7icj\|7icj]], [[7ick\|7ick]], [[7icl\|7icl]], [[7icm\|7icm]], [[7icn\|7icn]], [[7ico\|7ico]], [[7icp\|7icp]], [[7icq\|7icq]], [[7icr\|7icr]], [[7ics\|7ics]], [[7ict\|7ict]], [[7icu\|7icu]], [[7icv\|7icv]], [[8ica\|8ica]], [[8icb\|8icb]], [[8icc\|8icc]], [[8ice\|8ice]], [[8icf\|8icf]], [[8icg\|8icg]], [[8ich\|8ich]], [[8ici\|8ici]], [[8icj\|8icj]], [[8ick\|8ick]], [[8icl\|8icl]], [[8icm\|8icm]], [[8icn\|8icn]], [[8ico\|8ico]], [[8icp\|8icp]], [[8icq\|8icq]], [[8icr\|8icr]], [[8ics\|8ics]], [[8ict\|8ict]], [[8icu\|8icu]], [[8icv\|8icv]], [[8icw\|8icw]], [[8icx\|8icx]], [[8icy\|8icy]], [[8icz\|8icz]], [[9ica\|9ica]], [[9icb\|9icb]], [[9icc\|9icc]], [[9ice\|9ice]], [[9icf\|9icf]], [[9icg\|9icg]], [[9ich\|9ich]], [[9ici\|9ici]], [[9icj\|9icj]], [[9ick\|9ick]], [[9icl\|9icl]], [[9icm\|9icm]], [[9icn\|9icn]], [[9ico\|9ico]], [[9icp\|9icp]], [[9icq\|9icq]], [[9icr\|9icr]], [[9ics\|9ics]], [[9ict\|9ict]], [[9icu\|9icu]], [[9icv\|9icv]], [[9icw\|9icw]], [[9icx\|9icx]], [[9icy\|9icy]], [[1zqa\|1zqa]], [[1zqb\|1zqb]], [[1zqc\|1zqc]], [[1zqd\|1zqd]], [[1zqe\|1zqe]], [[1zqf\|1zqf]], [[1zqg\|1zqg]], [[1zqi\|1zqi]], [[1zqj\|1zqj]], [[1zqk\|1zqk]], [[1zql\|1zql]], [[1zqm\|1zqm]], [[1zqn\|1zqn]], [[1zqo\|1zqo]], [[1zqp\|1zqp]], [[1zqq\|1zqq]], [[1zqr\|1zqr]], [[1zqs\|1zqs]], [[1zqt\|1zqt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[7ice\|7ice]], [[7icf\|7icf]], [[7icg\|7icg]], [[7ich\|7ich]], [[7ici\|7ici]], [[7icj\|7icj]], [[7ick\|7ick]], [[7icl\|7icl]], [[7icm\|7icm]], [[7icn\|7icn]], [[7ico\|7ico]], [[7icp\|7icp]], [[7icq\|7icq]], [[7icr\|7icr]], [[7ics\|7ics]], [[7ict\|7ict]], [[7icu\|7icu]], [[7icv\|7icv]], [[8ica\|8ica]], [[8icb\|8icb]], [[8icc\|8icc]], [[8ice\|8ice]], [[8icf\|8icf]], [[8icg\|8icg]], [[8ich\|8ich]], [[8ici\|8ici]], [[8icj\|8icj]], [[8ick\|8ick]], [[8icl\|8icl]], [[8icm\|8icm]], [[8icn\|8icn]], [[8ico\|8ico]], [[8icp\|8icp]], [[8icq\|8icq]], [[8icr\|8icr]], [[8ics\|8ics]], [[8ict\|8ict]], [[8icu\|8icu]], [[8icv\|8icv]], [[8icw\|8icw]], [[8icx\|8icx]], [[8icy\|8icy]], [[8icz\|8icz]], [[9ica\|9ica]], [[9icb\|9icb]], [[9icc\|9icc]], [[9ice\|9ice]], [[9icf\|9icf]], [[9icg\|9icg]], [[9ich\|9ich]], [[9ici\|9ici]], [[9icj\|9icj]], [[9ick\|9ick]], [[9icl\|9icl]], [[9icm\|9icm]], [[9icn\|9icn]], [[9ico\|9ico]], [[9icp\|9icp]], [[9icq\|9icq]], [[9icr\|9icr]], [[9ics\|9ics]], [[9ict\|9ict]], [[9icu\|9icu]], [[9icv\|9icv]], [[9icw\|9icw]], [[9icx\|9icx]], [[9icy\|9icy]], [[1zqa\|1zqa]], [[1zqb\|1zqb]], [[1zqc\|1zqc]], [[1zqd\|1zqd]], [[1zqe\|1zqe]], [[1zqf\|1zqf]], [[1zqg\|1zqg]], [[1zqi\|1zqi]], [[1zqj\|1zqj]], [[1zqk\|1zqk]], [[1zql\|1zql]], [[1zqm\|1zqm]], [[1zqn\|1zqn]], [[1zqo\|1zqo]], [[1zqp\|1zqp]], [[1zqq\|1zqq]], [[1zqr\|1zqr]], [[1zqs\|1zqs]], [[1zqt\|1zqt]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zqh OCA], [http://pdbe.org/1zqh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zqh RCSB], [http://www.ebi.ac.uk/pdbsum/1zqh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zqh OCA], [http://pdbe.org/1zqh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zqh RCSB], [http://www.ebi.ac.uk/pdbsum/1zqh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zqh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zq/1zqh_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zq/1zqh_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1zqh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1zqh" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[DNA polymerase\|DNA polymerase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 03:04, 9 February 2016

OCA — Tue, 09 Feb 2016 03:04:34 GMT

←Older revision		Revision as of 03:04, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zqh ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:59, 10 September 2015

OCA — Thu, 10 Sep 2015 17:59:26 GMT

←Older revision		Revision as of 17:59, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1zqh' size='340' side='right' caption='[[1zqh]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='1zqh' size='340' side='right' caption='[[1zqh]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zqh]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZQH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZQH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zqh]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZQH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZQH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[7ice\|7ice]], [[7icf\|7icf]], [[7icg\|7icg]], [[7ich\|7ich]], [[7ici\|7ici]], [[7icj\|7icj]], [[7ick\|7ick]], [[7icl\|7icl]], [[7icm\|7icm]], [[7icn\|7icn]], [[7ico\|7ico]], [[7icp\|7icp]], [[7icq\|7icq]], [[7icr\|7icr]], [[7ics\|7ics]], [[7ict\|7ict]], [[7icu\|7icu]], [[7icv\|7icv]], [[8ica\|8ica]], [[8icb\|8icb]], [[8icc\|8icc]], [[8ice\|8ice]], [[8icf\|8icf]], [[8icg\|8icg]], [[8ich\|8ich]], [[8ici\|8ici]], [[8icj\|8icj]], [[8ick\|8ick]], [[8icl\|8icl]], [[8icm\|8icm]], [[8icn\|8icn]], [[8ico\|8ico]], [[8icp\|8icp]], [[8icq\|8icq]], [[8icr\|8icr]], [[8ics\|8ics]], [[8ict\|8ict]], [[8icu\|8icu]], [[8icv\|8icv]], [[8icw\|8icw]], [[8icx\|8icx]], [[8icy\|8icy]], [[8icz\|8icz]], [[9ica\|9ica]], [[9icb\|9icb]], [[9icc\|9icc]], [[9ice\|9ice]], [[9icf\|9icf]], [[9icg\|9icg]], [[9ich\|9ich]], [[9ici\|9ici]], [[9icj\|9icj]], [[9ick\|9ick]], [[9icl\|9icl]], [[9icm\|9icm]], [[9icn\|9icn]], [[9ico\|9ico]], [[9icp\|9icp]], [[9icq\|9icq]], [[9icr\|9icr]], [[9ics\|9ics]], [[9ict\|9ict]], [[9icu\|9icu]], [[9icv\|9icv]], [[9icw\|9icw]], [[9icx\|9icx]], [[9icy\|9icy]], [[1zqa\|1zqa]], [[1zqb\|1zqb]], [[1zqc\|1zqc]], [[1zqd\|1zqd]], [[1zqe\|1zqe]], [[1zqf\|1zqf]], [[1zqg\|1zqg]], [[1zqi\|1zqi]], [[1zqj\|1zqj]], [[1zqk\|1zqk]], [[1zql\|1zql]], [[1zqm\|1zqm]], [[1zqn\|1zqn]], [[1zqo\|1zqo]], [[1zqp\|1zqp]], [[1zqq\|1zqq]], [[1zqr\|1zqr]], [[1zqs\|1zqs]], [[1zqt\|1zqt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[7ice\|7ice]], [[7icf\|7icf]], [[7icg\|7icg]], [[7ich\|7ich]], [[7ici\|7ici]], [[7icj\|7icj]], [[7ick\|7ick]], [[7icl\|7icl]], [[7icm\|7icm]], [[7icn\|7icn]], [[7ico\|7ico]], [[7icp\|7icp]], [[7icq\|7icq]], [[7icr\|7icr]], [[7ics\|7ics]], [[7ict\|7ict]], [[7icu\|7icu]], [[7icv\|7icv]], [[8ica\|8ica]], [[8icb\|8icb]], [[8icc\|8icc]], [[8ice\|8ice]], [[8icf\|8icf]], [[8icg\|8icg]], [[8ich\|8ich]], [[8ici\|8ici]], [[8icj\|8icj]], [[8ick\|8ick]], [[8icl\|8icl]], [[8icm\|8icm]], [[8icn\|8icn]], [[8ico\|8ico]], [[8icp\|8icp]], [[8icq\|8icq]], [[8icr\|8icr]], [[8ics\|8ics]], [[8ict\|8ict]], [[8icu\|8icu]], [[8icv\|8icv]], [[8icw\|8icw]], [[8icx\|8icx]], [[8icy\|8icy]], [[8icz\|8icz]], [[9ica\|9ica]], [[9icb\|9icb]], [[9icc\|9icc]], [[9ice\|9ice]], [[9icf\|9icf]], [[9icg\|9icg]], [[9ich\|9ich]], [[9ici\|9ici]], [[9icj\|9icj]], [[9ick\|9ick]], [[9icl\|9icl]], [[9icm\|9icm]], [[9icn\|9icn]], [[9ico\|9ico]], [[9icp\|9icp]], [[9icq\|9icq]], [[9icr\|9icr]], [[9ics\|9ics]], [[9ict\|9ict]], [[9icu\|9icu]], [[9icv\|9icv]], [[9icw\|9icw]], [[9icx\|9icx]], [[9icy\|9icy]], [[1zqa\|1zqa]], [[1zqb\|1zqb]], [[1zqc\|1zqc]], [[1zqd\|1zqd]], [[1zqe\|1zqe]], [[1zqf\|1zqf]], [[1zqg\|1zqg]], [[1zqi\|1zqi]], [[1zqj\|1zqj]], [[1zqk\|1zqk]], [[1zql\|1zql]], [[1zqm\|1zqm]], [[1zqn\|1zqn]], [[1zqo\|1zqo]], [[1zqp\|1zqp]], [[1zqq\|1zqq]], [[1zqr\|1zqr]], [[1zqs\|1zqs]], [[1zqt\|1zqt]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zqh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zqh RCSB], [http://www.ebi.ac.uk/pdbsum/1zqh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zqh OCA], [http://pdbe.org/1zqh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zqh RCSB], [http://www.ebi.ac.uk/pdbsum/1zqh PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1zqh" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Pelletier, H]]		[[Category: Pelletier, H]]
	[[Category: Sawaya, M R]]		[[Category: Sawaya, M R]]

OCA at 09:31, 8 January 2015

OCA — Thu, 08 Jan 2015 09:31:32 GMT

←Older revision		Revision as of 09:31, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zqh]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZQH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZQH FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zqh]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZQH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZQH FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[7ice\|7ice]], [[7icf\|7icf]], [[7icg\|7icg]], [[7ich\|7ich]], [[7ici\|7ici]], [[7icj\|7icj]], [[7ick\|7ick]], [[7icl\|7icl]], [[7icm\|7icm]], [[7icn\|7icn]], [[7ico\|7ico]], [[7icp\|7icp]], [[7icq\|7icq]], [[7icr\|7icr]], [[7ics\|7ics]], [[7ict\|7ict]], [[7icu\|7icu]], [[7icv\|7icv]], [[8ica\|8ica]], [[8icb\|8icb]], [[8icc\|8icc]], [[8ice\|8ice]], [[8icf\|8icf]], [[8icg\|8icg]], [[8ich\|8ich]], [[8ici\|8ici]], [[8icj\|8icj]], [[8ick\|8ick]], [[8icl\|8icl]], [[8icm\|8icm]], [[8icn\|8icn]], [[8ico\|8ico]], [[8icp\|8icp]], [[8icq\|8icq]], [[8icr\|8icr]], [[8ics\|8ics]], [[8ict\|8ict]], [[8icu\|8icu]], [[8icv\|8icv]], [[8icw\|8icw]], [[8icx\|8icx]], [[8icy\|8icy]], [[8icz\|8icz]], [[9ica\|9ica]], [[9icb\|9icb]], [[9icc\|9icc]], [[9ice\|9ice]], [[9icf\|9icf]], [[9icg\|9icg]], [[9ich\|9ich]], [[9ici\|9ici]], [[9icj\|9icj]], [[9ick\|9ick]], [[9icl\|9icl]], [[9icm\|9icm]], [[9icn\|9icn]], [[9ico\|9ico]], [[9icp\|9icp]], [[9icq\|9icq]], [[9icr\|9icr]], [[9ics\|9ics]], [[9ict\|9ict]], [[9icu\|9icu]], [[9icv\|9icv]], [[9icw\|9icw]], [[9icx\|9icx]], [[9icy\|9icy]], [[1zqa\|1zqa]], [[1zqb\|1zqb]], [[1zqc\|1zqc]], [[1zqd\|1zqd]], [[1zqe\|1zqe]], [[1zqf\|1zqf]], [[1zqg\|1zqg]], [[1zqi\|1zqi]], [[1zqj\|1zqj]], [[1zqk\|1zqk]], [[1zql\|1zql]], [[1zqm\|1zqm]], [[1zqn\|1zqn]], [[1zqo\|1zqo]], [[1zqp\|1zqp]], [[1zqq\|1zqq]], [[1zqr\|1zqr]], [[1zqs\|1zqs]], [[1zqt\|1zqt]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[7ice\|7ice]], [[7icf\|7icf]], [[7icg\|7icg]], [[7ich\|7ich]], [[7ici\|7ici]], [[7icj\|7icj]], [[7ick\|7ick]], [[7icl\|7icl]], [[7icm\|7icm]], [[7icn\|7icn]], [[7ico\|7ico]], [[7icp\|7icp]], [[7icq\|7icq]], [[7icr\|7icr]], [[7ics\|7ics]], [[7ict\|7ict]], [[7icu\|7icu]], [[7icv\|7icv]], [[8ica\|8ica]], [[8icb\|8icb]], [[8icc\|8icc]], [[8ice\|8ice]], [[8icf\|8icf]], [[8icg\|8icg]], [[8ich\|8ich]], [[8ici\|8ici]], [[8icj\|8icj]], [[8ick\|8ick]], [[8icl\|8icl]], [[8icm\|8icm]], [[8icn\|8icn]], [[8ico\|8ico]], [[8icp\|8icp]], [[8icq\|8icq]], [[8icr\|8icr]], [[8ics\|8ics]], [[8ict\|8ict]], [[8icu\|8icu]], [[8icv\|8icv]], [[8icw\|8icw]], [[8icx\|8icx]], [[8icy\|8icy]], [[8icz\|8icz]], [[9ica\|9ica]], [[9icb\|9icb]], [[9icc\|9icc]], [[9ice\|9ice]], [[9icf\|9icf]], [[9icg\|9icg]], [[9ich\|9ich]], [[9ici\|9ici]], [[9icj\|9icj]], [[9ick\|9ick]], [[9icl\|9icl]], [[9icm\|9icm]], [[9icn\|9icn]], [[9ico\|9ico]], [[9icp\|9icp]], [[9icq\|9icq]], [[9icr\|9icr]], [[9ics\|9ics]], [[9ict\|9ict]], [[9icu\|9icu]], [[9icv\|9icv]], [[9icw\|9icw]], [[9icx\|9icx]], [[9icy\|9icy]], [[1zqa\|1zqa]], [[1zqb\|1zqb]], [[1zqc\|1zqc]], [[1zqd\|1zqd]], [[1zqe\|1zqe]], [[1zqf\|1zqf]], [[1zqg\|1zqg]], [[1zqi\|1zqi]], [[1zqj\|1zqj]], [[1zqk\|1zqk]], [[1zql\|1zql]], [[1zqm\|1zqm]], [[1zqn\|1zqn]], [[1zqo\|1zqo]], [[1zqp\|1zqp]], [[1zqq\|1zqq]], [[1zqr\|1zqr]], [[1zqs\|1zqs]], [[1zqt\|1zqt]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zqh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zqh RCSB], [http://www.ebi.ac.uk/pdbsum/1zqh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zqh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zqh RCSB], [http://www.ebi.ac.uk/pdbsum/1zqh PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Pelletier, H.]]	+	[[Category: Pelletier, H]]
-	[[Category: Sawaya, M R.]]	+	[[Category: Sawaya, M R]]
	[[Category: Dna repair]]		[[Category: Dna repair]]
	[[Category: Dna replication]]		[[Category: Dna replication]]

OCA at 03:36, 29 September 2014

OCA — Mon, 29 Sep 2014 03:36:29 GMT

←Older revision		Revision as of 03:36, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1zqh.~~png~~\|~~left~~\|200px]]	+	==DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF A SODIUM-FREE ARTIFICIAL MOTHER LIQUOR AT PH 7.5==
		+	<StructureSection load='1zqh' size='340' side='right' caption='[[1zqh]], [[Resolution\|resolution]] 3.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1zqh]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZQH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZQH FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[7ice\|7ice]], [[7icf\|7icf]], [[7icg\|7icg]], [[7ich\|7ich]], [[7ici\|7ici]], [[7icj\|7icj]], [[7ick\|7ick]], [[7icl\|7icl]], [[7icm\|7icm]], [[7icn\|7icn]], [[7ico\|7ico]], [[7icp\|7icp]], [[7icq\|7icq]], [[7icr\|7icr]], [[7ics\|7ics]], [[7ict\|7ict]], [[7icu\|7icu]], [[7icv\|7icv]], [[8ica\|8ica]], [[8icb\|8icb]], [[8icc\|8icc]], [[8ice\|8ice]], [[8icf\|8icf]], [[8icg\|8icg]], [[8ich\|8ich]], [[8ici\|8ici]], [[8icj\|8icj]], [[8ick\|8ick]], [[8icl\|8icl]], [[8icm\|8icm]], [[8icn\|8icn]], [[8ico\|8ico]], [[8icp\|8icp]], [[8icq\|8icq]], [[8icr\|8icr]], [[8ics\|8ics]], [[8ict\|8ict]], [[8icu\|8icu]], [[8icv\|8icv]], [[8icw\|8icw]], [[8icx\|8icx]], [[8icy\|8icy]], [[8icz\|8icz]], [[9ica\|9ica]], [[9icb\|9icb]], [[9icc\|9icc]], [[9ice\|9ice]], [[9icf\|9icf]], [[9icg\|9icg]], [[9ich\|9ich]], [[9ici\|9ici]], [[9icj\|9icj]], [[9ick\|9ick]], [[9icl\|9icl]], [[9icm\|9icm]], [[9icn\|9icn]], [[9ico\|9ico]], [[9icp\|9icp]], [[9icq\|9icq]], [[9icr\|9icr]], [[9ics\|9ics]], [[9ict\|9ict]], [[9icu\|9icu]], [[9icv\|9icv]], [[9icw\|9icw]], [[9icx\|9icx]], [[9icy\|9icy]], [[1zqa\|1zqa]], [[1zqb\|1zqb]], [[1zqc\|1zqc]], [[1zqd\|1zqd]], [[1zqe\|1zqe]], [[1zqf\|1zqf]], [[1zqg\|1zqg]], [[1zqi\|1zqi]], [[1zqj\|1zqj]], [[1zqk\|1zqk]], [[1zql\|1zql]], [[1zqm\|1zqm]], [[1zqn\|1zqn]], [[1zqo\|1zqo]], [[1zqp\|1zqp]], [[1zqq\|1zqq]], [[1zqr\|1zqr]], [[1zqs\|1zqs]], [[1zqt\|1zqt]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zqh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zqh RCSB], [http://www.ebi.ac.uk/pdbsum/1zqh PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zq/1zqh_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	X-ray crystallographic studies have shown that DNA binding by human polymerase beta (pol beta) occurs primarily through two structurally and sequentially homologous helix-hairpin-helix (HhH) motifs, one in the fingers subdomain and the other in the 8-kDa domain [Pelletier, H., Sawaya, M. R., Wolfle, W., Wilson, S. H., & Kraut, J. (1996a) Biochemistry 35, 12742-12761]. In that DNA binding by each HhH motif is facilitated by a metal ion, we set out to determine the identity of the metal ion that most likely binds to the HhH motif in vivo. Crystal soaking experiments were performed on human pol beta-DNA cocrystals with Mg2+, Ca2+, Na+, and K+, the four most prevalent metal ions in the cell, and in each case a data set was collected and the resulting structure was refined. Under the conditions tested, the HhH motifs of pol beta have an affinity for these biologically prevalent metal ions in the order Mg2+ < Ca2+ < Na+ < K+, with K+ displaying the strongest binding. Crystals soaked in the presence of Tl+, a commonly used spectroscopic probe for K+, were too X-ray-sensitive to establish the binding behavior of Tl+, but soaking experiments with Ba2+ and Cs+ resulted in relatively stable crystals that gave evidence of metal ion binding in both HhH motifs, confirming that larger monovalent and divalent metal ions are capable of binding to the HhH metal sites. Although Mn2+, which has been categorized as a potent polymerase mutagen, binds to the HhH motifs with a greater affinity than Mg2+, Mn2+ does not bind to the HhH motifs in the presence of equimolar concentrations of Na+. These results suggest that in vivo, where Mn2+ is present only in trace amounts, Mn2+ probably does not have a large effect on DNA binding and may instead manifest a mutagenic effect on pol beta primarily by distorting nucleotide binding or by directly affecting the catalytic step [Pelletier, H., Sawaya, M. R., Wolfle, W., Wilson, S. H., & Kraut, J. (1996b) Biochemistry 35, 12762-12777]. Crystal soaking experiments with 31-kDa apoenzyme crystals show that, in the absence of DNA, the HhH motif in the fingers subdomain binds metal ions with either much lower occupancy or not at all, indicating that metal ion binding is dependent on the presence of the DNA substrate.

-	~~{{STRUCTURE_1zqh\| PDB=1zqh \| SCENE= }}~~	+	Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis.,Pelletier H, Sawaya MR Biochemistry. 1996 Oct 1;35(39):12778-87. PMID:8841120<ref>PMID:8841120</ref>

-	~~===DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA~~; ~~SOAKED IN THE PRESENCE OF A SODIUM-FREE ARTIFICIAL MOTHER LIQUOR AT PH 7.5===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_8841120}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1zqh]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1ZQH OCA].~~	+

	==See Also==		==See Also==
	*[[DNA polymerase\|DNA polymerase]]		*[[DNA polymerase\|DNA polymerase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:008841120<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Pelletier, H.]]		[[Category: Pelletier, H.]]

OCA at 12:25, 20 October 2012

OCA — Sat, 20 Oct 2012 12:25:30 GMT

←Older revision		Revision as of 12:25, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1zqh]] is a 3 chain structure ~~of [[DNA polymerase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZQH OCA].	+	[[1zqh]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZQH OCA].

	==See Also==		==See Also==

OCA: Protected "1zqh" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 08:40:44 GMT

Protected "1zqh" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:40, 26 July 2012